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USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.

Jean-Charles PY, Wu JH, Zhang L, Kaur S, Nepliouev I, Stiber JA, Brian L, Qi R, Wertman V, Shenoy SK, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2295-2305. doi: 10.1161/ATVBAHA.118.311071.


Drebrin regulates angiotensin II-induced aortic remodelling.

Zhang L, Wu JH, Huang TQ, Nepliouev I, Brian L, Zhang Z, Wertman V, Rudemiller NP, McMahon TJ, Shenoy SK, Miller FJ, Crowley SD, Freedman NJ, Stiber JA.

Cardiovasc Res. 2018 Nov 1;114(13):1806-1815. doi: 10.1093/cvr/cvy151.


Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.

Zhang L, Wu JH, Otto JC, Gurley SB, Hauser ER, Shenoy SK, Nagi K, Brian L, Wertman V, Mattocks N, Lawson JH, Freedman NJ.

Cardiovasc Res. 2017 Nov 1;113(13):1551-1559. doi: 10.1093/cvr/cvx177.


C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways.

Smith JS, Alagesan P, Desai NK, Pack TF, Wu JH, Inoue A, Freedman NJ, Rajagopal S.

Mol Pharmacol. 2017 Aug;92(2):136-150. doi: 10.1124/mol.117.108522. Epub 2017 May 30.


Regulation of inflammation by β-arrestins: Not just receptor tales.

Freedman NJ, Shenoy SK.

Cell Signal. 2018 Jan;41:41-45. doi: 10.1016/j.cellsig.2017.02.008. Epub 2017 Feb 9. Review.


Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination.

Jean-Charles PY, Freedman NJ, Shenoy SK.

Prog Mol Biol Transl Sci. 2016;141:339-69. doi: 10.1016/bs.pmbts.2016.04.003. Epub 2016 May 7. Review.


The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.

Stiber JA, Wu JH, Zhang L, Nepliouev I, Zhang ZS, Bryson VG, Brian L, Bentley RC, Gordon-Weeks PR, Rosenberg PB, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):984-93. doi: 10.1161/ATVBAHA.115.306140. Epub 2016 Mar 24.


Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.

Jean-Charles PY, Zhang L, Wu JH, Han SO, Brian L, Freedman NJ, Shenoy SK.

J Biol Chem. 2016 Apr 1;291(14):7450-64. doi: 10.1074/jbc.M115.687129. Epub 2016 Feb 2.


Kruppel-like factor 15 is critical for vascular inflammation.

Lu Y, Zhang L, Liao X, Sangwung P, Prosdocimo DA, Zhou G, Votruba AR, Brian L, Han YJ, Gao H, Wang Y, Shimizu K, Weinert-Stein K, Khrestian M, Simon DI, Freedman NJ, Jain MK.

J Clin Invest. 2013 Oct;123(10):4232-41. doi: 10.1172/JCI68552. Epub 2013 Sep 3.


Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion.

Chandra R, Wang Y, Shahid RA, Vigna SR, Freedman NJ, Liddle RA.

J Clin Invest. 2013 Aug;123(8):3343-52. doi: 10.1172/JCI68587. Epub 2013 Jul 25.


Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.

Wu JH, Fanaroff AC, Sharma KC, Smith LS, Brian L, Eipper BA, Mains RE, Freedman NJ, Zhang L.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):702-8. doi: 10.1161/ATVBAHA.112.300234. Epub 2013 Jan 3.


MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.

Han SO, Xiao K, Kim J, Wu JH, Wisler JW, Nakamura N, Freedman NJ, Shenoy SK.

J Cell Biol. 2012 Nov 26;199(5):817-30. doi: 10.1083/jcb.201208192. Epub 2012 Nov 19.


Vein graft neointimal hyperplasia is exacerbated by CXCR4 signaling in vein graft-extrinsic cells.

Zhang L, Brian L, Freedman NJ.

J Vasc Surg. 2012 Nov;56(5):1390-7. doi: 10.1016/j.jvs.2012.03.254. Epub 2012 Jul 15.


G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

Wu JH, Zhang L, Fanaroff AC, Cai X, Sharma KC, Brian L, Exum ST, Shenoy SK, Peppel K, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):308-16. doi: 10.1161/ATVBAHA.111.239608. Epub 2011 Nov 17.


Human umbilical cord blood-derived endothelial cells reendothelialize vein grafts and prevent thrombosis.

Brown MA, Zhang L, Levering VW, Wu JH, Satterwhite LL, Brian L, Freedman NJ, Truskey GA.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2150-5. doi: 10.1161/ATVBAHA.110.207076. Epub 2010 Aug 26.


Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice.

Zhu S, Malhotra A, Zhang L, Deng S, Zhang T, Freedman NJ, Storms R, Peppel K, Goldschmidt-Clermont PJ, Dong C.

Atherosclerosis. 2010 Sep;212(1):63-9. doi: 10.1016/j.atherosclerosis.2010.04.018. Epub 2010 Apr 21.


Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.

Zhang L, Connelly JJ, Peppel K, Brian L, Shah SH, Nelson S, Crosslin DR, Wang T, Allen A, Kraus WE, Gregory SG, Hauser ER, Freedman NJ.

Hum Mol Genet. 2010 Jul 15;19(14):2754-66. doi: 10.1093/hmg/ddq172. Epub 2010 Apr 26.


Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly JJ, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJ, Vance J, Sketch MH, Granger CB, Newgard CB, Gregory SG, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER.

PLoS Genet. 2009 Jan;5(1):e1000318. doi: 10.1371/journal.pgen.1000318. Epub 2009 Jan 2.


Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.

Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ.

Mol Pharmacol. 2009 Mar;75(3):626-36. doi: 10.1124/mol.108.050278. Epub 2008 Dec 17.


Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.

Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM.

J Biol Chem. 2008 Aug 8;283(32):22166-76. doi: 10.1074/jbc.M709668200. Epub 2008 Jun 10.


Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.

Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ.

Circ Res. 2008 Jul 3;103(1):70-9. doi: 10.1161/CIRCRESAHA.108.172338. Epub 2008 Jun 2.


Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.

Wang L, Hauser ER, Shah SH, Seo D, Sivashanmugam P, Exum ST, Gregory SG, Granger CB, Haines JL, Jones CJ, Crossman D, Haynes C, Kraus WE, Freedman NJ, Pericak-Vance MA, Goldschmidt-Clermont PJ, Vance JM.

Ann Hum Genet. 2008 Jul;72(Pt 4):443-53. doi: 10.1111/j.1469-1809.2008.00433.x. Epub 2008 Jul 3.


Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery.

Zhang L, Sivashanmugam P, Wu JH, Brian L, Exum ST, Freedman NJ, Peppel K.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):284-9. Epub 2007 Nov 15.


Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.

Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H.

Mol Pharmacol. 2007 Sep;72(3):582-91. Epub 2007 Jun 15.


Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis.

Zhang L, Peppel K, Sivashanmugam P, Orman ES, Brian L, Exum ST, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1087-94.


Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.

Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ.

J Biol Chem. 2006 Dec 8;281(49):37758-72. Epub 2006 Oct 3.


Novel--and "neu"--therapeutic possibilities for heart failure.

Freedman NJ, Ginsburg GS.

J Am Coll Cardiol. 2006 Oct 3;48(7):1448-50. Epub 2006 Sep 14. No abstract available.


New therapeutic possibilities for vein graft disease in the post-edifoligide era.

Cai X, Freedman NJ.

Future Cardiol. 2006 Jul;2(4):493-501. doi: 10.2217/14796678.2.4.493.


The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.

Wu JH, Goswami R, Kim LK, Miller WE, Peppel K, Freedman NJ.

J Biol Chem. 2005 Sep 2;280(35):31027-35. Epub 2005 Jul 1.


Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms.

Peppel K, Zhang L, Orman ES, Hagen PO, Amalfitano A, Brian L, Freedman NJ.

Cardiovasc Res. 2005 Feb 15;65(3):674-82.


Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells.

Zhang L, Peppel K, Brian L, Chien L, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2277-83. Epub 2004 Oct 14.


Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.

Freedman NJ, Lefkowitz RJ.

J Clin Invest. 2004 May;113(10):1379-82. Review.


Graft-extrinsic cells predominate in vein graft arterialization.

Zhang L, Freedman NJ, Brian L, Peppel K.

Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):470-6. Epub 2004 Jan 15.


The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.

Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, Exum ST, Freedman NJ.

J Biol Chem. 2003 Nov 7;278(45):44238-45. Epub 2003 Aug 27.


Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.

Peppel K, Zhang L, Huynh TT, Huang X, Jacobson A, Brian L, Exum ST, Hagen PO, Freedman NJ.

J Mol Cell Cardiol. 2002 Oct;34(10):1399-1409.


Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model.

Zhang L, Hagen PO, Kisslo J, Peppel K, Freedman NJ.

J Vasc Surg. 2002 Oct;36(4):824-32.


Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.

Liang M, Freedman NJ, Theiss CT, Liggett SB.

Biochemistry. 2001 Dec 11;40(49):15031-7.


G protein-coupled receptor kinases.

Pitcher JA, Freedman NJ, Lefkowitz RJ.

Annu Rev Biochem. 1998;67:653-92. Review.


Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.

Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ.

J Biol Chem. 1997 Jul 11;272(28):17734-43.


Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

Oppermann M, Diversé-Pierluissi M, Drazner MH, Dyer SL, Freedman NJ, Peppel KC, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7649-54.


Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ.

J Biol Chem. 1996 May 31;271(22):13266-72.


Desensitization of G protein-coupled receptors.

Freedman NJ, Lefkowitz RJ.

Recent Prog Horm Res. 1996;51:319-51; discussion 352-3. Review.


A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

Barak LS, Tiberi M, Freedman NJ, Kwatra MM, Lefkowitz RJ, Caron MG.

J Biol Chem. 1994 Jan 28;269(4):2790-5.


Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR.

J Biol Chem. 1994 Jan 14;269(2):1125-30.


Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level.

Freedman SF, Freedman NJ, Shields MB, Lobaugh B, Samsa GP, Keates EU, Ollie A.

Am J Ophthalmol. 1993 Nov 15;116(5):600-11.


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