Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 50

1.
2.

Potential Therapeutic Effects of Mepacrine against Clostridium perfringens Enterotoxin in a Mouse Model of Enterotoxemia.

Navarro MA, Shrestha A, Freedman JC, Beingesser J, McClane BA, Uzal FA.

Infect Immun. 2019 Mar 25;87(4). pii: e00670-18. doi: 10.1128/IAI.00670-18. Print 2019 Apr.

PMID:
30642896
3.

The Borrelia burgdorferi c-di-GMP Binding Receptors, PlzA and PlzB, Are Functionally Distinct.

Kostick-Dunn JL, Izac JR, Freedman JC, Szkotnicki LT, Oliver LD Jr, Marconi RT.

Front Cell Infect Microbiol. 2018 Jul 11;8:213. doi: 10.3389/fcimb.2018.00213. eCollection 2018.

4.

Comparative pathogenesis of enteric clostridial infections in humans and animals.

Uzal FA, Navarro MA, Li J, Freedman JC, Shrestha A, McClane BA.

Anaerobe. 2018 Oct;53:11-20. doi: 10.1016/j.anaerobe.2018.06.002. Epub 2018 Jun 5. Review.

PMID:
29883627
5.

Evidence that Clostridium perfringens Enterotoxin-Induced Intestinal Damage and Enterotoxemic Death in Mice Can Occur Independently of Intestinal Caspase-3 Activation.

Freedman JC, Navarro MA, Morrell E, Beingesser J, Shrestha A, McClane BA, Uzal FA.

Infect Immun. 2018 Jun 21;86(7). pii: e00931-17. doi: 10.1128/IAI.00931-17. Print 2018 Jul.

6.

12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.

Tourdot BE, Adili R, Isingizwe ZR, Ebrahem M, Freedman JC, Holman TR, Holinstat M.

Blood Adv. 2017 Jun 23;1(15):1124-1131. doi: 10.1182/bloodadvances.2017006155. eCollection 2017 Jun 27.

7.

The Potential Therapeutic Agent Mepacrine Protects Caco-2 Cells against Clostridium perfringens Enterotoxin Action.

Freedman JC, Hendricks MR, McClane BA.

mSphere. 2017 Aug 30;2(4). pii: e00352-17. doi: 10.1128/mSphere.00352-17. eCollection 2017 Jul-Aug.

8.

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.

Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1828-1839. doi: 10.1161/ATVBAHA.117.309868. Epub 2017 Aug 3.

9.

NanR Regulates nanI Sialidase Expression by Clostridium perfringens F4969, a Human Enteropathogenic Strain.

Li J, Evans DR, Freedman JC, McClane BA.

Infect Immun. 2017 Aug 18;85(9). pii: e00241-17. doi: 10.1128/IAI.00241-17. Print 2017 Sep.

10.

Pathology of Naturally Occurring Bacillary Hemoglobinuria in Cattle.

Navarro MA, Dutra F, Briano C, Romero A, Persiani M, Freedman JC, Morrell E, Beingesser J, Uzal FA.

Vet Pathol. 2017 May;54(3):457-466. doi: 10.1177/0300985816688945. Epub 2017 Jan 1.

PMID:
28438111
11.

CodY Promotes Sporulation and Enterotoxin Production by Clostridium perfringens Type A Strain SM101.

Li J, Freedman JC, Evans DR, McClane BA.

Infect Immun. 2017 Feb 23;85(3). pii: e00855-16. doi: 10.1128/IAI.00855-16. Print 2017 Mar.

12.

Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions.

Mallory KL, Miller DP, Oliver LD Jr, Freedman JC, Kostick-Dunn JL, Carlyon JA, Marion JD, Bell JK, Marconi RT.

Pathog Dis. 2016 Nov;74(8). pii: ftw105. Epub 2016 Oct 18.

PMID:
27852620
13.

Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency.

Armstrong M, van Hoorebeke C, Horn T, Deschamps J, Freedman JC, Kalyanaraman C, Jacobson MP, Holman T.

Bioorg Med Chem. 2016 Nov 1;24(21):5380-5387. doi: 10.1016/j.bmc.2016.08.063. Epub 2016 Aug 31.

14.

New insights into Clostridium perfringens epsilon toxin activation and action on the brain during enterotoxemia.

Freedman JC, McClane BA, Uzal FA.

Anaerobe. 2016 Oct;41:27-31. doi: 10.1016/j.anaerobe.2016.06.006. Epub 2016 Jun 16. Review.

PMID:
27321761
15.

Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications.

Freedman JC, Shrestha A, McClane BA.

Toxins (Basel). 2016 Mar 16;8(3). pii: E73. doi: 10.3390/toxins8030073. Review.

16.

NanI Sialidase, CcpA, and CodY Work Together To Regulate Epsilon Toxin Production by Clostridium perfringens Type D Strain CN3718.

Li J, Freedman JC, McClane BA.

J Bacteriol. 2015 Oct;197(20):3339-53. doi: 10.1128/JB.00349-15. Epub 2015 Aug 10.

17.

Proteolytic processing and activation of Clostridium perfringens epsilon toxin by caprine small intestinal contents.

Freedman JC, Li J, Uzal FA, McClane BA.

MBio. 2014 Oct 21;5(5):e01994-14. doi: 10.1128/mBio.01994-14.

18.

Clostridium perfringens type A-E toxin plasmids.

Freedman JC, Theoret JR, Wisniewski JA, Uzal FA, Rood JI, McClane BA.

Res Microbiol. 2015 May;166(4):264-79. doi: 10.1016/j.resmic.2014.09.004. Epub 2014 Oct 2. Review.

19.

Synergistic effects of Clostridium perfringens enterotoxin and beta toxin in rabbit small intestinal loops.

Ma M, Gurjar A, Theoret JR, Garcia JP, Beingesser J, Freedman JC, Fisher DJ, McClane BA, Uzal FA.

Infect Immun. 2014 Jul;82(7):2958-70. doi: 10.1128/IAI.01848-14. Epub 2014 Apr 28.

20.

Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.

Uzal FA, Freedman JC, Shrestha A, Theoret JR, Garcia J, Awad MM, Adams V, Moore RJ, Rood JI, McClane BA.

Future Microbiol. 2014;9(3):361-77. doi: 10.2217/fmb.13.168. Review.

21.

Clostridium perfringens type A enterotoxin damages the rabbit colon.

Garcia JP, Li J, Shrestha A, Freedman JC, Beingesser J, McClane BA, Uzal FA.

Infect Immun. 2014 Jun;82(6):2211-8. doi: 10.1128/IAI.01659-14. Epub 2014 Mar 18.

22.

Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi.

Freedman JC, Rogers EA, Kostick JL, Zhang H, Iyer R, Schwartz I, Marconi RT.

FEMS Immunol Med Microbiol. 2010 Mar;58(2):285-94. doi: 10.1111/j.1574-695X.2009.00635.x. Epub 2009 Nov 23.

23.

Identification of an antiparallel coiled-coil/loop domain required for ligand binding by the Borrelia hermsii FhbA protein: additional evidence for the role of FhbA in the host-pathogen interaction.

Hovis KM, Freedman JC, Zhang H, Forbes JL, Marconi RT.

Infect Immun. 2008 May;76(5):2113-22. doi: 10.1128/IAI.01266-07. Epub 2008 Feb 25. Erratum in: Infect Immun. 2008 Jul;76(7):3358.

24.

Segmental pulmonary vascular responses to ATP in rat lungs: role of nitric oxide.

Hakim TS, Ferrario L, Freedman JC, Carlin RE, Camporesi EM.

J Appl Physiol (1985). 1997 Mar;82(3):852-8.

26.
27.

Cellular deformability of normoxic and hypoxic mammalian red blood cells.

Kaniewski WS, Hakim TS, Freedman JC.

Biorheology. 1994 Jan-Feb;31(1):91-101.

PMID:
8173047
28.

Proton (or hydroxide) fluxes and the biphasic osmotic response of human red blood cells.

Bisognano JD, Dix JA, Pratap PR, Novak TS, Freedman JC.

J Gen Physiol. 1993 Jul;102(1):99-123.

29.

Quantitative analysis of oxonol V fluorescence in submitochondrial particles.

Freedman JC, Novak TS, Penefsky HS, Stein WD.

Ann N Y Acad Sci. 1992 Nov 30;671:493-6. No abstract available.

PMID:
1337685
30.
31.

Use of triphenylmethylphosphonium to measure membrane potentials in red blood cells.

Freedman JC, Novak TS.

Methods Enzymol. 1989;173:94-100. No abstract available.

PMID:
2779444
32.

Optical measurement of membrane potential in cells, organelles, and vesicles.

Freedman JC, Novak TS.

Methods Enzymol. 1989;172:102-22. No abstract available.

PMID:
2747524
33.

Impermeant potential-sensitive oxonol dyes: III. The dependence of the absorption signal on membrane potential.

George EB, Nyirjesy P, Pratap PR, Freedman JC, Waggoner AS.

J Membr Biol. 1988 Oct;105(1):55-64.

PMID:
3225836
34.

Impermeant potential-sensitive oxonol dyes: II. The dependence of the absorption signal on the length of alkyl substituents attached to the dye.

Nyirjesy P, George EB, Gupta RK, Basson M, Pratap PR, Freedman JC, Raman K, Waggoner AS.

J Membr Biol. 1988 Oct;105(1):45-53.

PMID:
3225835
35.

Membrane lipid fluidity and filterability of red blood cells from adults and newborns.

Crespo LM, Bifano EM, Freedman JC.

Pediatr Res. 1988 Oct;24(4):433-7.

PMID:
3140204
36.

Impermeant potential-sensitive oxonol dyes: I. Evidence for an "on-off" mechanism.

George EB, Nyirjesy P, Basson M, Ernst LA, Pratap PR, Freedman JC, Waggoner AS.

J Membr Biol. 1988 Aug;103(3):245-53.

PMID:
3184175
37.

Membrane potential and the cytotoxic Ca cascade of human red blood cells.

Freedman JC, Bifano EM, Crespo LM, Pratap PR, Walenga R, Bailey RE, Zuk S, Novak TS.

Soc Gen Physiol Ser. 1988;43:217-31. Review. No abstract available.

PMID:
3077548
38.

Calcium, cell shrinkage, and prolytic state of human red blood cells.

Crespo LM, Novak TS, Freedman JC.

Am J Physiol. 1987 Feb;252(2 Pt 1):C138-52.

PMID:
3103462
39.

Inhibition of renal Na+, K+-adenosine triphosphatase by gentamicin.

Williams PD, Trimble ME, Crespo L, Holohan PD, Freedman JC, Ross CR.

J Pharmacol Exp Ther. 1984 Nov;231(2):248-53.

PMID:
6092609
40.

Relationship between the shape and the membrane potential of human red blood cells.

Bifano EM, Novak TS, Freedman JC.

J Membr Biol. 1984;82(1):1-13.

PMID:
6502697
41.

Partial requirements for in vitro survival of human red blood cells.

Freedman JC.

J Membr Biol. 1983;75(3):225-31.

PMID:
6631943
43.

A slow process in the effect of lithium therapy on countertransport.

Diamond JM, Ehrlich BE, Freedman JC.

N Engl J Med. 1982 Dec 23;307(26):1646. No abstract available.

PMID:
7144858
44.

Electrophysiology of cells and organelles: studies with optical potentiometric indicators.

Freedman JC, Laris PC.

Int Rev Cytol Suppl. 1981;12:177-246. Review. No abstract available.

PMID:
7019119
45.

Electrical resistance of the red cell membrane and the relation between net anion transport and the anion exchange mechanism.

Hoffman JF, Kaplan JH, Callahan TJ, Freedman JC.

Ann N Y Acad Sci. 1980;341:357-60. No abstract available.

PMID:
6930839
46.

Ionic and osmotic equilibria of human red blood cells treated with nystatin.

Freedman JC, Hoffman JF.

J Gen Physiol. 1979 Aug;74(2):157-85.

48.

Partial restoration of sodium and potassium gradients by human erythrocyte membranes.

Freedman JC.

Biochim Biophys Acta. 1976 Dec 14;455(3):989-92. No abstract available.

PMID:
999949
49.

Lack of erythrocyte superoxide dismutase change during human senescence.

Stevens C, Goldblatt MJ, Freedman JC.

Mech Ageing Dev. 1975 Sep-Dec;4(5-6):415-21.

PMID:
1228339
50.

Do red cell ghosts pump sodium or potassium?

Freedman JC.

Ann N Y Acad Sci. 1973 Mar 30;204:609-15. No abstract available.

PMID:
4267494

Supplemental Content

Loading ...
Support Center