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Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts.

Jana S, Zhang H, Lopaschuk GD, Freed DH, Sergi C, Kantor PF, Oudit GY, Kassiri Z.

J Am Heart Assoc. 2018 Oct 2;7(19):e010427. doi: 10.1161/JAHA.118.010427.


Preoperative Predictors of Mortality in Short-Term Continuous-Flow Ventricular Assist Devices.

Bozso SJ, Buchholz H, Pidborochynski T, Freed DH, MacArthur RG, Conway J.

ASAIO J. 2018 Oct 10. doi: 10.1097/MAT.0000000000000902. [Epub ahead of print]


High-frequency dielectric response of a spheroidal particle with a thin double layer.

Freed DE.

Phys Rev E. 2018 Aug;98(2-1):022607. doi: 10.1103/PhysRevE.98.022607.


Ex vivo perfusion induces a time- and perfusate-dependent molecular repair response in explanted porcine lungs.

Dromparis P, Aboelnazar NS, Wagner S, Himmat S, White CW, Hatami S, Luc JGY, Rotich S, Freed DH, Nagendran J, Mengel M, Adam BA.

Am J Transplant. 2018 Sep 19. doi: 10.1111/ajt.15123. [Epub ahead of print]


An mHealth App for Self-Management of Chronic Lower Back Pain (Limbr): Pilot Study.

Selter A, Tsangouri C, Ali SB, Freed D, Vatchinsky A, Kizer J, Sahuguet A, Vojta D, Vad V, Pollak JP, Estrin D.

JMIR Mhealth Uhealth. 2018 Sep 17;6(9):e179. doi: 10.2196/mhealth.8256.


Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors after Circulatory Death: A Systematic Review and Meta-Analysis.

Nostedt JJ, Skubleny DT, Shapiro AMJ, Campbell S, Freed DH, Bigam DL.

HPB Surg. 2018 Apr 23;2018:6867986. doi: 10.1155/2018/6867986. eCollection 2018.


Determination of Minimal Hemoglobin Level Necessary for Normothermic Porcine Ex Situ Liver Perfusion.

Bral M, Gala-Lopez B, Thiesen A, Hatami S, Bigam DL, Freed DM, James Shapiro AM.

Transplantation. 2018 Aug;102(8):1284-1292. doi: 10.1097/TP.0000000000002272.


Ex situ liver perfusion: Organ preservation into the future.

Bral M, Gala-Lopez B, Bigam DL, Freed DH, Shapiro AMJ.

Transplant Rev (Orlando). 2018 Jul;32(3):132-141. doi: 10.1016/j.trre.2018.03.002. Epub 2018 Apr 5. Review.


Low frequency complex dielectric (conductivity) response of dilute clay suspensions: Modeling and experiments.

Hou CY, Feng L, Seleznev N, Freed DE.

J Colloid Interface Sci. 2018 Sep 1;525:62-75. doi: 10.1016/j.jcis.2018.04.048. Epub 2018 Apr 11.


Evidence-based occupational hearing screening II: validation of a screening methodology using measures of functional hearing ability.

Soli SD, Amano-Kusumoto A, Clavier O, Wilbur J, Casto K, Freed D, Laroche C, Vaillancourt V, Giguère C, Dreschler WA, Rhebergen KS.

Int J Audiol. 2018 May;57(5):323-334. doi: 10.1080/14992027.2017.1411623.


Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device.

Miskew Nichols B, Nikhanj A, Wang F, Freed DH, Oudit GY.

Circ Heart Fail. 2018 Apr;11(4):e004960. doi: 10.1161/CIRCHEARTFAILURE.118.004960. No abstract available.


Transplantation of Hearts Donated after Circulatory Death.

White CW, Messer SJ, Large SR, Conway J, Kim DH, Kutsogiannis DJ, Nagendran J, Freed DH.

Front Cardiovasc Med. 2018 Feb 13;5:8. doi: 10.3389/fcvm.2018.00008. eCollection 2018. Review.


Coronary Artery Bypass Surgery Improves Outcomes in Patients With Diabetes and Left Ventricular Dysfunction.

Nagendran J, Bozso SJ, Norris CM, McAlister FA, Appoo JJ, Moon MC, Freed DH, Nagendran J.

J Am Coll Cardiol. 2018 Feb 27;71(8):819-827. doi: 10.1016/j.jacc.2017.12.024.


Corrigendum to "Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts".

Wang J, Xiang B, Deng J, Lin HY, Freed DH, Arora RC, Tian G.

Biomed Res Int. 2017;2017:6490349. doi: 10.1155/2017/6490349. Epub 2017 Dec 31.


Steroids Limit Myocardial Edema During Ex Vivo Perfusion of Hearts Donated After Circulatory Death.

Sandha JK, White CW, Müller A, Avery E, Thliveris J, Dixon IMC, Arora RC, Tian G, Hryshko LV, Nagendran J, Freed DH.

Ann Thorac Surg. 2018 Jun;105(6):1763-1770. doi: 10.1016/j.athoracsur.2018.01.004. Epub 2018 Jan 31.


Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.

Liu L, Thaker TM, Freed DM, Frazier N, Malhotra K, Lemmon MA, Jura N.

Structure. 2018 Feb 6;26(2):270-281.e4. doi: 10.1016/j.str.2017.12.012. Epub 2018 Jan 18.


A Decrease in Hypoxic Pulmonary Vasoconstriction Correlates With Increased Inflammation During Extended Normothermic Ex Vivo Lung Perfusion.

Himmat S, Alzamil A, Aboelnazar N, Hatami S, White C, Dromparis P, Mengel M, Freed D, Nagendran J.

Artif Organs. 2018 Mar;42(3):271-279. doi: 10.1111/aor.13017. Epub 2017 Dec 20.


Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination.

Li F, Freed DC, Tang A, Rustandi RR, Troutman MC, Espeseth AS, Zhang N, An Z, McVoy M, Zhu H, Ha S, Wang D, Adler SP, Fu TM.

NPJ Vaccines. 2017 Dec 14;2:36. doi: 10.1038/s41541-017-0038-0. eCollection 2017.


Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion.

Aboelnazar NS, Himmat S, Hatami S, White CW, Burhani MS, Dromparis P, Matsumura N, Tian G, Dyck JRB, Mengel M, Freed DH, Nagendran J.

J Heart Lung Transplant. 2018 Apr;37(4):520-530. doi: 10.1016/j.healun.2017.09.007. Epub 2017 Sep 14.


Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection.

Xia L, Tang A, Meng W, Freed DC, He L, Wang D, Li F, Li L, Xiong W, Gui X, Schultz RD, Chen H, He X, Swoyer R, Ha S, Liu Y, Morris CD, Zhou Y, Wang IM, Zhao Q, Luo W, Xia N, Espeseth AS, Hazuda DJ, Rupp RE, Barrett AD, Zhang N, Zhu J, Fu TM, An Z.

Oncotarget. 2017 Jun 3;8(43):73654-73669. doi: 10.18632/oncotarget.18359. eCollection 2017 Sep 26.


Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.

Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR.

Sci Transl Med. 2017 Oct 25;9(413). pii: eaao4583. doi: 10.1126/scitranslmed.aao4583.


Targeting Human-Cytomegalovirus-Infected Cells by Redirecting T Cells Using an Anti-CD3/Anti-Glycoprotein B Bispecific Antibody.

Meng W, Tang A, Ye X, Gui X, Li L, Fan X, Schultz RD, Freed DC, Ha S, Wang D, Zhang N, Fu TM, An Z.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01719-17. doi: 10.1128/AAC.01719-17. Print 2018 Jan.


Driveline Site Is Not a Predictor of Infection After Ventricular Assist Device Implantation.

Martin BJ, Luc JGY, Maruyama M, MacArthur R, Bates AR, Buchholz H, Freed DH, Conway J.

ASAIO J. 2018 Sep/Oct;64(5):616-622. doi: 10.1097/MAT.0000000000000690.


EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.

Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA.

Cell. 2017 Oct 19;171(3):683-695.e18. doi: 10.1016/j.cell.2017.09.017. Epub 2017 Oct 5.


Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death-Summary Report.

Weiss MJ, Hornby L, Rochwerg B, van Manen M, Dhanani S, Sivarajan VB, Appleby A, Bennett M, Buchman D, Farrell C, Goldberg A, Greenberg R, Singh R, Nakagawa TA, Witteman W, Barter J, Beck A, Coughlin K, Conradi A, Cupido C, Dawson R, Dipchand A, Freed D, Hornby K, Langlois V, Mack C, Mahoney M, Manhas D, Tomlinson C, Zavalkoff S, Shemie SD.

Pediatr Crit Care Med. 2017 Nov;18(11):1035-1046. doi: 10.1097/PCC.0000000000001320.


Feasibility of Lung Transplantation From Donation After Circulatory Death Donors Following Portable Ex Vivo Lung Perfusion: A Pilot Study.

Luc JGY, Jackson K, Weinkauf JG, Freed DH, Nagendran J.

Transplant Proc. 2017 Oct;49(8):1885-1892. doi: 10.1016/j.transproceed.2017.04.010.


Hypoxia enhances the therapeutic potential of superparamagnetic iron oxide-labeled adipose-derived stem cells for myocardial infarction.

Wang J, Xiang B, Deng JX, Lin HY, Freed DH, Arora RC, Tian GH.

J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):516-522. doi: 10.1007/s11596-017-1766-0. Epub 2017 Aug 8.


Multimodality cardiac imaging of infective endocarditis.

Karlstedt E, Jassal DS, Kirkpatrick IDC, Freed D, Seifer CM.

J Cardiovasc Med (Hagerstown). 2017 Sep;18(9):729-730. doi: 10.2459/JCM.0000000000000013. No abstract available.


New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report.

Dieudé M, West LJ, Muruve DA, Gunaratman L, Mohanakumar T, Zorn E, Cairo CW, Freed DH, Schultz KR, Fairchild RL, Hébert MJ.

Transplantation. 2018 Feb;102(2):209-214. doi: 10.1097/TP.0000000000001872. Review.


Extended Bridge to Heart and Lung Transplantation Using Pumpless Extracorporeal Lung Assist.

Vasanthan V, Garg M, Maruyama M, Michelakis E, Freed DH, Nagendran J.

Can J Cardiol. 2017 Jul;33(7):950.e11-950.e13. doi: 10.1016/j.cjca.2017.03.014. Epub 2017 Mar 25.


Low-frequency dielectric response of charged oblate spheroidal particles immersed in an electrolyte.

Hou CY, Freed DE, Sen PN.

Phys Rev E. 2017 Apr;95(4-1):042601. doi: 10.1103/PhysRevE.95.042601. Epub 2017 Apr 5.


Functionally inactivated dominant viral antigens of human cytomegalovirus delivered in replication incompetent adenovirus type 6 vectors as vaccine candidates.

Tang A, Freed DC, Li F, Meschino S, Prokop M, Bett A, Casimiro D, Wang D, Fu TM.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2763-2771. doi: 10.1080/21645515.2017.1308988. Epub 2017 May 11.


Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network.

Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review.


Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts.

Wang J, Xiang B, Deng J, Lin HY, Freed DH, Arora RC, Tian G.

Biomed Res Int. 2017;2017:4107587. doi: 10.1155/2017/4107587. Epub 2017 Mar 20. Erratum in: Biomed Res Int. 2017;2017:6490349.


Impact of Antibodies and Strain Polymorphisms on Cytomegalovirus Entry and Spread in Fibroblasts and Epithelial Cells.

Cui X, Freed DC, Wang D, Qiu P, Li F, Fu TM, Kauvar LM, McVoy MA.

J Virol. 2017 Jun 9;91(13). pii: e01650-16. doi: 10.1128/JVI.01650-16. Print 2017 Jul 1.


Ten Core Competencies for Hospital Administrators.

Freed DH.

Health Care Manag (Frederick). 2017 Apr/Jun;36(2):108-115. doi: 10.1097/HCM.0000000000000154.


A Leukocyte Filter Does Not Provide Further Benefit During Ex Vivo Lung Perfusion.

Luc JGY, Aboelnazar NS, Himmat S, Hatami S, Haromy A, Matsumura N, Vasanthan V, White CW, Mengel M, Freed DH, Nagendran J.

ASAIO J. 2017 Sep/Oct;63(5):672-678. doi: 10.1097/MAT.0000000000000550.


Impact of Obesity on Heart and Lung Transplantation: Does Pre-Transplant Obesity Affect Outcomes?

Bozso SJ, Nagendran J, Gill RS, Freed DH, Nagendran J.

Transplant Proc. 2017 Mar;49(2):344-347. doi: 10.1016/j.transproceed.2016.12.002. Review.


Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.

Ha S, Li F, Troutman MC, Freed DC, Tang A, Loughney JW, Wang D, Wang IM, Vlasak J, Nickle DC, Rustandi RR, Hamm M, DePhillips PA, Zhang N, McLellan JS, Zhu H, Adler SP, McVoy MA, An Z, Fu TM.

J Virol. 2017 Mar 13;91(7). pii: e02033-16. doi: 10.1128/JVI.02033-16. Print 2017 Apr 1.


Eight Leadership Emergency Codes Worth Calling.

Freed DH.

Health Care Manag (Frederick). 2017 Jan/Mar;36(1):50-59. doi: 10.1097/HCM.0000000000000140.


Functional assessment and transplantation of the donor heart after circulatory death.

Messer SJ, Axell RG, Colah S, White PA, Ryan M, Page AA, Parizkova B, Valchanov K, White CW, Freed DH, Ashley E, Dunning J, Goddard M, Parameshwar J, Watson CJ, Krieg T, Ali A, Tsui S, Large SR.

J Heart Lung Transplant. 2016 Dec;35(12):1443-1452. doi: 10.1016/j.healun.2016.07.004. Epub 2016 Jul 16.


A replication-defective human cytomegalovirus vaccine for prevention of congenital infection.

Wang D, Freed DC, He X, Li F, Tang A, Cox KS, Dubey SA, Cole S, Medi MB, Liu Y, Xu J, Zhang ZQ, Finnefrock AC, Song L, Espeseth AS, Shiver JW, Casimiro DR, Fu TM.

Sci Transl Med. 2016 Oct 26;8(362):362ra145.


The Contribution of Mosaic Variants to Autism Spectrum Disorder.

Freed D, Pevsner J.

PLoS Genet. 2016 Sep 15;12(9):e1006245. doi: 10.1371/journal.pgen.1006245. eCollection 2016 Sep.


Impact of Reperfusion Calcium and pH on the Resuscitation of Hearts Donated After Circulatory Death.

White C, Ambrose E, Müller A, Hatami S, Li Y, Le H, Thliveris J, Arora R, Lee T, Dixon I, Tian G, Nagendran J, Hryshko L, Freed D.

Ann Thorac Surg. 2017 Jan;103(1):122-130. doi: 10.1016/j.athoracsur.2016.05.084. Epub 2016 Aug 12.


Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron-Labeled Adipose-Derived Stem Cells in Infarcted Hearts.

Wang J, Xiang B, Deng J, Lin HY, Zheng D, Freed DH, Arora RC, Tian G.

Stem Cells Transl Med. 2016 Oct;5(10):1380-1393. Epub 2016 Jul 8.


Deletion Mutations Keep Kinase Inhibitors in the Loop.

Freed DM, Park JH, Radhakrishnan R, Lemmon MA.

Cancer Cell. 2016 Apr 11;29(4):423-425. doi: 10.1016/j.ccell.2016.03.017.


Preclinical evaluations of peptide-conjugate vaccines targeting the antigenic domain-2 of glycoprotein B of human cytomegalovirus.

Finnefrock AC, Freed DC, Tang A, Li F, He X, Wu C, Nahas D, Wang D, Fu TM.

Hum Vaccin Immunother. 2016 Aug 2;12(8):2106-2112. Epub 2016 Mar 17.


The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.

Lemmon MA, Freed DM, Schlessinger J, Kiyatkin A.

Cell. 2016 Mar 10;164(6):1172-1184. doi: 10.1016/j.cell.2016.02.047. Review.


Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.

Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z.

Transl Res. 2016 Jun;172:30-44. doi: 10.1016/j.trsl.2016.02.006. Epub 2016 Feb 23.


High Spinal Anesthesia Enhances Anti-Inflammatory Responses in Patients Undergoing Coronary Artery Bypass Graft Surgery and Aortic Valve Replacement: Randomized Pilot Study.

Lee TW, Kowalski S, Falk K, Maguire D, Freed DH, HayGlass KT.

PLoS One. 2016 Mar 1;11(3):e0149942. doi: 10.1371/journal.pone.0149942. eCollection 2016.

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