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Items: 1 to 50 of 138

1.

Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease.

Zhou W, Barkow JC, Freed CR.

PLoS One. 2017 Dec 22;12(12):e0190160. doi: 10.1371/journal.pone.0190160. eCollection 2017.

2.

Consolidating the Academic End of a Community-Based Participatory Research Venture to Address Health Disparities.

Arrieta MI, Fisher L, Shaw T, Bryan V, Hudson A, Hansberry S, Eastburn S, Freed CR, Shelley-Tremblay S, Hanks RS, Washington-Lewis C, Roussel L, Dagenais PA, Icenogle M, Slagle ML, Parker LL, Crook E.

J High Educ Outreach Engagem. 2017;21(3):113-134.

3.

Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease.

Gao L, Zhou W, Symmes B, Freed CR.

PLoS One. 2016 Aug 11;11(8):e0160847. doi: 10.1371/journal.pone.0160847. eCollection 2016.

4.

DJ-1 Modulates Nuclear Erythroid 2-Related Factor-2-Mediated Protection in Human Primary Alveolar Type II Cells in Smokers.

Bahmed K, Messier EM, Zhou W, Tuder RM, Freed CR, Chu HW, Kelsen SG, Bowler RP, Mason RJ, Kosmider B.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):439-49. doi: 10.1165/rcmb.2015-0304OC.

5.

A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.

Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D.

Mol Pharmacol. 2015 Dec;88(6):1045-54. doi: 10.1124/mol.115.101451. Epub 2015 Sep 24.

6.

A nerve guidance conduit with topographical and biochemical cues: potential application using human neural stem cells.

Jenkins PM, Laughter MR, Lee DJ, Lee YM, Freed CR, Park D.

Nanoscale Res Lett. 2015 Dec;10(1):972. doi: 10.1186/s11671-015-0972-6. Epub 2015 Jun 12.

7.

Substantial Differentiation of Human Neural Stem Cells Into Motor Neurons on a Biomimetic Polyurea.

Yun D, Lee YM, Laughter MR, Freed CR, Park D.

Macromol Biosci. 2015 Sep;15(9):1206-11. doi: 10.1002/mabi.201500066. Epub 2015 May 29.

9.

Biomimetic poly(serinol hexamethylene urea) for promotion of neurite outgrowth and guidance.

Yun D, Famili A, Lee YM, Jenkins PM, Freed CR, Park D.

J Biomater Sci Polym Ed. 2014;25(4):354-69. doi: 10.1080/09205063.2013.861170. Epub 2013 Nov 27.

PMID:
24279744
10.

Medical trainees need more than simple role modeling to be prepared for professional and ethical decisions.

Freed CR, Franks RD.

Acad Med. 2013 Aug;88(8):1053. doi: 10.1097/ACM.0b013e31829a6e5f. No abstract available.

PMID:
23899844
11.

International and American medical graduates in a U.S. pediatric residency program: a qualitative study about challenges during post-graduate year 1.

Rao A, Freed CR, Trimm RF.

Med Teach. 2013 Oct;35(10):815-9. doi: 10.3109/0142159X.2013.802297. Epub 2013 Jun 11.

PMID:
23758181
12.

Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection.

Lee KS, Zhou W, Scott-McKean JJ, Emmerling KL, Cai GY, Krah DL, Costa AC, Freed CR, Levin MJ.

PLoS One. 2012;7(12):e53010. doi: 10.1371/journal.pone.0053010. Epub 2012 Dec 28.

13.

Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials.

Freed CR, Zhou W, Breeze RE.

Neurotherapeutics. 2011 Oct;8(4):549-61. doi: 10.1007/s13311-011-0082-9. Review.

14.

Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease.

Zhou W, Bercury K, Cummiskey J, Luong N, Lebin J, Freed CR.

J Biol Chem. 2011 Apr 29;286(17):14941-51. doi: 10.1074/jbc.M110.211029. Epub 2011 Mar 3.

15.

In the Spirit of Selden Bacon: The Sociology Of Drinking and Drug Problems.

Freed CR.

Sociol Compass. 2010 Oct;4(10):856-868. doi: 10.1111/j.1751-9020.2010.00325.x. Epub 2010 Oct 3.

16.

Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft.

Richardson RM, Freed CR, Shimamoto SA, Starr PA.

J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):266-71. doi: 10.1136/jnnp.2009.201129. Epub 2010 Aug 27.

PMID:
20802212
17.

Addiction medicine and addiction psychiatry in America: Commonalities in the medical treatment of addiction.

Freed CR.

Contemp Drug Probl. 2010 Spring;37(1):139-163. doi: 10.1177/009145091003700107.

18.

Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice.

Zhou W, Lee YM, Guy VC, Freed CR.

Stem Cells. 2009 Dec;27(12):2952-61. doi: 10.1002/stem.216.

19.

Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells.

Zhou W, Freed CR.

Stem Cells. 2009 Nov;27(11):2667-74. doi: 10.1002/stem.201.

20.

Transplantation.

Freed CR, Michael Zawada W, Leehey M, Zhou W, Breeze RE.

Handb Clin Neurol. 2007;84:279-90. doi: 10.1016/S0072-9752(07)84044-9. No abstract available.

PMID:
18808953
21.

Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats.

Chiba S, Lee YM, Zhou W, Freed CR.

Stem Cells. 2008 Nov;26(11):2810-20. doi: 10.1634/stemcells.2008-0085. Epub 2008 Sep 4.

22.

Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.

Zhou W, Milder JB, Freed CR.

J Biol Chem. 2008 Apr 11;283(15):9863-70. doi: 10.1074/jbc.M710232200. Epub 2008 Jan 30.

23.

Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventions.

Goetz CG, Wuu J, McDermott MP, Adler CH, Fahn S, Freed CR, Hauser RA, Olanow WC, Shoulson I, Tandon PK; Parkinson Study Group, Leurgans S.

Mov Disord. 2008 Apr 15;23(5):690-9. doi: 10.1002/mds.21894.

PMID:
18228568
25.

Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity.

Bjugstad KB, Crnic LS, Goodman SI, Freed CR.

J Inherit Metab Dis. 2006 Oct;29(5):612-9. Epub 2006 Aug 30.

PMID:
16944278
26.

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.

Zhou W, Freed CR.

J Biol Chem. 2005 Dec 30;280(52):43150-8. Epub 2005 Oct 14.

27.

Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblasts.

Simpson SA, Manchak MD, Hager EJ, Krummenacher C, Whitbeck JC, Levin MJ, Freed CR, Wilcox CL, Cohen GH, Eisenberg RJ, Pizer LI.

J Neurovirol. 2005 Apr;11(2):208-18.

PMID:
16036799
28.

Characterization of the Bex gene family in humans, mice, and rats.

Alvarez E, Zhou W, Witta SE, Freed CR.

Gene. 2005 Aug 29;357(1):18-28.

PMID:
15958283
29.

Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.

Schilling B, Bharath M M S, Row RH, Murray J, Cusack MP, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW.

Mol Cell Proteomics. 2005 Jan;4(1):84-96. Epub 2004 Dec 10.

31.

Reaction time and movement time after embryonic cell implantation in Parkinson disease.

Gordon PH, Yu Q, Qualls C, Winfield H, Dillon S, Greene PE, Fahn S, Breeze RE, Freed CR, Pullman SL.

Arch Neurol. 2004 Jun;61(6):858-61.

PMID:
15210522
32.

Preoperative response to levodopa is the best predictor of transplant outcome.

Freed CR, Breeze RE, Fahn S, Eidelberg D.

Ann Neurol. 2004 Jun;55(6):896; author reply 896-7. No abstract available.

PMID:
15174028
33.

Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.

McRae C, Cherin E, Yamazaki TG, Diem G, Vo AH, Russell D, Ellgring JH, Fahn S, Greene P, Dillon S, Winfield H, Bjugstad KB, Freed CR.

Arch Gen Psychiatry. 2004 Apr;61(4):412-20. Erratum in: Arch Gen Psychiatry. 2004 Jun;61(6):627.

PMID:
15066900
34.

Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity.

Zhou W, Freed CR.

J Biol Chem. 2004 Mar 12;279(11):10128-35. Epub 2003 Dec 29.

35.

The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons.

Ahmadi FA, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM.

J Neurochem. 2003 Nov;87(4):914-21.

36.

Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

Freed CR, Leehey MA, Zawada M, Bjugstad K, Thompson L, Breeze RE.

J Neurol. 2003 Oct;250 Suppl 3:III44-6.

PMID:
14579124
37.

Neural transplantation for the treatment of Parkinson's disease.

Björklund A, Dunnett SB, Brundin P, Stoessl AJ, Freed CR, Breeze RE, Levivier M, Peschanski M, Studer L, Barker R.

Lancet Neurol. 2003 Jul;2(7):437-45. Review. No abstract available.

PMID:
12849125
38.

Cognition following bilateral implants of embryonic dopamine neurons in PD: a double blind study.

Trott CT, Fahn S, Greene P, Dillon S, Winfield H, Winfield L, Kao R, Eidelberg D, Freed CR, Breeze RE, Stern Y.

Neurology. 2003 Jun 24;60(12):1938-43.

PMID:
12821736
39.

Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells.

Nahreini P, Andreatta C, Kumar B, Hanson A, Edwards-Prasad J, Freed CR, Prasad KN.

Cell Mol Neurobiol. 2003 Feb;23(1):27-42.

PMID:
12701882
40.

Gambling disorders among homeless persons with substance use disorders seeking treatment at a community center.

Shaffer HJ, Freed CR, Healea D.

Psychiatr Serv. 2002 Sep;53(9):1112-7.

PMID:
12221309
41.

Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats.

Veng LM, Bjugstad KB, Freed CR, Marrack P, Clarkson ED, Bell KP, Hutt C, Zawada WM.

Cell Transplant. 2002;11(1):5-16.

PMID:
12095220
42.
43.

Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture.

Zhou W, Schaack J, Zawada WM, Freed CR.

Brain Res. 2002 Feb 1;926(1-2):42-50.

PMID:
11814405
44.

IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures.

Bjugstad KB, Zawada WM, Goodman S, Freed CR.

J Inherit Metab Dis. 2001 Nov;24(6):631-47.

PMID:
11768583
45.

Establishment of human embryonic brain cell lines.

Kumar B, Hovland AR, Prasad JE, Clarkson E, Cole WC, Nahreini P, Freed CR, Prasad KN.

In Vitro Cell Dev Biol Anim. 2001 May;37(5):259-62. No abstract available.

PMID:
11513078
46.

Segregation of human neural stem cells in the developing primate forebrain.

Ourednik V, Ourednik J, Flax JD, Zawada WM, Hutt C, Yang C, Park KI, Kim SU, Sidman RL, Freed CR, Snyder EY.

Science. 2001 Sep 7;293(5536):1820-4. Epub 2001 Jul 26.

47.

Transplantation of embryonic dopamine neurons for severe Parkinson's disease.

Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S.

N Engl J Med. 2001 Mar 8;344(10):710-9.

48.

IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands.

Clarkson ED, Zawada WM, Bell KP, Esplen JE, Choi PK, Heidenreich KA, Freed CR.

Exp Neurol. 2001 Mar;168(1):183-91.

PMID:
11170733
49.

Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons.

Zawada WM, Meintzer MK, Rao P, Marotti J, Wang X, Esplen JE, Clarkson ED, Freed CR, Heidenreich KA.

Brain Res. 2001 Feb 9;891(1-2):185-96.

PMID:
11164822
50.

Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type 1.

Bjugstad KB, Goodman SI, Freed CR.

J Pediatr. 2000 Nov;137(5):681-6.

PMID:
11060535

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