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The N-Terminal Segment of the Voltage-Dependent Anion Channel: A Possible Membrane-Bound Intermediate in Pore Unbinding.

Reif MM, Fischer M, Fredriksson K, Hagn F, Zacharias M.

J Mol Biol. 2019 Jan 18;431(2):223-243. doi: 10.1016/j.jmb.2018.09.015. Epub 2018 Oct 17.


Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.

Fredriksson K, Lottmann P, Hinz S, Onila I, Shymanets A, Harteneck C, Müller CE, Griesinger C, Exner TE.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5750-5754. doi: 10.1002/anie.201612547. Epub 2017 Apr 21.


Automated assignment of NMR chemical shifts based on a known structure and 4D spectra.

Trautwein M, Fredriksson K, Möller HM, Exner TE.

J Biomol NMR. 2016 Aug;65(3-4):217-236. doi: 10.1007/s10858-016-0050-0. Epub 2016 Aug 2.


On-the-Fly Integration of Data from a Spin-Diffusion-Based NMR Experiment into Protein-Ligand Docking.

Onila I, ten Brink T, Fredriksson K, Codutti L, Mazur A, Griesinger C, Carlomagno T, Exner TE.

J Chem Inf Model. 2015 Sep 28;55(9):1962-72. doi: 10.1021/acs.jcim.5b00235. Epub 2015 Aug 14.


Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks.

Fredriksson K, Van Itallie CM, Aponte A, Gucek M, Tietgens AJ, Anderson JM.

PLoS One. 2015 Mar 19;10(3):e0117074. doi: 10.1371/journal.pone.0117074. eCollection 2015.


The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.

Fredriksson K, Mishra A, Lam JK, Mushaben EM, Cuento RA, Meyer KS, Yao X, Keeran KJ, Nugent GZ, Qu X, Yu ZX, Yang Y, Raghavachari N, Dagur PK, McCoy JP, Levine SJ.

J Immunol. 2014 May 15;192(10):4497-509. doi: 10.4049/jimmunol.1301234. Epub 2014 Apr 14.


Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.

Van Itallie CM, Tietgens AJ, Aponte A, Fredriksson K, Fanning AS, Gucek M, Anderson JM.

J Cell Sci. 2014 Feb 15;127(Pt 4):885-95. doi: 10.1242/jcs.140475. Epub 2013 Dec 11.


The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks.

Van Itallie CM, Aponte A, Tietgens AJ, Gucek M, Fredriksson K, Anderson JM.

J Biol Chem. 2013 May 10;288(19):13775-88. doi: 10.1074/jbc.M113.466193. Epub 2013 Apr 3.


Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase.

Bakke SS, Moro C, Nikolić N, Hessvik NP, Badin PM, Lauvhaug L, Fredriksson K, Hesselink MK, Boekschoten MV, Kersten S, Gaster M, Thoresen GH, Rustan AC.

Biochim Biophys Acta. 2012 Oct;1821(10):1323-33. doi: 10.1016/j.bbalip.2012.07.001. Epub 2012 Jul 13.


Paradoxical effects of rapamycin on experimental house dust mite-induced asthma.

Fredriksson K, Fielhaber JA, Lam JK, Yao X, Meyer KS, Keeran KJ, Zywicke GJ, Qu X, Yu ZX, Moss J, Kristof AS, Levine SJ.

PLoS One. 2012;7(5):e33984. doi: 10.1371/journal.pone.0033984. Epub 2012 May 25.


Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice.

Yao X, Dai C, Fredriksson K, Lam J, Gao M, Keeran KJ, Nugent GZ, Qu X, Yu ZX, Jeffries N, Lin J, Kaler M, Shamburek R, Costello R, Csako G, Dahl M, Nordestgaard BG, Remaley AT, Levine SJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 15;302(2):L206-15. doi: 10.1152/ajplung.00110.2011. Epub 2011 Nov 4.


5A, an apolipoprotein A-I mimetic peptide, attenuates the induction of house dust mite-induced asthma.

Yao X, Dai C, Fredriksson K, Dagur PK, McCoy JP, Qu X, Yu ZX, Keeran KJ, Zywicke GJ, Amar MJ, Remaley AT, Levine SJ.

J Immunol. 2011 Jan 1;186(1):576-83. doi: 10.4049/jimmunol.1001534. Epub 2010 Nov 29.


Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway.

Yao X, Fredriksson K, Yu ZX, Xu X, Raghavachari N, Keeran KJ, Zywicke GJ, Kwak M, Amar MJ, Remaley AT, Levine SJ.

Am J Respir Crit Care Med. 2010 Nov 15;182(10):1228-38. doi: 10.1164/rccm.201002-0308OC. Epub 2010 Jul 9.


Metabolic switching of human myotubes is improved by n-3 fatty acids.

Hessvik NP, Bakke SS, Fredriksson K, Boekschoten MV, Fjørkenstad A, Koster G, Hesselink MK, Kersten S, Kase ET, Rustan AC, Thoresen GH.

J Lipid Res. 2010 Aug;51(8):2090-104. doi: 10.1194/jlr.M003319. Epub 2010 Apr 2.


Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure.

Düringer C, Grundström G, Gürcan E, Dainty IA, Lawson M, Korn SH, Jerre A, Håkansson HF, Wieslander E, Fredriksson K, Sköld CM, Löfdahl M, Löfdahl CG, Nicholls DJ, Silberstein DS.

Br J Pharmacol. 2009 Sep;158(1):169-79. doi: 10.1111/j.1476-5381.2009.00262.x. Epub 2009 Jun 22.


Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course.

Ahlbeck K, Fredriksson K, Rooyackers O, Måbäck G, Remahl S, Ansved T, Eriksson L, Radell P.

Acta Anaesthesiol Scand. 2009 Jul;53(6):717-23. doi: 10.1111/j.1399-6576.2009.01952.x. Epub 2009 Apr 14.


Glutathione and amino acid concentrations in human liver during short warm ischaemia and reperfusion: a pilot study.

Westman B, Thörne A, Rooyackers O, Fredriksson K, Wernerman J, Hammarqvist F.

Clin Sci (Lond). 2009 Sep 1;117(9):339-44. doi: 10.1042/CS20080654.


PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts.

Togo S, Liu X, Wang X, Sugiura H, Kamio K, Kawasaki S, Kobayashi T, Ertl RF, Ahn Y, Holz O, Magnussen H, Fredriksson K, Skold CM, Rennard SI.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. doi: 10.1152/ajplung.00508.2007. Epub 2009 Mar 20.


Muscle mitochondrial activity increases rapidly after an endotoxin challenge in human volunteers.

Fredriksson K, Fläring U, Guillet C, Wernerman J, Rooyackers O.

Acta Anaesthesiol Scand. 2009 Mar;53(3):299-304. doi: 10.1111/j.1399-6576.2008.01851.x.


Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.

Vollaard NB, Constantin-Teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff PL, Timmons JA, Sundberg CJ.

J Appl Physiol (1985). 2009 May;106(5):1479-86. doi: 10.1152/japplphysiol.91453.2008. Epub 2009 Feb 5.


FOXO, the spindle in the net for wasting diseases?

Fredriksson K.

J Physiol. 2008 Nov 15;586(22):5285. doi: 10.1113/jphysiol.2008.164459. No abstract available.


Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure.

Fredriksson K, Tjäder I, Keller P, Petrovic N, Ahlman B, Schéele C, Wernerman J, Timmons JA, Rooyackers O.

PLoS One. 2008;3(11):e3686. doi: 10.1371/journal.pone.0003686. Epub 2008 Nov 10. Erratum in: PLoS ONE. 2008;3(12)doi: 10.1371/annotation/68d951f9-a236-472f-98af-24e4cc4c1a20..


The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins.

Nuutinen T, Tossavainen H, Fredriksson K, Pirilä P, Permi P, Pospiech H, Syvaoja JE.

Nucleic Acids Res. 2008 Sep;36(15):5102-10. doi: 10.1093/nar/gkn497. Epub 2008 Aug 2.


Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.

Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, Mueller KC, Branscheid D, Welker L, Watz H, Magnussen H, Rennard SI.

Am J Respir Crit Care Med. 2008 Aug 1;178(3):248-60. doi: 10.1164/rccm.200706-929OC. Epub 2008 May 8.


Human T cells stimulate fibroblast-mediated degradation of extracellular matrix in vitro.

Mikko M, Fredriksson K, Wahlström J, Eriksson P, Grunewald J, Sköld CM.

Clin Exp Immunol. 2008 Feb;151(2):317-25. Epub 2007 Dec 6.


Mitochondrial function in sepsis: respiratory versus leg muscle.

Fredriksson K, Rooyackers O.

Crit Care Med. 2007 Sep;35(9 Suppl):S449-53. Review.


Knee replacement surgery as a human clinical model of the effects of ischaemia/reperfusion upon skeletal muscle.

Westman B, Weidenhielm L, Rooyackers O, Fredriksson K, Wernerman J, Hammarqvist F.

Clin Sci (Lond). 2007 Oct;113(7):313-8.


The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function.

Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L, Timmons JA.

BMC Genomics. 2007 Mar 15;8:74.


Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis.

Klaude M, Fredriksson K, Tjäder I, Hammarqvist F, Ahlman B, Rooyackers O, Wernerman J.

Clin Sci (Lond). 2007 Jul;112(9):499-506.


Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure.

Fredriksson K, Hammarqvist F, Strigård K, Hultenby K, Ljungqvist O, Wernerman J, Rooyackers O.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1044-50. Epub 2006 Jun 27. Erratum in: Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1240.


Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond.

von Ossowski L, Tossavainen H, von Ossowski I, Cai C, Aitio O, Fredriksson K, Permi P, Annila A, Keinänen K.

Biochemistry. 2006 May 2;45(17):5567-75.


Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro.

Fredriksson K, Liu XD, Lundahl J, Klominek J, Rennard SI, Skold CM.

Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L326-33.


Similar calcification process in acute and chronic human brain pathologies.

Ramonet D, de Yebra L, Fredriksson K, Bernal F, Ribalta T, Mahy N.

J Neurosci Res. 2006 Jan;83(1):147-56.


Effect of prolonged mechanical ventilation on diaphragm muscle mitochondria in piglets.

Fredriksson K, Radell P, Eriksson LI, Hultenby K, Rooyackers O.

Acta Anaesthesiol Scand. 2005 Sep;49(8):1101-7.


A set of HA-detected experiments for measuring scalar and residual dipolar couplings.

Würtz P, Fredriksson K, Permi P.

J Biomol NMR. 2005 Apr;31(4):321-30.


Long-term follow-up of patients with alcoholic liver disease after liver transplantation in Sweden: impact of structured management on recidivism.

Björnsson E, Olsson J, Rydell A, Fredriksson K, Eriksson C, Sjöberg C, Olausson M, Bäckman L, Castedal M, Friman S.

Scand J Gastroenterol. 2005 Feb;40(2):206-16.


Separation effect and perception of pain and discomfort from two types of orthodontic separators.

Bondemark L, Fredriksson K, Ilros S.

World J Orthod. 2004 Summer;5(2):172-6.


On the interpretation of residual dipolar couplings as reporters of molecular dynamics.

Fredriksson K, Louhivuori M, Permi P, Annila A.

J Am Chem Soc. 2004 Oct 6;126(39):12646-50.


In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.

Ramonet D, Rodríguez MJ, Fredriksson K, Bernal F, Mahy N.

Hippocampus. 2004;14(5):586-94.


Alignment of chain-like molecules.

Louhivuori M, Fredriksson K, Pääkkönen K, Permi P, Annila A.

J Biomol NMR. 2004 Aug;29(4):517-24.


Red blood cells inhibit proliferation and stimulate apoptosis in human lung fibroblasts in vitro.

Fredriksson K, Stridh H, Lundahl J, Rennard SI, Skold CM.

Scand J Immunol. 2004 Jun;59(6):559-65.


On the origin of residual dipolar couplings from denatured proteins.

Louhivuori M, Pääkkönen K, Fredriksson K, Permi P, Lounila J, Annila A.

J Am Chem Soc. 2003 Dec 17;125(50):15647-50.


Platelets stimulate fibroblast-mediated contraction of collagen gels.

Zagai U, Fredriksson K, Rennard SI, Lundahl J, Sköld CM.

Respir Res. 2003;4:13. Epub 2003 Oct 17.


Red blood cells stimulate human lung fibroblasts to secrete interleukin-8.

Fredriksson K, Lundahl J, Palmberg L, Romberger DJ, Liu XD, Rennard SI, Skold CM.

Inflammation. 2003 Apr;27(2):71-8.


Seeking care for low back pain in the general population: a two-year follow-up study: results from the MUSIC-Norrtälje Study.

Vingård E, Mortimer M, Wiktorin C, Pernold R P T G, Fredriksson K, Németh G, Alfredsson L; Musculoskeletal Intervention Center-Norrtälje Study Group.

Spine (Phila Pa 1976). 2002 Oct 1;27(19):2159-65.


Red blood cells stimulate fibroblast-mediated contraction of three dimensional collagen gels in co-culture.

Fredriksson K, Lundahl J, Fernvik E, Liu XD, Rennard SI, Sköld CM.

Inflamm Res. 2002 May;51(5):245-51.


Work environment and neck and shoulder pain: the influence of exposure time. Results from a population based case-control study.

Fredriksson K, Alfredsson L, Ahlberg G, Josephson M, Kilbom A, Wigaeus Hjelm E, Wiktorin C, Vingård E; MUSIC/Norrtälje Study Group. Musculoskeletal Intervention Centre.

Occup Environ Med. 2002 Mar;59(3):182-8.


Risk factors for neck and shoulder disorders: a nested case-control study covering a 24-year period.

Fredriksson K, Alfredsson L, Thorbjörnsson CB, Punnett L, Toomingas A, Torgén M, Kilbom A.

Am J Ind Med. 2000 Nov;38(5):516-28.


Physical and psychosocial factors related to low back pain during a 24-year period. A nested case-control analysis.

Thorbjörnsson CB, Alfredsson L, Fredriksson K, Michélsen H, Punnett L, Vingård E, Torgén M, Kilbom A.

Spine (Phila Pa 1976). 2000 Feb 1;25(3):369-74; discussion 375.


Risk factors for neck and upper limb disorders: results from 24 years of follow up.

Fredriksson K, Alfredsson L, Köster M, Thorbjörnsson CB, Toomingas A, Torgén M, Kilbom A.

Occup Environ Med. 1999 Jan;56(1):59-66. Erratum in: Occup Environ Med 1999 May;56(5):358.

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