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Analysis of porcine body size variation using re-sequencing data of miniature and large pigs.

Reimer C, Rubin CJ, Sharifi AR, Ha NT, Weigend S, Waldmann KH, Distl O, Pant SD, Fredholm M, Schlather M, Simianer H.

BMC Genomics. 2018 Sep 19;19(1):687. doi: 10.1186/s12864-018-5009-y.


Inotropic and lusitropic effects of levosimendan and milrinone assessed by strain echocardiography-A randomised trial.

Fredholm M, Jörgensen K, Houltz E, Ricksten SE.

Acta Anaesthesiol Scand. 2018 Oct;62(9):1246-1254. doi: 10.1111/aas.13170. Epub 2018 Jun 21.


Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in healthy dogs.

Höglund K, Häggström J, Hanås S, Merveille AC, Gouni V, Wiberg M, Lundgren Willesen J, Entee KM, Mejer Sørensen L, Tiret L, Seppälä EH, Lohi H, Chetboul V, Fredholm M, Lequarré AS, Ljungvall I.

J Vet Cardiol. 2018 Aug;20(4):244-253. doi: 10.1016/j.jvc.2018.05.002. Epub 2018 Jun 18.


Identification of the mutation causing progressive retinal atrophy in Old Danish Pointing Dog.

Karlskov-Mortensen P, Proschowsky HF, Gao F, Fredholm M.

Anim Genet. 2018 Jun;49(3):237-241. doi: 10.1111/age.12659. Epub 2018 Apr 6.


A targeted genotyping approach enhances identification of variants in taste receptor and appetite/reward genes of potential functional importance for obesity-related porcine traits.

Cirera S, Clop A, Jacobsen MJ, Guerin M, Lesnik P, Jørgensen CB, Fredholm M, Karlskov-Mortensen P.

Anim Genet. 2018 Apr;49(2):110-118. doi: 10.1111/age.12641. Epub 2018 Feb 14.


Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs.

Pan X, Gong D, Nguyen DN, Zhang X, Hu Q, Lu H, Fredholm M, Sangild PT, Gao F.

DNA Res. 2018 Jan 19. doi: 10.1093/dnares/dsy001. [Epub ahead of print]


Ascaris Suum Infection Downregulates Inflammatory Pathways in the Pig Intestine In Vivo and in Human Dendritic Cells In Vitro.

Midttun HLE, Acevedo N, Skallerup P, Almeida S, Skovgaard K, Andresen L, Skov S, Caraballo L, van Die I, Jørgensen CB, Fredholm M, Thamsborg SM, Nejsum P, Williams AR.

J Infect Dis. 2018 Jan 4;217(2):310-319. doi: 10.1093/infdis/jix585.


Deregulation of obesity-relevant genes is associated with progression in BMI and the amount of adipose tissue in pigs.

Mentzel CMJ, Cardoso TF, Pipper CB, Jacobsen MJ, Jørgensen CB, Cirera S, Fredholm M.

Mol Genet Genomics. 2018 Feb;293(1):129-136. doi: 10.1007/s00438-017-1369-2. Epub 2017 Sep 14.


Load-dependence of myocardial deformation variables - a clinical strain-echocardiographic study.

Fredholm M, Jörgensen K, Houltz E, Ricksten SE.

Acta Anaesthesiol Scand. 2017 Oct;61(9):1155-1165. doi: 10.1111/aas.12954. Epub 2017 Aug 13.


Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.

Frederiksen SD, Karlskov-Mortensen P, Pant SD, Guerin M, Lesnik P, Jørgensen CB, Cirera S, Bruun CS, Mark T, Fredholm M.

PLoS One. 2017 Jun 1;12(6):e0178828. doi: 10.1371/journal.pone.0178828. eCollection 2017.


Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs-old enemy or new entity? A case series.

Jäderlund KH, Rohdin C, Berendt M, Stigen Ø, Fredholm M, Espenes A, Bjerkås I, Moe L.

Acta Vet Scand. 2017 May 2;59(1):26. doi: 10.1186/s13028-017-0295-y.


Fat and carbohydrate content in the diet induces drastic changes in gene expression in young Göttingen minipigs.

Mentzel CMJ, Cardoso TF, Lex AMJ, Sørensen DB, Fredholm M, Cirera S.

Mamm Genome. 2017 Jun;28(5-6):166-175. doi: 10.1007/s00335-017-9690-y. Epub 2017 Apr 10.


FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome.

Wucher V, Legeai F, Hédan B, Rizk G, Lagoutte L, Leeb T, Jagannathan V, Cadieu E, David A, Lohi H, Cirera S, Fredholm M, Botherel N, Leegwater PAJ, Le Béguec C, Fieten H, Johnson J, Alföldi J, André C, Lindblad-Toh K, Hitte C, Derrien T.

Nucleic Acids Res. 2017 May 5;45(8):e57. doi: 10.1093/nar/gkw1306.


Transcriptional immune response in mesenteric lymph nodes in pigs with different levels of resistance to Ascaris suum.

Skallerup P, Nejsum P, Cirera S, Skovgaard K, Pipper CB, Fredholm M, Jørgensen CB, Thamsborg SM.

Acta Parasitol. 2017 Mar 1;62(1):141-153. doi: 10.1515/ap-2017-0017.


Joint Profiling of miRNAs and mRNAs Reveals miRNA Mediated Gene Regulation in the Göttingen Minipig Obesity Model.

Mentzel CM, Alkan F, Keinicke H, Jacobsen MJ, Gorodkin J, Fredholm M, Cirera S.

PLoS One. 2016 Nov 30;11(11):e0167285. doi: 10.1371/journal.pone.0167285. eCollection 2016.


Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.

Clop A, Sharaf A, Castelló A, Ramos-Onsins S, Cirera S, Mercadé A, Derdak S, Beltran S, Huisman A, Fredholm M, van As P, Sánchez A.

BMC Genomics. 2016 Aug 26;17:685. doi: 10.1186/s12864-016-2972-z.


Differential Analysis of the Nasal Microbiome of Pig Carriers or Non-Carriers of Staphylococcus aureus.

Espinosa-Gongora C, Larsen N, Schønning K, Fredholm M, Guardabassi L.

PLoS One. 2016 Aug 10;11(8):e0160331. doi: 10.1371/journal.pone.0160331. eCollection 2016.


Hepatic expression of inflammatory genes and microRNAs in pigs with high "cholesteryl ester transfer protein" (CETP) activity.

Cirera S, Tørsleff BC, Ritz C, Fredholm M, Heegaard PM, Skovgaard K.

Mamm Genome. 2016 Oct;27(9-10):503-10. doi: 10.1007/s00335-016-9649-4. Epub 2016 May 30.


A large insertion in intron 2 of the TYRP1 gene associated with American Palomino phenotype in American mink.

Cirera S, Markakis MN, Kristiansen T, Vissenberg K, Fredholm M, Christensen K, Anistoroaei R.

Mamm Genome. 2016 Apr;27(3-4):135-43. doi: 10.1007/s00335-016-9620-4. Epub 2016 Feb 17.


Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs.

Höglund K, Lequarré AS, Ljungvall I, Mc Entee K, Merveille AC, Wiberg M, Gouni V, Lundgren Willesen J, Hanås S, Wess G, Mejer Sørensen L, Tiret L, Kierczak M, Forsberg SK, Seppälä E, Lindblad-Toh K, Lohi H, Chetboul V, Fredholm M, Häggström J.

J Vet Intern Med. 2016 Mar-Apr;30(2):566-73. doi: 10.1111/jvim.13829. Epub 2016 Jan 27.


The prevalence of the electrocardiographic J wave in the Petit Basset Griffon Vendéen compared to 10 different dog breeds.

Rudling EH, Schlamowitz S, Pipper CB, Nilsson E, Höllmer M, Willesen JL, Berendt M, Fredholm M, Gulløv CH, Christiansen M, Koch J.

J Vet Cardiol. 2016 Mar;18(1):26-33. doi: 10.1016/j.jvc.2015.12.001. Epub 2016 Jan 21.


Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity.

Jacobsen MJ, Mentzel CM, Olesen AS, Huby T, Jørgensen CB, Barrès R, Fredholm M, Simar D.

J Diabetes Res. 2016;2016:8539057. doi: 10.1155/2016/8539057. Epub 2015 Dec 21.


Circulating let-7g is down-regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomas - a prospective study.

Børresen B, Nielsen LN, Jessen LR, Kristensen AT, Fredholm M, Cirera S.

Vet Comp Oncol. 2017 Jun;15(2):525-533. doi: 10.1111/vco.12196. Epub 2016 Jan 21.


Discrepancy in compliance between the clinical and genetic diagnosis of choroidal hypoplasia in Danish Rough Collies and Shetland Sheepdogs.

Fredholm M, Larsen RC, Jönsson M, Söderlund MA, Hardon T, Proschowsky HF.

Anim Genet. 2016 Apr;47(2):250-2. doi: 10.1111/age.12405. Epub 2016 Jan 6.


Physical training and weight loss in dogs lead to transcriptional changes in genes involved in the glucose-transport pathway in muscle and adipose tissues.

Herrera Uribe J, Vitger AD, Ritz C, Fredholm M, Bjørnvad CR, Cirera S.

Vet J. 2016 Feb;208:22-7. doi: 10.1016/j.tvjl.2015.11.002. Epub 2015 Nov 10.


Genome-wide association study reveals a locus for nasal carriage of Staphylococcus aureus in Danish crossbred pigs.

Skallerup P, Espinosa-Gongora C, Jørgensen CB, Guardabassi L, Fredholm M.

BMC Vet Res. 2015 Nov 26;11:290. doi: 10.1186/s12917-015-0599-y.


An integrative systems genetics approach reveals potential causal genes and pathways related to obesity.

Kogelman LJ, Zhernakova DV, Westra HJ, Cirera S, Fredholm M, Franke L, Kadarmideen HN.

Genome Med. 2015 Oct 20;7:105. doi: 10.1186/s13073-015-0229-0.


Prevalence and heritability of distichiasis in the English Cocker spaniel.

Petersen T, Proschowsky HF, Hardon T, Rasch SN, Fredholm M.

Canine Genet Epidemiol. 2015 Aug 2;2:11. doi: 10.1186/s40575-015-0024-7. eCollection 2015.


Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.

Pant SD, Karlskov-Mortensen P, Jacobsen MJ, Cirera S, Kogelman LJ, Bruun CS, Mark T, Jørgensen CB, Grarup N, Appel EV, Galjatovic EA, Hansen T, Pedersen O, Guerin M, Huby T, Lesnik P, Meuwissen TH, Kadarmideen HN, Fredholm M.

PLoS One. 2015 Sep 8;10(9):e0137356. doi: 10.1371/journal.pone.0137356. eCollection 2015.


Expression study of GLUT4 translocation-related genes in a porcine pre-diabetic model.

Kristensen T, Fredholm M, Cirera S.

Mamm Genome. 2015 Dec;26(11-12):650-7. doi: 10.1007/s00335-015-9601-z. Epub 2015 Sep 7.


Gender and Obesity Specific MicroRNA Expression in Adipose Tissue from Lean and Obese Pigs.

Mentzel CM, Anthon C, Jacobsen MJ, Karlskov-Mortensen P, Bruun CS, Jørgensen CB, Gorodkin J, Cirera S, Fredholm M.

PLoS One. 2015 Jul 29;10(7):e0131650. doi: 10.1371/journal.pone.0131650. eCollection 2015.


The Shepherds' Tale: A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds.

Forsberg SK, Kierczak M, Ljungvall I, Merveille AC, Gouni V, Wiberg M, Lundgren Willesen J, Hanås S, Lequarré AS, Mejer Sørensen L, Tiret L, McEntee K, Seppälä E, Koch J, Battaille G, Lohi H, Fredholm M, Chetboul V, Häggström J, Carlborg Ö, Lindblad-Toh K, Höglund K.

PLoS One. 2015 May 13;10(5):e0123173. doi: 10.1371/journal.pone.0123173. eCollection 2015.


Detection of a quantitative trait locus associated with resistance to infection with Trichuris suis in pigs.

Skallerup P, Thamsborg SM, Jørgensen CB, Mejer H, Göring HH, Archibald AL, Fredholm M, Nejsum P.

Vet Parasitol. 2015 Jun 15;210(3-4):264-9. doi: 10.1016/j.vetpar.2015.03.014. Epub 2015 Mar 27.


A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle.

Grossi AB, Agerholm JS, Christensen K, Jensen HE, Leifsson PS, Bendixen C, Karlskov-Mortensen P, Fredholm M.

Acta Vet Scand. 2014 Dec 10;56:85. doi: 10.1186/s13028-014-0085-8.


Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates.

Thøfner MS, Stougaard CL, Westrup U, Madry AA, Knudsen CS, Berg H, Jensen CS, Handby RM, Gredal H, Fredholm M, Berendt M.

J Vet Intern Med. 2015 Jan;29(1):243-50. doi: 10.1111/jvim.12475. Epub 2014 Oct 10.


Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model.

Kogelman LJ, Cirera S, Zhernakova DV, Fredholm M, Franke L, Kadarmideen HN.

BMC Med Genomics. 2014 Sep 30;7:57. doi: 10.1186/1755-8794-7-57.


Perosomus elumbis in Danish Holstein cattle.

Agerholm JS, Holm W, Schmidt M, Hyttel P, Fredholm M, McEvoy FJ.

BMC Vet Res. 2014 Sep 26;10:227. doi: 10.1186/s12917-014-0227-2.


Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network, and pathway analyses.

Kogelman LJ, Pant SD, Fredholm M, Kadarmideen HN.

Front Genet. 2014 Jul 9;5:214. doi: 10.3389/fgene.2014.00214. eCollection 2014.


Structured RNAs and synteny regions in the pig genome.

Anthon C, Tafer H, Havgaard JH, Thomsen B, Hedegaard J, Seemann SE, Pundhir S, Kehr S, Bartschat S, Nielsen M, Nielsen RO, Fredholm M, Stadler PF, Gorodkin J.

BMC Genomics. 2014 Jun 10;15:459. doi: 10.1186/1471-2164-15-459.


Clinical findings and prevalence of the mutation associated with primary ciliary dyskinesia in Old English Sheepdogs.

Merveille AC, Battaille G, Billen F, Deleuze S, Fredholm M, Thomas A, Clercx C, Lequarré AS.

J Vet Intern Med. 2014 May-Jun;28(3):771-8. doi: 10.1111/jvim.12336. Epub 2014 Mar 12.


Functional study of a genetic marker allele associated with resistance to Ascaris suum in pigs.

Skallerup P, Thamsborg SM, Jørgensen CB, Enemark HL, Yoshida A, Göring HH, Fredholm M, Nejsum P.

Parasitology. 2014 May;141(6):777-87. doi: 10.1017/S0031182013002175.


Breed differences in natriuretic peptides in healthy dogs.

Sjöstrand K, Wess G, Ljungvall I, Häggström J, Merveille AC, Wiberg M, Gouni V, Lundgren Willesen J, Hanås S, Lequarré AS, Mejer Sørensen L, Wolf J, Tiret L, Kierczak M, Forsberg S, McEntee K, Battaille G, Seppälä E, Lindblad-Toh K, Georges M, Lohi H, Chetboul V, Fredholm M, Höglund K.

J Vet Intern Med. 2014 Mar-Apr;28(2):451-7. doi: 10.1111/jvim.12310. Epub 2014 Feb 3.


Identifying QTL and genetic correlations between fur quality traits in mink (Neovison vison).

Thirstrup JP, Anistoroaei R, Guldbrandtsen B, Christensen K, Fredholm M, Nielsen VH.

Anim Genet. 2014 Feb;45(1):105-10. doi: 10.1111/age.12102. Epub 2013 Dec 5.


Functional characterization of a porcine emphysema model.

Bruun CS, Jensen LK, Leifsson PS, Nielsen J, Cirera S, Jørgensen CB, Jensen HE, Fredholm M.

Lung. 2013 Dec;191(6):669-75. doi: 10.1007/s00408-013-9504-2. Epub 2013 Sep 17.


Expression studies of six human obesity-related genes in seven tissues from divergent pig breeds.

Cirera S, Jensen MS, Elbrønd VS, Moesgaard SG, Christoffersen BØ, Kadarmideen HN, Skovgaard K, Bruun CV, Karlskov-Mortensen P, Jørgensen CB, Fredholm M.

Anim Genet. 2014 Feb;45(1):59-66. doi: 10.1111/age.12082. Epub 2013 Aug 23.


Characterization of the genetic profile of five Danish dog breeds.

Pertoldi C, Kristensen TN, Loeschcke V, Berg P, Praebel A, Stronen AV, Proschowsky HF, Fredholm M.

J Anim Sci. 2013 Nov;91(11):5122-7. doi: 10.2527/jas.2013-6617. Epub 2013 Aug 29.


Comparison of the levels of bioactive benzoxazinoids in different wheat and rye fractions and the transformation of these compounds in homemade foods.

Tanwir F, Fredholm M, Gregersen PL, Fomsgaard IS.

Food Chem. 2013 Nov 1;141(1):444-50. doi: 10.1016/j.foodchem.2013.02.109. Epub 2013 Mar 7.


An f2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: design and genetic parameters.

Kogelman LJ, Kadarmideen HN, Mark T, Karlskov-Mortensen P, Bruun CS, Cirera S, Jacobsen MJ, Jørgensen CB, Fredholm M.

Front Genet. 2013 Mar 18;4:29. doi: 10.3389/fgene.2013.00029. eCollection 2013.


Potential role of the porcine superoxide dismutase 1 (SOD1) gene in pig reproduction.

Bjerre D, Madsen LB, Mark T, Cirera S, Larsen K, Jørgensen CB, Fredholm M.

Anim Biotechnol. 2013 Jan;24(1):1-9. doi: 10.1080/10495398.2012.723083.


A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.

Bruun CS, Jäderlund KH, Berendt M, Jensen KB, Spodsberg EH, Gredal H, Shelton GD, Mickelson JR, Minor KM, Lohi H, Bjerkås I, Stigen O, Espenes A, Rohdin C, Edlund R, Ohlsson J, Cizinauskas S, Leifsson PS, Drögemüller C, Moe L, Cirera S, Fredholm M.

PLoS One. 2013;8(2):e54547. doi: 10.1371/journal.pone.0054547. Epub 2013 Feb 5.

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