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Items: 48

1.

Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis.

Schenck EJ, Ma KC, Price DR, Nicholson T, Oromendia C, Gentzler ER, Sanchez E, Baron RM, Fredenburgh LE, Huh JW, Siempos II, Choi AM.

JCI Insight. 2019 May 2;4(9). pii: 127143. doi: 10.1172/jci.insight.127143. eCollection 2019 May 2.

2.

Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension.

Hudalla H, Michael Z, Christodoulou N, Willis GR, Fernandez-Gonzalez A, Filatava EJ, Dieffenbach P, Fredenburgh LE, Stearman RS, Geraci MW, Kourembanas S, Christou H.

Am J Respir Cell Mol Biol. 2019 Apr 5. doi: 10.1165/rcmb.2018-0232OC. [Epub ahead of print]

PMID:
30951642
3.

Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.

Englert JA, Cho MH, Lamb AE, Shumyatcher M, Barragan-Bradford D, Basil MC, Higuera A, Isabelle C, Vera MP, Dieffenbach PB, Fredenburgh LE, Kang JB, Bhatt AS, Antin JH, Ho VT, Soiffer RJ, Howrylak JA, Himes BE, Baron RM.

Respir Res. 2019 Jan 21;20(1):15. doi: 10.1186/s12931-019-0981-6.

4.

Plasma mitochondrial DNA and metabolomic alterations in severe critical illness.

Johansson PI, Nakahira K, Rogers AJ, McGeachie MJ, Baron RM, Fredenburgh LE, Harrington J, Choi AMK, Christopher KB.

Crit Care. 2018 Dec 29;22(1):360. doi: 10.1186/s13054-018-2275-7.

5.

Identification of miRNA-rich vesicles in bronchoalveolar lavage fluid: Insights into the function and heterogeneity of extracellular vesicles.

Lee H, Groot M, Pinilla-Vera M, Fredenburgh LE, Jin Y.

J Control Release. 2019 Jan 28;294:43-52. doi: 10.1016/j.jconrel.2018.12.008. Epub 2018 Dec 7.

PMID:
30529727
6.

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM.

JCI Insight. 2018 Dec 6;3(23). pii: 124039. doi: 10.1172/jci.insight.124039.

7.

T1 , T1 contrast, and Ernst-angle images of four rat-lung pathologies.

Kuethe DO, Hix JM, Fredenburgh LE.

Magn Reson Med. 2019 Apr;81(4):2489-2500. doi: 10.1002/mrm.27582. Epub 2018 Nov 12.

PMID:
30417929
8.

Mechanobiological Feedback in Pulmonary Vascular Disease.

Dieffenbach PB, Maracle M, Tschumperlin DJ, Fredenburgh LE.

Front Physiol. 2018 Jul 25;9:951. doi: 10.3389/fphys.2018.00951. eCollection 2018. Review.

9.

Circulating RIPK3 levels are associated with mortality and organ failure during critical illness.

Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelsztein EJ, Pabon MA, Oromendia C, Ballman KV, Baron RM, Fredenburgh LE, Higuera A, Lee JY, Chung CR, Jeon K, Yang JH, Howrylak JA, Huh JW, Suh GY, Choi AM.

JCI Insight. 2018 Jul 12;3(13). pii: 99692. doi: 10.1172/jci.insight.99692.

10.

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap7294. doi: 10.1126/scitranslmed.aap7294.

11.

RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury.

Siempos II, Ma KC, Imamura M, Baron RM, Fredenburgh LE, Huh JW, Moon JS, Finkelsztein EJ, Jones DS, Lizardi MT, Schenck EJ, Ryter SW, Nakahira K, Choi AM.

JCI Insight. 2018 May 3;3(9). pii: 97102. doi: 10.1172/jci.insight.97102.

12.

Aging and anatomical variations in lung tissue stiffness.

Sicard D, Haak AJ, Choi KM, Craig AR, Fredenburgh LE, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L946-L955. doi: 10.1152/ajplung.00415.2017. Epub 2018 Feb 22.

13.

Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury.

Abdulnour RE, Howrylak JA, Tavares AH, Douda DN, Henkels KM, Miller TE, Fredenburgh LE, Baron RM, Gomez-Cambronero J, Levy BD.

J Leukoc Biol. 2018 May;103(5):919-932. doi: 10.1002/JLB.3A0617-252RR. Epub 2018 Feb 13.

14.

Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts.

Park J, Pabon M, Choi AMK, Siempos II, Fredenburgh LE, Baron RM, Jeon K, Chung CR, Yang JH, Park CM, Suh GY.

BMC Pulm Med. 2017 Dec 15;17(1):204. doi: 10.1186/s12890-017-0532-1.

15.

Metabolome alterations in severe critical illness and vitamin D status.

Lasky-Su J, Dahlin A, Litonjua AA, Rogers AJ, McGeachie MJ, Baron RM, Gazourian L, Barragan-Bradford D, Fredenburgh LE, Choi AMK, Mogensen KM, Quraishi SA, Amrein K, Christopher KB.

Crit Care. 2017 Jul 28;21(1):193. doi: 10.1186/s13054-017-1794-y.

16.

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22.

17.

Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions.

Sicard D, Fredenburgh LE, Tschumperlin DJ.

J Mech Behav Biomed Mater. 2017 Oct;74:118-127. doi: 10.1016/j.jmbbm.2017.05.039. Epub 2017 May 31.

18.

Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome.

Putman RK, Hunninghake GM, Dieffenbach PB, Barragan-Bradford D, Serhan K, Adams U, Hatabu H, Nishino M, Padera RF, Fredenburgh LE, Baron RM, Englert JA.

Am J Respir Crit Care Med. 2017 Jan 1;195(1):138-141. doi: 10.1164/rccm.201604-0818LE. No abstract available.

19.

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.

Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, Fredenburgh LE, Englert JA, Piantadosi CA, Choi AM, Perrella MA.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):300-309. doi: 10.1165/rcmb.2016-0061OC.

20.

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.

Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA.

Crit Care Med. 2016 Dec;44(12):e1236-e1245.

21.

Metabolites Associated With Malnutrition in the Intensive Care Unit Are Also Associated With 28-Day Mortality.

Mogensen KM, Lasky-Su J, Rogers AJ, Baron RM, Fredenburgh LE, Rawn J, Robinson MK, Massarro A, Choi AM, Christopher KB.

JPEN J Parenter Enteral Nutr. 2017 Feb;41(2):188-197. doi: 10.1177/0148607116656164. Epub 2016 Jul 19.

PMID:
27406941
22.

Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.

Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinković A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE.

JCI Insight. 2016 Jun 2;1(8). pii: e86987.

23.

Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury.

Kuethe DO, Filipczak PT, Hix JM, Gigliotti AP, Estépar RS, Washko GR, Baron RM, Fredenburgh LE.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L208-18. doi: 10.1152/ajplung.00459.2015. Epub 2016 Jun 10.

24.

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY.

Cell Rep. 2015 Nov 3;13(5):1016-32. doi: 10.1016/j.celrep.2015.09.049. Epub 2015 Oct 22.

25.

Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.

Fredenburgh LE, Kraft BD, Hess DR, Harris RS, Wolf MA, Suliman HB, Roggli VL, Davies JD, Winkler T, Stenzler A, Baron RM, Thompson BT, Choi AM, Welty-Wolf KE, Piantadosi CA.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L834-46. doi: 10.1152/ajplung.00240.2015. Epub 2015 Aug 28.

26.

Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity.

Englert JA, Macias AA, Amador-Munoz D, Pinilla Vera M, Isabelle C, Guan J, Magaoay B, Suarez Velandia M, Coronata A, Lee A, Fredenburgh LE, Culley DJ, Crosby G, Baron RM.

Anesthesiology. 2015 Aug;123(2):377-88. doi: 10.1097/ALN.0000000000000742.

27.

Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures.

Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ.

Cardiovasc Toxicol. 2016 Apr;16(2):163-71. doi: 10.1007/s12012-015-9325-z.

28.

NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury.

Filipczak PT, Senft AP, Seagrave J, Weber W, Kuehl PJ, Fredenburgh LE, McDonald JD, Baron RM.

Toxicol Sci. 2015 Jul;146(1):89-100. doi: 10.1093/toxsci/kfv072. Epub 2015 Apr 13.

29.

Haeme oxygenase signalling pathway: implications for cardiovascular disease.

Fredenburgh LE, Merz AA, Cheng S.

Eur Heart J. 2015 Jun 21;36(24):1512-8. doi: 10.1093/eurheartj/ehv114. Epub 2015 Mar 31. Review.

30.

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide.

Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CN.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):314-25. doi: 10.1165/rcmb.2014-0299OC.

31.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12.

32.

Circadian rhythm reprogramming during lung inflammation.

Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM.

Nat Commun. 2014 Sep 11;5:4753. doi: 10.1038/ncomms5753.

33.

Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.

Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC.

34.

Metabolomic derangements are associated with mortality in critically ill adult patients.

Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM.

PLoS One. 2014 Jan 30;9(1):e87538. doi: 10.1371/journal.pone.0087538. eCollection 2014.

35.

Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation.

Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM.

PLoS Med. 2013 Dec;10(12):e1001577; discussion e1001577. doi: 10.1371/journal.pmed.1001577. Epub 2013 Dec 31.

36.

Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.

Lee S, Lee SJ, Coronata AA, Fredenburgh LE, Chung SW, Perrella MA, Nakahira K, Ryter SW, Choi AM.

Antioxid Redox Signal. 2014 Jan 20;20(3):432-42. doi: 10.1089/ars.2013.5368. Epub 2013 Oct 5.

37.

An integrated clinico-metabolomic model improves prediction of death in sepsis.

Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF.

Sci Transl Med. 2013 Jul 24;5(195):195ra95. doi: 10.1126/scitranslmed.3005893.

38.

Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia.

Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L829-37. doi: 10.1152/ajplung.00347.2011. Epub 2012 Feb 10.

39.

Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.

Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA.

J Immunol. 2011 Nov 15;187(10):5255-67. doi: 10.4049/jimmunol.1101186. Epub 2011 Oct 3.

40.

Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility.

Fredenburgh LE, Ma J, Perrella MA.

Trends Cardiovasc Med. 2009 Feb;19(2):31-7. doi: 10.1016/j.tcm.2009.04.003.

41.

High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.

Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA.

Am J Respir Cell Mol Biol. 2009 Aug;41(2):129-35. doi: 10.1165/rcmb.2008-0331OC. Epub 2008 Dec 18.

42.

Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.

Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA.

Circulation. 2008 Apr 22;117(16):2114-22. doi: 10.1161/CIRCULATIONAHA.107.716241. Epub 2008 Apr 7.

43.

Clinical Decisions. Mild persistent asthma--polling results.

Fredenburgh LE, Campion EW, Drazen JM.

N Engl J Med. 2007 Jul 12;357(2):179-80. Epub 2007 Jun 20. No abstract available.

PMID:
17582063
44.

The role of heme oxygenase-1 in pulmonary disease.

Fredenburgh LE, Perrella MA, Mitsialis SA.

Am J Respir Cell Mol Biol. 2007 Feb;36(2):158-65. Epub 2006 Sep 15. Review.

45.

Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels.

Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA.

Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):513-20.

PMID:
16309574
46.

Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury.

Fukunaga K, Kohli P, Bonnans C, Fredenburgh LE, Levy BD.

J Immunol. 2005 Apr 15;174(8):5033-9.

47.

Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.

Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA.

J Immunol. 2004 Sep 15;173(6):4147-53.

48.

Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice.

Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA.

FASEB J. 2004 Aug;18(11):1276-8. Epub 2004 Jun 18.

PMID:
15208261

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