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Items: 1 to 50 of 104

1.

Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations.

Wolf S, Amaral M, Lowinski M, Vallée F, Musil D, Güldenhaupt J, Dreyer MK, Bomke J, Frech M, Schlitter J, Gerwert K.

J Chem Inf Model. 2019 Nov 22. doi: 10.1021/acs.jcim.9b00592. [Epub ahead of print]

PMID:
31697501
2.

Generation of the Niemann-Pick type C2 patient-derived iPSC line AKOSi001-A.

Völkner C, Peter F, Liedtke M, Krohn S, Lindner I, Murua Escobar H, Cimmaruta C, Lukas J, Hermann A, Frech MJ.

Stem Cell Res. 2019 Oct 15;41:101606. doi: 10.1016/j.scr.2019.101606. [Epub ahead of print]

3.

Determination of the Pathological Features of NPC1 Variants in a Cellular Complementation Test.

Feng X, Cozma C, Pantoom S, Hund C, Iwanov K, Petters J, Völkner C, Bauer C, Vogel F, Bauer P, Weiss FU, Lerch MM, Knospe AM, Hermann A, Frech MJ, Luo J, Rolfs A, Lukas J.

Int J Mol Sci. 2019 Oct 19;20(20). pii: E5185. doi: 10.3390/ijms20205185.

4.

Stimulation of mGluR1/5 Improves Defective Internalization of AMPA Receptors in NPC1 Mutant Mouse.

Feng X, Yang F, Rabenstein M, Wang Z, Frech MJ, Wree A, Bräuer AU, Witt M, Gläser A, Hermann A, Rolfs A, Luo J.

Cereb Cortex. 2019 Oct 10. pii: bhz179. doi: 10.1093/cercor/bhz179. [Epub ahead of print]

PMID:
31599924
5.

The Role of Dietary Fiber in Rheumatoid Arthritis Patients: A Feasibility Study.

Häger J, Bang H, Hagen M, Frech M, Träger P, Sokolova MV, Steffen U, Tascilar K, Sarter K, Schett G, Rech J, Zaiss MM.

Nutrients. 2019 Oct 7;11(10). pii: E2392. doi: 10.3390/nu11102392.

6.

How and Why Different Forms of Expertise Moderate Anchor Precision in Price Decisions.

Frech ML, Loschelder DD, Friese M.

Exp Psychol. 2019 Mar;66(2):165-175. doi: 10.1027/1618-3169/a000441.

PMID:
31044670
7.

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.

Lukas J, Pospech J, Oppermann C, Hund C, Iwanov K, Pantoom S, Petters J, Frech M, Seemann S, Thiel FG, Modenbach JM, Bolsmann R, de Freitas Chama L, Kraatz F, El-Hage F, Gronbach M, Klein A, Müller R, Salloch S, Weiss FU, Simon P, Wagh P, Klemenz A, Krüger E, Mayerle J, Delcea M, Kragl U, Beller M, Rolfs A, Lerch MM, Sendler M.

Adv Med Sci. 2019 Sep;64(2):315-323. doi: 10.1016/j.advms.2019.03.004. Epub 2019 Apr 9. Review.

PMID:
30978662
8.

Young carers and young adult carers in Switzerland: Caring roles, ways into care and the meaning of communication.

Leu A, Frech M, Jung C.

Health Soc Care Community. 2018 Nov;26(6):925-934. doi: 10.1111/hsc.12622. Epub 2018 Aug 3.

PMID:
30074654
9.

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM.

Cell Rep. 2018 Jul 3;24(1):169-180. doi: 10.1016/j.celrep.2018.06.005.

10.

MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia.

Frech M, Teichler S, Feld C, Bouchard C, Berberich H, Sorg K, Mernberger M, Bullinger L, Bauer UM, Neubauer A.

Oncotarget. 2018 Apr 27;9(32):22423-22435. doi: 10.18632/oncotarget.25051. eCollection 2018 Apr 27.

11.

Ligand-Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free-Towards a Conformational Activity Screening for Drug Discovery.

Güldenhaupt J, Amaral M, Kötting C, Schartner J, Musil D, Frech M, Gerwert K.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9955-9960. doi: 10.1002/anie.201802603. Epub 2018 Jul 3.

12.

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.

Kokh DB, Amaral M, Bomke J, Grädler U, Musil D, Buchstaller HP, Dreyer MK, Frech M, Lowinski M, Vallee F, Bianciotto M, Rak A, Wade RC.

J Chem Theory Comput. 2018 Jul 10;14(7):3859-3869. doi: 10.1021/acs.jctc.8b00230. Epub 2018 Jun 4.

13.

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

Schuetz DA, Richter L, Amaral M, Grandits M, Grädler U, Musil D, Buchstaller HP, Eggenweiler HM, Frech M, Ecker GF.

J Med Chem. 2018 May 24;61(10):4397-4411. doi: 10.1021/acs.jmedchem.8b00080. Epub 2018 May 10.

PMID:
29701469
14.

"You don't look for it"-A study of Swiss professionals' awareness of young carers and their support needs.

Leu A, Frech M, Jung C.

Health Soc Care Community. 2018 Jul;26(4):e560-e570. doi: 10.1111/hsc.12574. Epub 2018 Apr 11.

PMID:
29642272
15.

Study protocol: young carers and young adult carers in Switzerland.

Leu A, Jung C, Frech M, Sempik J, Moser U, Verner M, Becker S.

BMC Health Serv Res. 2018 Mar 15;18(1):183. doi: 10.1186/s12913-018-2981-5.

16.

Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.

Feld C, Sahu P, Frech M, Finkernagel F, Nist A, Stiewe T, Bauer UM, Neubauer A.

Nucleic Acids Res. 2018 Apr 20;46(7):3412-3428. doi: 10.1093/nar/gky119.

17.

Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice.

Rabenstein M, Peter F, Rolfs A, Frech MJ.

Sci Rep. 2018 Feb 20;8(1):3318. doi: 10.1038/s41598-018-21805-z.

18.

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding.

Amaral M, Kokh DB, Bomke J, Wegener A, Buchstaller HP, Eggenweiler HM, Matias P, Sirrenberg C, Wade RC, Frech M.

Nat Commun. 2017 Dec 22;8(1):2276. doi: 10.1038/s41467-017-02258-w.

19.

Activation of PKC triggers rescue of NPC1 patient specific iPSC derived glial cells from gliosis.

Peter F, Rost S, Rolfs A, Frech MJ.

Orphanet J Rare Dis. 2017 Aug 25;12(1):145. doi: 10.1186/s13023-017-0697-y.

20.

Non-canonical pathway induced by Wnt3a regulates β-catenin via Pyk2 in differentiating human neural progenitor cells.

Narendra Talabattula VA, Morgan P, Frech MJ, Uhrmacher AM, Herchenröder O, Pützer BM, Rolfs A, Luo J.

Biochem Biophys Res Commun. 2017 Sep 9;491(1):40-46. doi: 10.1016/j.bbrc.2017.07.030. Epub 2017 Jul 8.

PMID:
28694190
21.

[Principles of the EU Clinical Trials Regulation No 536/2014 : What will change?]

Mende A, Frech M, Riedel C.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Aug;60(8):795-803. doi: 10.1007/s00103-017-2575-0. Review. German.

PMID:
28685215
22.

Decreased calcium flux in Niemann-Pick type C1 patient-specific iPSC-derived neurons due to higher amount of calcium-impermeable AMPA receptors.

Rabenstein M, Peter F, Joost S, Trilck M, Rolfs A, Frech MJ.

Mol Cell Neurosci. 2017 Sep;83:27-36. doi: 10.1016/j.mcn.2017.06.007. Epub 2017 Jun 27.

PMID:
28666962
23.

[Changes in the German Medicinal Product Act imposed by the EU regulation on clinical trials].

Nickel L, Seibel Y, Frech M, Sudhop T.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Aug;60(8):804-811. doi: 10.1007/s00103-017-2574-1. Review. German.

PMID:
28664271
24.

Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acid.

Killer MC, Nold P, Henkenius K, Fritz L, Riedlinger T, Barckhausen C, Frech M, Hackstein H, Neubauer A, Brendel C.

Stem Cell Res Ther. 2017 Apr 26;8(1):100. doi: 10.1186/s13287-017-0553-y.

26.

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, IJzerman AP, Müller-Fahrnow A, Ecker GF.

Drug Discov Today. 2017 Jun;22(6):896-911. doi: 10.1016/j.drudis.2017.02.002. Epub 2017 Apr 13. Review.

PMID:
28412474
27.

Dasatinib and allogeneic stem cell transplantation enable sustained response in an elderly patient with RCSD1-ABL1-positive acute lymphoblastic leukemia.

Frech M, Jehn LB, Stabla K, Mielke S, Steffen B, Einsele H, Metzelder SK, Neubauer A.

Haematologica. 2017 Apr;102(4):e160-e162. doi: 10.3324/haematol.2016.160531. Epub 2017 Jan 5. No abstract available.

28.

Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons.

Trilck M, Peter F, Zheng C, Frank M, Dobrenis K, Mascher H, Rolfs A, Frech MJ.

Brain Res. 2017 Feb 15;1657:52-61. doi: 10.1016/j.brainres.2016.11.031. Epub 2016 Dec 5.

PMID:
27923633
29.

[Still invisible, but not forgotten].

Leu A, Frech M.

Krankenpfl Soins Infirm. 2015;108(8):8-10, 56-8, 78-80. French, German, Italian. No abstract available.

PMID:
26411071
30.

Cyclodextrin Alters GABAergic Input to CA1 Pyramidal Cells in Wild-Type But Not in NPC1-Deficient Mice.

Frech MJ, Rabenstein M, Bovensiepen K, Rost S, Rolfs A.

Biores Open Access. 2015 Aug 1;4(1):358-62. doi: 10.1089/biores.2015.0023. eCollection 2015.

31.

[Safety monitoring of cell-based medicinal products (CBMPs)].

Funk MB, Frech M, Spranger R, Keller-Stanislawski B.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2015 Nov;58(11-12):1239-46. doi: 10.1007/s00103-015-2240-4. Review. German.

PMID:
26391098
32.

Generation and Neuronal Differentiation of Patient-Specific Induced Pluripotent Stem Cells Derived from Niemann-Pick Type C1 Fibroblasts.

Trilck M, Hübner R, Frech MJ.

Methods Mol Biol. 2016;1353:233-59. doi: 10.1007/7651_2014_166.

PMID:
25520288
33.

HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.

Mußmann C, Hübner R, Trilck M, Rolfs A, Frech MJ.

Stem Cells Dev. 2014 Jun 15;23(12):1328-39. doi: 10.1089/scd.2013.0557. Epub 2014 Mar 25.

PMID:
24548083
34.

The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells.

Kretzschmar C, Roolf C, Langhammer TS, Sekora A, Pews-Davtyan A, Beller M, Frech MJ, Eisenlöffel C, Rolfs A, Junghanss C.

BMC Cancer. 2014 Feb 6;14:71. doi: 10.1186/1471-2407-14-71.

35.

Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks.

Trilck M, Hübner R, Seibler P, Klein C, Rolfs A, Frech MJ.

Orphanet J Rare Dis. 2013 Sep 18;8:144. doi: 10.1186/1750-1172-8-144.

36.

Combined therapy with cyclodextrin/allopregnanolone and miglustat improves motor but not cognitive functions in Niemann-Pick Type C1 mice.

Hovakimyan M, Maass F, Petersen J, Holzmann C, Witt M, Lukas J, Frech MJ, Hübner R, Rolfs A, Wree A.

Neuroscience. 2013 Nov 12;252:201-11. doi: 10.1016/j.neuroscience.2013.08.001. Epub 2013 Aug 13.

PMID:
23948640
37.

Spontaneous calcium transients in human neural progenitor cells mediated by transient receptor potential channels.

Morgan PJ, Hübner R, Rolfs A, Frech MJ.

Stem Cells Dev. 2013 Sep 15;22(18):2477-86. doi: 10.1089/scd.2013.0061. Epub 2013 Jun 11.

PMID:
23631375
38.

Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells.

Eisenlöffel C, Schmöle AC, Pews-Davtyan A, Brennführer A, Kuznetsov SA, Hübner R, Frech S, Schult C, Junghanss C, Beller M, Rolfs A, Frech MJ.

Biochem Pharmacol. 2013 Mar 15;85(6):763-71. doi: 10.1016/j.bcp.2012.12.013. Epub 2012 Dec 26.

PMID:
23274302
39.

Structural and biophysical characterization of the Syk activation switch.

Grädler U, Schwarz D, Dresing V, Musil D, Bomke J, Frech M, Greiner H, Jäkel S, Rysiok T, Müller-Pompalla D, Wegener A.

J Mol Biol. 2013 Jan 23;425(2):309-33. doi: 10.1016/j.jmb.2012.11.007. Epub 2012 Nov 12.

PMID:
23154170
40.

Small molecules in stem cell research.

Schmöle AC, Hübner R, Beller M, Rolfs A, Frech MJ.

Curr Pharm Biotechnol. 2013;14(1):36-45. Review.

PMID:
23092256
41.

Cultivation of human neural progenitor cells in a 3-dimensional self-assembling peptide hydrogel.

Liedmann A, Rolfs A, Frech MJ.

J Vis Exp. 2012 Jan 11;(59):e3830. doi: 10.3791/3830.

42.

Differentiation of human neural progenitor cells in functionalized hydrogel matrices.

Liedmann A, Frech S, Morgan PJ, Rolfs A, Frech MJ.

Biores Open Access. 2012 Jan;1(1):16-24. doi: 10.1089/biores.2012.0209.

43.

Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding.

Seshire A, Rößiger T, Frech M, Beez S, Hagemeyer H, Puccetti E.

Leukemia. 2012 Jun;26(6):1338-47. doi: 10.1038/leu.2011.331. Epub 2011 Nov 22. Erratum in: Leukemia. 2012 Nov;26(11):2445-6.

PMID:
22105598
44.

Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse.

Yan X, Lukas J, Witt M, Wree A, Hübner R, Frech M, Köhling R, Rolfs A, Luo J.

Metab Brain Dis. 2011 Dec;26(4):299-306. doi: 10.1007/s11011-011-9263-9. Epub 2011 Sep 21.

PMID:
21938520
45.

Human neural progenitor cells show functional neuronal differentiation and regional preference after engraftment onto hippocampal slice cultures.

Morgan PJ, Liedmann A, Hübner R, Hovakimyan M, Rolfs A, Frech MJ.

Stem Cells Dev. 2012 Jun 10;21(9):1501-12. doi: 10.1089/scd.2011.0335. Epub 2011 Dec 23.

PMID:
21867424
46.

Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation.

Mazemondet O, Hubner R, Frahm J, Koczan D, Bader BM, Weiss DG, Uhrmacher AM, Frech MJ, Rolfs A, Luo J.

Cell Mol Biol Lett. 2011 Dec;16(4):515-38. doi: 10.2478/s11658-011-0021-0. Epub 2011 Jul 29.

47.

Morphological alterations of the cornea in the mouse model of niemann-pick disease type c1.

Hovakimyan M, Stachs O, Reichard M, Mascher H, Lukas J, Frech MJ, Guthoff R, Witt M, Rolfs A, Wree A.

Cornea. 2011 Jul;30(7):796-803. doi: 10.1097/ICO.0b013e3182012a33.

PMID:
21317782
48.

Erythropoietin and the effect of oxygen during proliferation and differentiation of human neural progenitor cells.

Giese AK, Frahm J, Hübner R, Luo J, Wree A, Frech MJ, Rolfs A, Ortinau S.

BMC Cell Biol. 2010 Dec 2;11:94. doi: 10.1186/1471-2121-11-94.

49.

Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells.

Ortinau S, Schmich J, Block S, Liedmann A, Jonas L, Weiss DG, Helm CA, Rolfs A, Frech MJ.

Biomed Eng Online. 2010 Nov 11;9:70. doi: 10.1186/1475-925X-9-70.

50.

Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells.

Lange C, Mix E, Frahm J, Glass A, Müller J, Schmitt O, Schmöle AC, Klemm K, Ortinau S, Hübner R, Frech MJ, Wree A, Rolfs A.

Neurosci Lett. 2011 Jan 13;488(1):36-40. doi: 10.1016/j.neulet.2010.10.076. Epub 2010 Nov 5.

PMID:
21056624

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