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SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.

Chen LL, Zhu J, Schumacher J, Wei C, Ramdas L, Prieto VG, Jimenez A, Velasco MA, Tripp SR, Andtbacka RHI, Gouw L, Rodgers GM, Zhang L, Chan BK, Cassidy PB, Benjamin RS, Leachman SA, Frazier ML.

PLoS One. 2017 Sep 7;12(9):e0184154. doi: 10.1371/journal.pone.0184154. eCollection 2017.


A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer.

Balasenthil S, Huang Y, Liu S, Marsh T, Chen J, Stass SA, KuKuruga D, Brand R, Chen N, Frazier ML, Jack Lee J, Srivastava S, Sen S, McNeill Killary A.

J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw341.


Identification of genetic variants predictive of early onset pancreatic cancer through a population science analysis of functional genomic datasets.

Chen J, Wu X, Huang Y, Chen W, Brand RE, Killary AM, Sen S, Frazier ML.

Oncotarget. 2016 Aug 30;7(35):56480-56490. doi: 10.18632/oncotarget.10924.


CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment.

Zhang T, Tseng C, Zhang Y, Sirin O, Corn PG, Li-Ning-Tapia EM, Troncoso P, Davis J, Pettaway C, Ward J, Frazier ML, Logothetis C, Kolonin MG.

Nat Commun. 2016 May 31;7:11674. doi: 10.1038/ncomms11674.


Definitive Characterization of CA 19-9 in Resectable Pancreatic Cancer Using a Reference Set of Serum and Plasma Specimens.

Haab BB, Huang Y, Balasenthil S, Partyka K, Tang H, Anderson M, Allen P, Sasson A, Zeh H, Kaul K, Kletter D, Ge S, Bern M, Kwon R, Blasutig I, Srivastava S, Frazier ML, Sen S, Hollingsworth MA, Rinaudo JA, Killary AM, Brand RE.

PLoS One. 2015 Oct 2;10(10):e0139049. doi: 10.1371/journal.pone.0139049. eCollection 2015.


Erratum to: Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers.

Wei C, Peng B, Han Y, Chen WV, Rother J, Tomlinson GE, Richard Boland C, Chaussabel D, Frazier ML, Amos CI.

Fam Cancer. 2015 Jun;14(2):307. doi: 10.1007/s10689-015-9801-4. No abstract available.


Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers.

Wei C, Peng B, Han Y, Chen WV, Rother J, Tomlinson GE, Boland CR, Chaussabel D, Frazier ML, Amos CI.

Fam Cancer. 2015 Jun;14(2):297-306. doi: 10.1007/s10689-014-9758-8. Erratum in: Fam Cancer. 2015 Jun;14(2):307. Chaussabel, Marc [corrected to Chaussabel, Damien].


Distribution of cholecystokinin-B receptor genotype between patients with pancreatic cancer and controls and its impact on survival.

Smith JP, Whitcomb DC, Matters GL, Brand RE, Liao J, Huang YJ, Frazier ML.

Pancreas. 2015 Mar;44(2):236-42. doi: 10.1097/MPA.0000000000000263.


Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions.

Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S.

Cancer Lett. 2015 Jan 28;356(2 Pt B):404-9. doi: 10.1016/j.canlet.2014.09.029. Epub 2014 Oct 7.


Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer.

Wang J, Raimondo M, Guha S, Chen J, Diao L, Dong X, Wallace MB, Killary AM, Frazier ML, Woodward TA, Wang J, Sen S.

J Cancer. 2014 Sep 16;5(8):696-705. doi: 10.7150/jca.10094. eCollection 2014.


Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer.

Huang YJ, Frazier ML, Zhang N, Liu Q, Wei C.

Dig Dis Sci. 2014 May;59(5):968-75. doi: 10.1007/s10620-013-2938-9. Epub 2013 Nov 19.


DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition.

Chen N, Balasenthil S, Reuther J, Frayna A, Wang Y, Chandler DS, Abruzzo LV, Rashid A, Rodriguez J, Lozano G, Cao Y, Lokken E, Chen J, Frazier ML, Sahin AA, Wistuba II, Sen S, Lott ST, Killary AM.

Cancer Discov. 2013 Oct;3(10):1172-89. doi: 10.1158/2159-8290.CD-12-0499. Epub 2013 Jul 9.


Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma.

Liu Q, Chen J, Wang J, Amos C, Killary AM, Sen S, Wei C, Frazier ML.

Mol Carcinog. 2014 Sep;53(9):711-21. doi: 10.1002/mc.22023. Epub 2013 May 9.


A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients with Lynch syndrome.

Wei C, Chen J, Pande M, Lynch PM, Frazier ML.

J Cancer Res Clin Oncol. 2013 Jul;139(7):1241-50. doi: 10.1007/s00432-013-1437-x. Epub 2013 Apr 21.


Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y.

BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67.


Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families.

Burton-Chase AM, Hovick SR, Peterson SK, Marani SK, Vernon SW, Amos CI, Frazier ML, Lynch PM, Gritz ER.

Clin Genet. 2013 Mar;83(3):215-20. doi: 10.1111/cge.12091.


Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.

Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK 3rd, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2804-9. doi: 10.1073/pnas.1219701110. Epub 2013 Jan 28.


Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans.

Walsh KM, Amos CI, Wenzlaff AS, Gorlov IP, Sison JD, Wu X, Spitz MR, Hansen HM, Lu EY, Wei C, Zhang H, Chen W, Lloyd SM, Frazier ML, Bracci PM, Seldin MF, Wrensch MR, Schwartz AG, Wiencke JK.

Oncotarget. 2012 Nov;3(11):1428-38.


Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.

Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu EY, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos CI.

Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):251-60. doi: 10.1158/1055-9965.EPI-12-1007-T. Epub 2012 Dec 5.


Genetic variants in the vitamin D pathway and breast cancer disease-free survival.

Pande M, Thompson PA, Do KA, Sahin AA, Amos CI, Frazier ML, Bondy ML, Brewster AM.

Carcinogenesis. 2013 Mar;34(3):587-94. doi: 10.1093/carcin/bgs369. Epub 2012 Nov 24.


Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.

Chen J, Pande M, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott RJ, Frazier ML.

Carcinogenesis. 2013 Feb;34(2):299-306. doi: 10.1093/carcin/bgs344. Epub 2012 Nov 3.


Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry.

Pande M, Wei C, Chen J, Amos CI, Lynch PM, Lu KH, Lucio LA, Boyd-Rogers SG, Bannon SA, Mork ME, Frazier ML.

Fam Cancer. 2012 Sep;11(3):441-7. doi: 10.1007/s10689-012-9534-6.


Exploiting antitumor immunity to overcome relapse and improve remission duration.

Chen LL, Chen X, Choi H, Sang H, Chen LC, Zhang H, Gouw L, Andtbacka RH, Chan BK, Rodesch CK, Jimenez A, Cano P, Jones KA, Oyedeji CO, Martins T, Hill HR, Schumacher J, Willmore C, Scaife CL, Ward JH, Morton K, Randall RL, Lazar AJ, Patel S, Trent JC, Frazier ML, Lin P, Jensen P, Benjamin RS.

Cancer Immunol Immunother. 2012 Jul;61(7):1113-24. doi: 10.1007/s00262-011-1185-1. Epub 2011 Dec 24.


Microsatellite instability in saliva from patients with hereditary non-polyposis colon cancer and siblings carrying germline mismatch repair gene mutations.

Hu P, Lee CW, Xu JP, Simien C, Fan CL, Tam M, Ramagli L, Brown BW, Lynch P, Frazier ML, Siciliano MJ, Coolbaugh-Murphy M.

Ann Clin Lab Sci. 2011 Fall;41(4):321-30.


A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.

Wei C, Han Y, Spitz MR, Wu X, Chancoco H, Akiva P, Rechavi G, Brand H, Wun I, Frazier ML, Amos CI.

Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2603-9. doi: 10.1158/1055-9965.EPI-11-0749. Epub 2011 Oct 25.


Circulation of progenitor cells in obese and lean colorectal cancer patients.

Bellows CF, Zhang Y, Chen J, Frazier ML, Kolonin MG.

Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2461-8. doi: 10.1158/1055-9965.EPI-11-0556. Epub 2011 Sep 19.


Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer.

Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML.

Pancreas. 2011 Aug;40(6):872-5. doi: 10.1097/MPA.0b013e318219dafe.


A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians.

Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML.

Mol Carcinog. 2012 May;51(5):433-8. doi: 10.1002/mc.20808. Epub 2011 Jun 7.


A migration signature and plasma biomarker panel for pancreatic adenocarcinoma.

Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary AM.

Cancer Prev Res (Phila). 2011 Jan;4(1):137-49. doi: 10.1158/1940-6207.CAPR-10-0025. Epub 2010 Nov 11.


Evolutionary evidence of the effect of rare variants on disease etiology.

Gorlov IP, Gorlova OY, Frazier ML, Spitz MR, Amos CI.

Clin Genet. 2011 Mar;79(3):199-206. doi: 10.1111/j.1399-0004.2010.01535.x. Epub 2010 Sep 10. Review.


Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center.

Pande M, Lynch PM, Hopper JL, Jenkins MA, Gallinger S, Haile RW, LeMarchand L, Lindor NM, Campbell PT, Newcomb PA, Potter JD, Baron JA, Frazier ML, Amos CI.

Clin Cancer Res. 2010 Feb 15;16(4):1331-9. doi: 10.1158/1078-0432.CCR-09-1877. Epub 2010 Feb 9.


Microsatellite instability in the peripheral blood leukocytes of HNPCC patients.

Coolbaugh-Murphy MI, Xu JP, Ramagli LS, Ramagli BC, Brown BW, Lynch PM, Hamilton SR, Frazier ML, Siciliano MJ.

Hum Mutat. 2010 Mar;31(3):317-24. doi: 10.1002/humu.21190.


Health and lifestyle behaviors among persons at risk of Lynch syndrome.

Burton AM, Peterson SK, Marani SK, Vernon SW, Amos CI, Frazier ML, Lynch PM, Gritz ER.

Cancer Causes Control. 2010 Apr;21(4):513-21. doi: 10.1007/s10552-009-9482-0. Epub 2009 Dec 10.


Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.

Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML.

Pancreas. 2010 Jan;39(1):1-4. doi: 10.1097/MPA.0b013e3181bd51c8.


MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease.

Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S.

Cancer Prev Res (Phila). 2009 Sep;2(9):807-13. doi: 10.1158/1940-6207.CAPR-09-0094. Epub 2009 Sep 1.


Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome.

Chen J, Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lindor NM, Lynch PM, Frazier ML.

Cancer Causes Control. 2009 Nov;20(9):1769-77. doi: 10.1007/s10552-009-9416-x. Epub 2009 Aug 19.


Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin.

Kennedy SA, Frazier ML, Steiniger M, Mast AM, Marzluff WF, Redinbo MR.

J Mol Biol. 2009 Sep 11;392(1):115-28. doi: 10.1016/j.jmb.2009.06.062. Epub 2009 Jul 1.


DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer.

Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM.

PLoS Med. 2009 May 26;6(5):e1000068. doi: 10.1371/journal.pmed.1000068. Epub 2009 May 5.


Work stressors, role-based performance, and the moderating influence of organizational support.

Wallace JC, Edwards BD, Arnold T, Frazier ML, Finch DM.

J Appl Psychol. 2009 Jan;94(1):254-62. doi: 10.1037/a0013090.


Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.

Wei C, Amos CI, Zhang N, Zhu J, Wang X, Frazier ML.

Cancer Lett. 2009 May 18;277(2):149-54. doi: 10.1016/j.canlet.2008.11.036. Epub 2009 Jan 14.


Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.

Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML.

Ann Surg Oncol. 2009 Feb;16(2):431-9. doi: 10.1245/s10434-008-0220-8. Epub 2008 Nov 20.


Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions.

Ye Y, Lippman SM, Lee JJ, Chen M, Frazier ML, Spitz MR, Wu X.

Cancer. 2008 Nov 1;113(9):2488-95. doi: 10.1002/cncr.23854.


Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.

Pande M, Amos CI, Osterwisch DR, Chen J, Lynch PM, Broaddus R, Frazier ML.

Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2393-401. doi: 10.1158/1055-9965.EPI-08-0326.


Phase II trial of imatinib mesylate in patients with metastatic melanoma.

Kim KB, Eton O, Davis DW, Frazier ML, McConkey DJ, Diwan AH, Papadopoulos NE, Bedikian AY, Camacho LH, Ross MI, Cormier JN, Gershenwald JE, Lee JE, Mansfield PF, Billings LA, Ng CS, Charnsangavej C, Bar-Eli M, Johnson MM, Murgo AJ, Prieto VG.

Br J Cancer. 2008 Sep 2;99(5):734-40. doi: 10.1038/sj.bjc.6604482. Epub 2008 Aug 19.


Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.

Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML.

Cancer Lett. 2008 Dec 8;272(1):32-9. doi: 10.1016/j.canlet.2008.06.022. Epub 2008 Aug 9.


Active nuclear receptors exhibit highly correlated AF-2 domain motions.

Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BR, Redinbo MR.

PLoS Comput Biol. 2008 Jul 11;4(7):e1000111. doi: 10.1371/journal.pcbi.1000111.


Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression.

Chen LL, Holden JA, Choi H, Zhu J, Wu EF, Jones KA, Ward JH, Andtbacka RH, Randall RL, Scaife CL, Hunt KK, Prieto VG, Raymond AK, Zhang W, Trent JC, Benjamin RS, Frazier ML.

Mod Pathol. 2008 Jul;21(7):826-36. doi: 10.1038/modpathol.2008.46. Epub 2008 May 16.


Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling.

Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML.

Clin Cancer Res. 2008 Feb 15;14(4):1167-71. doi: 10.1158/1078-0432.CCR-07-4007.

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