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Ten reasons why every junior doctor should spend time working in a remote and rural hospital.

Fox K, Corstorphine W, Frazer J, Johnstone A, Miller A, Shepherd N, Cooper P.

Future Healthc J. 2020 Feb;7(1):12-14. doi: 10.7861/fhj.2019-0050. No abstract available.


Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays.

Ren A, Zhu X, Feichtinger K, Lehman J, Kasem M, Schrader TO, Wong A, Dang H, Le M, Frazer J, Unett DJ, Grottick AJ, Whelan KT, Morgan ME, Sage CR, Semple G.

Bioorg Med Chem Lett. 2020 Mar 1;30(5):126929. doi: 10.1016/j.bmcl.2019.126929. Epub 2019 Dec 26.


Tackling Acute Lymphoblastic Leukemia-One Fish at a Time.

Sinha AA, Park G, Frazer JK.

Int J Mol Sci. 2019 Oct 25;20(21). pii: E5313. doi: 10.3390/ijms20215313. Review.


Variability in body temperature in healthy adults and in patients receiving chemotherapy: prospective observational cohort study.

Frazer JS, Barnes GE, Woodcock V, Flanagan E, Littlewood T, Stevens RJ, Fleming S, Ashdown HF.

J Med Eng Technol. 2019 Jul;43(5):323-333. doi: 10.1080/03091902.2019.1667446. Epub 2019 Oct 3.


Targeted sequencing of candidate genes of dyslipidemia in Punjabi Sikhs: Population-specific rare variants in GCKR promote ectopic fat deposition.

Sanghera DK, Hopkins R, Malone-Perez MW, Bejar C, Tan C, Mussa H, Whitby P, Fowler B, Rao CV, Fung KA, Lightfoot S, Frazer JK.

PLoS One. 2019 Aug 1;14(8):e0211661. doi: 10.1371/journal.pone.0211661. eCollection 2019.


Recurrent ovarian immature teratoma in a 12-year-old girl: Implications for management.

Frazer JL, Hook CE, Addley HC, Jackson CR, Latimer JA, Nicholson JC, Murray MJ.

Gynecol Oncol. 2019 Aug;154(2):259-265. doi: 10.1016/j.ygyno.2019.05.032. Epub 2019 Jun 5.


Anticoagulation: a practical guide for strabismus surgeons.

Robbins SL, Wang JW, Frazer JR, Greenberg M.

J AAPOS. 2019 Aug;23(4):193-199. doi: 10.1016/j.jaapos.2018.12.008. Epub 2019 Apr 11. Review.


Zebrafish MYC-induced leukemia models: unique in vivo systems to study B and T cell acute lymphoblastic leukemia.

Borga C, Frazer JK.

Int J Hematol Oncol. 2019 Mar 1;8(1):IJH12. doi: 10.2217/ijh-2018-0013. eCollection 2019 Feb. No abstract available.


Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish.

Burroughs-Garcia J, Hasan A, Park G, Borga C, Frazer JK.

J Vis Exp. 2019 Feb 22;(144). doi: 10.3791/59191.


Molecularly distinct models of zebrafish Myc-induced B cell leukemia.

Borga C, Foster CA, Iyer S, Garcia SP, Langenau DM, Frazer JK.

Leukemia. 2019 Feb;33(2):559-562. doi: 10.1038/s41375-018-0328-1. Epub 2018 Dec 20. No abstract available.


Excellent outcomes in children and adolescents with CNS+ Burkitt lymphoma or other mature B-NHL using only intrathecal and systemic chemoimmunotherapy: results from FAB/LMB96 and COG ANHL01P1.

Frazer JK, Li KJ, Galardy PJ, Perkins SL, Auperin A, Anderson JR, Pinkerton R, Buxton A, Gross TG, Michon J, Leverger G, Weinstein HJ, Harrison L, Shiramizu B, Barth MJ, Goldman SC, Patte C, Cairo MS.

Br J Haematol. 2019 Apr;185(2):374-377. doi: 10.1111/bjh.15520. Epub 2018 Aug 16. No abstract available.


Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis.

Borga C, Park G, Foster C, Burroughs-Garcia J, Marchesin M, Shah R, Hasan A, Ahmed ST, Bresolin S, Batchelor L, Scordino T, Miles RR, Te Kronnie G, Regens JL, Frazer JK.

Leukemia. 2019 Feb;33(2):333-347. doi: 10.1038/s41375-018-0226-6. Epub 2018 Aug 15.


Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.

Gaidarov I, Adams J, Frazer J, Anthony T, Chen X, Gatlin J, Semple G, Unett DJ.

Cell Signal. 2018 Oct;50:9-24. doi: 10.1016/j.cellsig.2018.06.007. Epub 2018 Jun 19.


Endosymbiont-based immunity in Drosophila melanogaster against parasitic nematode infection.

Yadav S, Frazer J, Banga A, Pruitt K, Harsh S, Jaenike J, Eleftherianos I.

PLoS One. 2018 Feb 21;13(2):e0192183. doi: 10.1371/journal.pone.0192183. eCollection 2018.


The Future Role of the United States in Global Health: Emphasis on Cardiovascular Disease.

Fuster V, Frazer J, Snair M, Vedanthan R, Dzau V; Committee on Global Health and the Future of the United States: A Report of the National Academies of Sciences, Engineering and Medicine.

J Am Coll Cardiol. 2017 Dec 26;70(25):3140-3156. doi: 10.1016/j.jacc.2017.11.009. Epub 2017 Nov 30. Review.


Investing in Global Health for Our Future.

Dzau V, Fuster V, Frazer J, Snair M.

N Engl J Med. 2017 Sep 28;377(13):1292-1296. doi: 10.1056/NEJMsr1707974. No abstract available.


MIF and D-DT are potential disease severity modifiers in male MS subjects.

Benedek G, Meza-Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, Li J, Siu E, Frazer J, Piecychna M, Du X, Sreih A, Leng L, Wiedrick J, Caillier SJ, Offner H, Oksenberg JR, Yadav V, Bourdette D, Bucala R, Vandenbark AA.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8421-E8429. doi: 10.1073/pnas.1712288114. Epub 2017 Sep 18.


Creation of a human T-ALL cell line online database.

Squiban B, Ahmed ST, Frazer JK.

Leuk Lymphoma. 2017 Nov;58(11):2728-2730. doi: 10.1080/10428194.2017.1300896. Epub 2017 Jun 13. No abstract available.


Characteristics predicting outcomes of allogeneic stem-cell transplantation in relapsed acute myelogenous leukemia.

Frazer J, Couban S, Doucette S, Shivakumar S.

Curr Oncol. 2017 Apr;24(2):e123-e130. doi: 10.3747/co.24.3485. Epub 2017 Apr 27.


Go West, Allergy Sufferers.

Frazer J.

Sci Am. 2017 Jan 17;316(2):19. doi: 10.1038/scientificamerican0217-19. No abstract available.


Simple Emergent Power Spectra from Complex Inflationary Physics.

Dias M, Frazer J, Marsh MC.

Phys Rev Lett. 2016 Sep 30;117(14):141303. Epub 2016 Sep 30.


Duration of first remission and hematopoietic cell transplantation-specific comorbidity index but not age predict survival of patients with AML transplanted in CR2: a retrospective multicenter study.

Michelis FV, Atenafu EG, Couban S, Frazer J, Shivakumar S, Hogge DE, Toze CL, Rajkhan W, Kim HJ, Daly A, Slaby J, Finke J, Kiss T, Bredeson C, Sabloff M, Sheppard D, Bakkar M, Brune M, Wall DA, Paulson K, Popradi G, Walker I, Messner HA.

Bone Marrow Transplant. 2016 Jul;51(7):1019-21. doi: 10.1038/bmt.2016.60. Epub 2016 Mar 14. No abstract available.


Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.

Miles RR, Shah RK, Frazer JK.

Br J Haematol. 2016 May;173(4):582-96. doi: 10.1111/bjh.14011. Epub 2016 Mar 11. Review. Erratum in: Br J Haematol. 2016 Nov;175(3):548.


Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt leukaemia: a Children's Oncology Group Pilot Study Report.

Shiramizu B, Goldman S, Smith L, Agsalda-Garcia M, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Barth MJ, Mussolin L, Cairo MS.

Br J Haematol. 2015 Aug;170(3):367-71. doi: 10.1111/bjh.13443. Epub 2015 Apr 8.


Gravitational wave consistency relations for multifield inflation.

Price LC, Peiris HV, Frazer J, Easther R.

Phys Rev Lett. 2015 Jan 23;114(3):031301. Epub 2015 Jan 22.


Amoebas on deathwatch.

Frazer J.

Sci Am. 2014 Oct;311(4):24-5. No abstract available.


Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report.

Goldman S, Smith L, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo MS.

Br J Haematol. 2014 Nov;167(3):394-401. doi: 10.1111/bjh.13040. Epub 2014 Jul 26.


Danio rerio: Small Fish Making a Big Splash in Leukemia.

Squiban B, Frazer JK.

Curr Pathobiol Rep. 2014 Jun;2(2):61-73.


Simple predictions from multifield inflationary models.

Easther R, Frazer J, Peiris HV, Price LC.

Phys Rev Lett. 2014 Apr 25;112(16):161302. Epub 2014 Apr 22.


Unusual fluorescent granulomas and myonecrosis in Danio rerio infected by the microsporidian pathogen Pseudoloma neurophilia.

West K, Miles R, Kent ML, Frazer JK.

Zebrafish. 2014 Jun;11(3):283-90. doi: 10.1089/zeb.2013.0933. Epub 2014 Apr 7.


Fungi on the march.

Frazer J.

Sci Am. 2013 Dec;309(6):50-7. No abstract available.


Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration.

Unett DJ, Gatlin J, Anthony TL, Buzard DJ, Chang S, Chen C, Chen X, Dang HT, Frazer J, Le MK, Sadeque AJ, Xing C, Gaidarov I.

J Pharmacol Exp Ther. 2013 Dec;347(3):645-59. doi: 10.1124/jpet.113.207670. Epub 2013 Sep 18.


UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.

Christoph S, Deryckere D, Schlegel J, Frazer JK, Batchelor LA, Trakhimets AY, Sather S, Hunter DM, Cummings CT, Liu J, Yang C, Kireev D, Simpson C, Norris-Drouin J, Hull-Ryde EA, Janzen WP, Johnson GL, Wang X, Frye SV, Earp HS 3rd, Graham DK.

Mol Cancer Ther. 2013 Nov;12(11):2367-77. doi: 10.1158/1535-7163.MCT-13-0040. Epub 2013 Aug 30.


VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD.

Leukemia. 2014 Jan;28(1):216-20. doi: 10.1038/leu.2013.223. Epub 2013 Jul 24. No abstract available.


Pediatric T- and NK-cell lymphomas: new biologic insights and treatment strategies.

El-Mallawany NK, Frazer JK, Van Vlierberghe P, Ferrando AA, Perkins S, Lim M, Chu Y, Cairo MS.

Blood Cancer J. 2012 Apr;2(4):e65. doi: 10.1038/bcj.2012.8. Epub 2012 Apr 13.


Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization.

Kuang YQ, Charette N, Frazer J, Holland PJ, Attwood KM, Dellaire G, Dupré DJ.

PLoS One. 2012;7(7):e40522. doi: 10.1371/journal.pone.0040522. Epub 2012 Jul 16.


Genomic amplification of an endogenous retrovirus in zebrafish T-cell malignancies.

Frazer JK, Batchelor LA, Bradley DF, Brown KH, Dobrinski KP, Lee C, Trede NS.

Adv Hematol. 2012;2012:627920. doi: 10.1155/2012/627920. Epub 2012 Jun 13.


Coronary artery dilation in acute Kawasaki disease and acute illnesses associated with Fever.

Bratincsak A, Reddy VD, Purohit PJ, Tremoulet AH, Molkara DP, Frazer JR, Dyar D, Bush RA, Sim JY, Sang N, Burns JC, Melish MA.

Pediatr Infect Dis J. 2012 Sep;31(9):924-6. doi: 10.1097/INF.0b013e31826252b3.


Zebrafish screen identifies novel compound with selective toxicity against leukemia.

Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Müschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede NS.

Blood. 2012 Jun 14;119(24):5621-31. doi: 10.1182/blood-2011-12-398818. Epub 2012 Apr 9.


Infectious disease: Blowing in the wind.

Frazer J.

Nature. 2012 Apr 4;484(7392):21-3. doi: 10.1038/484021a. No abstract available.


Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.

Xiong Y, Ullman B, Choi JS, Cherrier M, Strah-Pleynet S, Decaire M, Feichtinger K, Frazer JM, Yoon WH, Whelan K, Sanabria EK, Grottick AJ, Al-Shamma H, Semple G.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1870-3. doi: 10.1016/j.bmcl.2012.01.080. Epub 2012 Jan 28.


Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).

Semple G, Santora VJ, Smith JM, Covel JA, Hayashi R, Gallardo C, Ibarra JB, Schultz JA, Park DM, Estrada SA, Hofilena BJ, Smith BM, Ren A, Suarez M, Frazer J, Edwards JE, Hart R, Hauser EK, Lorea J, Grottick AJ.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):71-5. doi: 10.1016/j.bmcl.2011.11.075. Epub 2011 Nov 30.


Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R, Cullis C, Driscoll DL, Elder A, Forsyth N, Frazer J, Guo J, Guo L, Hyer ML, Janowick D, Kulkarni B, Lai SJ, Lasky K, Li G, Li J, Liao D, Little J, Peng B, Qian MG, Reynolds DJ, Rezaei M, Scott MP, Sells TB, Shinde V, Shi QJ, Sintchak MD, Soucy F, Sprott KT, Stroud SG, Nestor M, Visiers I, Weatherhead G, Ye Y, D'Amore N.

J Med Chem. 2012 Jan 12;55(1):197-208. doi: 10.1021/jm2011172. Epub 2011 Dec 5.


Cardiovascular biomarkers in acute Kawasaki disease.

Sato YZ, Molkara DP, Daniels LB, Tremoulet AH, Shimizu C, Kanegaye JT, Best BM, Snider JV, Frazer JR, Maisel A, Burns JC.

Int J Cardiol. 2013 Mar 20;164(1):58-63. doi: 10.1016/j.ijcard.2011.06.065. Epub 2011 Jul 20.


Role of personal decontamination in preventing the spread of equine influenza.

Frazer JL, Perkins NR, Pitt D.

Aust Vet J. 2011 Jul;89 Suppl 1:120-4. doi: 10.1111/j.1751-0813.2011.00763.x.


Dependence on different Rab GTPases for the trafficking of CXCR4 and CCR5 homo or heterodimers between the endoplasmic reticulum and plasma membrane in Jurkat cells.

Charette N, Holland P, Frazer J, Allen H, Dupré DJ.

Cell Signal. 2011 Nov;23(11):1738-49. doi: 10.1016/j.cellsig.2011.06.008. Epub 2011 Jun 24.


Shared acquired genomic changes in zebrafish and human T-ALL.

Rudner LA, Brown KH, Dobrinski KP, Bradley DF, Garcia MI, Smith AC, Downie JM, Meeker ND, Look AT, Downing JR, Gutierrez A, Mullighan CG, Schiffman JD, Lee C, Trede NS, Frazer JK.

Oncogene. 2011 Oct 13;30(41):4289-96. doi: 10.1038/onc.2011.138. Epub 2011 May 9.


Intervention to decrease glyburide use in elderly patients with renal insufficiency.

Aspinall SL, Zhao X, Good CB, Stone RA, Boresi J, Cox S, Bartholomew C, Jansen D, Guterman S, Patino M, Rivera-Miranda G, Burlingame M, Frazer J, Sellers J, Stanard Steele V, Witt L, Cunningham FE.

Am J Geriatr Pharmacother. 2011 Feb;9(1):58-68. doi: 10.1016/j.amjopharm.2011.02.001. Review.


Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.

Shimizu C, Jain S, Davila S, Hibberd ML, Lin KO, Molkara D, Frazer JR, Sun S, Baker AL, Newburger JW, Rowley AH, Shulman ST, Burgner D, Breunis WB, Kuijpers TW, Wright VJ, Levin M, Eleftherohorinou H, Coin L, Popper SJ, Relman DA, Fury W, Lin C, Mellis S, Tremoulet AH, Burns JC.

Circ Cardiovasc Genet. 2011 Feb;4(1):16-25. doi: 10.1161/CIRCGENETICS.110.940858. Epub 2010 Dec 2. Erratum in: Circ Cardiovasc Genet. 2011 Apr;4(2):e9. Davila, Sonia [removed].


A pediatric B lineage leukemia with coincident MYC and MLL translocations.

Meeker ND, Cherry AM, Bangs CD, Frazer JK.

J Pediatr Hematol Oncol. 2011 Mar;33(2):158-60. doi: 10.1097/MPH.0b013e3181e65c39.


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