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Antibody-Free Multiplex Measurement of 23 Human Cytokines in Primary Cell Culture Secretome Using Targeted Mass Spectrometry.

Krueger A, Stoll T, Shah AK, Sinha R, Frazer IH, Hill MM.

Anal Chem. 2020 Feb 18. doi: 10.1021/acs.analchem.9b05028. [Epub ahead of print]


Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers.

Tang KD, Menezes L, Baeten K, Walsh LJ, Whitfield BCS, Batstone MD, Kenny L, Frazer IH, Scheper GC, Punyadeera C.

Biomolecules. 2020 Feb 3;10(2). pii: E223. doi: 10.3390/biom10020223.


Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial.

Chandra J, Woo WP, Dutton JL, Xu Y, Li B, Kinrade S, Druce J, Finlayson N, Griffin P, Laing KJ, Koelle DM, Frazer IH.

PLoS One. 2019 Dec 17;14(12):e0226320. doi: 10.1371/journal.pone.0226320. eCollection 2019.


Selective Persistence of HPV Cross-Neutralising Antibodies following Reduced-Dose HPV Vaccine Schedules.

Toh ZQ, Kosasih J, Russell FM, Reyburn R, Fong J, Tuivaga E, Ratu FT, Nguyen CD, Matanitobua S, Do LAH, Menheniott T, Frazer IH, Garland SM, Mulholland EK, Licciardi PV.

Vaccines (Basel). 2019 Nov 28;7(4). pii: E200. doi: 10.3390/vaccines7040200.


Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage.

Tuong ZK, Lewandowski A, Bridge JA, Cruz JLG, Yamada M, Lambie D, Lewandowski R, Steptoe RJ, Leggatt GR, Simpson F, Frazer IH, Soyer HP, Wells JW.

Sci Rep. 2019 Nov 28;9(1):17754. doi: 10.1038/s41598-019-54435-0.


Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses.

Ng HI, Tuong ZK, Fernando GJP, Depelsenaire ACI, Meliga SC, Frazer IH, Kendall MAF.

NPJ Vaccines. 2019 Oct 11;4:41. doi: 10.1038/s41541-019-0134-4. eCollection 2019.


Human papillomavirus infection among head and neck squamous cell carcinomas in southern China.

Ni G, Huang K, Luan Y, Cao Z, Chen S, Ma B, Yuan J, Wu X, Chen G, Wang T, Li H, Walton S, Liu F, Chen B, Wang Y, Pan X, Liu X, Frazer IH.

PLoS One. 2019 Sep 23;14(9):e0221045. doi: 10.1371/journal.pone.0221045. eCollection 2019.


Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System.

Zhou C, Tuong ZK, Frazer IH.

Front Oncol. 2019 Aug 2;9:682. doi: 10.3389/fonc.2019.00682. eCollection 2019. Review.


Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions.

Devitt K, Hanson SJ, Tuong ZK, McMeniman E, Soyer HP, Frazer IH, Lukowski SW.

Virology. 2019 Nov;537:14-19. doi: 10.1016/j.virol.2019.08.007. Epub 2019 Aug 13.


Acute exercise does not improve immune response to HPV vaccination series in adolescents.

Bohn-Goldbaum E, Lee VY, Skinner SR, Frazer IH, Khan BA, Booy R, Edwards KM.

Papillomavirus Res. 2019 Dec;8:100178. doi: 10.1016/j.pvr.2019.100178. Epub 2019 Jul 15. No abstract available.


Immunotherapy for HPV associated cancer.

Frazer IH, Chandra J.

Papillomavirus Res. 2019 Dec;8:100176. doi: 10.1016/j.pvr.2019.100176. Epub 2019 Jul 13. Review. No abstract available.


HPV16 E7-Driven Epithelial Hyperplasia Promotes Impaired Antigen Presentation and Regulatory T-Cell Development.

Bashaw AA, Teoh SM, Tuong ZK, Leggatt GR, Frazer IH, Chandra J.

J Invest Dermatol. 2019 Dec;139(12):2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162. Epub 2019 Jun 15.


Unlocking the Potential of Saliva-Based Test to Detect HPV-16-Driven Oropharyngeal Cancer.

Tang KD, Baeten K, Kenny L, Frazer IH, Scheper G, Punyadeera C.

Cancers (Basel). 2019 Apr 3;11(4). pii: E473. doi: 10.3390/cancers11040473.


Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.

Kuo P, Teoh SM, Tuong ZK, Leggatt GR, Mattarollo SR, Frazer IH.

Front Immunol. 2018 Dec 18;9:2896. doi: 10.3389/fimmu.2018.02896. eCollection 2018.


High-risk human papillomavirus detection in oropharyngeal cancers: Comparison of saliva sampling methods.

Tang KD, Kenny L, Frazer IH, Punyadeera C.

Head Neck. 2019 May;41(5):1484-1489. doi: 10.1002/hed.25578. Epub 2018 Dec 23.


Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing: A prospective observational study.

Zammit AP, Sinha R, Cooper CL, Perry CFL, Frazer IH, Tuong ZK.

PLoS One. 2018 Oct 11;13(10):e0205406. doi: 10.1371/journal.pone.0205406. eCollection 2018.


A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes.

Wood DLA, Lachner N, Tan JM, Tang S, Angel N, Laino A, Linedale R, Lê Cao KA, Morrison M, Frazer IH, Soyer HP, Hugenholtz P.

mBio. 2018 Oct 9;9(5). pii: e01432-18. doi: 10.1128/mBio.01432-18.


The projected timeframe until cervical cancer elimination in Australia: a modelling study.

Hall MT, Simms KT, Lew JB, Smith MA, Brotherton JM, Saville M, Frazer IH, Canfell K.

Lancet Public Health. 2019 Jan;4(1):e19-e27. doi: 10.1016/S2468-2667(18)30183-X. Epub 2018 Oct 2.


Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous Squamous Cell Carcinoma.

Jung JW, Veitch M, Bridge JA, Overgaard NH, Cruz JL, Linedale R, Franklin ME, Saunders NA, Simpson F, Frazer IH, Steptoe RJ, Wells JW.

Oncoimmunology. 2018 Jul 30;7(9):e1479627. doi: 10.1080/2162402X.2018.1479627. eCollection 2018.


HLA and KIR Associations of Cervical Neoplasia.

Bao X, Hanson AL, Madeleine MM, Wang SS, Schwartz SM, Newell F, Pettersson-Kymmer U, Hemminki K, Tiews S, Steinberg W, Rader JS, Castro F, Safaeian M, Franco EL, Coutlée F, Ohlsson C, Cortes A, Marshall M, Mukhopadhyay P, Cremin K, Johnson LG, Garland SM, Tabrizi SN, Wentzensen N, Sitas F, Trimble C, Little J, Cruickshank M, Frazer IH, Hildesheim A, Brown MA, Duncan EL, Sun YP, Leo PJ.

J Infect Dis. 2018 Nov 5;218(12):2006-2015. doi: 10.1093/infdis/jiy483.


An Ex Vivo Human Tumor Assay Shows Distinct Patterns of EGFR Trafficking in Squamous Cell Carcinoma Correlating to Therapeutic Outcomes.

Joseph SR, Gaffney D, Barry R, Hu L, Banushi B, Wells JW, Lambie D, Strutton G, Porceddu SV, Burmeister B, Leggatt GR, Schaider H, Dolcetti R, Frazer IH, Saunders NA, Foote M, Soyer HP, Simpson F.

J Invest Dermatol. 2019 Jan;139(1):213-223. doi: 10.1016/j.jid.2018.06.190. Epub 2018 Aug 2.


Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis.

Lukowski SW, Tuong ZK, Noske K, Senabouth A, Nguyen QH, Andersen SB, Soyer HP, Frazer IH, Powell JE.

J Invest Dermatol. 2018 Dec;138(12):2558-2567. doi: 10.1016/j.jid.2018.06.169. Epub 2018 Jun 30.


Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions.

Tuong ZK, Noske K, Kuo P, Bashaw AA, Teoh SM, Frazer IH.

Papillomavirus Res. 2018 Jun;5:6-20. doi: 10.1016/j.pvr.2017.10.001. Epub 2017 Oct 19. Review.


Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™).

Fernando GJP, Hickling J, Jayashi Flores CM, Griffin P, Anderson CD, Skinner SR, Davies C, Witham K, Pryor M, Bodle J, Rockman S, Frazer IH, Forster AH.

Vaccine. 2018 Jun 18;36(26):3779-3788. doi: 10.1016/j.vaccine.2018.05.053. Epub 2018 May 17.


No Vacillation on HPV Vaccination.

Sipp D, Frazer IH, Rasko JEJ.

Cell. 2018 Mar 8;172(6):1163-1167. doi: 10.1016/j.cell.2018.02.045.


Correction: Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.

Leo PJ, Madeleine MM, Wang S, Schwartz SM, Newell F, Pettersson-Kymmer U, Hemminki K, Hallmans G, Tiews S, Steinberg W, Rader JS, Castro F, Safaeian M, Franco EL, Coutlée F, Ohlsson C, Cortes A, Marshall M, Mukhopadhyay P, Cremin K, Johnson LG, Trimble CL, Garland S, Tabrizi SN, Wentzensen N, Sitas F, Little J, Cruickshank M, Frazer IH, Hildesheim A, Brown MA.

PLoS Genet. 2018 Mar 1;14(3):e1007257. doi: 10.1371/journal.pgen.1007257. eCollection 2018 Mar.


Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells.

Bhat P, Bergot AS, Waterhouse N, Frazer IH.

Oncotarget. 2017 Dec 14;9(5):6015-6027. doi: 10.18632/oncotarget.23210. eCollection 2018 Jan 19.


Eradicating HPV-Associated Cancer Through Immunization: A Glass Half Full….

Frazer IH.

Viral Immunol. 2018 Mar;31(2):80-85. doi: 10.1089/vim.2017.0119. Epub 2018 Jan 3. Review.


HPV16E7-Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T-Cell Migration to Skin.

Kuo P, Tuong ZK, Teoh SM, Frazer IH, Mattarollo SR, Leggatt GR.

J Invest Dermatol. 2018 Jun;138(6):1348-1359. doi: 10.1016/j.jid.2017.12.021. Epub 2017 Dec 23.


Modulation of antigen presenting cell functions during chronic HPV infection.

Bashaw AA, Leggatt GR, Chandra J, Tuong ZK, Frazer IH.

Papillomavirus Res. 2017 Dec;4:58-65. doi: 10.1016/j.pvr.2017.08.002. Epub 2017 Aug 18. Review.


CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury.

Chakraborty R, Chandra J, Cui S, Tolley L, Cooper MA, Kendall M, Frazer IH.

Exp Dermatol. 2018 Jan;27(1):71-79. doi: 10.1111/exd.13436. Epub 2017 Dec 6.


RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers.

Hoang VLT, Tom LN, Quek XC, Tan JM, Payne EJ, Lin LL, Sinnya S, Raphael AP, Lambie D, Frazer IH, Dinger ME, Soyer HP, Prow TW.

PeerJ. 2017 Aug 21;5:e3631. doi: 10.7717/peerj.3631. eCollection 2017.


Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.

Leo PJ, Madeleine MM, Wang S, Schwartz SM, Newell F, Pettersson-Kymmer U, Hemminki K, Hallmans G, Tiews S, Steinberg W, Rader JS, Castro F, Safaeian M, Franco EL, Coutlée F, Ohlsson C, Cortes A, Marshall M, Mukhopadhyay P, Cremin K, Johnson LG, Trimble CL, Garland S, Tabrizi SN, Wentzensen N, Sitas F, Little J, Cruickshank M, Frazer IH, Hildesheim A, Brown MA.

PLoS Genet. 2017 Aug 14;13(8):e1006866. doi: 10.1371/journal.pgen.1006866. eCollection 2017 Aug. Erratum in: PLoS Genet. 2018 Mar 1;14 (3):e1007257.


CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin.

Overgaard NH, Cruz JL, Bridge JA, Nel HJ, Frazer IH, La Gruta NL, Blumenthal A, Steptoe RJ, Wells JW.

J Leukoc Biol. 2017 Sep;102(3):837-844. doi: 10.1189/jlb.1AB0217-065R. Epub 2017 Jun 21.


Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity.

Bhat P, Leggatt G, Waterhouse N, Frazer IH.

Cell Death Dis. 2017 Jun 1;8(6):e2836. doi: 10.1038/cddis.2017.67.


HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts.

Jazayeri SD, Kuo PT, Leggatt GR, Frazer IH.

Front Immunol. 2017 May 4;8:524. doi: 10.3389/fimmu.2017.00524. eCollection 2017.


DNA Vaccine Encoding HPV16 Oncogenes E6 and E7 Induces Potent Cell-mediated and Humoral Immunity Which Protects in Tumor Challenge and Drives E7-expressing Skin Graft Rejection.

Chandra J, Dutton JL, Li B, Woo WP, Xu Y, Tolley LK, Yong M, Wells JW, R Leggatt G, Finlayson N, Frazer IH.

J Immunother. 2017 Feb/Mar;40(2):62-70. doi: 10.1097/CJI.0000000000000156.


Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function.

Chandra J, Kuo PT, Hahn AM, Belz GT, Frazer IH.

Immunol Cell Biol. 2017 Feb;95(2):215-223. doi: 10.1038/icb.2016.83. Epub 2016 Nov 29.


An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1.

Dutton JL, Woo WP, Chandra J, Xu Y, Li B, Finlayson N, Griffin P, Frazer IH.

Hum Vaccin Immunother. 2016 Dec;12(12):3079-3088. doi: 10.1080/21645515.2016.1221872.


A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.

Zhussupbekova S, Sinha R, Kuo P, Lambert PF, Frazer IH, Tuong ZK.

EBioMedicine. 2016 Jul;9:314-323. doi: 10.1016/j.ebiom.2016.06.011. Epub 2016 Jun 7.


Role of Ultraviolet Radiation in Papillomavirus-Induced Disease.

Uberoi A, Yoshida S, Frazer IH, Pitot HC, Lambert PF.

PLoS Pathog. 2016 May 31;12(5):e1005664. doi: 10.1371/journal.ppat.1005664. eCollection 2016 May.


Epithelium Expressing the E7 Oncoprotein of HPV16 Attracts Immune-Modulatory Dendritic Cells to the Skin and Suppresses Their Antigen-Processing Capacity.

Chandra J, Miao Y, Romoff N, Frazer IH.

PLoS One. 2016 Mar 31;11(3):e0152886. doi: 10.1371/journal.pone.0152886. eCollection 2016.


A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16(INK4a) expression in head and neck squamous cell carcinoma patients.

Chai RC, Lim Y, Frazer IH, Wan Y, Perry C, Jones L, Lambie D, Punyadeera C.

BMC Cancer. 2016 Mar 3;16:178. doi: 10.1186/s12885-016-2217-1.


Consensus nomenclature for CD8+ T cell phenotypes in cancer.

Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC.

Oncoimmunology. 2015 Feb 25;4(4):e998538. eCollection 2015 Apr.


Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis.

Abd Warif NM, Stoitzner P, Leggatt GR, Mattarollo SR, Frazer IH, Hibma MH.

PLoS One. 2015 May 18;10(5):e0127155. doi: 10.1371/journal.pone.0127155. eCollection 2015.


Interleukin-17A Promotes Arginase-1 Production and 2,4-Dinitrochlorobenzene-Induced Acute Hyperinflammation in Human Papillomavirus E7 Oncoprotein-Expressing Skin.

Tran le S, Mittal D, Mattarollo SR, Frazer IH.

J Innate Immun. 2015;7(4):392-404. doi: 10.1159/000374115. Epub 2015 Feb 14.


Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?

Jung JW, Overgaard NH, Burke MT, Isbel N, Frazer IH, Simpson F, Wells JW.

Int J Cancer. 2016 Jan 15;138(2):281-92. doi: 10.1002/ijc.29450. Epub 2015 Feb 5. Review.


HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions.

Bergot AS, Monnet N, Le Tran S, Mittal D, Al-Kouba J, Steptoe RJ, Grimbaldeston MA, Frazer IH, Wells JW.

Immunol Cell Biol. 2015 Jul;93(6):540-7. doi: 10.1038/icb.2014.123. Epub 2015 Jan 20.


The actinic keratosis virome: can we prevent squamous cell carcinoma with a vaccine?

Frazer IH.

Curr Probl Dermatol. 2015;46:28-35. doi: 10.1159/000366532. Epub 2014 Dec 18. Review.


Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study.

Velentzis LS, Sitas F, O'Connell DL, Darlington-Brown J, Egger S, Sinha R, Banks E, Frazer IH, Canfell K.

BMC Infect Dis. 2014 Dec 21;14:3861. doi: 10.1186/s12879-014-0676-z.

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