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Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumes.

Sriram K, Lin GX, Jefferson AM, Stone S, Afshari A, Keane MJ, McKinney W, Jackson M, Chen BT, Schwegler-Berry D, Cumpston A, Cumpston JL, Roberts JR, Frazer DG, Antonini JM.

Toxicology. 2015 Feb 3;328:168-78. doi: 10.1016/j.tox.2014.12.015. Epub 2014 Dec 27.


Neurotoxicity following acute inhalation of aerosols generated during resistance spot weld-bonding of carbon steel.

Sriram K, Jefferson AM, Lin GX, Afshari A, Zeidler-Erdely PC, Meighan TG, McKinney W, Jackson M, Cumpston A, Cumpston JL, Leonard HD, Frazer DG, Antonini JM.

Inhal Toxicol. 2014 Oct;26(12):720-32. doi: 10.3109/08958378.2014.954654.


Development and characterization of a resistance spot welding aerosol generator and inhalation exposure system.

Afshari A, Zeidler-Erdely PC, McKinney W, Chen BT, Jackson M, Schwegler-Berry D, Friend S, Cumpston A, Cumpston JL, Leonard HD, Meighan TG, Frazer DG, Antonini JM.

Inhal Toxicol. 2014 Oct;26(12):708-19. doi: 10.3109/08958378.2014.941118. Epub 2014 Aug 20.


Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats.

Zeidler-Erdely PC, Meighan TG, Erdely A, Fedan JS, Thompson JA, Bilgesu S, Waugh S, Anderson S, Marshall NB, Afshari A, McKinney W, Frazer DG, Antonini JM.

Inhal Toxicol. 2014 Oct;26(12):697-707. doi: 10.3109/08958378.2014.944287. Epub 2014 Aug 20.


Evaluation of Pulmonary and Systemic Toxicity of Oil Dispersant (COREXIT EC9500A(®)) Following Acute Repeated Inhalation Exposure.

Roberts JR, Anderson SE, Kan H, Krajnak K, Thompson JA, Kenyon A, Goldsmith WT, McKinney W, Frazer DG, Jackson M, Fedan JS.

Environ Health Insights. 2015 Feb 9;8(Suppl 1):63-74. doi: 10.4137/EHI.S15262. eCollection 2014.


A model of the recruitment-derecruitment and volume of lung units in an excised lung as it is inflated-deflated between minimum and maximum lung volume.

Frazer DG, Lindsley WG, McKinney W, Reynolds JS, Franz GN, Jackson M, Goldsmith WT.

J Biomech Eng. 2013 Mar 1;135(3):34503. doi: 10.1115/1.4023372.


Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology.

Erdely A, Dahm M, Chen BT, Zeidler-Erdely PC, Fernback JE, Birch ME, Evans DE, Kashon ML, Deddens JA, Hulderman T, Bilgesu SA, Battelli L, Schwegler-Berry D, Leonard HD, McKinney W, Frazer DG, Antonini JM, Porter DW, Castranova V, Schubauer-Berigan MK.

Part Fibre Toxicol. 2013 Oct 21;10(1):53. doi: 10.1186/1743-8977-10-53.


Popcorn flavoring effects on reactivity of rat airways in vivo and in vitro.

Zaccone EJ, Thompson JA, Ponnoth DS, Cumpston AM, Goldsmith WT, Jackson MC, Kashon ML, Frazer DG, Hubbs AF, Shimko MJ, Fedan JS.

J Toxicol Environ Health A. 2013;76(11):669-89. doi: 10.1080/15287394.2013.796302.


Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles.

Roberts JR, McKinney W, Kan H, Krajnak K, Frazer DG, Thomas TA, Waugh S, Kenyon A, MacCuspie RI, Hackley VA, Castranova V.

J Toxicol Environ Health A. 2013;76(11):651-68. doi: 10.1080/15287394.2013.792024.


Diacetyl increases sensory innervation and substance P production in rat trachea.

Goravanahally MP, Hubbs AF, Fedan JS, Kashon ML, Battelli LA, Mercer RR, Goldsmith WT, Jackson MC, Cumpston A, Frazer DG, Dey RD.

Toxicol Pathol. 2014;42(3):582-90. doi: 10.1177/0192623313493689. Epub 2013 Jul 11.


Computer-automated silica aerosol generator and animal inhalation exposure system.

McKinney W, Chen B, Schwegler-Berry D, Frazer DG.

Inhal Toxicol. 2013 Jun;25(7):363-72. doi: 10.3109/08958378.2013.788105.


Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation.

Lechner J, Dash DP, Muszynska D, Hosseini M, Segev F, George S, Frazer DG, Moore JE, Kaye SB, Young T, Simpson DA, Churchill AJ, Héon E, Willoughby CE.

Invest Ophthalmol Vis Sci. 2013 May 3;54(5):3215-23. doi: 10.1167/iovs.13-11781.


Nanotechnology: toxicologic pathology.

Hubbs AF, Sargent LM, Porter DW, Sager TM, Chen BT, Frazer DG, Castranova V, Sriram K, Nurkiewicz TR, Reynolds SH, Battelli LA, Schwegler-Berry D, McKinney W, Fluharty KL, Mercer RR.

Toxicol Pathol. 2013 Feb;41(2):395-409. doi: 10.1177/0192623312467403. Epub 2013 Feb 6. Review.


Commentaries on viewpoint: unresolved mysteries.

Weibel ER, Nieman GF, Gatto LA, Frazer DG, Schittny JC, Woods JC, Conradi MS, Yablonskiy DA.

J Appl Physiol (1985). 2012 Dec 15;113(12):1948-9. doi: 10.1152/japplphysiol.01203.2012. No abstract available.


Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study.

Stapleton PA, Minarchick VC, Cumpston AM, McKinney W, Chen BT, Sager TM, Frazer DG, Mercer RR, Scabilloni J, Andrew ME, Castranova V, Nurkiewicz TR.

Int J Mol Sci. 2012 Oct 24;13(11):13781-803. doi: 10.3390/ijms131113781.


Multi-walled carbon nanotubes: sampling criteria and aerosol characterization.

Chen BT, Schwegler-Berry D, McKinney W, Stone S, Cumpston JL, Friend S, Porter DW, Castranova V, Frazer DG.

Inhal Toxicol. 2012 Oct;24(12):798-820. doi: 10.3109/08958378.2012.720741.


Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats.

Hubbs AF, Cumpston AM, Goldsmith WT, Battelli LA, Kashon ML, Jackson MC, Frazer DG, Fedan JS, Goravanahally MP, Castranova V, Kreiss K, Willard PA, Friend S, Schwegler-Berry D, Fluharty KL, Sriram K.

Am J Pathol. 2012 Sep;181(3):829-44. doi: 10.1016/j.ajpath.2012.05.021. Epub 2012 Aug 13.


Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes.

Porter DW, Hubbs AF, Chen BT, McKinney W, Mercer RR, Wolfarth MG, Battelli L, Wu N, Sriram K, Leonard S, Andrew M, Willard P, Tsuruoka S, Endo M, Tsukada T, Munekane F, Frazer DG, Castranova V.

Nanotoxicology. 2013 Nov;7(7):1179-94. doi: 10.3109/17435390.2012.719649. Epub 2012 Sep 13. Erratum in: Nanotoxicology. 2013 Dec;7(8):1399.


Type I interferon and pattern recognition receptor signaling following particulate matter inhalation.

Erdely A, Antonini JM, Salmen-Muniz R, Liston A, Hulderman T, Simeonova PP, Kashon ML, Li S, Gu JK, Stone S, Chen BT, Frazer DG, Zeidler-Erdely PC.

Part Fibre Toxicol. 2012 Jul 9;9:25. doi: 10.1186/1743-8977-9-25.


Keratoconus in 18 pairs of twins.

Tuft SJ, Hassan H, George S, Frazer DG, Willoughby CE, Liskova P.

Acta Ophthalmol. 2012 Sep;90(6):e482-6. doi: 10.1111/j.1755-3768.2012.02448.x. Epub 2012 Jun 8.


Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles.

McKinney W, Jackson M, Sager TM, Reynolds JS, Chen BT, Afshari A, Krajnak K, Waugh S, Johnson C, Mercer RR, Frazer DG, Thomas TA, Castranova V.

Inhal Toxicol. 2012 Jun;24(7):447-57. doi: 10.3109/08958378.2012.685111.


Pulmonary particulate matter and systemic microvascular dysfunction.

Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Moseley AM, Cumpston JL, Goodwill AG, Frisbee SJ, Perrotta PL, Brock RW, Frisbee JC, Boegehold MA, Frazer DG, Chen BT, Castranova V; HEI Health Review Committee.

Res Rep Health Eff Inst. 2011 Dec;(164):3-48.


Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A.

Sriram K, Lin GX, Jefferson AM, Goldsmith WT, Jackson M, McKinney W, Frazer DG, Robinson VA, Castranova V.

J Toxicol Environ Health A. 2011;74(21):1405-18. doi: 10.1080/15287394.2011.606796.


Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in rats.

Roberts JR, Reynolds JS, Thompson JA, Zaccone EJ, Shimko MJ, Goldsmith WT, Jackson M, McKinney W, Frazer DG, Kenyon A, Kashon ML, Piedimonte G, Castranova V, Fedan JS.

J Toxicol Environ Health A. 2011;74(21):1381-96. doi: 10.1080/15287394.2011.606794.


Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways.

Knuckles TL, Yi J, Frazer DG, Leonard HD, Chen BT, Castranova V, Nurkiewicz TR.

Nanotoxicology. 2012 Nov;6(7):724-35. doi: 10.3109/17435390.2011.606926. Epub 2011 Aug 10.


Noninvasive pulmonary function screening in spontaneously breathing rodents: an engineering systems perspective.

Reynolds JS, Frazer DG.

Pharmacol Ther. 2011 Sep;131(3):359-68. doi: 10.1016/j.pharmthera.2011.05.003. Epub 2011 May 27. Review.


Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface.

Moore JE, Vasey GT, Dartt DA, McGilligan VE, Atkinson SD, Grills C, Lamey PJ, Leccisotti A, Frazer DG, Moore TC.

Invest Ophthalmol Vis Sci. 2011 Aug 3;52(9):6174-80. doi: 10.1167/iovs.10-7022.


Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice.

Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, Chen BT, Stone S, Frazer DG, Antonini JM, Simeonova PP.

Toxicol Lett. 2011 Jul 4;204(1):12-6. doi: 10.1016/j.toxlet.2011.03.030. Epub 2011 Apr 14.


Recurrent erosion syndrome--the patient's perspective.

Moutray TN, Frazer DG, Jackson AJ.

Cont Lens Anterior Eye. 2011 Jun;34(3):139-43. doi: 10.1016/j.clae.2010.11.006. Epub 2011 Feb 11.


Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice.

Zeidler-Erdely PC, Battelli LA, Stone S, Chen BT, Frazer DG, Young SH, Erdely A, Kashon ML, Andrews R, Antonini JM.

Inhal Toxicol. 2011 Feb;23(2):112-20. doi: 10.3109/08958378.2010.548838.


Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity.

Antonini JM, Keane M, Chen BT, Stone S, Roberts JR, Schwegler-Berry D, Andrews RN, Frazer DG, Sriram K.

Nanotoxicology. 2011 Dec;5(4):700-10. doi: 10.3109/17435390.2010.550695. Epub 2011 Feb 1.


Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments.

LeBuf RF, Stefaniak AB, Chen BT, Frazer DG, Virji MA.

Nanotoxicology. 2011 Dec;5(4):687-99. doi: 10.3109/17435390.2010.546951. Epub 2011 Jan 24.


Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistance.

Frazer DG, Reynolds JS, Jackson MC.

J Toxicol Environ Health A. 2011;74(5):287-95. doi: 10.1080/15287394.2010.514235.


Nanoparticles-containing spray can aerosol: characterization, exposure assessment, and generator design.

Chen BT, Afshari A, Stone S, Jackson M, Schwegler-Berry D, Frazer DG, Castranova V, Thomas TA.

Inhal Toxicol. 2010 Nov;22(13):1072-82. doi: 10.3109/08958378.2010.518323. Epub 2010 Oct 12.


Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats.

Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Chapman R, Zeidler-Erdely PC, Andrews RN, Frazer DG.

Arch Toxicol. 2011 May;85(5):487-98. doi: 10.1007/s00204-010-0601-1. Epub 2010 Oct 6.


Effectiveness and safety of fentanyl compared with morphine for out-of-hospital analgesia.

Fleischman RJ, Frazer DG, Daya M, Jui J, Newgard CD.

Prehosp Emerg Care. 2010 Apr-Jun;14(2):167-75. doi: 10.3109/10903120903572301.


Classification of voluntary cough sound and airflow patterns for detecting abnormal pulmonary function.

Abaza AA, Day JB, Reynolds JS, Mahmoud AM, Goldsmith WT, McKinney WG, Petsonk EL, Frazer DG.

Cough. 2009 Nov 20;5:8. doi: 10.1186/1745-9974-5-8.


A system for recording high fidelity cough sound and airflow characteristics.

Goldsmith WT, Mahmoud AM, Reynolds JS, McKinney WG, Afshari AA, Abaza AA, Frazer DG.

Ann Biomed Eng. 2010 Feb;38(2):469-77. doi: 10.1007/s10439-009-9830-y. Epub 2009 Oct 30.


Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure.

Antonini JM, Sriram K, Benkovic SA, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Jefferson AM, Billig BK, Felton CM, Hammer MA, Ma F, Frazer DG, O'Callaghan JP, Miller DB.

Neurotoxicology. 2009 Nov;30(6):915-25. doi: 10.1016/j.neuro.2009.09.006. Epub 2009 Sep 25.


Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling.

Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Chen BT, Frazer DG, Boegehold MA, Castranova V.

Toxicol Sci. 2009 Jul;110(1):191-203. doi: 10.1093/toxsci/kfp051. Epub 2009 Mar 6.


Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats.

Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Frazer DG.

Inhal Toxicol. 2009 Feb;21(3):182-92. doi: 10.1080/08958370802360661 .


Unrestrained acoustic plethysmograph for measuring specific airway resistance in mice.

Reynolds JS, Johnson VJ, Frazer DG.

J Appl Physiol (1985). 2008 Aug;105(2):711-7. doi: 10.1152/japplphysiol.00949.2007. Epub 2008 May 1.


Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction.

Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V.

Part Fibre Toxicol. 2008 Feb 12;5:1. doi: 10.1186/1743-8977-5-1.


Clinical studies: visual acuities beyond Snellen.

Lim LT, Frazer DG, Jackson AJ.

Br J Ophthalmol. 2008 Jan;92(1):153. No abstract available.


Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats.

Antonini JM, Stone S, Roberts JR, Chen B, Schwegler-Berry D, Afshari AA, Frazer DG.

Toxicol Appl Pharmacol. 2007 Sep 15;223(3):234-45. Epub 2007 Jul 6.


Traumatic graft dehiscence after penetrating keratoplasty.

Williams MA, Gawley SD, Jackson AJ, Frazer DG.

Ophthalmology. 2008 Feb;115(2):276-278.e1. Epub 2007 Jun 27.


Unrestrained acoustic plethysmograph for measuring tidal volume in mice.

Reynolds JS, Frazer DG.

Ann Biomed Eng. 2006 Sep;34(9):1494-9. Epub 2006 Aug 1.


Increased susceptibility of the lungs of hyperthyroid rats to oxidant injury: specificity of effects.

Huffman LJ, Beighley CM, Frazer DG, McKinney WG, Porter DW.

Toxicology. 2006 Aug 15;225(2-3):119-27. Epub 2006 May 20.


Increased susceptibility of hyperthyroid rats to ozone: early events and mechanisms.

Huffman LJ, Beighley CM, Frazer DG, McKinney WG, Porter DW.

J Toxicol Environ Health A. 2006 Mar;69(6):465-79.


Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals.

Antonini JM, Afshari AA, Stone S, Chen B, Schwegler-Berry D, Fletcher WG, Goldsmith WT, Vandestouwe KH, McKinney W, Castranova V, Frazer DG.

J Occup Environ Hyg. 2006 Apr;3(4):194-203; quiz D45.


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