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High-resolution T2-FLAIR and non-contrast CT brain atlas of the elderly.

Rajashekar D, Wilms M, MacDonald ME, Ehrhardt J, Mouches P, Frayne R, Hill MD, Forkert ND.

Sci Data. 2020 Feb 17;7(1):56. doi: 10.1038/s41597-020-0379-9.


Cerebral degeneration in amyotrophic lateral sclerosis: A prospective multicenter magnetic resonance spectroscopy study.

Srivastava O, Hanstock C, Chenji S, Mah D, Eurich D, Ta D, Seres P, Luk C, Zinman L, Abrahao A, Graham SJ, Genge A, Korngut L, Frayne R, Kalra S.

Neurol Clin Pract. 2019 Oct;9(5):400-407. doi: 10.1212/CPJ.0000000000000674.


Meeting international aerobic physical activity guidelines is associated with enhanced cardiovagal baroreflex sensitivity in healthy older adults.

O'Brien MW, Johns JA, Dorey TW, Frayne RJ, Fowles JR, Mekary S, Kimmerly DS.

Clin Auton Res. 2019 Oct 12. doi: 10.1007/s10286-019-00641-9. [Epub ahead of print]


Convolutional neural networks for skull-stripping in brain MR imaging using silver standard masks.

Lucena O, Souza R, Rittner L, Frayne R, Lotufo R.

Artif Intell Med. 2019 Jul;98:48-58. doi: 10.1016/j.artmed.2019.06.008. Epub 2019 Jul 23.


The Use of Random Forests to Classify Amyloid Brain PET.

Zukotynski K, Gaudet V, Kuo PH, Adamo S, Goubran M, Scott C, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce R Jr, Noseworthy MD, Prato FS, Sahlas DJ, Smith EE, Sossi V, Thiel A, Soucy JP, Tardif JC, Black SE.

Clin Nucl Med. 2019 Oct;44(10):784-788. doi: 10.1097/RLU.0000000000002747.


Automatic identification of atherosclerosis subjects in a heterogeneous MR brain imaging data set.

Bento M, Souza R, Salluzzi M, Rittner L, Zhang Y, Frayne R.

Magn Reson Imaging. 2019 Oct;62:18-27. doi: 10.1016/j.mri.2019.06.007. Epub 2019 Jun 19.


Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.

Thrippleton MJ, Backes WH, Sourbron S, Ingrisch M, van Osch MJP, Dichgans M, Fazekas F, Ropele S, Frayne R, van Oostenbrugge RJ, Smith EE, Wardlaw JM.

Alzheimers Dement. 2019 Jun;15(6):840-858. doi: 10.1016/j.jalz.2019.01.013. Epub 2019 Apr 25. Review.


Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.

Smith EE, Biessels GJ, De Guio F, de Leeuw FE, Duchesne S, Düring M, Frayne R, Ikram MA, Jouvent E, MacIntosh BJ, Thrippleton MJ, Vernooij MW, Adams H, Backes WH, Ballerini L, Black SE, Chen C, Corriveau R, DeCarli C, Greenberg SM, Gurol ME, Ingrisch M, Job D, Lam BYK, Launer LJ, Linn J, McCreary CR, Mok VCT, Pantoni L, Pike GB, Ramirez J, Reijmer YD, Romero JR, Ropele S, Rost NS, Sachdev PS, Scott CJM, Seshadri S, Sharma M, Sourbron S, Steketee RME, Swartz RH, van Oostenbrugge R, van Osch M, van Rooden S, Viswanathan A, Werring D, Dichgans M, Wardlaw JM.

Alzheimers Dement (Amst). 2019 Feb 26;11:191-204. doi: 10.1016/j.dadm.2019.01.002. eCollection 2019 Dec. Review.


Longitudinal Brain Atrophy Rates in Transient Ischemic Attack and Minor Ischemic Stroke Patients and Cognitive Profiles.

Munir M, Ursenbach J, Reid M, Gupta Sah R, Wang M, Sitaram A, Aftab A, Tariq S, Zamboni G, Griffanti L, Smith EE, Frayne R, Sajobi TT, Coutts SB, d'Esterre CD, Barber PA; Alzheimer's Disease Neuroimaging Initiative.

Front Neurol. 2019 Feb 19;10:18. doi: 10.3389/fneur.2019.00018. eCollection 2019.


Diffusion-weighted imaging lesion growth occurs despite recanalization in acute ischemic stroke: Implications for future treatment trials.

Sah RG, d'Esterre CD, Hill MD, Hafeez M, Tariq S, Forkert ND, Frayne R, Demchuk AM, Goyal M, Barber PA.

Int J Stroke. 2019 Apr;14(3):257-264. doi: 10.1177/1747493018798550. Epub 2018 Sep 4.


Interdatabase Variability in Cortical Thickness Measurements.

MacDonald ME, Williams RJ, Forkert ND, Berman AJL, McCreary CR, Frayne R, Pike GB.

Cereb Cortex. 2019 Jul 22;29(8):3282-3293. doi: 10.1093/cercor/bhy197.


A longitudinal magnetic resonance imaging study of neurodegenerative and small vessel disease, and clinical cognitive trajectories in non demented patients with transient ischemic attack: the PREVENT study.

Tariq S, d'Esterre CD, Sajobi TT, Smith EE, Longman RS, Frayne R, Coutts SB, Forkert ND, Barber PA.

BMC Geriatr. 2018 Jul 16;18(1):163. doi: 10.1186/s12877-018-0858-4.


Cortical Microinfarcts on 3T Magnetic Resonance Imaging in Cerebral Amyloid Angiopathy.

van den Brink H, Zwiers A, Switzer AR, Charlton A, McCreary CR, Goodyear BG, Frayne R, Biessels GJ, Smith EE.

Stroke. 2018 Aug;49(8):1899-1905. doi: 10.1161/STROKEAHA.118.020810.


Achieving Canadian physical activity guidelines is associated with better vascular function independent of aerobic fitness and sedentary time in older adults.

O'Brien MW, Robinson SA, Frayne R, Mekary S, Fowles JR, Kimmerly DS.

Appl Physiol Nutr Metab. 2018 Oct;43(10):1003-1009. doi: 10.1139/apnm-2018-0033. Epub 2018 Apr 19.


Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion.

Clough M, Mutimer S, Wright DK, Tsang A, Costello DM, Gardner AJ, Stanwell P, Mychasiuk R, Sun M, Brady RD, McDonald SJ, Webster KM, Johnstone MR, Semple BD, Agoston DV, White OB, Frayne R, Fielding J, O'Brien TJ, Shultz SR.

J Neurotrauma. 2018 Mar 1;35(5):730-738. doi: 10.1089/neu.2017.5204. Epub 2018 Feb 9.


An open, multi-vendor, multi-field-strength brain MR dataset and analysis of publicly available skull stripping methods agreement.

Souza R, Lucena O, Garrafa J, Gobbi D, Saluzzi M, Appenzeller S, Rittner L, Frayne R, Lotufo R.

Neuroimage. 2018 Apr 15;170:482-494. doi: 10.1016/j.neuroimage.2017.08.021. Epub 2017 Aug 12. Review.


White Matter Structural Connectivity Is Not Correlated to Cortical Resting-State Functional Connectivity over the Healthy Adult Lifespan.

Tsang A, Lebel CA, Bray SL, Goodyear BG, Hafeez M, Sotero RC, McCreary CR, Frayne R.

Front Aging Neurosci. 2017 May 18;9:144. doi: 10.3389/fnagi.2017.00144. eCollection 2017.


Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment.

Smith EE, Cieslak A, Barber P, Chen J, Chen YW, Donnini I, Edwards JD, Frayne R, Field TS, Hegedus J, Hanganu V, Ismail Z, Kanji J, Nakajima M, Noor R, Peca S, Sahlas D, Sharma M, Sposato LA, Swartz RH, Zerna C, Black SE, Hachinski V.

J Am Heart Assoc. 2017 May 5;6(5). pii: e005568. doi: 10.1161/JAHA.117.005568. No abstract available.


Functional magnetic resonance imaging responses in CADASIL.

Cheema I, Switzer AR, McCreary CR, Hill MD, Frayne R, Goodyear BG, Smith EE.

J Neurol Sci. 2017 Apr 15;375:248-254. doi: 10.1016/j.jns.2017.02.004. Epub 2017 Feb 3.


MR imaging of carotid webs.

Boesen ME, Eswaradass PV, Singh D, Mitha AP, Goyal M, Frayne R, Menon BK.

Neuroradiology. 2017 Apr;59(4):361-365. doi: 10.1007/s00234-017-1797-z. Epub 2017 Mar 6.


Identification of neurovascular changes associated with cerebral amyloid angiopathy from subject-specific hemodynamic response functions.

Williams RJ, Goodyear BG, Peca S, McCreary CR, Frayne R, Smith EE, Pike GB.

J Cereb Blood Flow Metab. 2017 Oct;37(10):3433-3445. doi: 10.1177/0271678X17691056. Epub 2017 Feb 1.


Flow and pressure measurements in aneurysms and arteriovenous malformations with phase contrast MR imaging.

MacDonald ME, Dolati P, Mitha AP, Wong JH, Frayne R.

Magn Reson Imaging. 2016 Nov;34(9):1322-1328. doi: 10.1016/j.mri.2016.07.007. Epub 2016 Jul 25.


Application of a Novel Measure of In Vivo Knee Joint Laxity.

Küpper JC, Westover L, Frayne R, Ronsky JL.

J Biomech Eng. 2016 Oct 1;138(10). doi: 10.1115/1.4034169.


Quantitative Perfusion and Permeability Biomarkers in Brain Cancer from Tomographic CT and MR Images.

Eilaghi A, Yeung T, d'Esterre C, Bauman G, Yartsev S, Easaw J, Fainardi E, Lee TY, Frayne R.

Biomark Cancer. 2016 Jul 3;8(Suppl 2):47-59. doi: 10.4137/BIC.S31801. eCollection 2016. Review.


Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment.

Case NF, Charlton A, Zwiers A, Batool S, McCreary CR, Hogan DB, Ismail Z, Zerna C, Coutts SB, Frayne R, Goodyear B, Haffenden A, Smith EE.

Stroke. 2016 Aug;47(8):2010-6. doi: 10.1161/STROKEAHA.116.012999. Epub 2016 Jun 23.


Multislice T1 -prepared 2D single-shot EPI: analysis of a clinical T1 mapping method unbiased by B0 or B1 inhomogeneity.

Lauzon ML, McCreary CR, Frayne R.

NMR Biomed. 2016 Aug;29(8):1056-69. doi: 10.1002/nbm.3566. Epub 2016 Jun 22.


Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy.

Switzer AR, McCreary C, Batool S, Stafford RB, Frayne R, Goodyear BG, Smith EE.

Neuroimage Clin. 2016 Mar 3;11:461-467. doi: 10.1016/j.nicl.2016.02.020. eCollection 2016.


Phase Error Correction in Time-Averaged 3D Phase Contrast Magnetic Resonance Imaging of the Cerebral Vasculature.

MacDonald ME, Forkert ND, Pike GB, Frayne R.

PLoS One. 2016 Feb 24;11(2):e0149930. doi: 10.1371/journal.pone.0149930. eCollection 2016.


Quantitative susceptibility mapping at 3 T: comparison of acquisition methodologies.

Lauzon ML, McCreary CR, McLean DA, Salluzzi M, Frayne R.

NMR Biomed. 2017 Apr;30(4). doi: 10.1002/nbm.3492. Epub 2016 Feb 17.


Time-Dependent Computed Tomographic Perfusion Thresholds for Patients With Acute Ischemic Stroke.

d'Esterre CD, Boesen ME, Ahn SH, Pordeli P, Najm M, Minhas P, Davari P, Fainardi E, Rubiera M, Khaw AV, Zini A, Frayne R, Hill MD, Demchuk AM, Sajobi TT, Forkert ND, Goyal M, Lee TY, Menon BK.

Stroke. 2015 Dec;46(12):3390-7. doi: 10.1161/STROKEAHA.115.009250. Epub 2015 Oct 29.


A systematic literature review of the effect of carotid atherosclerosis on local vessel stiffness and elasticity.

Boesen ME, Singh D, Menon BK, Frayne R.

Atherosclerosis. 2015 Nov;243(1):211-22. doi: 10.1016/j.atherosclerosis.2015.09.008. Epub 2015 Sep 8. Review.


Development and verification of a protocol to quantify hip joint kinematics: an evaluation of ice hockey goaltender pads on hip motion.

Frayne RJ, Kelleher LK, Wegscheider PK, Dickey JP.

Am J Sports Med. 2015 Sep;43(9):2157-63. doi: 10.1177/0363546515588941. Epub 2015 Jun 29.


Phase contrast MR imaging measurements of blood flow in healthy human cerebral vessel segments.

MacDonald ME, Frayne R.

Physiol Meas. 2015 Jul;36(7):1517-27. doi: 10.1088/0967-3334/36/7/1517. Epub 2015 May 28.


Cerebrovascular MRI: a review of state-of-the-art approaches, methods and techniques.

MacDonald ME, Frayne R.

NMR Biomed. 2015 Jul;28(7):767-91. doi: 10.1002/nbm.3322. Epub 2015 May 26. Review.


Reduced blood flow in normal white matter predicts development of leukoaraiosis.

Bernbaum M, Menon BK, Fick G, Smith EE, Goyal M, Frayne R, Coutts SB.

J Cereb Blood Flow Metab. 2015 Oct;35(10):1610-5. doi: 10.1038/jcbfm.2015.92. Epub 2015 May 13.


Hemodynamic alterations measured with phase-contrast MRI in a giant cerebral aneurysm treated with a flow-diverting stent.

MacDonald ME, Dolati P, Mitha AP, Eesa M, Wong JH, Frayne R.

Radiol Case Rep. 2016 Feb 17;10(2):1109. doi: 10.2484/rcr.v10i2.1109. eCollection 2015.


Final infarct volume estimation on 1-week follow-up MR imaging is feasible and is dependent on recanalization status.

Krongold M, Almekhlafi MA, Demchuk AM, Coutts SB, Frayne R, Eilaghi A.

Neuroimage Clin. 2014 Nov 8;7:1-6. doi: 10.1016/j.nicl.2014.10.010. eCollection 2015.


Early cerebral small vessel disease and brain volume, cognition, and gait.

Smith EE, O'Donnell M, Dagenais G, Lear SA, Wielgosz A, Sharma M, Poirier P, Stotts G, Black SE, Strother S, Noseworthy MD, Benavente O, Modi J, Goyal M, Batool S, Sanchez K, Hill V, McCreary CR, Frayne R, Islam S, DeJesus J, Rangarajan S, Teo K, Yusuf S; PURE Investigators.

Ann Neurol. 2015 Feb;77(2):251-61. doi: 10.1002/ana.24320.


Fast spin echo imaging of carotid artery dynamics.

Boesen ME, Maior Neto LA, Pulwicki A, Yerly J, Lebel RM, Frayne R.

Magn Reson Med. 2015 Oct;74(4):1103-9. doi: 10.1002/mrm.25494. Epub 2014 Oct 13.


Incidental magnetic resonance diffusion-weighted imaging-positive lesions are rare in neurologically asymptomatic community-dwelling adults.

Batool S, O'Donnell M, Sharma M, Islam S, Dagenais GR, Poirier P, Lear SA, Wielgosz A, Teo K, Stotts G, McCreary CR, Frayne R, DeJesus J, Rangarajan S, Yusuf S, Smith EE; PURE Study Investigators.

Stroke. 2014 Jul;45(7):2115-7. doi: 10.1161/STROKEAHA.114.005782. Epub 2014 Jun 12.


Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple sclerosis.

Costello F, Modi J, Lautner D, Bhayana D, Scott JN, Davenport WJ, Trufyn J, Frayne R, Ciura VA, Goyal M, Mah J, Hill MD.

CMAJ. 2014 Aug 5;186(11):E418-26. doi: 10.1503/cmaj.131431. Epub 2014 Jun 2.


The prevalence of incidental findings in multiple sclerosis patients.

Trufyn J, Hill MD, Scott JN, Modi J, Ciura V, Frayne R, Goyal M, Lautner D, Bhayana D, Davenport WJ, Mah JK, Burton JM, Costello F.

Can J Neurol Sci. 2014 Jan;41(1):49-52.


Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy.

Peca S, McCreary CR, Donaldson E, Kumarpillai G, Shobha N, Sanchez K, Charlton A, Steinback CD, Beaudin AE, Flück D, Pillay N, Fick GH, Poulin MJ, Frayne R, Goodyear BG, Smith EE.

Neurology. 2013 Nov 5;81(19):1659-65. doi: 10.1212/01.wnl.0000435291.49598.54. Epub 2013 Oct 4.


Reliability of neuroanatomical measurements in a multisite longitudinal study of youth at risk for psychosis.

Cannon TD, Sun F, McEwen SJ, Papademetris X, He G, van Erp TG, Jacobson A, Bearden CE, Walker E, Hu X, Zhou L, Seidman LJ, Thermenos HW, Cornblatt B, Olvet DM, Perkins D, Belger A, Cadenhead K, Tsuang M, Mirzakhanian H, Addington J, Frayne R, Woods SW, McGlashan TH, Constable RT, Qiu M, Mathalon DH, Thompson P, Toga AW.

Hum Brain Mapp. 2014 May;35(5):2424-34. doi: 10.1002/hbm.22338. Epub 2013 Aug 24.


Susceptibility-weighted imaging is more reliable than T2*-weighted gradient-recalled echo MRI for detecting microbleeds.

Cheng AL, Batool S, McCreary CR, Lauzon ML, Frayne R, Goyal M, Smith EE.

Stroke. 2013 Oct;44(10):2782-6. doi: 10.1161/STROKEAHA.113.002267. Epub 2013 Aug 6.


A statistical method for characterizing the noise in nonlinearly reconstructed images from undersampled MR data: the POCS example.

Sabati M, Peng H, Lauzon ML, Frayne R.

Magn Reson Imaging. 2013 Nov;31(9):1587-98. doi: 10.1016/j.mri.2013.06.011. Epub 2013 Jul 27.


Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1).

Lancet Neurol. 2013 Aug;12(8):822-38. doi: 10.1016/S1474-4422(13)70124-8.


Atherosclerosis imaging and the Canadian Atherosclerosis Imaging Network.

Tardif JC, Spence JD, Heinonen TM, Moody A, Pressacco J, Frayne R, L'allier P, Chow BJ, Friedrich M, Black SE, Fenster A, Rutt B, Beanlands R.

Can J Cardiol. 2013 Mar;29(3):297-303. doi: 10.1016/j.cjca.2012.09.017. Epub 2012 Dec 12. Review.


Investigating cervical muscle response and head kinematics during right, left, frontal and rear-seated perturbations.

Sacher N, Frayne RJ, Dickey JP.

Traffic Inj Prev. 2012 Sep;13(5):529-36. doi: 10.1080/15389588.2012.672783.


Accelerated passive MR catheter tracking into the carotid artery of canines.

Macdonald ME, Stafford RB, Yerly J, Andersen LB, McCreary CR, Frayne R.

Magn Reson Imaging. 2013 Jan;31(1):120-9. doi: 10.1016/j.mri.2012.06.033. Epub 2012 Aug 13.


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