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Items: 1 to 50 of 299

1.

Turning over our fat stores: the key to metabolic health Blaxter Award Lecture 2018.

Frayn KN.

Proc Nutr Soc. 2019 Aug;78(3):398-406. doi: 10.1017/S0029665118002598. Epub 2018 Oct 29.

PMID:
30370886
2.

Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome.

Bucci M, Karmi AC, Iozzo P, Fielding BA, Viljanen A, Badeau RM, Borra R, Saunavaara V, Pham T, Hannukainen JC, Kalliokoski K, Haaparanta-Solin M, Viljanen T, Parkkola R, Frayn KN, Nuutila P.

Diabetologia. 2015 Jan;58(1):158-64. doi: 10.1007/s00125-014-3402-x. Epub 2014 Oct 21.

PMID:
25331375
3.

Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.

Pinnick KE, Nicholson G, Manolopoulos KN, McQuaid SE, Valet P, Frayn KN, Denton N, Min JL, Zondervan KT, Fleckner J; MolPAGE Consortium, McCarthy MI, Holmes CC, Karpe F.

Diabetes. 2014 Nov;63(11):3785-97. doi: 10.2337/db14-0385. Epub 2014 Jun 19.

4.

Regulation of human subcutaneous adipose tissue blood flow.

Frayn KN, Karpe F.

Int J Obes (Lond). 2014 Aug;38(8):1019-26. doi: 10.1038/ijo.2013.200. Epub 2013 Oct 29. Review.

PMID:
24166067
5.

Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro.

Sell H, Blüher M, Klöting N, Schlich R, Willems M, Ruppe F, Knoefel WT, Dietrich A, Fielding BA, Arner P, Frayn KN, Eckel J.

Diabetes Care. 2013 Dec;36(12):4083-90. doi: 10.2337/dc13-0496. Epub 2013 Oct 15.

6.

Metabolic signatures of human adipose tissue hypoxia in obesity.

Hodson L, Humphreys SM, Karpe F, Frayn KN.

Diabetes. 2013 May;62(5):1417-25. doi: 10.2337/db12-1032. Epub 2012 Dec 28.

7.

Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.

Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1128-33. doi: 10.1016/j.numecd.2012.11.003. Epub 2012 Dec 8.

PMID:
23228218
8.

Marked resistance of femoral adipose tissue blood flow and lipolysis to adrenaline in vivo.

Manolopoulos KN, Karpe F, Frayn KN.

Diabetologia. 2012 Nov;55(11):3029-37. doi: 10.1007/s00125-012-2676-0. Epub 2012 Aug 17.

PMID:
22898765
9.

Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.

Pinnick KE, Neville MJ, Fielding BA, Frayn KN, Karpe F, Hodson L.

Diabetes. 2012 Jun;61(6):1399-403. doi: 10.2337/db11-1810. Epub 2012 Apr 9.

10.

Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast.

Frayn KN, Humphreys SM.

Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E468-75. doi: 10.1152/ajpendo.00527.2011. Epub 2011 Dec 13.

11.

Subcutaneous adipose tissue from obese and lean adults does not release hepcidin in vivo.

Tussing-Humphreys L, Frayn KN, Smith SR, Westerman M, Dennis AL, Nemeth E, Thomson J, Pusatcioglu C.

ScientificWorldJournal. 2011;11:2197-206. doi: 10.1100/2011/634861. Epub 2011 Nov 9.

12.

Fatty acids, obesity, and insulin resistance: time for a reevaluation.

Karpe F, Dickmann JR, Frayn KN.

Diabetes. 2011 Oct;60(10):2441-9. doi: 10.2337/db11-0425. Review. No abstract available.

13.

Dynamics of human adipose lipid turnover in health and metabolic disease.

Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, Buchholz BA, Eriksson M, Arner E, Hauner H, Skurk T, Rydén M, Frayn KN, Spalding KL.

Nature. 2011 Sep 25;478(7367):110-3. doi: 10.1038/nature10426.

14.

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus.

McCulloch LJ, van de Bunt M, Braun M, Frayn KN, Clark A, Gloyn AL.

Mol Genet Metab. 2011 Dec;104(4):648-53. doi: 10.1016/j.ymgme.2011.08.026. Epub 2011 Aug 28.

PMID:
21920790
15.

Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation.

Ardilouze JL, Sotorník R, Dennis LA, Fielding BA, Frayn KN, Karpe F.

Diabetes Metab. 2012 Feb;38(1):27-33. doi: 10.1016/j.diabet.2011.06.005. Epub 2011 Aug 23.

PMID:
21865069
16.

Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport.

Miller NE, Michel CC, Nanjee MN, Olszewski WL, Miller IP, Hazell M, Olivecrona G, Sutton P, Humphreys SM, Frayn KN.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E659-67. doi: 10.1152/ajpendo.00058.2011. Epub 2011 Jul 12.

17.

De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation.

Collins JM, Neville MJ, Pinnick KE, Hodson L, Ruyter B, van Dijk TH, Reijngoud DJ, Fielding MD, Frayn KN.

J Lipid Res. 2011 Sep;52(9):1683-92. doi: 10.1194/jlr.M012195. Epub 2011 Jun 15.

18.

Hepatic fatty acid partitioning.

Hodson L, Frayn KN.

Curr Opin Lipidol. 2011 Jun;22(3):216-24. doi: 10.1097/MOL.0b013e3283462e16. Review.

PMID:
21494141
19.

Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men.

Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA.

Br J Nutr. 2011 Mar;105(6):857-65. doi: 10.1017/S0007114510004472. Epub 2011 Jan 21.

PMID:
21251339
20.

Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F.

Diabetes. 2011 Jan;60(1):47-55. doi: 10.2337/db10-0867. Epub 2010 Oct 13.

21.

Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids.

McQuaid SE, Humphreys SM, Hodson L, Fielding BA, Karpe F, Frayn KN.

Diabetes. 2010 Oct;59(10):2465-73. doi: 10.2337/db10-0678. Epub 2010 Aug 3.

22.

Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

Hodson L, McQuaid SE, Humphreys SM, Milne R, Fielding BA, Frayn KN, Karpe F.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E584-92. doi: 10.1152/ajpendo.00272.2010. Epub 2010 Jul 13.

23.

Regulation of human metabolism by hypoxia-inducible factor.

Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Ratcliffe PJ, Smith TG, Treacy M, Frayn KN, Greenhaff PL, Karpe F, Clarke K, Robbins PA.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12722-7. doi: 10.1073/pnas.1002339107. Epub 2010 Jun 28.

24.

Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.

Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttilä J, Seppänen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Orešič M, Yki-Järvinen H.

Gastroenterology. 2010 Dec;139(6):1961-1971.e1. doi: 10.1053/j.gastro.2010.06.064. Epub 2010 Jun 27.

PMID:
20600015
25.

Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load.

Tran C, Jacot-Descombes D, Lecoultre V, Fielding BA, Carrel G, Lê KA, Schneiter P, Bortolotti M, Frayn KN, Tappy L.

Br J Nutr. 2010 Oct;104(8):1139-47. doi: 10.1017/S000711451000190X. Epub 2010 Jun 14.

PMID:
20540820
26.

Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function.

Funada J, Dennis AL, Roberts R, Karpe F, Frayn KN.

Clin Sci (Lond). 2010 Jul 6;119(8):313-22. doi: 10.1042/CS20100066.

PMID:
20518748
27.

Fat as a fuel: emerging understanding of the adipose tissue-skeletal muscle axis.

Frayn KN.

Acta Physiol (Oxf). 2010 Aug;199(4):509-18. doi: 10.1111/j.1748-1716.2010.02128.x. Epub 2010 Mar 26. Review.

PMID:
20353493
28.

Mapping of the fibroblast growth factors in human white adipose tissue.

Mejhert N, Galitzky J, Pettersson AT, Bambace C, Blomqvist L, Bouloumié A, Frayn KN, Dahlman I, Arner P, Rydén M.

J Clin Endocrinol Metab. 2010 May;95(5):2451-7. doi: 10.1210/jc.2009-2049. Epub 2010 Mar 12.

PMID:
20228166
29.

Dietary fat and insulin sensitivity.

Frayn KN, Hodson L, Karpe F.

Diabetologia. 2010 May;53(5):799-801. doi: 10.1007/s00125-010-1688-x. Epub 2010 Feb 25. No abstract available.

PMID:
20182858
30.

Gluteofemoral body fat as a determinant of metabolic health.

Manolopoulos KN, Karpe F, Frayn KN.

Int J Obes (Lond). 2010 Jun;34(6):949-59. doi: 10.1038/ijo.2009.286. Epub 2010 Jan 12. Review.

PMID:
20065965
31.

Development of an arterio-venous difference method to study the metabolic physiology of the femoral adipose tissue depot.

McQuaid SE, Manolopoulos KN, Dennis AL, Cheeseman J, Karpe F, Frayn KN.

Obesity (Silver Spring). 2010 May;18(5):1055-8. doi: 10.1038/oby.2009.486. Epub 2010 Jan 7.

32.

De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury.

Collins JM, Neville MJ, Hoppa MB, Frayn KN.

J Biol Chem. 2010 Feb 26;285(9):6044-52. doi: 10.1074/jbc.M109.053280. Epub 2009 Dec 23.

33.

Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling.

Funada J, Betts TR, Hodson L, Humphreys SM, Timperley J, Frayn KN, Karpe F.

PLoS One. 2009 Oct 21;4(10):e7533. doi: 10.1371/journal.pone.0007533.

34.

Dietary Approaches to Stop Hypertension (DASH) diet: applicability and acceptability to a UK population.

Harnden KE, Frayn KN, Hodson L.

J Hum Nutr Diet. 2010 Feb;23(1):3-10. doi: 10.1111/j.1365-277X.2009.01007.x. Epub 2009 Oct 15.

PMID:
19843201
35.

Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus.

Mostad IL, Bjerve KS, Basu S, Sutton P, Frayn KN, Grill V.

Metabolism. 2009 Dec;58(12):1753-61. doi: 10.1016/j.metabol.2009.06.003. Epub 2009 Aug 27.

PMID:
19716144
36.

Does the DASH diet lower blood pressure by altering peripheral vascular function?

Hodson L, Harnden KE, Roberts R, Dennis AL, Frayn KN.

J Hum Hypertens. 2010 May;24(5):312-9. doi: 10.1038/jhh.2009.65. Epub 2009 Aug 6.

PMID:
19657359
37.

Liver fat and lipid oxidation in humans.

Kotronen A, Seppälä-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Järvinen H.

Liver Int. 2009 Oct;29(9):1439-46. doi: 10.1111/j.1478-3231.2009.02076.x. Epub 2009 Jul 7.

PMID:
19602132
38.

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.

Roberts R, Hodson L, Dennis AL, Neville MJ, Humphreys SM, Harnden KE, Micklem KJ, Frayn KN.

Diabetologia. 2009 May;52(5):882-90. doi: 10.1007/s00125-009-1300-4. Epub 2009 Feb 28.

PMID:
19252892
39.

Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.

Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2009 May;94(5):1781-8. doi: 10.1210/jc.2008-2090. Epub 2009 Feb 17.

PMID:
19223522
40.

Transcriptional control of human adipose tissue blood flow.

Perez-Matute P, Neville MJ, Tan GD, Frayn KN, Karpe F.

Obesity (Silver Spring). 2009 Apr;17(4):681-8. doi: 10.1038/oby.2008.606. Epub 2009 Jan 22.

41.

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.

Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P.

Diabetes. 2009 Jan;58(1):125-33. doi: 10.2337/db08-0400. Epub 2008 Oct 24.

42.

Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate.

Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E64-71. doi: 10.1152/ajpendo.90730.2008. Epub 2008 Oct 21.

43.

Fatty acid metabolism in patients with PPARgamma mutations.

Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2008 Nov;93(11):4462-70. doi: 10.1210/jc.2007-2356. Epub 2008 Aug 19.

PMID:
18713822
44.

Adipose tissue fatty acid metabolism in insulin-resistant men.

Bickerton AS, Roberts R, Fielding BA, Tornqvist H, Blaak EE, Wagenmakers AJ, Gilbert M, Humphreys SM, Karpe F, Frayn KN.

Diabetologia. 2008 Aug;51(8):1466-74. doi: 10.1007/s00125-008-1040-x. Epub 2008 May 27. Erratum in: Diabetologia. 2008 Oct;51(10):1936.

PMID:
18504545
45.

Reduced oxidation of dietary fat after a short term high-carbohydrate diet.

Roberts R, Bickerton AS, Fielding BA, Blaak EE, Wagenmakers AJ, Chong MF, Gilbert M, Karpe F, Frayn KN.

Am J Clin Nutr. 2008 Apr;87(4):824-31.

PMID:
18400703
46.

Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.

Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA.

Am J Clin Nutr. 2008 Apr;87(4):817-23.

PMID:
18400702
47.

Remodeling phenotype of human subcutaneous adipose tissue macrophages.

Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M, Sengenes C, Galitzky J, Lafontan M, Karpe F, Frayn KN, Bouloumié A.

Circulation. 2008 Feb 12;117(6):806-15. doi: 10.1161/CIRCULATIONAHA.107.724096. Epub 2008 Jan 28.

PMID:
18227385
48.

Leukocyte activation by triglyceride-rich lipoproteins.

Alipour A, van Oostrom AJ, Izraeljan A, Verseyden C, Collins JM, Frayn KN, Plokker TW, Elte JW, Castro Cabezas M.

Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):792-7. doi: 10.1161/ATVBAHA.107.159749. Epub 2008 Jan 24.

PMID:
18218988
50.

Effects of short-term low- and high-carbohydrate diets on postprandial metabolism in non-diabetic and diabetic subjects.

Culling KS, Neil HA, Gilbert M, Frayn KN.

Nutr Metab Cardiovasc Dis. 2009 Jun;19(5):345-51. Epub 2007 Dec 20.

PMID:
18083355

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