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Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenografts.

Ricci F, Brunelli L, Affatato R, Chilà R, Verza M, Indraccolo S, Falcetta F, Fratelli M, Fruscio R, Pastorelli R, Damia G.

Ther Adv Med Oncol. 2019 Jun 24;11:1758835919839543. doi: 10.1177/1758835919839543. eCollection 2019.


HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.

Paroni G, Bolis M, Zanetti A, Ubezio P, Helin K, Staller P, Gerlach LO, Fratelli M, Neve RM, Terao M, Garattini E.

Oncogene. 2019 Apr;38(15):2675-2689. doi: 10.1038/s41388-018-0620-6. Epub 2018 Dec 11.


S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia.

Gianni M, Terao M, Kurosaki M, Paroni G, Brunelli L, Pastorelli R, Zanetti A, Lupi M, Acquavita A, Bolis M, Fratelli M, Rochette-Egly C, Garattini E.

Oncogene. 2019 Apr;38(14):2482-2500. doi: 10.1038/s41388-018-0599-z. Epub 2018 Dec 7.


Platinum sensitivity and DNA repair in a recently established panel of patient-derived ovarian carcinoma xenografts.

Guffanti F, Fratelli M, Ganzinelli M, Bolis M, Ricci F, Bizzaro F, Chilà R, Sina FP, Fruscio R, Lupia M, Cavallaro U, Cappelletti MR, Generali D, Giavazzi R, Damia G.

Oncotarget. 2018 May 15;9(37):24707-24717. doi: 10.18632/oncotarget.25185. eCollection 2018 May 15.


Massive NGS data analysis reveals hundreds of potential novel gene fusions in human cell lines.

Gioiosa S, Bolis M, Flati T, Massini A, Garattini E, Chillemi G, Fratelli M, Castrignanò T.

Gigascience. 2018 Oct 1;7(10). doi: 10.1093/gigascience/giy062.


Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2β and AP-2δ proteins.

Barzago MM, Kurosaki M, Fratelli M, Bolis M, Giudice C, Nordio L, Cerri E, Domenici L, Terao M, Garattini E.

Sci Rep. 2017 Sep 11;7(1):11140. doi: 10.1038/s41598-017-11752-6.


Network-guided modeling allows tumor-type independent prediction of sensitivity to all-trans-retinoic acid.

Bolis M, Garattini E, Paroni G, Zanetti A, Kurosaki M, Castrignanò T, Garattini SK, Biancardi F, Barzago MM, Gianni' M, Terao M, Pattini L, Fratelli M.

Ann Oncol. 2017 Mar 1;28(3):611-621. doi: 10.1093/annonc/mdw660.


Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.

Terao M, Barzago MM, Kurosaki M, Fratelli M, Bolis M, Borsotti A, Bigini P, Micotti E, Carli M, Invernizzi RW, Bagnati R, Passoni A, Pastorelli R, Brunelli L, Toschi I, Cesari V, Sanoh S, Garattini E.

Sci Rep. 2016 Jul 26;6:30343. doi: 10.1038/srep30343.


RARα2 and PML-RAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cells.

Gianni M, Fratelli M, Bolis M, Kurosaki M, Zanetti A, Paroni G, Rambaldi A, Borleri G, Rochette-Egly C, Terao M, Garattini E.

Oncotarget. 2017 Jun 6;8(23):37041-37060. doi: 10.18632/oncotarget.10556.


Structure and function of mammalian aldehyde oxidases.

Terao M, Romão MJ, Leimkühler S, Bolis M, Fratelli M, Coelho C, Santos-Silva T, Garattini E.

Arch Toxicol. 2016 Apr;90(4):753-80. doi: 10.1007/s00204-016-1683-1. Epub 2016 Feb 26. Review.


Patient-derived ovarian cancer xenografts re-growing after a cisplatinum treatment are less responsive to a second drug re-challenge: a new experimental setting to study response to therapy.

Ricci F, Fratelli M, Guffanti F, Porcu L, Spriano F, Dell'Anna T, Fruscio R, Damia G.

Oncotarget. 2017 Jan 31;8(5):7441-7451. doi: 10.18632/oncotarget.7465.


Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer.

Garattini E, Bolis M, Gianni' M, Paroni G, Fratelli M, Terao M.

Oncotarget. 2016 Jul 5;7(27):42661-42682. doi: 10.18632/oncotarget.7410. Review.


Association of CFHR1 homozygous deletion with acute myelogenous leukemia in the European population.

Fratelli M, Bolis M, Kurosaki M, Dori M, Guarnaccia V, Spinelli O, Alberti M, Valoti E, Pileggi S, Noris M, Remuzzi G, Rambaldi A, Terao M, Garattini E.

Leuk Lymphoma. 2016 May;57(5):1234-7. doi: 10.3109/10428194.2015.1082180. Epub 2016 Mar 2. No abstract available.


All-trans-retinoic Acid Modulates the Plasticity and Inhibits the Motility of Breast Cancer Cells: ROLE OF NOTCH1 AND TRANSFORMING GROWTH FACTOR (TGFβ).

Zanetti A, Affatato R, Centritto F, Fratelli M, Kurosaki M, Barzago MM, Bolis M, Terao M, Garattini E, Paroni G.

J Biol Chem. 2015 Jul 17;290(29):17690-709. doi: 10.1074/jbc.M115.638510. Epub 2015 May 27.


MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells.

Fisher JN, Terao M, Fratelli M, Kurosaki M, Paroni G, Zanetti A, Gianni M, Bolis M, Lupi M, Tsykin A, Goodall GJ, Garattini E.

Oncotarget. 2015 May 30;6(15):13176-200.


Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.

Centritto F, Paroni G, Bolis M, Garattini SK, Kurosaki M, Barzago MM, Zanetti A, Fisher JN, Scott MF, Pattini L, Lupi M, Ubezio P, Piccotti F, Zambelli A, Rizzo P, Gianni' M, Fratelli M, Terao M, Garattini E.

EMBO Mol Med. 2015 Jul;7(7):950-72. doi: 10.15252/emmm.201404670.


Retinoids and breast cancer: from basic studies to the clinic and back again.

Garattini E, Bolis M, Garattini SK, Fratelli M, Centritto F, Paroni G, Gianni' M, Zanetti A, Pagani A, Fisher JN, Zambelli A, Terao M.

Cancer Treat Rev. 2014 Jul;40(6):739-49. doi: 10.1016/j.ctrv.2014.01.001. Epub 2014 Jan 18. Review.


A novel classification method for multispectral imaging combined with portable Raman spectroscopy for the analysis of a painting by Vincent Van Gogh.

Cesaratto A, Nevin A, Valentini G, Brambilla L, Castiglioni C, Toniolo L, Fratelli M, Comelli D.

Appl Spectrosc. 2013 Nov;67(11):1234-41. doi: 10.1366/13-07032.


Long-duration epilepsy affects cell morphology and glutamatergic synapses in type IIB focal cortical dysplasia.

Finardi A, Colciaghi F, Castana L, Locatelli D, Marras CE, Nobili P, Fratelli M, Bramerio MA, Lorusso G, Battaglia GS.

Acta Neuropathol. 2013 Aug;126(2):219-35. doi: 10.1007/s00401-013-1143-4. Epub 2013 Jun 21.


Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression.

Kurosaki M, Bolis M, Fratelli M, Barzago MM, Pattini L, Perretta G, Terao M, Garattini E.

Cell Mol Life Sci. 2013 May;70(10):1807-30. doi: 10.1007/s00018-012-1229-5. Epub 2012 Dec 21.


New insights into the molecular mechanisms underlying sensitivity/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome.

Fratelli M, Fisher JN, Paroni G, Di Francesco AM, Pierri F, Pisano C, Godl K, Marx S, Tebbe A, Valli C, Gianni M, Stravalaci M, Gobbi M, Terao M, Garattini E.

Eur J Cancer. 2013 Apr;49(6):1491-500. doi: 10.1016/j.ejca.2012.11.013. Epub 2012 Dec 11.


Human axonal survival of motor neuron (a-SMN) protein stimulates axon growth, cell motility, C-C motif ligand 2 (CCL2), and insulin-like growth factor-1 (IGF1) production.

Locatelli D, Terao M, Fratelli M, Zanetti A, Kurosaki M, Lupi M, Barzago MM, Uggetti A, Capra S, D'Errico P, Battaglia GS, Garattini E.

J Biol Chem. 2012 Jul 27;287(31):25782-94. doi: 10.1074/jbc.M112.362830. Epub 2012 Jun 5.


Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA.

Paroni G, Fratelli M, Gardini G, Bassano C, Flora M, Zanetti A, Guarnaccia V, Ubezio P, Centritto F, Terao M, Garattini E.

Oncogene. 2012 Jul 19;31(29):3431-43. doi: 10.1038/onc.2011.506. Epub 2011 Nov 7.


Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets.

Terao M, Fratelli M, Kurosaki M, Zanetti A, Guarnaccia V, Paroni G, Tsykin A, Lupi M, Gianni M, Goodall GJ, Garattini E.

J Biol Chem. 2011 Feb 4;286(5):4027-42. doi: 10.1074/jbc.M110.184994. Epub 2010 Dec 3.


Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.

Binaschi M, Boldetti A, Gianni M, Maggi CA, Gensini M, Bigioni M, Parlani M, Giolitti A, Fratelli M, Valli C, Terao M, Garattini E.

ACS Med Chem Lett. 2010 Jul 20;1(8):411-5. doi: 10.1021/ml1001163. eCollection 2010 Nov 11.


The mammalian aldehyde oxidase gene family.

Garattini E, Fratelli M, Terao M.

Hum Genomics. 2009 Dec;4(2):119-30.


Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse.

Terao M, Kurosaki M, Barzago MM, Fratelli M, Bagnati R, Bastone A, Giudice C, Scanziani E, Mancuso A, Tiveron C, Garattini E.

Mol Cell Biol. 2009 Jan;29(2):357-77. doi: 10.1128/MCB.01385-08. Epub 2008 Nov 3.


Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity.

Valli C, Paroni G, Di Francesco AM, Riccardi R, Tavecchio M, Erba E, Boldetti A, Gianni' M, Fratelli M, Pisano C, Merlini L, Antoccia A, Cenciarelli C, Terao M, Garattini E.

Mol Cancer Ther. 2008 Sep;7(9):2941-54. doi: 10.1158/1535-7163.MCT-08-0419.


Mammalian aldehyde oxidases: genetics, evolution and biochemistry.

Garattini E, Fratelli M, Terao M.

Cell Mol Life Sci. 2008 Apr;65(7-8):1019-48. Review.


Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways.

Parrella E, Giannì M, Fratelli M, Barzago MM, Raska I Jr, Diomede L, Kurosaki M, Pisano C, Carminati P, Merlini L, Dallavalle S, Tavecchio M, Rochette-Egly C, Terao M, Garattini E.

Mol Pharmacol. 2006 Sep;70(3):909-24. Epub 2006 Jun 20.


Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes.

Terao M, Kurosaki M, Barzago MM, Varasano E, Boldetti A, Bastone A, Fratelli M, Garattini E.

J Biol Chem. 2006 Jul 14;281(28):19748-61. Epub 2006 May 3.


Redox regulation of cyclophilin A by glutathionylation.

Ghezzi P, Casagrande S, Massignan T, Basso M, Bellacchio E, Mollica L, Biasini E, Tonelli R, Eberini I, Gianazza E, Dai WW, Fratelli M, Salmona M, Sherry B, Bonetto V.

Proteomics. 2006 Feb;6(3):817-25.


Gene expression profiling reveals a signaling role of glutathione in redox regulation.

Fratelli M, Goodwin LO, Ørom UA, Lombardi S, Tonelli R, Mengozzi M, Ghezzi P.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13998-4003. Epub 2005 Sep 19.


Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation.

Ghezzi P, Bonetto V, Fratelli M.

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):964-72. Review.


Redox proteomics: identification and functional role of glutathionylated proteins.

Fratelli M, Gianazza E, Ghezzi P.

Expert Rev Proteomics. 2004 Oct;1(3):365-76. Review.


Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor.

Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14907-12. Epub 2004 Sep 29.


Derivatives of erythropoietin that are tissue protective but not erythropoietic.

Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P, Larsen AK, Helboe L, Christensen S, Pedersen LO, Nielsen M, Torup L, Sager T, Sfacteria A, Erbayraktar S, Erbayraktar Z, Gokmen N, Yilmaz O, Cerami-Hand C, Xie QW, Coleman T, Cerami A, Brines M.

Science. 2004 Jul 9;305(5681):239-42.


Identification of proteins undergoing glutathionylation in oxidatively stressed hepatocytes and hepatoma cells.

Fratelli M, Demol H, Puype M, Casagrande S, Villa P, Eberini I, Vandekerckhove J, Gianazza E, Ghezzi P.

Proteomics. 2003 Jul;3(7):1154-61.


Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

Erbayraktar S, Grasso G, Sfacteria A, Xie QW, Coleman T, Kreilgaard M, Torup L, Sager T, Erbayraktar Z, Gokmen N, Yilmaz O, Ghezzi P, Villa P, Fratelli M, Casagrande S, Leist M, Helboe L, Gerwein J, Christensen S, Geist MA, Pedersen LØ, Cerami-Hand C, Wuerth JP, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6741-6. Epub 2003 May 13. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102.


Inhibition of nuclear factor-kappaB by a nitro-derivative of flurbiprofen: a possible mechanism for antiinflammatory and antiproliferative effect.

Fratelli M, Minto M, Crespi A, Erba E, Vandenabeele P, Del Soldato P, Ghezzi P.

Antioxid Redox Signal. 2003 Apr;5(2):229-35.


Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.

Casagrande S, Bonetto V, Fratelli M, Gianazza E, Eberini I, Massignan T, Salmona M, Chang G, Holmgren A, Ghezzi P.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9745-9. Epub 2002 Jul 15.


Monitoring the effects of drug treatment in rat models of disease by serum protein analysis.

Gianazza E, Eberini I, Villa P, Fratelli M, Pinna C, Wait R, Gemeiner M, Miller I.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 5;771(1-2):107-30. Review.


Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes.

Fratelli M, Demol H, Puype M, Casagrande S, Eberini I, Salmona M, Bonetto V, Mengozzi M, Duffieux F, Miclet E, Bachi A, Vandekerckhove J, Gianazza E, Ghezzi P.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3505-10.


Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection.

Ghezzi P, Romines B, Fratelli M, Eberini I, Gianazza E, Casagrande S, Laragione T, Mengozzi M, Herzenberg LA, Herzenberg LA.

Mol Immunol. 2002 Feb;38(10):773-80.


Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress.

Sirén AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4044-9. Epub 2001 Mar 20.


Proteins of rat serum V: adjuvant arthritis and its modulation by nonsteroidal anti-inflammatory drugs.

Ebrini I, Agnello D, Miller I, Villa P, Fratelli M, Ghezzi P, Gemeiner M, Chan J, Aebersold R, Gianazza E.

Electrophoresis. 2000 Jun;21(11):2170-9.


Protective effect of ciliary neurotrophic factor (CNTF) in a model of endotoxic shock: action mechanisms and role of CNTF receptor alpha.

Demitri MT, Benigni F, Meazza C, Zinetti M, Fratelli M, Villa P, Acheson A, Panayotatos N, Ghezzi P.

J Inflamm. 1998;48(2):47-55.


Mycobacterial Cpn10 promotes recognition of the mammalian homologue by a mycobacterium-specific antiserum.

Minto M, Galli G, Gianazza E, Eberini I, Legname G, Fossati G, Modena D, Marcucci F, Mascagni P, Ghezzi P, Fratelli M.

Biochim Biophys Acta. 1998 Jun 22;1403(2):151-7.


Regional production of nitric oxide after a peripheral or central low dose of LPS in mice.

Zinetti M, Benigni F, Sacco S, Minto M, Galli G, Salmona S, Andreoni G, Vezzani A, Ghezzi P, Fratelli M.

Neuroimmunomodulation. 1996 Nov-Dec;3(6):364-70.


Mycobacterium tuberculosis heat shock protein 10 increases both proliferation and death in mouse P19 teratocarcinoma cells.

Galli G, Ghezzi P, Mascagni P, Marcucci F, Fratelli M.

In Vitro Cell Dev Biol Anim. 1996 Jul-Aug;32(7):446-50.


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