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Metabolite profiling characterises chemotypes of Musa diploids and triploids at juvenile and pre-flowering growth stages.

Drapal M, de Carvalho EB, Rouard M, Amah D, Sardos J, Van den Houwe I, Brown A, Roux N, Swennen R, Fraser PD.

Sci Rep. 2019 Mar 15;9(1):4657. doi: 10.1038/s41598-019-41037-z.


Carotenoid biosynthesis and sequestration in red chilli pepper fruit and its impact on colour intensity traits.

Berry HM, Rickett DV, Baxter C, Enfissi EMA, Fraser PD.

J Exp Bot. 2019 Mar 1. pii: erz086. doi: 10.1093/jxb/erz086. [Epub ahead of print]


The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies.

Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG.

Front Cell Neurosci. 2019 Feb 5;13:17. doi: 10.3389/fncel.2019.00017. eCollection 2019.


The road to astaxanthin production in tomato fruit reveals plastid and metabolic adaptation resulting in an unintended high lycopene genotype with delayed over-ripening properties.

Enfissi EMA, Nogueira M, D'Ambrosio C, Stigliani AL, Giorio G, Misawa N, Fraser PD.

Plant Biotechnol J. 2019 Jan 8. doi: 10.1111/pbi.13073. [Epub ahead of print]


Metabolic diversity in sweet potato (Ipomoea batatas, Lam.) leaves and storage roots.

Drapal M, Rossel G, Heider B, Fraser PD.

Hortic Res. 2019 Jan 1;6:2. doi: 10.1038/s41438-018-0075-5. eCollection 2019.


Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.

Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM.

Cell. 2019 Feb 7;176(4):816-830.e18. doi: 10.1016/j.cell.2018.11.036. Epub 2018 Dec 27.


SLAF-based construction of a high-density genetic map and its application in QTL mapping of carotenoids content in citrus fruit.

Zheng X, Tang Y, Ye J, Pan Z, Tan M, Xie Z, Chai L, Xu Q, Fraser PD, Deng X.

J Agric Food Chem. 2018 Dec 27. doi: 10.1021/acs.jafc.8b05176. [Epub ahead of print]


Construction of a fusion enzyme for astaxanthin formation and its characterisation in microbial and plant hosts: A new tool for engineering ketocarotenoids.

Nogueira M, Enfissi EMA, Welsch R, Beyer P, Zurbriggen MD, Fraser PD.

Metab Eng. 2019 Mar;52:243-252. doi: 10.1016/j.ymben.2018.12.006. Epub 2018 Dec 20.


Capturing biochemical diversity in cassava (Manihot esculenta Crantz) through the application of metabolite profiling.

Drapal M, Barros de Carvalho E, Ovalle Rivera TM, Becerra Lopez-Lavalle LA, Fraser PD.

J Agric Food Chem. 2018 Dec 17. doi: 10.1021/acs.jafc.8b04769. [Epub ahead of print]


Aggregation of the diabetes-related peptide ProIAPP1-48 measured by dynamic light scattering.

Shardlow E, Rao C, Sattarov R, Wu L, Fraser PE, Exley C.

J Trace Elem Med Biol. 2019 Jan;51:1-8. doi: 10.1016/j.jtemb.2018.09.001. Epub 2018 Sep 10.


Characterization of CRISPR Mutants Targeting Genes Modulating Pectin Degradation in Ripening Tomato.

Wang D, Samsulrizal NH, Yan C, Allcock NS, Craigon J, Blanco-Ulate B, Ortega-Salazar I, Marcus SE, Bagheri HM, Perez Fons L, Fraser PD, Foster T, Fray R, Knox JP, Seymour GB.

Plant Physiol. 2019 Feb;179(2):544-557. doi: 10.1104/pp.18.01187. Epub 2018 Nov 20.


Parkinsonism due to A53E α-synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features.

Picillo M, Lizarraga KJ, Friesen EL, Chau H, Zhang M, Sato C, Rooke G, Munhoz RP, Rogaeva E, Fraser PE, Kalia SK, Kalia LV.

Mov Disord. 2018 Dec;33(12):1950-1955. doi: 10.1002/mds.27506. Epub 2018 Nov 13.


Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD.

Nat Commun. 2018 Nov 12;9(1):4792. doi: 10.1038/s41467-018-07399-0.


Pesticide exposure and risk of systemic lupus erythematosus in an urban population of predominantly African-American women.

Williams JN, Chang SC, Sinnette C, Malspeis S, Parks CG, Karlson EW, Fraser P, Costenbader K.

Lupus. 2018 Nov;27(13):2129-2134. doi: 10.1177/0961203318805844. Epub 2018 Oct 11.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S.

Mol Psychiatry. 2018 Oct 3. doi: 10.1038/s41380-018-0258-3. [Epub ahead of print]


Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME.

Nat Genet. 2018 Oct;50(10):1352-1358. doi: 10.1038/s41588-018-0236-3. Epub 2018 Sep 27. Review.


Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.

Koohy H, Bolland DJ, Matheson LS, Schoenfelder S, Stellato C, Dimond A, Várnai C, Chovanec P, Chessa T, Denizot J, Manzano Garcia R, Wingett SW, Freire-Pritchett P, Nagano T, Hawkins P, Stephens L, Elderkin S, Spivakov M, Fraser P, Corcoran AE, Varga-Weisz PD.

Genome Biol. 2018 Sep 5;19(1):126. doi: 10.1186/s13059-018-1489-y.


Efficient production of a mature and functional gamma secretase protease.

Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, Berger I, Schaffitzel C, Fraser PE, Martins RN, Verdile G.

Sci Rep. 2018 Aug 27;8(1):12834. doi: 10.1038/s41598-018-30788-w.


Effect of diflufenican on total carotenoid and phytoene production in carrot suspension-cultured cells.

Miras-Moreno B, Pedreño MA, Fraser PD, Sabater-Jara AB, Almagro L.

Planta. 2019 Jan;249(1):113-122. doi: 10.1007/s00425-018-2966-y. Epub 2018 Aug 6.


Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions.

Schoenfelder S, Javierre BM, Furlan-Magaril M, Wingett SW, Fraser P.

J Vis Exp. 2018 Jun 28;(136). doi: 10.3791/57320.


Carotenoids moderate the effectiveness of a Bt gene against the European corn borer, Ostrinia nubilalis.

Zanga D, Sanahuja G, Eizaguirre M, Albajes R, Christou P, Capell T, Fraser P, Gerrisch C, López C.

PLoS One. 2018 Jul 10;13(7):e0199317. doi: 10.1371/journal.pone.0199317. eCollection 2018.


Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD.

Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. Erratum in: Nat Commun. 2018 Nov 12;9(1):4792.


The assessment of changes to the nontuberculous mycobacterial metabolome in response to anti-TB drugs.

Drapal M, Wheeler PR, Fraser PD.

FEMS Microbiol Lett. 2018 Aug 1;365(15). doi: 10.1093/femsle/fny153.


Comparison of rider stability in a flapless saddle versus a conventional saddle.

Clayton HM, Hampson A, Fraser P, White A, Egenvall A.

PLoS One. 2018 Jun 6;13(6):e0196960. doi: 10.1371/journal.pone.0196960. eCollection 2018.


The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia.

Beekman R, Chapaprieta V, Russiñol N, Vilarrasa-Blasi R, Verdaguer-Dot N, Martens JHA, Duran-Ferrer M, Kulis M, Serra F, Javierre BM, Wingett SW, Clot G, Queirós AC, Castellano G, Blanc J, Gut M, Merkel A, Heath S, Vlasova A, Ullrich S, Palumbo E, Enjuanes A, Martín-García D, Beà S, Pinyol M, Aymerich M, Royo R, Puiggros M, Torrents D, Datta A, Lowy E, Kostadima M, Roller M, Clarke L, Flicek P, Agirre X, Prosper F, Baumann T, Delgado J, López-Guillermo A, Fraser P, Yaspo ML, Guigó R, Siebert R, Martí-Renom MA, Puente XS, López-Otín C, Gut I, Stunnenberg HG, Campo E, Martin-Subero JI.

Nat Med. 2018 Jun;24(6):868-880. doi: 10.1038/s41591-018-0028-4. Epub 2018 May 21.


Protocol for an economic evaluation of WHO STOPS childhood obesity stepped-wedge cluster randomised controlled trial.

Sweeney R, Moodie M, Nguyen P, Fraser P, Bolton K, Brown A, Marks J, Crooks N, Strugnell C, Bell C, Millar L, Orellana L, Allender S.

BMJ Open. 2018 May 14;8(5):e020551. doi: 10.1136/bmjopen-2017-020551.


Allele-specific control of replication timing and genome organization during development.

Rivera-Mulia JC, Dimond A, Vera D, Trevilla-Garcia C, Sasaki T, Zimmerman J, Dupont C, Gribnau J, Fraser P, Gilbert DM.

Genome Res. 2018 Jun;28(6):800-811. doi: 10.1101/gr.232561.117. Epub 2018 May 7.


Carotenoid profiling of yams: Clarity, comparisons and diversity.

Price EJ, Bhattacharjee R, Lopez-Montes A, Fraser PD.

Food Chem. 2018 Sep 1;259:130-138. doi: 10.1016/j.foodchem.2018.03.066. Epub 2018 Mar 27.


FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, Kaminski Schierle GS, Kaminski CF, Holt CE, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P.

Cell. 2018 Apr 19;173(3):720-734.e15. doi: 10.1016/j.cell.2018.03.056.


Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age.

Kent BA, Heath CJ, Kim CH, Ahrens R, Fraser PE, St George-Hyslop P, Bussey TJ, Saksida LM.

Brain Behav. 2017 Dec 18;8(1):e00896. doi: 10.1002/brb3.896. eCollection 2018 Jan.


Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies.

Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O'Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL.

J Alzheimers Dis. 2018;62(3):965-992. doi: 10.3233/JAD-171145.


Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition.

Novo CL, Javierre BM, Cairns J, Segonds-Pichon A, Wingett SW, Freire-Pritchett P, Furlan-Magaril M, Schoenfelder S, Fraser P, Rugg-Gunn PJ.

Cell Rep. 2018 Mar 6;22(10):2615-2627. doi: 10.1016/j.celrep.2018.02.040.


C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.

Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF, Schierle GSK.

Nat Commun. 2018 Feb 19;9(1):712. doi: 10.1038/s41467-018-03111-4.


Detection and Enhancement of Ketocarotenoid Accumulation in the Newly Isolated Sarcinoid Green Microalga Chlorosarcinopsis PY02.

Cherdchukeattisak P, Fraser PD, Purton S, Brocklehurst TW.

Biology (Basel). 2018 Feb 12;7(1). pii: E17. doi: 10.3390/biology7010017.


Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures.

Comoglio F, Park HJ, Schoenfelder S, Barozzi I, Bode D, Fraser P, Green AR.

Genome Res. 2018 Feb 2. pii: gr.227272.117. doi: 10.1101/gr.227272.117. [Epub ahead of print]


Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance.

Wijesekara N, Gonçalves RA, Ahrens R, De Felice FG, Fraser PE.

FASEB J. 2018 Jun;32(6):3166-3173. doi: 10.1096/fj.201701352. Epub 2018 Jan 18.


Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.

Wutz G, Várnai C, Nagasaka K, Cisneros DA, Stocsits RR, Tang W, Schoenfelder S, Jessberger G, Muhar M, Hossain MJ, Walther N, Koch B, Kueblbeck M, Ellenberg J, Zuber J, Fraser P, Peters JM.

EMBO J. 2017 Dec 15;36(24):3573-3599. doi: 10.15252/embj.201798004. Epub 2017 Dec 7.


SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model.

Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE.

Neurobiol Dis. 2018 Feb;110:154-165. doi: 10.1016/j.nbd.2017.11.015. Epub 2017 Dec 5.


Impaired peripheral glucose homeostasis and Alzheimer's disease.

Wijesekara N, Gonçalves RA, De Felice FG, Fraser PE.

Neuropharmacology. 2018 Jul 1;136(Pt B):172-181. doi: 10.1016/j.neuropharm.2017.11.027. Epub 2017 Nov 21. Review.


Commentary: Analysis of SUMO1-conjugation at synapses.

Wilkinson KA, Martin S, Tyagarajan SK, Arancio O, Craig TJ, Guo C, Fraser PE, Goldstein SAN, Henley JM.

Front Cell Neurosci. 2017 Oct 30;11:345. doi: 10.3389/fncel.2017.00345. eCollection 2017. No abstract available.


Metabolite profiling of yam (Dioscorea spp.) accessions for use in crop improvement programmes.

Price EJ, Bhattacharjee R, Lopez-Montes A, Fraser PD.

Metabolomics. 2017;13(11):144. doi: 10.1007/s11306-017-1279-7. Epub 2017 Oct 14.


Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus: Results of a Twenty-Four-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase IIb Study.

Merrill JT, Wallace DJ, Wax S, Kao A, Fraser PA, Chang P, Isenberg D; ADDRESS II Investigators.

Arthritis Rheumatol. 2018 Feb;70(2):266-276. doi: 10.1002/art.40360. Erratum in: Arthritis Rheumatol. 2018 Mar;70(3):467.


Capturing Three-Dimensional Genome Organization in Individual Cells by Single-Cell Hi-C.

Nagano T, Wingett SW, Fraser P.

Methods Mol Biol. 2017;1654:79-97. doi: 10.1007/978-1-4939-7231-9_6.


Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed.

Nogueira M, Enfissi EMA, Martínez Valenzuela ME, Menard GN, Driller RL, Eastmond PJ, Schuch W, Sandmann G, Fraser PD.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10876-10881. doi: 10.1073/pnas.1708349114. Epub 2017 Sep 25.


Chromosome contacts in activated T cells identify autoimmune disease candidate genes.

Burren OS, Rubio García A, Javierre BM, Rainbow DB, Cairns J, Cooper NJ, Lambourne JJ, Schofield E, Castro Dopico X, Ferreira RC, Coulson R, Burden F, Rowlston SP, Downes K, Wingett SW, Frontini M, Ouwehand WH, Fraser P, Spivakov M, Todd JA, Wicker LS, Cutler AJ, Wallace C.

Genome Biol. 2017 Sep 4;18(1):165. doi: 10.1186/s13059-017-1285-0.


Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Laws SM, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser PE, Porter T, Newsholme P, Wijesekara N, Burnham S, Doré V, Li QX, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Martins RN, Verdile G.

Sci Rep. 2017 Aug 29;7(1):9766. doi: 10.1038/s41598-017-09577-4.


Creating plant molecular factories for industrial and nutritional isoprenoid production.

Nogueira M, Enfissi EM, Almeida J, Fraser PD.

Curr Opin Biotechnol. 2018 Feb;49:80-87. doi: 10.1016/j.copbio.2017.08.002. Epub 2017 Aug 29. Review.


Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G.

PLoS One. 2017 Aug 23;12(8):e0182844. doi: 10.1371/journal.pone.0182844. eCollection 2017.


Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.

Wijesekara N, Ahrens R, Sabale M, Wu L, Ha K, Verdile G, Fraser PE.

FASEB J. 2017 Dec;31(12):5409-5418. doi: 10.1096/fj.201700431R. Epub 2017 Aug 14.


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