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Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107+ CD8+ T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge.

Khan AA, Srivastava R, Vahed H, Roy S, Walia SS, Kim GJ, Fouladi MA, Yamada T, Ly VT, Lam C, Lou A, Nguyen V, Boldbaatar U, Geertsema R, Fraser NW, BenMohamed L.

J Virol. 2018 Jul 31;92(16). pii: e00535-18. doi: 10.1128/JVI.00535-18. Print 2018 Aug 15.


Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque.

Fan S, Xu X, Liao Y, Wang Y, Wang J, Feng M, Wang L, Zhang Y, He Z, Yang F, Fraser NW, Li Q.

Viruses. 2018 May 2;10(5). pii: E234. doi: 10.3390/v10050234.


CTCF interacts with the lytic HSV-1 genome to promote viral transcription.

Lang F, Li X, Vladimirova O, Hu B, Chen G, Xiao Y, Singh V, Lu D, Li L, Han H, Wickramasinghe JM, Smith ST, Zheng C, Li Q, Lieberman PM, Fraser NW, Zhou J.

Sci Rep. 2017 Jan 3;7:39861. doi: 10.1038/srep39861.


Remembrance of Professor Steven Wechsler (1948-2016).

Ahmed R, Fraser NW, Ghiasi H, Jones C.

J Neurovirol. 2016 Oct;22(5):553-554. Epub 2016 Aug 4. No abstract available.


Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome.

Hu B, Li X, Huo Y, Yu Y, Zhang Q, Chen G, Zhang Y, Fraser NW, Wu D, Zhou J.

Sci Rep. 2016 Jun 29;6:28075. doi: 10.1038/srep28075.


Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System.

Li L, Li Z, Wang E, Yang R, Xiao Y, Han H, Lang F, Li X, Xia Y, Gao F, Li Q, Fraser NW, Zhou J.

J Virol. 2015 Oct 28;90(2):790-804. doi: 10.1128/JVI.02258-15. Print 2016 Jan 15.


Reactivation of HSV-1 following explant of tree shrew brain.

Li L, Li Z, Li X, Wang E, Lang F, Xia Y, Fraser NW, Gao F, Zhou J.

J Neurovirol. 2016 Jun;22(3):293-306. doi: 10.1007/s13365-015-0393-4. Epub 2015 Oct 26.


Bilateral single-site intracerebral injection of a nonpathogenic herpes simplex virus-1 vector decreases anxiogenic behavior in MPS VII mice.

Liu W, Griffin G, Clarke T, Parente MK, Valentino RJ, Wolfe JH, Fraser NW.

Mol Ther Methods Clin Dev. 2015 Jan 28;2:14059. doi: 10.1038/mtm.2014.59. eCollection 2015.


Genome wide nucleosome mapping for HSV-1 shows nucleosomes are deposited at preferred positions during lytic infection.

Oh J, Sanders IF, Chen EZ, Li H, Tobias JW, Isett RB, Penubarthi S, Sun H, Baldwin DA, Fraser NW.

PLoS One. 2015 Feb 24;10(2):e0117471. doi: 10.1371/journal.pone.0117471. eCollection 2015.


Early nucleosome deposition on, and replication of, HSV DNA requires cell factor PCNA.

Sanders I, Boyer M, Fraser NW.

J Neurovirol. 2015 Aug;21(4):358-69. doi: 10.1007/s13365-015-0321-7. Epub 2015 Feb 12.


HSV-1 remodels host telomeres to facilitate viral replication.

Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM.

Cell Rep. 2014 Dec 24;9(6):2263-78. doi: 10.1016/j.celrep.2014.11.019. Epub 2014 Dec 11.


Weight loss and reduced body temperature determine humane endpoints in a mouse model of ocular herpesvirus infection.

Hankenson FC, Ruskoski N, van Saun M, Ying GS, Oh J, Fraser NW.

J Am Assoc Lab Anim Sci. 2013;52(3):277-85.


DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line.

Volcy K, Fraser NW.

J Neurovirol. 2013 Feb;19(1):57-64. doi: 10.1007/s13365-012-0140-z. Epub 2013 Jan 26.


The half-life of the HSV-1 1.5-kb LAT intron is similar to the half-life of the 2.0-kb LAT intron.

Brinkman KK, Mishra P, Fraser NW.

J Neurovirol. 2013 Feb;19(1):102-8. doi: 10.1007/s13365-012-0146-6. Epub 2013 Jan 19.


Chromatin assembly on herpes simplex virus 1 DNA early during a lytic infection is Asf1a dependent.

Oh J, Ruskoski N, Fraser NW.

J Virol. 2012 Nov;86(22):12313-21. doi: 10.1128/JVI.01570-12. Epub 2012 Sep 5.


Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner.

Millhouse S, Wang X, Fraser NW, Faber L, Block TM.

J Neurovirol. 2012 Jun;18(3):231-43. doi: 10.1007/s13365-012-0105-2. Epub 2012 May 12.


The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing.

Jiang X, Chentoufi AA, Hsiang C, Carpenter D, Osorio N, BenMohamed L, Fraser NW, Jones C, Wechsler SL.

J Virol. 2011 Mar;85(5):2325-32. doi: 10.1128/JVI.01791-10. Epub 2010 Dec 22.


Evidence that herpes simplex virus DNA derived from quiescently infected cells in vitro, and latently infected cells in vivo, is physically damaged.

Millhouse S, Su YH, Zhang X, Wang X, Song BP, Zhu L, Oppenheim E, Fraser NW, Block TM.

J Neurovirol. 2010 Oct;16(5):384-98. doi: 10.3109/13550284.2010.515651.


Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters.

Husain T, Passini MA, Parente MK, Fraser NW, Wolfe JH.

Gene Ther. 2009 Jul;16(7):927-32. doi: 10.1038/gt.2009.52. Epub 2009 May 21.


The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1.

Placek BJ, Huang J, Kent JR, Dorsey J, Rice L, Fraser NW, Berger SL.

J Virol. 2009 Feb;83(3):1416-21. doi: 10.1128/JVI.01276-08. Epub 2008 Nov 12.


Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.

Benencia F, Courrèges MC, Fraser NW, Coukos G.

Cancer Biol Ther. 2008 Aug;7(8):1194-205. Epub 2008 Aug 1.


Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.

Gartner JJ, Sethupathy P, Hatzigeorgiou AG, Fraser NW.

Nature. 2008 Jan 31;451(7178):600. doi: 10.1038/nature06621. No abstract available.


Herpes simplex virus type 1 ICP4 deletion mutant virus d120 infection failed to induce apoptosis in nerve growth factor-differentiated PC12 cells.

Aiamkitsumrit B, Zhang X, Block TM, Norton P, Fraser NW, Su YH.

J Neurovirol. 2007 Aug;13(4):305-14.


Transduction of brain by herpes simplex virus vectors.

Berges BK, Wolfe JH, Fraser NW.

Mol Ther. 2007 Jan;15(1):20-9. Review.


The stability of herpes simplex virus type I genomes in infected Vero cells undergoing viral induced apoptosis.

Su YH, Zhang X, Aiamkitsumrit B, Tang Q, Maul G, Fraser NW, Block TM.

J Neurovirol. 2006 Oct;12(5):375-86.


Characterization of a spliced exon product of herpes simplex type-1 latency-associated transcript in productively infected cells.

Kang W, Mukerjee R, Gartner JJ, Hatzigeorgiou AG, Sandri-Goldin RM, Fraser NW.

Virology. 2006 Dec 5-20;356(1-2):106-14. Epub 2006 Aug 30.


Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.

Gupta A, Gartner JJ, Sethupathy P, Hatzigeorgiou AG, Fraser NW.

Nature. 2006 Jul 6;442(7098):82-5. Epub 2006 May 31. Retraction in: Gartner JJ, Sethupathy P, Hatzigeorgiou AG, Fraser NW. Nature. 2008 Jan 31;451(7178):600.


Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.

Huang J, Kent JR, Placek B, Whelan KA, Hollow CM, Zeng PY, Fraser NW, Berger SL.

J Virol. 2006 Jun;80(12):5740-6.


A mutant deleted for most of the herpes simplex virus type 1 (HSV-1) UOL gene does not affect the spontaneous reactivation phenotype in rabbits.

Chan D, Cohen J, Naito J, Mott KR, Osorio N, Jin L, Fraser NW, Jones C, Wechsler SL, Perng GC.

J Neurovirol. 2006 Feb;12(1):5-16.


The stable 2-kb LAT intron of herpes simplex stimulates the expression of heat shock proteins and protects cells from stress.

Atanasiu D, Kent JR, Gartner JJ, Fraser NW.

Virology. 2006 Jun 20;350(1):26-33. Epub 2006 Mar 6.


Widespread correction of lysosomal storage in the mucopolysaccharidosis type VII mouse brain with a herpes simplex virus type 1 vector expressing beta-glucuronidase.

Berges BK, Yellayi S, Karolewski BA, Miselis RR, Wolfe JH, Fraser NW.

Mol Ther. 2006 May;13(5):859-69. Epub 2006 Mar 3.


Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter region.

Naito J, Mukerjee R, Mott KR, Kang W, Osorio N, Fraser NW, Perng GC.

Virus Res. 2005 Mar;108(1-2):101-10.


Herpes simplex virus latency-associated transcript gene function.

Kent JR, Kang W, Miller CG, Fraser NW.

J Neurovirol. 2003 Jun;9(3):285-90. Review.


Stability and circularization of herpes simplex virus type 1 genomes in quiescently infected PC12 cultures.

Su YH, Moxley MJ, Ng AK, Lin J, Jordan R, Fraser NW, Block TM.

J Gen Virol. 2002 Dec;83(Pt 12):2943-50.


Herpes simplex virus type 1 infection prevents detachment of nerve growth factor-differentiated PC12 cells in culture.

Moxley MJ, Block TM, Liu HC, Fraser NW, Perng GC, Wechsler SL, Su YH.

J Gen Virol. 2002 Jul;83(Pt 7):1591-600.


Infection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1.

Springer SL, Vite CH, Polesky AC, Kesari S, Fraser NW, Wolfe JH.

J Neurovirol. 2001 Apr;7(2):149-54.


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