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Items: 46

1.

Salt stress in the renal tubules is linked to TAL-specific expression of uromodulin and an upregulation of heat shock genes.

Graham LA, Aman A, Campbell DD, Augley J, Graham D, McBride MW, Fraser NJ, Ferreri NR, Dominiczak AF, Padmanabhan S.

Physiol Genomics. 2018 Nov 1;50(11):964-972. doi: 10.1152/physiolgenomics.00057.2018. Epub 2018 Sep 14.

2.

Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation.

Howie J, Wypijewski KJ, Plain F, Tulloch LB, Fraser NJ, Fuller W.

Crit Rev Biochem Mol Biol. 2018 Apr;53(2):175-191. doi: 10.1080/10409238.2018.1432560. Epub 2018 Feb 9. Review.

PMID:
29424237
3.

Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?

Hopkins DH, Fraser NJ, Mabbitt PD, Carr PD, Oakeshott JG, Jackson CJ.

Biochemistry. 2017 Oct 17;56(41):5512-5525. doi: 10.1021/acs.biochem.7b00774. Epub 2017 Sep 29.

PMID:
28929747
4.

The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase.

Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG.

J Org Chem. 2017 Aug 4;82(15):7869-7886. doi: 10.1021/acs.joc.7b01062. Epub 2017 Jul 24.

PMID:
28671462
5.

Understanding the rules governing NCX1 palmitoylation.

Plain F, Turnbull D, Fraser NJ, Fuller W.

Channels (Austin). 2017 Sep 3;11(5):377-379. doi: 10.1080/19336950.2017.1342501. Epub 2017 Jun 15. No abstract available.

6.

An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger.

Plain F, Congreve SD, Yee RSZ, Kennedy J, Howie J, Kuo CW, Fraser NJ, Fuller W.

J Biol Chem. 2017 Jun 23;292(25):10745-10752. doi: 10.1074/jbc.M116.773945. Epub 2017 Apr 21.

7.

Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.

Younus F, Fraser NJ, Coppin CW, Liu JW, Correy GJ, Chertemps T, Pandey G, Maïbèche M, Jackson CJ, Oakeshott JG.

Sci Rep. 2017 Apr 10;7:46188. doi: 10.1038/srep46188.

8.

Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.

Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ.

Structure. 2016 Jun 7;24(6):977-87. doi: 10.1016/j.str.2016.04.009. Epub 2016 May 19.

9.

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability.

Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG, Weik M, Jackson CJ.

J Mol Biol. 2016 Jun 5;428(11):2359-2371. doi: 10.1016/j.jmb.2016.03.014. Epub 2016 Mar 22.

PMID:
27016206
10.

Defining the optimal formulation and schedule of a candidate toxoid vaccine against Clostridium difficile infection: A randomized Phase 2 clinical trial.

de Bruyn G, Saleh J, Workman D, Pollak R, Elinoff V, Fraser NJ, Lefebvre G, Martens M, Mills RE, Nathan R, Trevino M, van Cleeff M, Foglia G, Ozol-Godfrey A, Patel DM, Pietrobon PJ, Gesser R; H-030-012 Clinical Investigator Study Team.

Vaccine. 2016 Apr 27;34(19):2170-8. doi: 10.1016/j.vaccine.2016.03.028. Epub 2016 Mar 21.

11.

Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency.

Mabbitt PD, Correy GJ, Meirelles T, Fraser NJ, Coote ML, Jackson CJ.

Biochemistry. 2016 Mar 8;55(9):1408-17. doi: 10.1021/acs.biochem.5b01322. Epub 2016 Feb 26.

PMID:
26881849
12.

Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron.

Sugrue E, Fraser NJ, Hopkins DH, Carr PD, Khurana JL, Oakeshott JG, Scott C, Jackson CJ.

Appl Environ Microbiol. 2015 Apr;81(7):2612-24. doi: 10.1128/AEM.04016-14. Epub 2015 Jan 30.

13.

Substrate recognition by the cell surface palmitoyl transferase DHHC5.

Howie J, Reilly L, Fraser NJ, Vlachaki Walker JM, Wypijewski KJ, Ashford ML, Calaghan SC, McClafferty H, Tian L, Shipston MJ, Boguslavskyi A, Shattock MJ, Fuller W.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17534-9. doi: 10.1073/pnas.1413627111. Epub 2014 Nov 24.

14.

Validation of uromodulin as a candidate gene for human essential hypertension.

Graham LA, Padmanabhan S, Fraser NJ, Kumar S, Bates JM, Raffi HS, Welsh P, Beattie W, Hao S, Leh S, Hultstrom M, Ferreri NR, Dominiczak AF, Graham D, McBride MW.

Hypertension. 2014 Mar;63(3):551-8. doi: 10.1161/HYPERTENSIONAHA.113.01423. Epub 2013 Dec 9.

PMID:
24324041
15.

Correction to CHOBIMALT: A Cholesterol-Based Detergent.

Howell SC, Fraser NJ, Mittal R, Huang L, Travis B, Breyer RM, Sanders CR.

Biochemistry. 2013 Jan 15;52(2):445. doi: 10.1021/bi3017203. Epub 2013 Jan 4. No abstract available.

16.

LOV to BLUF: flavoprotein contributions to the optogenetic toolkit.

Christie JM, Gawthorne J, Young G, Fraser NJ, Roe AJ.

Mol Plant. 2012 May;5(3):533-44. doi: 10.1093/mp/sss020. Epub 2012 Mar 19. Review.

17.

Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity.

Biffen M, Matsui H, Edwards S, Leishman AJ, Eiho K, Holness E, Satterthwaite G, Doyle I, Wada H, Fraser NJ, Hawkins SL, Aoki M, Tomizawa H, Benjamin AD, Takaku H, McInally T, Murray CM.

Br J Pharmacol. 2012 May;166(2):573-86. doi: 10.1111/j.1476-5381.2011.01790.x.

18.

GPCR production in a novel yeast strain that makes cholesterol-like sterols.

Kitson SM, Mullen W, Cogdell RJ, Bill RM, Fraser NJ.

Methods. 2011 Dec;55(4):287-92. doi: 10.1016/j.ymeth.2011.09.023. Epub 2011 Oct 6.

PMID:
22001123
19.

A lipidic-sponge phase screen for membrane protein crystallization.

Wöhri AB, Johansson LC, Wadsten-Hindrichsen P, Wahlgren WY, Fischer G, Horsefield R, Katona G, Nyblom M, Oberg F, Young G, Cogdell RJ, Fraser NJ, Engström S, Neutze R.

Structure. 2008 Jul;16(7):1003-9. doi: 10.1016/j.str.2008.06.003.

20.
21.

Carotenoids and bacterial photosynthesis: The story so far...

Fraser NJ, Hashimoto H, Cogdell RJ.

Photosynth Res. 2001;70(3):249-56.

PMID:
16252170
22.

Selective chemical shift assignment of B800 and B850 bacteriochlorophylls in uniformly [13C,15N]-labeled light-harvesting complexes by solid-state NMR spectroscopy at ultra-high magnetic field.

van Gammeren AJ, Buda F, Hulsbergen FB, Kiihne S, Hollander JG, Egorova-Zachernyuk TA, Fraser NJ, Cogdell RJ, de Groot HJ.

J Am Chem Soc. 2005 Mar 9;127(9):3213-9.

PMID:
15740162
23.

Membrane protein stability: high pressure effects on the structure and chromophore-binding properties of the light-harvesting complex LH2.

Gall A, Ellervee A, Sturgis JN, Fraser NJ, Cogdell RJ, Freiberg A, Robert B.

Biochemistry. 2003 Nov 11;42(44):13019-26.

PMID:
14596617
24.

Molecular identification of high and low affinity receptors for nicotinic acid.

Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB.

J Biol Chem. 2003 Mar 14;278(11):9869-74. Epub 2003 Jan 9.

25.

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ.

J Biol Chem. 2003 Mar 28;278(13):11312-9. Epub 2002 Dec 19.

26.

Probing the binding sites of exchanged chlorophyll a in LH2 by Raman and site-selection fluorescence spectroscopies.

Gall A, Robert B, Cogdell RJ, Bellissent-Funel MC, Fraser NJ.

FEBS Lett. 2001 Feb 23;491(1-2):143-7.

27.

Efficient energy transfer from the carotenoid S(2) state in a photosynthetic light-harvesting complex.

Macpherson AN, Arellano JB, Fraser NJ, Cogdell RJ, Gillbro T.

Biophys J. 2001 Feb;80(2):923-30.

28.

The N-terminus of RAMPs is a critical determinant of the glycosylation state and ligand binding of calcitonin receptor-like receptor.

Foord SM, Wise A, Brown J, Main MJ, Fraser NJ.

Biochem Soc Trans. 1999 Aug;27(4):535-9. Review. No abstract available.

PMID:
10917636
29.

B800-->B850 energy transfer mechanism in bacterial LH2 complexes investigated by B800 pigment exchange.

Herek JL, Fraser NJ, Pullerits T, Martinsson P, Polívka T, Scheer H, Cogdell RJ, Sundström V.

Biophys J. 2000 May;78(5):2590-6.

30.

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.

Zumpe ET, Tilakaratne N, Fraser NJ, Christopoulos G, Foord SM, Sexton PM.

Biochem Biophys Res Commun. 2000 Jan 7;267(1):368-72.

PMID:
10623626
31.

Selective release, removal, and reconstitution of bacteriochlorophyll a molecules into the B800 sites of LH2 complexes from Rhodopseudomonas acidophila 10050.

Fraser NJ, Dominy PJ, Ucker B, Simonin I, Scheer H, Cogdell RJ.

Biochemistry. 1999 Jul 27;38(30):9684-92.

PMID:
10423247
32.

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product.

Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM.

Mol Pharmacol. 1999 Jul;56(1):235-42.

PMID:
10385705
33.

How photosynthetic bacteria harvest solar energy.

Cogdell RJ, Isaacs NW, Howard TD, McLuskey K, Fraser NJ, Prince SM.

J Bacteriol. 1999 Jul;181(13):3869-79. Review. No abstract available.

34.
35.
36.

The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins.

Main MJ, Brown J, Brown S, Fraser NJ, Foord SM.

FEBS Lett. 1998 Dec 11;441(1):6-10.

37.

Heterodimerization is required for the formation of a functional GABA(B) receptor.

White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH.

Nature. 1998 Dec 17;396(6712):679-82.

PMID:
9872316
38.

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM.

Nature. 1998 May 28;393(6683):333-9.

PMID:
9620797
39.

The structure of the prostaglandin EP4 receptor gene and related pseudogenes.

Foord SM, Marks B, Stolz M, Bufflier E, Fraser NJ, Lee MG.

Genomics. 1996 Jul 1;35(1):182-8.

PMID:
8661119
42.

A locus for X-linked congenital stationary night blindness is located on the proximal portion of the short arm of the X chromosome.

Bech-Hansen NT, Field LL, Schramm AM, Reedyk M, Craig IW, Fraser NJ, Pearce WG.

Hum Genet. 1990 Apr;84(5):406-8.

PMID:
1969841
43.

A highly informative X-chromosome probe, M27 beta, can be used for the determination of tumour clonality.

Abrahamson G, Fraser NJ, Boyd J, Craig I, Wainscoat JS.

Br J Haematol. 1990 Mar;74(3):371-2. No abstract available.

PMID:
2334646
44.

Close linkage of hypervariable marker DXS255 to disease locus of Wiskott-Aldrich syndrome.

de Saint Basile G, Arveiler B, Fraser NJ, Boyd Y, Graig IW, Griscelli G, Fischer A.

Lancet. 1989 Dec 2;2(8675):1319-21.

PMID:
2574264
45.

Isolation and characterization of a human variable copy number tandem repeat at Xcen-p11.22.

Fraser NJ, Boyd Y, Craig I.

Genomics. 1989 Jul;5(1):144-8. Erratum in: Genomics 1989 Nov;5(4):957.

PMID:
2570025
46.

Multi-allelic RFLP for M27 beta, an anonymous single copy genomic clone at Xp11.3-Xcen [HGM9 provisional no. DXS255].

Fraser NJ, Boyd Y, Brownlee GG, Craig IW.

Nucleic Acids Res. 1987 Nov 25;15(22):9616. No abstract available.

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