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Items: 19

1.

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

Letavic MA, Savall BM, Allison BD, Aluisio L, Andres JI, De Angelis M, Ao H, Beauchamp DA, Bonaventure P, Bryant S, Carruthers NI, Ceusters M, Coe KJ, Dvorak CA, Fraser IC, Gelin CF, Koudriakova T, Liang J, Lord B, Lovenberg TW, Otieno MA, Schoetens F, Swanson DM, Wang Q, Wickenden AD, Bhattacharya A.

J Med Chem. 2017 Jun 8;60(11):4559-4572. doi: 10.1021/acs.jmedchem.7b00408. Epub 2017 May 25.

PMID:
28493698
2.

Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

Letavic MA, Aluisio L, Apodaca R, Bajpai M, Barbier AJ, Bonneville A, Bonaventure P, Carruthers NI, Dugovic C, Fraser IC, Kramer ML, Lord B, Lovenberg TW, Li LY, Ly KS, Mcallister H, Mani NS, Morton KL, Ndifor A, Nepomuceno SD, Pandit CR, Sands SB, Shah CR, Shelton JE, Snook SS, Swanson DM, Xiao W.

ACS Med Chem Lett. 2015 Mar 13;6(4):450-4. doi: 10.1021/ml5005156. eCollection 2015 Apr 9.

3.

Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.

Bonaventure P, Aluisio L, Shoblock J, Boggs JD, Fraser IC, Lord B, Lovenberg TW, Galici R.

PLoS One. 2011;6(6):e20210. doi: 10.1371/journal.pone.0020210. Epub 2011 Jun 20.

4.

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.

Letavic MA, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Feinstein MA, Fraser IC, Hoey K, Jiang X, Keith JM, Koudriakova T, Leung P, Lord B, Lovenberg TW, Ly KS, Morton KL, Motley ST, Nepomuceno D, Rizzolio M, Rynberg R, Sepassi K, Shelton J.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4. doi: 10.1016/j.bmcl.2010.05.041. Epub 2010 May 16.

PMID:
20561786
5.

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

Dugovic C, Shelton JE, Aluisio LE, Fraser IC, Jiang X, Sutton SW, Bonaventure P, Yun S, Li X, Lord B, Dvorak CA, Carruthers NI, Lovenberg TW.

J Pharmacol Exp Ther. 2009 Jul;330(1):142-51. doi: 10.1124/jpet.109.152009. Epub 2009 Apr 10.

PMID:
19363060
6.

JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.

Galici R, Boggs JD, Aluisio L, Fraser IC, Bonaventure P, Lord B, Lovenberg TW.

Neuropharmacology. 2009 Jun;56(8):1131-7. doi: 10.1016/j.neuropharm.2009.03.011. Epub 2009 Apr 2.

PMID:
19345233
7.

In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.

Aluisio L, Lord B, Barbier AJ, Fraser IC, Wilson SJ, Boggs J, Dvorak LK, Letavic MA, Maryanoff BE, Carruthers NI, Bonaventure P, Lovenberg TW.

Eur J Pharmacol. 2008 Jun 10;587(1-3):141-6. doi: 10.1016/j.ejphar.2008.04.008. Epub 2008 Apr 10.

PMID:
18499098
8.

Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.

Keith JM, Barbier AJ, Wilson SJ, Miller K, Boggs JD, Fraser IC, Mazur C, Lovenberg TW, Carruthers NI.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5325-9. Epub 2007 Aug 15.

PMID:
17765543
9.

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.

Keith JM, Gomez LA, Wolin RL, Barbier AJ, Wilson SJ, Boggs JD, Mazur C, Fraser IC, Lord B, Aluisio L, Lovenberg TW, Carruthers NI.

Bioorg Med Chem Lett. 2007 May 1;17(9):2603-7. Epub 2007 Feb 4.

PMID:
17317177
10.

Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.

Keith JM, Gomez LA, Letavic MA, Ly KS, Jablonowski JA, Seierstad M, Barbier AJ, Wilson SJ, Boggs JD, Fraser IC, Mazur C, Lovenberg TW, Carruthers NI.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):702-6. Epub 2006 Nov 2.

PMID:
17107798
11.

"Trench foot" caused by the cold.

Fraser IC, Loftus JA.

Br Med J. 1979 Apr 14;1(6169):1017. No abstract available.

12.

"Trench foot" caused by the cold.

Fraser IC, Loftus JA.

Br Med J. 1979 Feb 10;1(6160):414. No abstract available.

13.

The Oxford Ophthalmological Congress.

Fraser IC.

Surv Ophthalmol. 1975 May-Jun;19(6):385-9. No abstract available.

PMID:
1096336
14.

EXPERIMENTAL OBSERVATIONS ON THE INTRAVITREOUS USE OF PENICILLIN AND OTHER DRUGS.

Duguid JP, Ginsberg M, Fraser IC, Macaskill J, Michaelson IC, Robson JM.

Br J Ophthalmol. 1947 Apr;31(4):193-211. No abstract available.

15.

Experimental diphtheroid infections of the rabbit's eye and their treatment.

FRASER IC, ROBSON JM, et al.

Br J Pharmacol Chemother. 1946 Dec;1(4):241-6. No abstract available.

16.

Experimental diphtheroid infections of the rabbit's eye and their treatment.

Fraser IC, Robson JM, Scott AA.

Br J Pharmacol Chemother. 1946 Dec;1(4):241-6. No abstract available.

17.

Penicillin treatment of ocular inflammation.

FRASER IC, SCOTT AA.

Br J Ophthalmol. 1946 Mar;30:168-76. No abstract available.

PMID:
21018068
18.

PENICILLIN TREATMENT OF OCULAR INFLAMMATION.

Fraser IC, Scott AA.

Br J Ophthalmol. 1946 Mar;30(3):168-76. No abstract available.

19.

EXPERIMENTAL CORNEAL LESIONS.

Fraser IC, Robson JM, Scott AA, Scott GI.

Br J Ophthalmol. 1945 Dec;29(12):667-8. No abstract available.

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