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Small population size and low genomic diversity have no effect on fitness in experimental translocations of a wild fish.

Yates MC, Bowles E, Fraser DJ.

Proc Biol Sci. 2019 Dec 4;286(1916):20191989. doi: 10.1098/rspb.2019.1989. Epub 2019 Nov 27.


Population variation in density-dependent growth, mortality and their trade-off in a stream fish.

Matte JM, Fraser DJ, Grant JWA.

J Anim Ecol. 2019 Oct 23. doi: 10.1111/1365-2656.13124. [Epub ahead of print]


Understanding Maladaptation by Uniting Ecological and Evolutionary Perspectives.

Brady SP, Bolnick DI, Barrett RDH, Chapman L, Crispo E, Derry AM, Eckert CG, Fraser DJ, Fussmann GF, Gonzalez A, Guichard F, Lamy T, Lane J, McAdam AG, Newman AEM, Paccard A, Robertson B, Rolshausen G, Schulte PM, Simons AM, Vellend M, Hendry A.

Am Nat. 2019 Oct;194(4):495-515. doi: 10.1086/705020. Epub 2019 Aug 27.


Conservation through the lens of (mal)adaptation: Concepts and meta-analysis.

Derry AM, Fraser DJ, Brady SP, Astorg L, Lawrence ER, Martin GK, Matte JM, Negrín Dastis JO, Paccard A, Barrett RDH, Chapman LJ, Lane JE, Ballas CG, Close M, Crispo E.

Evol Appl. 2019 Apr 6;12(7):1287-1304. doi: 10.1111/eva.12791. eCollection 2019 Aug.


Causes of maladaptation.

Brady SP, Bolnick DI, Angert AL, Gonzalez A, Barrett RDH, Crispo E, Derry AM, Eckert CG, Fraser DJ, Fussmann GF, Guichard F, Lamy T, McAdam AG, Newman AEM, Paccard A, Rolshausen G, Simons AM, Hendry AP.

Evol Appl. 2019 Aug 13;12(7):1229-1242. doi: 10.1111/eva.12844. eCollection 2019 Aug. Review.


Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis.

Brook AC, Jenkins RH, Clayton A, Kift-Morgan A, Raby AC, Shephard AP, Mariotti B, Cuff SM, Bazzoni F, Bowen T, Fraser DJ, Eberl M.

Sci Rep. 2019 Jul 12;9(1):10136. doi: 10.1038/s41598-019-46585-y.


Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis.

Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B.

Sci Rep. 2019 May 23;9(1):7753. doi: 10.1038/s41598-019-44219-x.


Geo-referenced population-specific microsatellite data across American continents, the MacroPopGen Database.

Lawrence ER, Benavente JN, Matte JM, Marin K, Wells ZRR, Bernos TA, Krasteva N, Habrich A, Nessel GA, Koumrouyan RA, Fraser DJ.

Sci Data. 2019 Apr 3;6(1):14. doi: 10.1038/s41597-019-0024-7.


A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplantation.

Khalid U, Newbury LJ, Simpson K, Jenkins RH, Bowen T, Bates L, Sheerin NS, Chavez R, Fraser DJ.

Sci Rep. 2019 Mar 5;9(1):3584. doi: 10.1038/s41598-019-38642-3.


ADRB2 p.Thr164Ile association with hospitalization depends upon asthma severity.

Condreay LD, Chiano MN, Li L, Harris E, Fraser DJ, Meyers DA, Bleecker ER, Crim C, Stempel D, Yancey SW, Ghosh S.

J Allergy Clin Immunol. 2019 May;143(5):1962-1965.e4. doi: 10.1016/j.jaci.2019.01.012. Epub 2019 Jan 23. No abstract available.


Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease.

Thomas MJ, Fraser DJ, Bowen T.

Noncoding RNA. 2018 Nov 3;4(4). pii: E30. doi: 10.3390/ncrna4040030. Review.


Population correlates of rapid captive-induced maladaptation in a wild fish.

Fraser DJ, Walker L, Yates MC, Marin K, Wood JLA, Bernos TA, Zastavniouk C.

Evol Appl. 2018 Jun 19;12(7):1305-1317. doi: 10.1111/eva.12649. eCollection 2019 Aug.


Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes.

Aponte JL, Chiano MN, Yerges-Armstrong LM, Hinds DA, Tian C, Gupta A, Guo C, Fraser DJ, Freudenberg JM, Rajpal DK, Ehm MG, Waterworth DM.

Hum Mol Genet. 2018 Aug 1;27(15):2762-2772. doi: 10.1093/hmg/ddy184.


Evaluating a 5-year metal contamination remediation and the biomonitoring potential of a freshwater gastropod along the Xiangjiang River, China.

Li D, Pi J, Zhang T, Tan X, Fraser DJ.

Environ Sci Pollut Res Int. 2018 Jul;25(21):21127-21137. doi: 10.1007/s11356-018-2263-0. Epub 2018 May 16.


Genetic diversity of small populations: Not always "doom and gloom"?

Fraser DJ.

Mol Ecol. 2017 Dec;26(23):6499-6501. doi: 10.1111/mec.14371.


A critical assessment of estimating census population size from genetic population size (or vice versa) in three fishes.

Yates MC, Bernos TA, Fraser DJ.

Evol Appl. 2017 Jul 4;10(9):935-945. doi: 10.1111/eva.12496. eCollection 2017 Oct.


The evolutionary consequences of habitat fragmentation: Body morphology and coloration differentiation among brook trout populations of varying size.

Zastavniouk C, Weir LK, Fraser DJ.

Ecol Evol. 2017 Jul 27;7(17):6850-6862. doi: 10.1002/ece3.3229. eCollection 2017 Sep.


MicroRNAs as biomarkers in chronic kidney disease.

Wonnacott A, Bowen T, Fraser DJ.

Curr Opin Nephrol Hypertens. 2017 Nov;26(6):460-466. doi: 10.1097/MNH.0000000000000356. Review.


Characterisation of the HLA-DRB1*07:01 biomarker for lapatinib-induced liver toxicity during treatment of early-stage breast cancer patients with lapatinib in combination with trastuzumab and/or taxanes.

Spraggs CF, Parham LR, Briley LP, Warren L, Williams LS, Fraser DJ, Jiang Z, Aziz Z, Ahmed S, Demetriou G, Mehta A, Jackson N, Byrne J, Andersson M, Toi M, Harris L, Gralow J, Zujewski JA, Crescenzo R, Armour A, Perez E, Piccart M.

Pharmacogenomics J. 2018 May 22;18(3):480-486. doi: 10.1038/tpj.2017.39. Epub 2017 Aug 8.


Current practice in total-body irradiation: results of a Canada-wide survey.

Studinski RCN, Fraser DJ, Samant RS, MacPherson MS.

Curr Oncol. 2017 Jun;24(3):181-186. doi: 10.3747/co.24.3484. Epub 2017 Jun 27.


Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence.

Lopez-Anton M, Rudolf A, Baird DM, Roger L, Jones RE, Witowski J, Fraser DJ, Bowen T.

Mech Ageing Dev. 2017 Jun;164:37-40. doi: 10.1016/j.mad.2017.03.010. Epub 2017 Apr 1.


Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.

Zhang J, Friberg IM, Kift-Morgan A, Parekh G, Morgan MP, Liuzzi AR, Lin CY, Donovan KL, Colmont CS, Morgan PH, Davis P, Weeks I, Fraser DJ, Topley N, Eberl M.

Kidney Int. 2017 Jul;92(1):179-191. doi: 10.1016/j.kint.2017.01.017. Epub 2017 Mar 17.


Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes.

Liao CT, Andrews R, Wallace LE, Khan MW, Kift-Morgan A, Topley N, Fraser DJ, Taylor PR.

Kidney Int. 2017 May;91(5):1088-1103. doi: 10.1016/j.kint.2016.10.030. Epub 2017 Jan 5.


Limited variability in upper thermal tolerance among pure and hybrid populations of a cold-water fish.

Wells ZR, McDonnell LH, Chapman LJ, Fraser DJ.

Conserv Physiol. 2016 Dec 15;4(1):cow063. eCollection 2016.


Striking Phenotypic Variation yet Low Genetic Differentiation in Sympatric Lake Trout (Salvelinus namaycush).

Marin K, Coon A, Carson R, Debes PV, Fraser DJ.

PLoS One. 2016 Sep 28;11(9):e0162325. doi: 10.1371/journal.pone.0162325. eCollection 2016.


Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling.

Liuzzi AR, Kift-Morgan A, Lopez-Anton M, Friberg IM, Zhang J, Brook AC, Roberts GW, Donovan KL, Colmont CS, Toleman MA, Bowen T, Johnson DW, Topley N, Moser B, Fraser DJ, Eberl M.

J Immunol. 2016 Sep 15;197(6):2195-207. doi: 10.4049/jimmunol.1600990. Epub 2016 Aug 15.


Spatiotemporal relationship between adult census size and genetic population size across a wide population size gradient.

Bernos TA, Fraser DJ.

Mol Ecol. 2016 Sep;25(18):4472-87. doi: 10.1111/mec.13790. Epub 2016 Sep 6.


IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation.

Liao CT, Rosas M, Davies LC, Giles PJ, Tyrrell VJ, O'Donnell VB, Topley N, Humphreys IR, Fraser DJ, Jones SA, Taylor PR.

Eur J Immunol. 2016 Sep;46(9):2222-32. doi: 10.1002/eji.201646528. Epub 2016 Jul 28.


Are heritability and selection related to population size in nature? Meta-analysis and conservation implications.

Wood JL, Yates MC, Fraser DJ.

Evol Appl. 2016 Apr 3;9(5):640-57. doi: 10.1111/eva.12375. eCollection 2016 Jun. Review.


MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy.

Simpson K, Wonnacott A, Fraser DJ, Bowen T.

Curr Diab Rep. 2016 Mar;16(3):35. doi: 10.1007/s11892-016-0724-8. Review.


Addressing Peritoneal Dialysis: In Vitro PD Models, In Vivo Rodent PD Model, Clinical Biobanks, and Underutilization of PD.

Beelen RH, Fraser DJ, Rutherford P, Witowski J.

Biomed Res Int. 2016;2016:4964316. doi: 10.1155/2016/4964316. Epub 2016 Jan 3. No abstract available.


MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation.

Khalid U, Ablorsu E, Szabo L, Jenkins RH, Bowen T, Chavez R, Fraser DJ.

Clin Transplant. 2016 Feb;30(2):99-104. doi: 10.1111/ctr.12679. Epub 2016 Jan 5.


A Localized Ischemic Preconditioning Regimen Increases Tumor Necrosis Factor α Expression in a Rat Model of Kidney Ischemia-Reperfusion Injury.

Khalid U, Jenkins RH, Pino-Chavez G, Bowen T, Fraser DJ, Chavez R.

Exp Clin Transplant. 2015 Dec;13(6):535-42.


HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.

Xu CF, Johnson T, Wang X, Carpenter C, Graves AP, Warren L, Xue Z, King KS, Fraser DJ, Stinnett S, Briley LP, Mitrica I, Spraggs CF, Nelson MR, Tada H, du Bois A, Powles T, Kaplowitz N, Pandite LN.

Clin Cancer Res. 2016 Mar 15;22(6):1371-7. doi: 10.1158/1078-0432.CCR-15-2044. Epub 2015 Nov 6.


Peritoneal Dialysis Fluid and Some of Its Components Potentiate Fibrocyte Differentiation.

Herlihy SE, Starke HE, Lopez-Anton M, Cox N, Keyhanian K, Fraser DJ, Gomer RH.

Perit Dial Int. 2016 Jul-Aug;36(4):367-73. doi: 10.3747/pdi.2014.00284. Epub 2015 Oct 22.


Stabilization of Urinary MicroRNAs by Association with Exosomes and Argonaute 2 Protein.

Beltrami C, Clayton A, Newbury LJ, Corish P, Jenkins RH, Phillips AO, Fraser DJ, Bowen T.

Noncoding RNA. 2015 Sep 14;1(2):151-166. doi: 10.3390/ncrna1020151.


Population size is weakly related to quantitative genetic variation and trait differentiation in a stream fish.

Wood JL, Tezel D, Joyal D, Fraser DJ.

Evolution. 2015 Sep;69(9):2303-18. doi: 10.1111/evo.12733. Epub 2015 Aug 20.


Does human-induced hybridization have long-term genetic effects? Empirical testing with domesticated, wild and hybridized fish populations.

Harbicht A, Wilson CC, Fraser DJ.

Evol Appl. 2014 Dec;7(10):1180-91. doi: 10.1111/eva.12199. Epub 2014 Aug 27.


Does source population size affect performance in new environments?

Yates MC, Fraser DJ.

Evol Appl. 2014 Sep;7(8):871-82. doi: 10.1111/eva.12181. Epub 2014 Jul 9. Review.


Relationship of habitat variability to population size in a stream fish.

Wood JL, Belmar-Lucero S, Hutchings IJ, Fraser DJ.

Ecol Appl. 2014 Jul;24(5):1085-100.


Acute kidney injury: a paradigm for miRNA regulation of the cell cycle.

Khalid U, Bowen T, Fraser DJ, Jenkins RH.

Biochem Soc Trans. 2014 Aug;42(4):1219-23. doi: 10.1042/BST20140093. Review.


Population size, habitat fragmentation, and the nature of adaptive variation in a stream fish.

Fraser DJ, Debes PV, Bernatchez L, Hutchings JA.

Proc Biol Sci. 2014 Sep 7;281(1790). pii: 20140370. doi: 10.1098/rspb.2014.0370.


Interleukin-6 in renal disease and therapy.

Jones SA, Fraser DJ, Fielding CA, Jones GW.

Nephrol Dial Transplant. 2015 Apr;30(4):564-74. doi: 10.1093/ndt/gfu233. Epub 2014 Jul 10. Review.


Evolutionary hypotheses for a constraint to life-history resilience in depleted Salmo salar populations.

Fraser DJ.

J Fish Biol. 2014 Jul;85(1):119-31. doi: 10.1111/jfb.12379. Epub 2014 Apr 28.


The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Rosas M, Davies LC, Giles PJ, Liao CT, Kharfan B, Stone TC, O'Donnell VB, Fraser DJ, Jones SA, Taylor PR.

Science. 2014 May 9;344(6184):645-648. doi: 10.1126/science.1251414. Epub 2014 Apr 24.


miR-192 induces G2/M growth arrest in aristolochic acid nephropathy.

Jenkins RH, Davies LC, Taylor PR, Akiyama H, Cumbes B, Beltrami C, Carrington CP, Phillips AO, Bowen T, Fraser DJ.

Am J Pathol. 2014 Apr;184(4):996-1009. doi: 10.1016/j.ajpath.2013.12.028. Epub 2014 Feb 5.


The between-population genetic architecture of growth, maturation, and plasticity in Atlantic salmon.

Debes PV, Fraser DJ, Yates M, Hutchings JA.

Genetics. 2014 Apr;196(4):1277-91. doi: 10.1534/genetics.114.161729. Epub 2014 Jan 28.


Multidisciplinary population monitoring when demographic data are sparse: a case study of remote trout populations.

Fraser DJ, Calvert AM, Bernatchez L, Coon A.

Ecol Evol. 2013 Dec;3(15):4954-69. doi: 10.1002/ece3.871. Epub 2013 Nov 8.


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