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Association Between Layer-Specific Longitudinal Strain and Risk Factors of Heart Failure and Dyspnea: A Population-Based Study.

Huttin O, Girerd N, Coiro S, Bozec E, Selton-Suty C, Lamiral Z, Frikha Z, Kobayashi M, Argulian E, Narula J, Fraser AG, Rossignol P, Zannad F.

J Am Soc Echocardiogr. 2019 May 16. pii: S0894-7317(19)30152-X. doi: 10.1016/j.echo.2019.03.011. [Epub ahead of print]


Transparency of clinical evidence for medical devices in Europe - Authors' reply.

Fraser AG, Butchart EG, Szymański P.

Lancet. 2019 Apr 27;393(10182):1693-1694. doi: 10.1016/S0140-6736(18)33063-0. No abstract available.


A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.

Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Koskimäki J, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC, Derry WB.

Nat Commun. 2019 Apr 17;10(1):1791. doi: 10.1038/s41467-019-09829-z.


Inaccuracies in Measuring Velocities and Timing of Flow and Tissue Motion Using High-End Ultrasound Systems.

Walker AR, Uejima T, Prinz C, Voigt JU, Fraser AG.

Ultrasound Med Biol. 2019 Jun;45(6):1446-1454. doi: 10.1016/j.ultrasmedbio.2019.02.010. Epub 2019 Apr 8.


Carotid artery wave intensity in mid- to late-life predicts cognitive decline: the Whitehall II study.

Chiesa ST, Masi S, Shipley MJ, Ellins EA, Fraser AG, Hughes AD, Patel RS, Khir AW, Halcox JP, Singh-Manoux A, Kivimaki M, Celermajer DS, Deanfield JE.

Eur Heart J. 2019 Apr 8. pii: ehz189. doi: 10.1093/eurheartj/ehz189. [Epub ahead of print]


Letter response: Prevalence of subclinical cardiac abnormalities in patients with metal-on-metal hip replacements.

Lodge F, John A, Fraser AG, Yousef Z.

Int J Cardiol. 2019 Feb 1;276:206. doi: 10.1016/j.ijcard.2018.11.018. No abstract available.


Tachycardia after acute deceleration injury.

Singh V, Rahman M, Fraser AG.

Heart. 2018 Nov 15. pii: heartjnl-2018-314082. doi: 10.1136/heartjnl-2018-314082. [Epub ahead of print]


Learning About Machine Learning to Create a Self-Driving Echocardiographic Laboratory.

D'hooge J, Fraser AG.

Circulation. 2018 Oct 16;138(16):1636-1638. doi: 10.1161/CIRCULATIONAHA.118.037094. No abstract available.


Diagnosis of Heart Failure With Preserved Ejection Fraction: Machine Learning of Spatiotemporal Variations in Left Ventricular Deformation.

Tabassian M, Sunderji I, Erdei T, Sanchez-Martinez S, Degiovanni A, Marino P, Fraser AG, D'hooge J.

J Am Soc Echocardiogr. 2018 Dec;31(12):1272-1284.e9. doi: 10.1016/j.echo.2018.07.013. Epub 2018 Aug 23.


Acute Effects of Drugs on Caenorhabditis elegans Movement Reveal Complex Responses and Plasticity.

Spensley M, Del Borrello S, Pajkic D, Fraser AG.

G3 (Bethesda). 2018 Aug 30;8(9):2941-2952. doi: 10.1534/g3.118.200374.

Free PMC Article

The need for transparency of clinical evidence for medical devices in Europe.

Fraser AG, Butchart EG, Szymański P, Caiani EG, Crosby S, Kearney P, Van de Werf F.

Lancet. 2018 Aug 11;392(10146):521-530. doi: 10.1016/S0140-6736(18)31270-4. Epub 2018 Jul 17.


Prevalence of subclinical cardiac abnormalities in patients with metal-on-metal hip replacements.

Lodge F, Khatun R, Lord R, John A, Fraser AG, Yousef Z.

Int J Cardiol. 2018 Nov 15;271:274-280. doi: 10.1016/j.ijcard.2018.05.047. Epub 2018 May 17.


Do We Need Independent Data Monitoring Boards and Adaptive Designs for Diagnostic Outcome Trials?

Fraser AG, Zaidi A.

JACC Cardiovasc Imaging. 2018 Aug;11(8):1119-1121. doi: 10.1016/j.jcmg.2018.04.023. Epub 2018 May 16. No abstract available.


Machine Learning Analysis of Left Ventricular Function to Characterize Heart Failure With Preserved Ejection Fraction.

Sanchez-Martinez S, Duchateau N, Erdei T, Kunszt G, Aakhus S, Degiovanni A, Marino P, Carluccio E, Piella G, Fraser AG, Bijnens BH.

Circ Cardiovasc Imaging. 2018 Apr;11(4):e007138. doi: 10.1161/CIRCIMAGING.117.007138.


Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging.

Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D'Hooge J, Donal E, Fraser AG, Marwick T, Mertens L, Popescu BA, Sengupta PP, Lancellotti P, Thomas JD, Voigt JU; Industry representatives; Reviewers: This document was reviewed by members of the 2016–2018 EACVI Scientific Documents Committee.

Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):591-600. doi: 10.1093/ehjci/jey042. Review. Erratum in: Eur Heart J Cardiovasc Imaging. 2018 Jul 1;19(7):830-833.


What Limits Functional Capacity in Heart Failure With Preserved Ejection Fraction?: Unravelling the Knots of an Enigma.

Fraser AG.

JACC Heart Fail. 2018 Feb;6(2):127-129. doi: 10.1016/j.jchf.2017.11.005. No abstract available.


The new European regulatory framework for medical devices: opportunities for engagement by electrophysiologists.

Szymanski P, Leggeri I, Kautzner J, Fraser AG.

Europace. 2018 Jun 1;20(6):902-905. doi: 10.1093/europace/eux344. No abstract available.


The combinatorial control of alternative splicing in C. elegans.

Tan JH, Fraser AG.

PLoS Genet. 2017 Nov 9;13(11):e1007033. doi: 10.1371/journal.pgen.1007033. eCollection 2017 Nov.


A manifesto for cardiovascular imaging: addressing the human factor.

Fraser AG.

Eur Heart J Cardiovasc Imaging. 2017 Dec 1;18(12):1311-1321. doi: 10.1093/ehjci/jex216. Review.


Non-invasive estimation of left heart filling pressures: another nail in the coffin for E/e'?

Donal E, Galli E, Fraser AG.

Eur J Heart Fail. 2017 Dec;19(12):1661-1663. doi: 10.1002/ejhf.944. Epub 2017 Oct 6. No abstract available.


Ventricular-arterial coupling in heart failure with preserved ejection fraction: the devil is in the details.

Fraser AG, Gillebert TC, Leite-Moreira AF.

Cardiovasc Res. 2017 Jul 1;113(8):844-846. doi: 10.1093/cvr/cvx107. No abstract available.


Taxonomically Restricted Genes with Essential Functions Frequently Play Roles in Chromosome Segregation in Caenorhabditis elegans and Saccharomyces cerevisiae.

Verster AJ, Styles EB, Mateo A, Derry WB, Andrews BJ, Fraser AG.

G3 (Bethesda). 2017 Oct 5;7(10):3337-3347. doi: 10.1534/g3.117.300193.


Editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for Helicobacter pylori.

Fraser AG.

Aliment Pharmacol Ther. 2017 Sep;46(5):550-551. doi: 10.1111/apt.14198. No abstract available.


C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.

Johnston WL, Krizus A, Ramani AK, Dunham W, Youn JY, Fraser AG, Gingras AC, Dennis JW.

BMC Biol. 2017 Jul 17;15(1):61. doi: 10.1186/s12915-017-0398-y.


Impact of Changes in Consensus Diagnostic Recommendations on the Echocardiographic Prevalence of Diastolic Dysfunction.

Huttin O, Fraser AG, Coiro S, Bozec E, Selton-Suty C, Lamiral Z, Frikha Z, Rossignol P, Zannad F, Girerd N.

J Am Coll Cardiol. 2017 Jun 27;69(25):3119-3121. doi: 10.1016/j.jacc.2017.04.039. No abstract available.


Impact of glycemic control on aortic stiffness, left ventricular mass and diastolic longitudinal function in type 2 diabetes mellitus.

Kozakova M, Morizzo C, Fraser AG, Palombo C.

Cardiovasc Diabetol. 2017 Jun 17;16(1):78. doi: 10.1186/s12933-017-0557-z.


The novel nematicide wact-86 interacts with aldicarb to kill nematodes.

Burns AR, Bagg R, Yeo M, Luciani GM, Schertzberg M, Fraser AG, Roy PJ.

PLoS Negl Trop Dis. 2017 Apr 5;11(4):e0005502. doi: 10.1371/journal.pntd.0005502. eCollection 2017 Apr.


Reproducibility of echocardiographic assessment of 2D-derived longitudinal strain parameters in a population-based study (the STANISLAS Cohort study).

Coiro S, Huttin O, Bozec E, Selton-Suty C, Lamiral Z, Carluccio E, Trinh A, Fraser AG, Ambrosio G, Rossignol P, Zannad F, Girerd N.

Int J Cardiovasc Imaging. 2017 Sep;33(9):1361-1369. doi: 10.1007/s10554-017-1117-z. Epub 2017 Mar 31.


Medical specialists' attitudes to prescribing biosimilars.

Hemmington A, Dalbeth N, Jarrett P, Fraser AG, Broom R, Browett P, Petrie KJ.

Pharmacoepidemiol Drug Saf. 2017 May;26(5):570-577. doi: 10.1002/pds.4186. Epub 2017 Feb 24.


Editorial: can we get more clinical benefit from thiopurine metabolite testing?

Fraser AG.

Aliment Pharmacol Ther. 2017 Mar;45(6):857-858. doi: 10.1111/apt.13942. No abstract available.


Noninvasive Estimation of the Severity of Aortic Stenosis: Going Beyond Bernoulli.

Fraser AG, Claus P.

Circ Cardiovasc Imaging. 2017 Jan;10(1). pii: e005967. doi: 10.1161/CIRCIMAGING.116.005967. No abstract available.


Heterogeneous responses of systolic and diastolic left ventricular function to exercise in patients with heart failure and preserved ejection fraction.

Kasner M, Sinning D, Lober J, Post H, Fraser AG, Pieske B, Burkhoff D, Tschöpe C.

ESC Heart Fail. 2015 Sep;2(3):121-132. Epub 2015 Aug 10.


Non-invasively estimated left atrial stiffness is associated with short-term recurrence of atrial fibrillation after electrical cardioversion.

Marino PN, Degiovanni A, Baduena L, Occhetta E, Dell'Era G, Erdei T, Fraser AG; Novara Atrial Fibrillation (NAIF) Study Group.

J Cardiol. 2017 May;69(5):731-738. doi: 10.1016/j.jjcc.2016.07.013. Epub 2016 Aug 25.


Editorial: serologic microbial-associated markers to predict Crohn's disease behaviour.

Fraser AG.

Aliment Pharmacol Ther. 2016 Aug;44(3):300-1. doi: 10.1111/apt.13681. No abstract available.


Characterization of myocardial motion patterns by unsupervised multiple kernel learning.

Sanchez-Martinez S, Duchateau N, Erdei T, Fraser AG, Bijnens BH, Piella G.

Med Image Anal. 2017 Jan;35:70-82. doi: 10.1016/ Epub 2016 Jun 11.


Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes.

Vu V, Verster AJ, Schertzberg M, Chuluunbaatar T, Spensley M, Pajkic D, Hart GT, Moffat J, Fraser AG.

Cell. 2015 Jul 16;162(2):391-402. doi: 10.1016/j.cell.2015.06.037.


Barriers to cardiovascular device innovation in Europe.

Pinto F, Fraser AG, Kautzner J, Kreutzer K, Piat S, Siebert M, Vardas P, Windecker S; Cardiovascular Round Table (CRT).

Eur Heart J. 2016 Jan 7;37(2):140-4. doi: 10.1093/eurheartj/ehv275. Epub 2015 Jul 1. Review. No abstract available.


Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.


Pathophysiological rationale and diagnostic targets for diastolic stress testing.

Erdei T, Aakhus S, Marino P, Paulus WJ, Smiseth OA, Fraser AG.

Heart. 2015 Sep;101(17):1355-60. doi: 10.1136/heartjnl-2014-307040. Epub 2015 May 22. Review.


Editorial: post hoc analysis of SONIC trial.

Fraser AG.

Aliment Pharmacol Ther. 2015 Jun;41(11):1210. doi: 10.1111/apt.13179. No abstract available.


Clinical evaluation of medical devices: light at the end of the tunnel?

Fraser AG.

Eur Heart J. 2015 Jan 7;36(2):64-6. No abstract available.


Do left atrial strain and strain rate reflect intrinsic atrial function, or are they determined by left ventricular function?

Margulescu AD, Rees E, Coulson RM, Rees AD, Vinereanu D, Fraser AG.

Kardiol Pol. 2015;73(7):539-48. doi: 10.5603/KP.a2015.0035. Epub 2015 Mar 3.


Overexpression of miR-595 and miR-1246 in the sera of patients with active forms of inflammatory bowel disease.

Krissansen GW, Yang Y, McQueen FM, Leung E, Peek D, Chan YC, Print C, Dalbeth N, Williams M, Fraser AG.

Inflamm Bowel Dis. 2015 Mar;21(3):520-30. doi: 10.1097/MIB.0000000000000285.


A systematic review of diastolic stress tests in heart failure with preserved ejection fraction, with proposals from the EU-FP7 MEDIA study group.

Erdei T, Smiseth OA, Marino P, Fraser AG.

Eur J Heart Fail. 2014 Dec;16(12):1345-61. doi: 10.1002/ejhf.184. Epub 2014 Nov 12. Review.


Updated standards and processes for accreditation of echocardiographic laboratories from The European Association of Cardiovascular Imaging: an executive summary.

Popescu BA, Stefanidis A, Nihoyannopoulos P, Fox KF, Ray S, Cardim N, Rigo F, Badano LP, Fraser AG, Pinto F, Zamorano JL, Habib G, Maurer G, Lancellotti P.

Eur Heart J Cardiovasc Imaging. 2014 Nov;15(11):1188-93. doi: 10.1093/ehjci/jeu057.


New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes.

Senni M, Paulus WJ, Gavazzi A, Fraser AG, Díez J, Solomon SD, Smiseth OA, Guazzi M, Lam CS, Maggioni AP, Tschöpe C, Metra M, Hummel SL, Edelmann F, Ambrosio G, Stewart Coats AJ, Filippatos GS, Gheorghiade M, Anker SD, Levy D, Pfeffer MA, Stough WG, Pieske BM.

Eur Heart J. 2014 Oct 21;35(40):2797-815. doi: 10.1093/eurheartj/ehu204. Epub 2014 Aug 7. Review.


Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk.

Rees E, Coulson R, Dunstan F, Evans WD, Blundell HL, Luzio SD, Dunseath G, Halcox JP, Fraser AG, Rees DA.

Hum Reprod. 2014 Sep;29(9):2041-9. doi: 10.1093/humrep/deu180. Epub 2014 Jul 17.


Cardiovascular function in children who had chronic lung disease of prematurity.

Joshi S, Wilson DG, Kotecha S, Pickerd N, Fraser AG, Kotecha S.

Arch Dis Child Fetal Neonatal Ed. 2014 Sep;99(5):F373-9. doi: 10.1136/archdischild-2013-305185. Epub 2014 Jun 13.


A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.

Norris AD, Gao S, Norris ML, Ray D, Ramani AK, Fraser AG, Morris Q, Hughes TR, Zhen M, Calarco JA.

Mol Cell. 2014 Jun 19;54(6):946-59. doi: 10.1016/j.molcel.2014.05.004. Epub 2014 Jun 5.


Heritability and genetic basis of protein level variation in an outbred population.

Parts L, Liu YC, Tekkedil MM, Steinmetz LM, Caudy AA, Fraser AG, Boone C, Andrews BJ, Rosebrock AP.

Genome Res. 2014 Aug;24(8):1363-70. doi: 10.1101/gr.170506.113. Epub 2014 May 13.

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