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Items: 1 to 50 of 110

1.

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration.

Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C.

J Control Release. 2019 Aug 6. pii: S0168-3659(19)30468-7. doi: 10.1016/j.jconrel.2019.08.004. [Epub ahead of print]

PMID:
31398360
2.

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation.

Dormenval C, Lokras A, Cano-Garcia G, Wadhwa A, Thanki K, Rose F, Thakur A, Franzyk H, Foged C.

Pharm Res. 2019 Aug 2;36(10):142. doi: 10.1007/s11095-019-2663-y.

PMID:
31376020
3.

Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics.

Baker KR, Jana B, Hansen AM, Nielsen HM, Franzyk H, Guardabassi L.

Front Cell Infect Microbiol. 2019 Jul 2;9:236. doi: 10.3389/fcimb.2019.00236. eCollection 2019.

4.

Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency.

Kachel HS, Franzyk H, Mellor IR.

J Med Chem. 2019 Jul 11;62(13):6214-6222. doi: 10.1021/acs.jmedchem.9b00519. Epub 2019 Jun 24.

PMID:
31244109
5.

Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model.

Jansen MAA, Klausen LH, Thanki K, Lyngsø J, Skov Pedersen J, Franzyk H, Nielsen HM, van Eden W, Dong M, Broere F, Foged C, Zeng X.

Eur J Pharm Biopharm. 2019 Jun 11. pii: S0939-6411(18)31325-0. doi: 10.1016/j.ejpb.2019.06.009. [Epub ahead of print]

PMID:
31199978
6.

Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration.

Schmidt ST, Olsen CL, Franzyk H, Wørzner K, Korsholm KS, Rades T, Andersen P, Foged C, Christensen D.

Eur J Pharm Biopharm. 2019 Jul;140:29-39. doi: 10.1016/j.ejpb.2019.04.020. Epub 2019 May 2.

7.

19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR.

Christensen MV, Kongstad KT, Sondergaard TE, Staerk D, Nielsen HM, Franzyk H, Wimmer R.

J Biomol NMR. 2019 Apr;73(3-4):167-182. doi: 10.1007/s10858-019-00239-3. Epub 2019 Mar 18.

PMID:
30887171
8.

Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients.

Molchanova N, Wang H, Hansen PR, Høiby N, Nielsen HM, Franzyk H.

Front Microbiol. 2019 Feb 20;10:275. doi: 10.3389/fmicb.2019.00275. eCollection 2019.

9.

Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae.

Hansen AM, Bonke G, Hogendorf WFJ, Björkling F, Nielsen J, Kongstad KT, Zabicka D, Tomczak M, Urbas M, Nielsen PE, Franzyk H.

Eur J Med Chem. 2019 Apr 15;168:134-145. doi: 10.1016/j.ejmech.2019.02.024. Epub 2019 Feb 10.

PMID:
30807888
10.

Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling.

Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R.

Mol Cell Proteomics. 2019 Apr;18(4):669-685. doi: 10.1074/mcp.RA118.000929. Epub 2019 Jan 11.

PMID:
30635358
11.

Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery.

Thanki K, Papai S, Lokras A, Rose F, Falkenberg E, Franzyk H, Foged C.

Pharm Res. 2019 Jan 9;36(3):37. doi: 10.1007/s11095-018-2566-3.

PMID:
30623253
12.

Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators.

Baker KR, Jana B, Hansen AM, Vissing KJ, Nielsen HM, Franzyk H, Guardabassi L.

Int J Antimicrob Agents. 2019 Jun;53(6):868-872. doi: 10.1016/j.ijantimicag.2018.10.025. Epub 2018 Nov 14.

PMID:
30447380
13.

Studies on acid stability and solid-phase block synthesis of peptide-peptoid hybrids: ligands for formyl peptide receptors.

Hansen AM, Skovbakke SL, Christensen SB, Perez-Gassol I, Franzyk H.

Amino Acids. 2019 Feb;51(2):205-218. doi: 10.1007/s00726-018-2656-x. Epub 2018 Sep 28.

PMID:
30267164
14.

Phorbol Rearrangements.

Zimmermann T, Franzyk H, Christensen SB.

J Nat Prod. 2018 Sep 28;81(9):2134-2137. doi: 10.1021/acs.jnatprod.8b00607. Epub 2018 Sep 14.

PMID:
30216064
15.

Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures.

McNair LKF, Siedler S, Vinther JMO, Hansen AM, Neves AR, Garrigues C, Jäger AK, Franzyk H, Staerk D.

FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy094.

PMID:
30137293
16.

High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans.

de Cássia Lemos Lima R, T Kongstad K, Kato L, José das Silva M, Franzyk H, Staerk D.

Molecules. 2018 Jul 17;23(7). pii: E1755. doi: 10.3390/molecules23071755.

17.

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein.

Rodrigues L, Raftopoulos KN, Tandrup Schmidt S, Schneider F, Dietz H, Rades T, Franzyk H, Pedersen AE, Papadakis CM, Christensen D, Winter G, Foged C, Hubert M.

J Control Release. 2018 Sep 10;285:12-22. doi: 10.1016/j.jconrel.2018.06.028. Epub 2018 Jun 28.

PMID:
29964134
18.

Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius.

Molchanova N, Hansen PR, Damborg P, Franzyk H.

J Pept Sci. 2018 Jul;24(7):e3098. doi: 10.1002/psc.3098. Epub 2018 Jul 2.

PMID:
29962075
19.

Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis.

Zimmermann T, Christensen SB, Franzyk H.

Molecules. 2018 Jun 15;23(6). pii: E1463. doi: 10.3390/molecules23061463.

20.

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.

de Groot AM, Thanki K, Gangloff M, Falkenberg E, Zeng X, van Bijnen DCJ, van Eden W, Franzyk H, Nielsen HM, Broere F, Gay NJ, Foged C, Sijts AJAM.

Mol Ther Nucleic Acids. 2018 Jun 1;11:159-169. doi: 10.1016/j.omtn.2018.02.003. Epub 2018 Feb 13.

21.

Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists.

Hansen AM, Peng P, Baldry M, Perez-Gassol I, Christensen SB, Vinther JMO, Ingmer H, Franzyk H.

Eur J Med Chem. 2018 May 25;152:370-376. doi: 10.1016/j.ejmech.2018.04.053. Epub 2018 Apr 28.

PMID:
29738955
22.

Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity.

Birch D, Christensen MV, Staerk D, Franzyk H, Nielsen HM.

Biochem J. 2018 May 24;475(10):1773-1788. doi: 10.1042/BCJ20180155.

PMID:
29686042
23.

Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction.

Hedegaard SF, Derbas MS, Lind TK, Kasimova MR, Christensen MV, Michaelsen MH, Campbell RA, Jorgensen L, Franzyk H, Cárdenas M, Nielsen HM.

Sci Rep. 2018 Apr 20;8(1):6327. doi: 10.1038/s41598-018-24154-z.

24.

The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics.

Skovbakke SL, Holdfeldt A, Forsman H, Bylund J, Franzyk H.

Curr Pharm Des. 2018;24(10):1100-1120. doi: 10.2174/1381612824666180403123233.

PMID:
29611477
25.

Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic.

Kłodzińska SN, Molchanova N, Franzyk H, Hansen PR, Damborg P, Nielsen HM.

Eur J Pharm Biopharm. 2018 Jul;128:1-9. doi: 10.1016/j.ejpb.2018.03.012. Epub 2018 Mar 29.

PMID:
29605468
26.

Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability.

Birch D, Christensen MV, Staerk D, Franzyk H, Nielsen HM.

Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2483-2494. doi: 10.1016/j.bbamem.2017.09.015. Epub 2017 Sep 15.

27.

Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

Molchanova N, Hansen PR, Franzyk H.

Molecules. 2017 Aug 29;22(9). pii: E1430. doi: 10.3390/molecules22091430. Review.

28.

Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach.

Thanki K, Zeng X, Justesen S, Tejlmann S, Falkenberg E, Van Driessche E, Mørck Nielsen H, Franzyk H, Foged C.

Eur J Pharm Biopharm. 2017 Nov;120:22-33. doi: 10.1016/j.ejpb.2017.07.014. Epub 2017 Jul 26.

PMID:
28756280
29.

Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.

Skovbakke SL, Holdfeldt A, Nielsen C, Hansen AM, Perez-Gassol I, Dahlgren C, Forsman H, Franzyk H.

J Med Chem. 2017 Aug 24;60(16):6991-6997. doi: 10.1021/acs.jmedchem.7b00489. Epub 2017 Aug 10.

PMID:
28700225
30.

Adjuvants Based on Synthetic Mycobacterial Cord Factor Analogues: Biophysical Properties of Neat Glycolipids and Nanoself-Assemblies with DDA.

Kallerup RS, Franzyk H, Schiøth ML, Justesen S, Martin-Bertelsen B, Rose F, Madsen CM, Christensen D, Korsholm KS, Yaghmur A, Foged C.

Mol Pharm. 2017 Jul 3;14(7):2294-2306. doi: 10.1021/acs.molpharmaceut.7b00170. Epub 2017 May 31.

PMID:
28497975
31.

On-resin N-formylation of peptides: a head-to-head comparison of reagents in solid-phase synthesis of ligands for formyl peptide receptors.

Christensen SB, Hansen AM, Franzyk H.

J Pept Sci. 2017 May;23(5):410-415. doi: 10.1002/psc.2998.

PMID:
28421689
32.

Lysine-Based α-Peptide/β-Peptoid Peptidomimetics: Influence of Hydrophobicity, Fluorination, and Distribution of Cationic Charge on Antimicrobial Activity and Cytotoxicity.

Molchanova N, Hansen PR, Damborg P, Nielsen HM, Franzyk H.

ChemMedChem. 2017 Feb 20;12(4):312-318. doi: 10.1002/cmdc.201600553. Epub 2017 Jan 12.

PMID:
28052595
33.

Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization.

Skovbakke SL, Franzyk H.

Methods Mol Biol. 2017;1548:369-386. doi: 10.1007/978-1-4939-6737-7_27.

PMID:
28013519
34.

Conserved Molecular Superlattices in a Series of Homologous Synthetic Mycobacterial Cell-Wall Lipids Forming Interdigitated Bilayers.

Martin-Bertelsen B, Yaghmur A, Franzyk H, Justesen S, Kirkensgaard JJ, Foged C.

Langmuir. 2016 Dec 6;32(48):12693-12701. Epub 2016 Nov 22.

PMID:
27934510
35.

Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition.

Kachel HS, Patel RN, Franzyk H, Mellor IR.

Sci Rep. 2016 Nov 30;6:38116. doi: 10.1038/srep38116.

36.

The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils.

Skovbakke SL, Winther M, Gabl M, Holdfeldt A, Linden S, Wang JM, Dahlgren C, Franzyk H, Forsman H.

Biochem Pharmacol. 2016 Nov 1;119:56-65. doi: 10.1016/j.bcp.2016.09.004. Epub 2016 Sep 8.

PMID:
27614010
37.

A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli.

Baker KR, Jana B, Franzyk H, Guardabassi L.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5995-6002. doi: 10.1128/AAC.00537-16. Print 2016 Oct.

38.

The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2 Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase.

Holdfeldt A, Skovbakke SL, Winther M, Gabl M, Nielsen C, Perez-Gassol I, Larsen CJ, Wang JM, Karlsson A, Dahlgren C, Forsman H, Franzyk H.

J Biol Chem. 2016 Sep 16;291(38):19888-99. doi: 10.1074/jbc.M116.736850. Epub 2016 Jul 15.

39.

Nano-Self-Assemblies Based on Synthetic Analogues of Mycobacterial Monomycoloyl Glycerol and DDA: Supramolecular Structure and Adjuvant Efficacy.

Martin-Bertelsen B, Korsholm KS, Roces CB, Nielsen MH, Christensen D, Franzyk H, Yaghmur A, Foged C.

Mol Pharm. 2016 Aug 1;13(8):2771-81. doi: 10.1021/acs.molpharmaceut.6b00368. Epub 2016 Jul 20.

PMID:
27377146
40.

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.

Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, Foged C, Lang R.

Innate Immun. 2016 Aug;22(6):405-18. doi: 10.1177/1753425916651132. Epub 2016 Jun 1.

41.

Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation.

Jensen CM, Chow HQ, Chen M, Zhai L, Frydenvang K, Liu H, Franzyk H, Christensen SB.

Eur J Med Chem. 2016 May 23;114:118-33. doi: 10.1016/j.ejmech.2016.02.037. Epub 2016 Feb 23.

PMID:
26974380
42.

Antibacterial Peptide Nucleic Acid-Antimicrobial Peptide (PNA-AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis.

Hansen AM, Bonke G, Larsen CJ, Yavari N, Nielsen PE, Franzyk H.

Bioconjug Chem. 2016 Apr 20;27(4):863-7. doi: 10.1021/acs.bioconjchem.6b00013. Epub 2016 Mar 10.

PMID:
26938833
43.

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.

Baldry M, Kitir B, Frøkiær H, Christensen SB, Taverne N, Meijerink M, Franzyk H, Olsen CA, Wells JM, Ingmer H.

PLoS One. 2016 Jan 5;11(1):e0145618. doi: 10.1371/journal.pone.0145618. eCollection 2016.

44.

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

Jing X, Foged C, Martin-Bertelsen B, Yaghmur A, Knapp KM, Malmsten M, Franzyk H, Nielsen HM.

Mol Pharm. 2016 Jun 6;13(6):1739-49. doi: 10.1021/acs.molpharmaceut.5b00309. Epub 2016 May 9.

PMID:
26654841
45.

An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action.

Oddo A, Thomsen TT, Kjelstrup S, Gorey C, Franzyk H, Frimodt-Møller N, Løbner-Olesen A, Hansen PR.

Antimicrob Agents Chemother. 2015 Nov 16;60(1):592-9. doi: 10.1128/AAC.01966-15. Print 2016 Jan.

46.

Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro.

Zeng X, de Groot AM, Sijts AJ, Broere F, Oude Blenke E, Colombo S, van Eden W, Franzyk H, Nielsen HM, Foged C.

Nanoscale. 2015 Dec 14;7(46):19687-98. doi: 10.1039/c5nr04807a.

PMID:
26553270
47.

Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs and antibiotics against human pathogenic bacteria.

Citterio L, Franzyk H, Palarasah Y, Andersen TE, Mateiu RV, Gram L.

Res Microbiol. 2016 Feb-Mar;167(2):72-82. doi: 10.1016/j.resmic.2015.10.002. Epub 2015 Oct 21.

PMID:
26499211
48.

Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices.

Steffensen SL, Vestergaard MH, Groenning M, Alm M, Franzyk H, Nielsen HM.

Eur J Pharm Biopharm. 2015 Aug;94:305-11. doi: 10.1016/j.ejpb.2015.05.014. Epub 2015 May 28.

PMID:
26028273
49.

Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation.

Kristensen M, Franzyk H, Klausen MT, Iversen A, Bahnsen JS, Skyggebjerg RB, Foderà V, Nielsen HM.

AAPS J. 2015 Sep;17(5):1200-9. doi: 10.1208/s12248-015-9747-3. Epub 2015 May 20.

50.

Soft hydrogels interpenetrating silicone--A polymer network for drug-releasing medical devices.

Steffensen SL, Vestergaard MH, Møller EH, Groenning M, Alm M, Franzyk H, Nielsen HM.

J Biomed Mater Res B Appl Biomater. 2016 Feb;104(2):402-10. doi: 10.1002/jbm.b.33371. Epub 2015 Apr 17.

PMID:
25892578

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