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Items: 1 to 50 of 89

1.

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond.

Capece D, Verzella D, Di Francesco B, Alesse E, Franzoso G, Zazzeroni F.

Semin Cell Dev Biol. 2019 Jun 12. pii: S1084-9521(18)30183-6. doi: 10.1016/j.semcdb.2019.05.021. [Epub ahead of print] Review.

PMID:
31132468
2.

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3.

Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G.

Toxicol Rep. 2019 Apr 19;6:369-379. doi: 10.1016/j.toxrep.2019.04.006. eCollection 2019.

3.

Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma.

Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G.

Br J Haematol. 2019 May;185(3):588-592. doi: 10.1111/bjh.15569. Epub 2018 Sep 26. No abstract available.

4.

Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry.

Rega C, Russo R, Focà A, Sandomenico A, Iaccarino E, Raimondo D, Milanetti E, Tornatore L, Franzoso G, Pedone PV, Ruvo M, Chambery A.

Int J Biol Macromol. 2018 Jul 15;114:114-123. doi: 10.1016/j.ijbiomac.2018.03.090. Epub 2018 Mar 20.

5.

Turning an old GADDget into a troublemaker.

Capece D, D'Andrea D, Verzella D, Tornatore L, Begalli F, Bennett J, Zazzeroni F, Franzoso G.

Cell Death Differ. 2018 Mar;25(4):642-644. doi: 10.1038/s41418-018-0087-6. Epub 2018 Mar 6. Review. No abstract available.

6.

GADD45β Loss Ablates Innate Immunosuppression in Cancer.

Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes SJ, Sica A, Alesse E, Zazzeroni F, Franzoso G.

Cancer Res. 2018 Mar 1;78(5):1275-1292. doi: 10.1158/0008-5472.CAN-17-1833. Epub 2017 Dec 26.

7.

NF-κB in the crosshairs: Rethinking an old riddle.

Bennett J, Capece D, Begalli F, Verzella D, D'Andrea D, Tornatore L, Franzoso G.

Int J Biochem Cell Biol. 2018 Feb;95:108-112. doi: 10.1016/j.biocel.2017.12.020. Epub 2017 Dec 23. Review.

8.

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.

Begalli F, Bennett J, Capece D, Verzella D, D'Andrea D, Tornatore L, Franzoso G.

Biomedicines. 2017 Aug 22;5(3). pii: E50. doi: 10.3390/biomedicines5030050. Review.

9.

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.

Koh CM, Khattar E, Leow SC, Liu CY, Muller J, Ang WX, Li Y, Franzoso G, Li S, Guccione E, Tergaonkar V.

J Clin Invest. 2015 May;125(5):2109-22. doi: 10.1172/JCI79134. Epub 2015 Apr 20.

10.

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors.

Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G.

Cancer Cell. 2014 Dec 8;26(6):938. doi: 10.1016/j.ccell.2014.11.021. Epub 2014 Dec 8. No abstract available.

11.

An effective tool to manage the distribution of medicines and monitor the treatment in hospital pharmacies.

Franzoso G.

Online J Public Health Inform. 2014 Oct 16;6(2):e183. doi: 10.5210/ojphi.v6i2.5315. eCollection 2014.

12.

Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors.

Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G.

Cancer Cell. 2014 Oct 13;26(4):495-508. doi: 10.1016/j.ccr.2014.07.027. Erratum in: Cancer Cell. 2014 Dec 8;26(6):938.

13.

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.

Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT, Botto M.

Nat Commun. 2014;5:3039. doi: 10.1038/ncomms4039.

14.

Tissue properties of the human vertebral body sub-structures evaluated by means of microindentation.

Dall'Ara E, Karl C, Mazza G, Franzoso G, Vena P, Pretterklieber M, Pahr D, Zysset P.

J Mech Behav Biomed Mater. 2013 Sep;25:23-32. doi: 10.1016/j.jmbbm.2013.04.020. Epub 2013 May 9.

PMID:
23726926
15.

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma.

Barbarulo A, Iansante V, Chaidos A, Naresh K, Rahemtulla A, Franzoso G, Karadimitris A, Haskard DO, Papa S, Bubici C.

Oncogene. 2013 Sep 5;32(36):4231-42. doi: 10.1038/onc.2012.448. Epub 2012 Oct 8.

16.

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation.

Tornatore L, Thotakura AK, Bennett J, Moretti M, Franzoso G.

Trends Cell Biol. 2012 Nov;22(11):557-66. doi: 10.1016/j.tcb.2012.08.001. Epub 2012 Sep 18. Review.

PMID:
22995730
17.

Cancer: NF-κB regulates energy metabolism.

Moretti M, Bennett J, Tornatore L, Thotakura AK, Franzoso G.

Int J Biochem Cell Biol. 2012 Dec;44(12):2238-43. doi: 10.1016/j.biocel.2012.08.002. Epub 2012 Aug 10. Review.

PMID:
22903018
18.

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, Chandel NS, Franzoso G.

Nat Cell Biol. 2011 Aug 28;13(10):1272-9. doi: 10.1038/ncb2324.

19.

Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice.

Luo Y, Boyle DL, Hammaker D, Edgar M, Franzoso G, Firestein GS.

Arthritis Rheum. 2011 Oct;63(10):2949-55. doi: 10.1002/art.30497.

20.

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.

Ma L, Mauro C, Cornish GH, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S, Marelli-Berg FM.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19461-6. doi: 10.1073/pnas.1011748107. Epub 2010 Oct 26.

21.

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation.

Yang H, Rivera Z, Jube S, Nasu M, Bertino P, Goparaju C, Franzoso G, Lotze MT, Krausz T, Pass HI, Bianchi ME, Carbone M.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12611-6. doi: 10.1073/pnas.1006542107. Epub 2010 Jun 28.

22.

Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.

Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle DL, Firestein GS.

Arthritis Rheum. 2009 Nov;60(11):3229-40. doi: 10.1002/art.24887.

23.

Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways.

Papa S, Bubici C, Zazzeroni F, Franzoso G.

Biol Chem. 2009 Oct;390(10):965-76. doi: 10.1515/BC.2009.111. Review.

24.

Gadd45beta dimerization does not affect MKK7 binding.

Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M.

Adv Exp Med Biol. 2009;611:367-8. No abstract available.

PMID:
19400229
25.

The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity.

Mauro C, Zazzeroni F, Papa S, Bubici C, Franzoso G.

Methods Mol Biol. 2009;512:169-207. doi: 10.1007/978-1-60327-530-9_10.

PMID:
19347278
26.

Getting away from it all in Capri: the 2008 EMBO workshop on NF-kappaB.

Gilmore TD, Perkins ND, Franzoso G.

Cell Death Differ. 2009 Apr;16(4):651-4. doi: 10.1038/cdd.2009.3. No abstract available.

27.

Elastic anisotropy of human cortical bone secondary osteons measured by nanoindentation.

Franzoso G, Zysset PK.

J Biomech Eng. 2009 Feb;131(2):021001. doi: 10.1115/1.3005162. Erratum in: J Biomech Eng. 2009 Nov;131(11):117001.

PMID:
19102560
28.

Finite element analysis of cancellous bone failure in the vertebral body of healthy and osteoporotic subjects.

Boccaccio A, Vena P, Gastaldi D, Franzoso G, Pietrabissa R, Pappalettere C.

Proc Inst Mech Eng H. 2008 Oct;222(7):1023-36.

PMID:
19024151
29.

Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries.

Liu B, Suyeoka G, Papa S, Franzoso G, Neufeld AH.

Neurobiol Dis. 2009 Jan;33(1):104-10. doi: 10.1016/j.nbd.2008.09.020. Epub 2008 Oct 14.

30.

T cell-derived lymphotoxin regulates liver regeneration.

Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, Papa S, Franzoso G, Nedospasov SA, Fu YX, Anders RA.

Gastroenterology. 2009 Feb;136(2):694-704.e4. doi: 10.1053/j.gastro.2008.09.015. Epub 2008 Sep 18.

31.

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling.

Papa S, Zazzeroni F, Fu YX, Bubici C, Alvarez K, Dean K, Christiansen PA, Anders RA, Franzoso G.

J Clin Invest. 2008 May;118(5):1911-23. doi: 10.1172/JCI33913.

32.

Gadd45 beta forms a homodimeric complex that binds tightly to MKK7.

Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM.

J Mol Biol. 2008 Apr 18;378(1):97-111. doi: 10.1016/j.jmb.2008.01.074. Epub 2008 Feb 4.

PMID:
18343408
33.

A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors.

Kuntzen C, Zazzeroni F, Pham CG, Papa S, Bubici C, Knabb JR, Franzoso G.

Methods Mol Biol. 2007;399:99-124. Review.

PMID:
18309928
34.

Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2.

Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G.

J Biol Chem. 2007 Jun 29;282(26):19029-41. Epub 2007 May 7.

35.

Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs.

Pham CG, Bubici C, Zazzeroni F, Knabb JR, Papa S, Kuntzen C, Franzoso G.

Mol Cell Biol. 2007 Jun;27(11):3920-35. Epub 2007 Apr 2.

36.

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance.

Bubici C, Papa S, Dean K, Franzoso G.

Oncogene. 2006 Oct 30;25(51):6731-48. Review.

PMID:
17072325
37.

TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis.

Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, Bubici C, Mossman BT, Pass HI, Testa JR, Franzoso G, Carbone M.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10397-10402. doi: 10.1073/pnas.0604008103. Epub 2006 Jun 23.

38.

Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons.

Centeno C, Repici M, Chatton JY, Riederer BM, Bonny C, Nicod P, Price M, Clarke PG, Papa S, Franzoso G, Borsello T.

Cell Death Differ. 2007 Feb;14(2):240-53. Epub 2006 Jun 23.

39.
40.

The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease.

Papa S, Bubici C, Zazzeroni F, Pham CG, Kuntzen C, Knabb JR, Dean K, Franzoso G.

Cell Death Differ. 2006 May;13(5):712-29. Review.

41.

NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes.

Mittal A, Papa S, Franzoso G, Sen R.

J Immunol. 2006 Feb 15;176(4):2183-9.

42.

In the Crosshairs: NF-κB Targets the JNK Signaling Cascade.

Pham CG, Papa S, Bubici C, Zazzeroni F, Franzoso G.

Curr Med Chem Anti Inflamm Anti Allergy Agents. 2005 Dec 1;4(6):569-576.

43.

The NF-kappaB-mediated control of ROS and JNK signaling.

Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso G.

Histol Histopathol. 2006 Jan;21(1):69-80. doi: 10.14670/HH-21.69. Review.

PMID:
16267788
44.

Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues.

Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX.

Blood. 2006 Feb 1;107(3):1048-55. Epub 2005 Sep 29.

45.

A finite element model of the L4-L5 spinal motion segment: biomechanical compatibility of an interspinous device.

Vena P, Franzoso G, Gastaldi D, Contro R, Dallolio V.

Comput Methods Biomech Biomed Engin. 2005 Feb;8(1):7-16.

PMID:
16154865
46.

NF-kappaB meets ROS: an 'iron-ic' encounter.

Papa S, Bubici C, Pham CG, Zazzeroni F, Franzoso G.

Cell Death Differ. 2005 Oct;12(10):1259-62. No abstract available.

47.

Oxygen JNKies: phosphatases overdose on ROS.

Pham CG, Papa S, Bubici C, Zazzeroni F, Franzoso G.

Dev Cell. 2005 Apr;8(4):452-4.

48.

NF-kappaB and JNK: an intricate affair.

Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso G.

Cell Cycle. 2004 Dec;3(12):1524-9. Epub 2004 Dec 19. Review.

PMID:
15611622
49.

Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species.

Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E, Cong R, Beaumont C, Torti FM, Torti SV, Franzoso G.

Cell. 2004 Nov 12;119(4):529-42.

50.

Linking JNK signaling to NF-kappaB: a key to survival.

Papa S, Zazzeroni F, Pham CG, Bubici C, Franzoso G.

J Cell Sci. 2004 Oct 15;117(Pt 22):5197-208. Review.

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