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Items: 23


Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin.

Mediani L, Guillén-Boixet J, Vinet J, Franzmann TM, Bigi I, Mateju D, Carrà AD, Morelli FF, Tiago T, Poser I, Alberti S, Carra S.

EMBO J. 2019 Aug 1;38(15):e101341. doi: 10.15252/embj.2018101341. Epub 2019 Jul 4.


Protein Phase Separation as a Stress Survival Strategy.

Franzmann TM, Alberti S.

Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6). pii: a034058. doi: 10.1101/cshperspect.a034058. Review.


A User's Guide for Phase Separation Assays with Purified Proteins.

Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA.

J Mol Biol. 2018 Nov 2;430(23):4806-4820. doi: 10.1016/j.jmb.2018.06.038. Epub 2018 Jun 23.


Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior.

Franzmann TM, Alberti S.

J Biol Chem. 2019 May 3;294(18):7128-7136. doi: 10.1074/jbc.TM118.001190. Epub 2018 Jun 19. Review.


Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery.

Kroschwald S, Munder MC, Maharana S, Franzmann TM, Richter D, Ruer M, Hyman AA, Alberti S.

Cell Rep. 2018 Jun 12;23(11):3327-3339. doi: 10.1016/j.celrep.2018.05.041.


RNA buffers the phase separation behavior of prion-like RNA binding proteins.

Maharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann TM, Jahnel M, Marrone L, Chang YT, Sterneckert J, Tomancak P, Hyman AA, Alberti S.

Science. 2018 May 25;360(6391):918-921. doi: 10.1126/science.aar7366. Epub 2018 Apr 12.


Phase separation of a yeast prion protein promotes cellular fitness.

Franzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S.

Science. 2018 Jan 5;359(6371). pii: eaao5654. doi: 10.1126/science.aao5654.


An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.

Mateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S.

EMBO J. 2017 Jun 14;36(12):1669-1687. doi: 10.15252/embj.201695957. Epub 2017 Apr 4.


A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S.

Cell. 2015 Aug 27;162(5):1066-77. doi: 10.1016/j.cell.2015.07.047.


Characterization of a highly flexible self-assembling protein system designed to form nanocages.

Patterson DP, Su M, Franzmann TM, Sciore A, Skiniotis G, Marsh EN.

Protein Sci. 2014 Feb;23(2):190-9. doi: 10.1002/pro.2405. Epub 2013 Dec 16.


Structural and functional analysis of the DEAF-1 and BS69 MYND domains.

Kateb F, Perrin H, Tripsianes K, Zou P, Spadaccini R, Bottomley M, Franzmann TM, Buchner J, Ansieau S, Sattler M.

PLoS One. 2013;8(1):e54715. doi: 10.1371/journal.pone.0054715. Epub 2013 Jan 25.


Identification of a hypochlorite-specific transcription factor from Escherichia coli.

Gebendorfer KM, Drazic A, Le Y, Gundlach J, Bepperling A, Kastenmüller A, Ganzinger KA, Braun N, Franzmann TM, Winter J.

J Biol Chem. 2012 Feb 24;287(9):6892-903. doi: 10.1074/jbc.M111.287219. Epub 2012 Jan 4.


Regulatory circuits of the AAA+ disaggregase Hsp104.

Franzmann TM, Czekalla A, Walter SG.

J Biol Chem. 2011 May 20;286(20):17992-8001. doi: 10.1074/jbc.M110.216176. Epub 2011 Mar 23.


The crystal structure of Escherichia coli group 4 capsule protein GfcC reveals a domain organization resembling that of Wza.

Sathiyamoorthy K, Mills E, Franzmann TM, Rosenshine I, Saper MA.

Biochemistry. 2011 Jun 21;50(24):5465-76. doi: 10.1021/bi101869h. Epub 2011 May 27.


Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.

Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH.

Angew Chem Int Ed Engl. 2011 Mar 14;50(12):2795-8. doi: 10.1002/anie.201005280. Epub 2011 Feb 23. No abstract available.


Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5.

Bertz M, Chen J, Feige MJ, Franzmann TM, Buchner J, Rief M.

J Mol Biol. 2010 Jul 30;400(5):1046-56. doi: 10.1016/j.jmb.2010.05.065. Epub 2010 Jun 2.


Regions outside the alpha-crystallin domain of the small heat shock protein Hsp26 are required for its dimerization.

Chen J, Feige MJ, Franzmann TM, Bepperling A, Buchner J.

J Mol Biol. 2010 Apr 23;398(1):122-31. doi: 10.1016/j.jmb.2010.02.022. Epub 2010 Feb 18.


Protein refolding by pH-triggered chaperone binding and release.

Tapley TL, Franzmann TM, Chakraborty S, Jakob U, Bardwell JC.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1071-6. doi: 10.1073/pnas.0911610107. Epub 2009 Dec 31.


The eye lens chaperone alpha-crystallin forms defined globular assemblies.

Peschek J, Braun N, Franzmann TM, Georgalis Y, Haslbeck M, Weinkauf S, Buchner J.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13272-7. doi: 10.1073/pnas.0902651106. Epub 2009 Jul 27.


Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain.

Franzmann TM, Menhorn P, Walter S, Buchner J.

Mol Cell. 2008 Feb 1;29(2):207-16. doi: 10.1016/j.molcel.2007.11.025.


Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26.

White HE, Orlova EV, Chen S, Wang L, Ignatiou A, Gowen B, Stromer T, Franzmann TM, Haslbeck M, Buchner J, Saibil HR.

Structure. 2006 Jul;14(7):1197-204.


Matrix-assisted refolding of oligomeric small heat-shock protein Hsp26.

Franzmann TM.

Int J Biol Macromol. 2006 Aug 15;39(1-3):104-10. Epub 2006 Apr 19.


The activation mechanism of Hsp26 does not require dissociation of the oligomer.

Franzmann TM, Wühr M, Richter K, Walter S, Buchner J.

J Mol Biol. 2005 Jul 29;350(5):1083-93.


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