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Items: 22

1.

Two-year carcinogenicity studies with the oral direct thrombin inhibitor ximelagatran in the rat and the mouse.

Stong DB, Carlsson SC, Bjurström S, Fransson-Steen R, Healing G, Skånberg I.

Int J Toxicol. 2012 Jul-Aug;31(4):348-57. doi: 10.1177/1091581812448881. Epub 2012 Jun 12.

PMID:
22692977
2.

An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: support for a proposal to modify current regulatory guidelines.

Sistare FD, Morton D, Alden C, Christensen J, Keller D, Jonghe SD, Storer RD, Reddy MV, Kraynak A, Trela B, Bienvenu JG, Bjurström S, Bosmans V, Brewster D, Colman K, Dominick M, Evans J, Hailey JR, Kinter L, Liu M, Mahrt C, Marien D, Myer J, Perry R, Potenta D, Roth A, Sherratt P, Singer T, Slim R, Soper K, Fransson-Steen R, Stoltz J, Turner O, Turnquist S, van Heerden M, Woicke J, DeGeorge JJ.

Toxicol Pathol. 2011 Jun;39(4):716-44. doi: 10.1177/0192623311406935.

PMID:
21666103
3.

Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone.

Löfgren S, Baldwin RM, Carlerös M, Terelius Y, Fransson-Steen R, Mwinyi J, Waxman DJ, Ingelman-Sundberg M.

Drug Metab Dispos. 2009 Jul;37(7):1505-12. doi: 10.1124/dmd.109.026963. Epub 2009 Apr 1.

4.

Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.

Löfgren S, Ekman S, Terelius Y, Fransson-Steen R.

Acta Vet Scand. 2008 Nov 27;50:47. doi: 10.1186/1751-0147-50-47.

5.

Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression.

Löfgren S, Baldwin RM, Hiratsuka M, Lindqvist A, Carlberg A, Sim SC, Schülke M, Snait M, Edenro A, Fransson-Steen R, Terelius Y, Ingelman-Sundberg M.

Drug Metab Dispos. 2008 May;36(5):955-62. doi: 10.1124/dmd.107.019349. Epub 2008 Feb 14.

6.

Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.

Gerdin AK, Surve VV, Jönsson M, Bjursell M, Björkman M, Edenro A, Schuelke M, Saad A, Bjurström S, Lundgren EJ, Snaith M, Fransson-Steen R, Törnell J, Berg AL, Bohlooly-Y M.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):825-32. Epub 2006 Aug 24.

PMID:
16945327
7.

Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.

Löfgren S, Hagbjörk AL, Ekman S, Fransson-Steen R, Terelius Y.

Xenobiotica. 2004 Sep;34(9):811-34.

PMID:
15742976
8.

Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice.

Goldsworthy TL, Fransson-Steen R.

Toxicol Pathol. 2002 Jan-Feb;30(1):97-105.

PMID:
11890483
9.

Xpa and Xpa/p53+/- knockout mice: overview of available data.

van Kreijl CF, McAnulty PA, Beems RB, Vynckier A, van Steeg H, Fransson-Steen R, Alden CL, Forster R, van der Laan JW, Vandenberghe J.

Toxicol Pathol. 2001;29 Suppl:117-27.

PMID:
11695547
10.

Analysis of rat liver foci growth with a quantitative two-cell model after treatment with 2,4,5,3',4'-pentachlorobiphenyl.

Haag-Grönlund M, Conolly R, Scheu G, Wärngård L, Fransson-Steen R.

Toxicol Sci. 2000 Sep;57(1):32-42.

PMID:
10966509
11.

Interactive effects of three structurally different polychlorinated biphenyls in a rat liver tumor promotion bioassay.

Haag-Grönlund M, Johansson N, Fransson-Steen R, Hâkansson H, Scheu G, Wärngård L.

Toxicol Appl Pharmacol. 1998 Sep;152(1):153-65.

PMID:
9772211
12.
13.

Promotion of enzyme altered foci in female rat 2,3,3',4,4',5-hexachlorobiphenyl.

Haag-Grönlund M, Kato Y, Fransson-Steen R, Scheu G, Wärngârd L.

Toxicol Appl Pharmacol. 1997 Nov;147(1):46-55.

PMID:
9356306
14.

Furan-induced liver cell proliferation and apoptosis in female B6C3F1 mice.

Fransson-Steen R, Goldsworthy TL, Kedderis GL, Maronpot RR.

Toxicology. 1997 Mar 28;118(2-3):195-204.

PMID:
9129173
15.

Promotion of altered hepatic foci by 2,3',4,4',5-pentachlorobiphenyl in Sprague-Dawley female rats.

Haag-Grönlund M, Wärngård L, Flodström S, Scheu G, Kronevi T, Ahlborg UG, Fransson-Steen R.

Fundam Appl Toxicol. 1997 Jan;35(1):120-30.

PMID:
9024679
16.

Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3F1 female mouse liver.

Moser GJ, Wong BA, Wolf DC, Fransson-Steen RL, Goldsworthy TL.

Carcinogenesis. 1996 Dec;17(12):2753-61.

PMID:
9006116
17.

Apoptosis and cancer risk assessment.

Goldsworthy TL, Conolly RB, Fransson-Steen R.

Mutat Res. 1996 Sep;365(1-3):71-90. Review.

PMID:
8898990
18.

Importance of and approaches to quantification of hepatocyte apoptosis.

Goldsworthy TL, Fransson-Steen R, Maronpot RR.

Toxicol Pathol. 1996 Jan-Feb;24(1):24-35. Review.

PMID:
8839278
19.

Application of the benchmark method to risk assessment of trichloroethene.

Haag-Grönlund M, Fransson-Steen R, Victorin K.

Regul Toxicol Pharmacol. 1995 Apr;21(2):261-9.

PMID:
7644716
21.

The insecticide endosulfan and its two stereoisomers promote the growth of altered hepatic foci in rats.

Fransson-Steen R, Flodström S, Wärngård L.

Carcinogenesis. 1992 Dec;13(12):2299-303.

PMID:
1473237
22.

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