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Items: 1 to 50 of 169

1.

The cyanobacterial neurotoxin β-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells.

Cheng F, Fransson LÅ, Mani K.

Exp Cell Res. 2019 Jun 15;379(2):172-181. doi: 10.1016/j.yexcr.2019.03.041. Epub 2019 Apr 3.

PMID:
30953622
2.

Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts.

Cheng F, Fransson LÅ, Mani K.

Exp Cell Res. 2018 Mar 15;364(2):133-142. doi: 10.1016/j.yexcr.2018.01.029. Epub 2018 Feb 8.

PMID:
29408503
3.
4.

Nucleolin is a nuclear target of heparan sulfate derived from glypican-1.

Cheng F, Belting M, Fransson LÅ, Mani K.

Exp Cell Res. 2017 May 1;354(1):31-39. doi: 10.1016/j.yexcr.2017.03.021. Epub 2017 Mar 12.

PMID:
28300561
5.

Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.

Cheng F, Bourseau-Guilmain E, Belting M, Fransson LÅ, Mani K.

Glycobiology. 2016 Jun;26(6):623-34. doi: 10.1093/glycob/cww007. Epub 2016 Jan 20.

PMID:
26791445
6.

Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts.

Cheng F, Fransson LÅ, Mani K.

Glycoconj J. 2015 Dec;32(9):675-84. doi: 10.1007/s10719-015-9616-4. Epub 2015 Aug 29.

PMID:
26318599
7.

Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects.

Kappe C, Fransson L, Wolbert P, Ortsäter H.

Clin Sci (Lond). 2015 Sep;129(5):405-14. doi: 10.1042/CS20140719. Epub 2015 Apr 8.

PMID:
25853863
8.

Rapid nuclear transit and impaired degradation of amyloid β and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.

Cheng F, Fransson LÅ, Mani K.

Glycobiology. 2015 May;25(5):548-56. doi: 10.1093/glycob/cwu185. Epub 2014 Dec 19.

PMID:
25527428
9.
10.

Inhibition of palmitate-induced GADD34 expression augments apoptosis in mouse insulinoma cells (MIN6).

Fransson L, Sjöholm A, Ortsäter H.

Cell Biochem Funct. 2014 Jul;32(5):445-52. doi: 10.1002/cbf.3036. Epub 2014 Mar 13.

PMID:
24633916
11.

Liraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome.

Fransson L, Dos Santos C, Wolbert P, Sjöholm A, Rafacho A, Ortsäter H.

Diabetol Metab Syndr. 2014 Jan 14;6(1):3. doi: 10.1186/1758-5996-6-3.

12.

Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and β-cells.

Fransson L, Rosengren V, Saha TK, Grankvist N, Islam T, Honkanen RE, Sjöholm Å, Ortsäter H.

Mol Cell Endocrinol. 2014 Mar 5;383(1-2):126-36. doi: 10.1016/j.mce.2013.12.010. Epub 2013 Dec 20.

PMID:
24361515
13.

β-Cell adaptation in a mouse model of glucocorticoid-induced metabolic syndrome.

Fransson L, Franzén S, Rosengren V, Wolbert P, Sjöholm Å, Ortsäter H.

J Endocrinol. 2013 Oct 28;219(3):231-41. doi: 10.1530/JOE-13-0189. Print 2013 Dec.

PMID:
24048967
14.

Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products.

Cheng F, Ruscher K, Fransson LÅ, Mani K.

Glycobiology. 2013 Dec;23(12):1510-9. doi: 10.1093/glycob/cwt079. Epub 2013 Sep 10.

PMID:
24026238
15.

Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage.

Cheng F, Svensson G, Fransson LÅ, Mani K.

Glycobiology. 2012 Nov;22(11):1480-6. doi: 10.1093/glycob/cws111. Epub 2012 Jul 16.

PMID:
22801553
16.

Early intervention with liraglutide improves glucose tolerance without affecting islet microcirculation in young Goto-Kakizaki rats.

Wu L, Olverling A, Fransson L, Ortsäter H, Kappe C, Gao X, Sjöholm A.

Regul Pept. 2012 Aug 20;177(1-3):92-6. doi: 10.1016/j.regpep.2012.05.091. Epub 2012 May 12.

PMID:
22587909
17.

Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells.

Rosengren V, Johansson H, Lehtiö J, Fransson L, Sjöholm A, Ortsäter H.

J Cell Biochem. 2012 May;113(5):1635-44. doi: 10.1002/jcb.24032.

PMID:
22189689
18.

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.

Cheng F, Cappai R, Ciccotosto GD, Svensson G, Multhaup G, Fransson LÅ, Mani K.

J Biol Chem. 2011 Aug 5;286(31):27559-72. doi: 10.1074/jbc.M111.243345. Epub 2011 Jun 3.

19.

Steric effects on the direct mutagenicity of N-acyloxy-N-alkoxyamides-probes for drug-DNA interactions.

Glover SA, Schumacher RR, Bonin AM, Fransson LE.

Mutat Res. 2011 May 18;722(1):32-8. doi: 10.1016/j.mrgentox.2011.02.007. Epub 2011 Feb 25.

PMID:
21356327
20.

Attenuation of tumor growth by formation of antiproliferative glycosaminoglycans correlates with low acetylation of histone H3.

Nilsson U, Johnsson R, Fransson LA, Ellervik U, Mani K.

Cancer Res. 2010 May 1;70(9):3771-9. doi: 10.1158/0008-5472.CAN-09-4331. Epub 2010 Apr 20.

21.

Minor enantiomer recycling: metal catalyst, organocatalyst and biocatalyst working in concert.

Wingstrand E, Laurell A, Fransson L, Hult K, Moberg C.

Chemistry. 2009 Nov 9;15(44):12107-13. doi: 10.1002/chem.200901338.

PMID:
19768712
22.

Dynamic modelling of the response of UK forest soils to changes in acid deposition using the SAFE model.

Langan S, Fransson L, Vanguelova E.

Sci Total Environ. 2009 Oct 15;407(21):5605-19. doi: 10.1016/j.scitotenv.2009.06.043. Epub 2009 Aug 5.

PMID:
19660786
23.

Lactone size dependent reactivity in Candida antarctica lipase B: a molecular dynamics and docking study.

Veld MA, Fransson L, Palmans AR, Meijer EW, Hult K.

Chembiochem. 2009 May 25;10(8):1330-4. doi: 10.1002/cbic.200900128.

PMID:
19425034
24.

Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.

Cheng F, Johnsson R, Nilsson J, Fransson LA, Ellervik U, Mani K.

Cancer Lett. 2009 Jan 8;273(1):148-54. doi: 10.1016/j.canlet.2008.07.036. Epub 2008 Sep 9.

PMID:
18783879
25.

Involvement of glypican-1 autoprocessing in scrapie infection.

Löfgren K, Cheng F, Fransson LA, Bedecs K, Mani K.

Eur J Neurosci. 2008 Sep;28(5):964-72. doi: 10.1111/j.1460-9568.2008.06386.x. Epub 2008 Aug 20.

PMID:
18717736
26.

Understanding promiscuous amidase activity of an esterase from Bacillus subtilis.

Kourist R, Bartsch S, Fransson L, Hult K, Bornscheuer UT.

Chembiochem. 2008 Jan 4;9(1):67-9. No abstract available.

PMID:
18022973
27.

Heparan sulfate degradation products can associate with oxidized proteins and proteasomes.

Mani K, Cheng F, Fransson LA.

J Biol Chem. 2007 Jul 27;282(30):21934-44. Epub 2007 May 31.

28.

Novel aspects of vitamin C: how important is glypican-1 recycling?

Fransson LA, Mani K.

Trends Mol Med. 2007 Apr;13(4):143-9. Epub 2007 Mar 6.

PMID:
17344097
29.

A water molecule in the stereospecificity pocket of Candida antarctica lipase B enhances enantioselectivity towards pentan-2-ol.

Léonard V, Fransson L, Lamare S, Hult K, Graber M.

Chembiochem. 2007 Apr 16;8(6):662-7.

PMID:
17328021
30.

Highly enantioselective kinetic resolution of two tertiary alcohols using mutants of an esterase from Bacillus subtilis.

Heinze B, Kourist R, Fransson L, Hult K, Bornscheuer UT.

Protein Eng Des Sel. 2007 Mar;20(3):125-31. Epub 2007 Feb 19.

PMID:
17309898
31.

Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.

Mani K, Cheng F, Fransson LA.

Glycobiology. 2006 Dec;16(12):1251-61. Epub 2006 Sep 12.

PMID:
16971378
32.

The role of steric effects in the direct mutagenicity of N-acyloxy-N-alkoxyamides.

Andrews LE, Bonin AM, Fransson LE, Gillson AM, Glover SA.

Mutat Res. 2006 Jun 16;605(1-2):51-62. Epub 2006 May 15.

PMID:
16698311
33.

Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.

Mani K, Cheng F, Fransson LA.

Glycobiology. 2006 Aug;16(8):711-8. Epub 2006 Apr 27.

PMID:
16645004
34.

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.

Cappai R, Cheng F, Ciccotosto GD, Needham BE, Masters CL, Multhaup G, Fransson LA, Mani K.

J Biol Chem. 2005 Apr 8;280(14):13913-20. Epub 2005 Jan 27.

35.

Novel aspects of glypican glycobiology.

Fransson LA, Belting M, Cheng F, Jönsson M, Mani K, Sandgren S.

Cell Mol Life Sci. 2004 May;61(9):1016-24. Review.

PMID:
15112050
36.

The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1.

Mani K, Cheng F, Sandgren S, Van Den Born J, Havsmark B, Ding K, Fransson LA.

Glycobiology. 2004 Jul;14(7):599-607. Epub 2004 Mar 24.

PMID:
15044385
37.

Tumor attenuation by 2(6-hydroxynaphthyl)-beta-D-xylopyranoside requires priming of heparan sulfate and nuclear targeting of the products.

Mani K, Belting M, Ellervik U, Falk N, Svensson G, Sandgren S, Cheng F, Fransson LA.

Glycobiology. 2004 May;14(5):387-97. Epub 2004 Jan 12.

PMID:
14718369
38.
39.

Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide.

Belting M, Mani K, Jönsson M, Cheng F, Sandgren S, Jonsson S, Ding K, Delcros JG, Fransson LA.

J Biol Chem. 2003 Nov 21;278(47):47181-9. Epub 2003 Sep 11.

40.

Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.

Mani K, Cheng F, Havsmark B, Jönsson M, Belting M, Fransson LA.

J Biol Chem. 2003 Oct 3;278(40):38956-65. Epub 2003 May 5.

41.

Initiation of the decorin glycosaminoglycan chain in the endoplasmic reticulum-Golgi intermediate compartment.

Jönsson M, Eklund E, Fransson LA, Oldberg A.

J Biol Chem. 2003 Jun 13;278(24):21415-20. Epub 2003 Mar 31.

42.

The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules.

Lehtiö J, Sugiyama J, Gustavsson M, Fransson L, Linder M, Teeri TT.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):484-9. Epub 2003 Jan 9.

43.

Glypicans.

Fransson LA.

Int J Biochem Cell Biol. 2003 Feb;35(2):125-9. Review.

PMID:
12479862
44.

Interfacial orientation of Thermomyces lanuginosa lipase on phospholipid vesicles investigated by electron spin resonance relaxation spectroscopy.

Hedin EM, Høyrup P, Patkar SA, Vind J, Svendsen A, Fransson L, Hult K.

Biochemistry. 2002 Dec 3;41(48):14185-96.

PMID:
12450382
45.

Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes.

Cheng F, Mani K, van den Born J, Ding K, Belting M, Fransson LA.

J Biol Chem. 2002 Nov 15;277(46):44431-9. Epub 2002 Sep 10.

46.

Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols.

Ding K, Mani K, Cheng F, Belting M, Fransson LA.

J Biol Chem. 2002 Sep 6;277(36):33353-60. Epub 2002 Jun 25.

47.
48.

Size as a parameter for solvent effects on Candida antarctica lipase B enantioselectivity.

Ottosson J, Fransson L, King JW, Hult K.

Biochim Biophys Acta. 2002 Feb 11;1594(2):325-34.

PMID:
11904228
49.

[Supragenomic strategies. Cancer research after HUGO].

Fransson LA.

Lakartidningen. 2001 Nov 7;98(45):4976-8. Review. Swedish.

PMID:
11816899
50.

Tumor attenuation by combined heparan sulfate and polyamine depletion.

Belting M, Borsig L, Fuster MM, Brown JR, Persson L, Fransson LA, Esko JD.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):371-6. Epub 2001 Dec 18.

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