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Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness.

Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W.

Sleep. 2019 Feb 5. doi: 10.1093/sleep/zsz031. [Epub ahead of print]


GABA and glutamate neurons in the VTA regulate sleep and wakefulness.

Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W.

Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17.


nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta.

Paul EJ, Kalk E, Tossell K, Irvine EE, Franks NP, Wisden W, Withers DJ, Leiper J, Ungless MA.

eNeuro. 2018 Nov 16;5(5). pii: ENEURO.0381-18.2018. doi: 10.1523/ENEURO.0381-18.2018. eCollection 2018 Sep-Oct.


Histamine: neural circuits and new medications.

Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y.

Sleep. 2019 Jan 1;42(1). doi: 10.1093/sleep/zsy183.


A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.

Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP.

Curr Biol. 2018 Jul 23;28(14):2263-2273.e4. doi: 10.1016/j.cub.2018.05.054. Epub 2018 Jul 12.


Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems.

Yu X, Franks NP, Wisden W.

Front Neural Circuits. 2018 Jan 26;12:4. doi: 10.3389/fncir.2018.00004. eCollection 2018. Review.


Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.

Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, Franks NP.

Curr Biol. 2018 Feb 19;28(4):580-587.e5. doi: 10.1016/j.cub.2017.12.050. Epub 2018 Feb 1.


Xenon Protects against Blast-Induced Traumatic Brain Injury in an In Vitro Model.

Campos-Pires R, Koziakova M, Yonis A, Pau A, Macdonald W, Harris K, Edge CJ, Franks NP, Mahoney PF, Dickinson R.

J Neurotrauma. 2018 Apr 15;35(8):1037-1044. doi: 10.1089/neu.2017.5360. Epub 2018 Feb 8.


GABA Receptors and the Pharmacology of Sleep.

Wisden W, Yu X, Franks NP.

Handb Exp Pharmacol. 2017 Oct 10. doi: 10.1007/164_2017_56. [Epub ahead of print]


Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits.

Ye Z, Yu X, Houston CM, Aboukhalil Z, Franks NP, Wisden W, Brickley SG.

Front Cell Neurosci. 2017 Apr 4;11:95. doi: 10.3389/fncel.2017.00095. eCollection 2017.


Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.

Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W.

J Neurosci. 2016 Nov 2;36(44):11171-11184.


Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G.

Br J Pharmacol. 2016 Nov;173(21):3110-3120. doi: 10.1111/bph.13566. Epub 2016 Sep 6.


Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial.

Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD.

Lancet Neurol. 2016 Feb;15(2):145-153. doi: 10.1016/S1474-4422(15)00347-6. Epub 2015 Dec 19.


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G.

Mol Pharmacol. 2015 Oct;88(4):736-45. doi: 10.1124/mol.115.100347. Epub 2015 Jul 23.


Wakefulness Is Governed by GABA and Histamine Cotransmission.

Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W.

Neuron. 2015 Jul 1;87(1):164-78. doi: 10.1016/j.neuron.2015.06.003. Epub 2015 Jun 18.


Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.

Zhang Z, Ferretti V, Güntan İ, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP.

Nat Neurosci. 2015 Apr;18(4):553-561. doi: 10.1038/nn.3957. Epub 2015 Feb 23.


Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels.

MacKenzie G, Franks NP, Brickley SG.

Pflugers Arch. 2015 May;467(5):989-99. doi: 10.1007/s00424-014-1660-6. Epub 2014 Dec 9. Review.


The role of K₂p channels in anaesthesia and sleep.

Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden W.

Pflugers Arch. 2015 May;467(5):907-16. doi: 10.1007/s00424-014-1654-4. Epub 2014 Dec 9. Review.


Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture.

Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W.

Curr Biol. 2014 Dec 1;24(23):2838-44. doi: 10.1016/j.cub.2014.10.019. Epub 2014 Nov 13.


Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics.

Bertaccini EJ, Dickinson R, Trudell JR, Franks NP.

ACS Chem Neurosci. 2014 Dec 17;5(12):1246-52. doi: 10.1021/cn500172e. Epub 2014 Oct 31.


Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia.

Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NP.

J Neurosci. 2014 Oct 1;34(40):13326-35. doi: 10.1523/JNEUROSCI.1519-14.2014.


Xenon improves neurologic outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury.

Campos-Pires R, Armstrong SP, Sebastiani A, Luh C, Gruss M, Radyushkin K, Hirnet T, Werner C, Engelhard K, Franks NP, Thal SC, Dickinson R.

Crit Care Med. 2015 Jan;43(1):149-158. doi: 10.1097/CCM.0000000000000624.


Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep.

Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DW, Vyssotski AL, van Lith HA, Wisden W, Franks NP.

Eur J Neurosci. 2014 Jul;40(1):2311-9. doi: 10.1111/ejn.12570. Epub 2014 Mar 27.


A propofol binding site on mammalian GABAA receptors identified by photolabeling.

Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP.

Nat Chem Biol. 2013 Nov;9(11):715-20. doi: 10.1038/nchembio.1340. Epub 2013 Sep 22.


Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site.

Harris K, Armstrong SP, Campos-Pires R, Kiru L, Franks NP, Dickinson R.

Anesthesiology. 2013 Nov;119(5):1137-48. doi: 10.1097/ALN.0b013e3182a2a265.


Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS.

Anesthesiology. 2012 Dec;117(6):1262-75. doi: 10.1097/ALN.0b013e3182746b81.


GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.

Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W.

J Neurosci. 2012 Sep 19;32(38):13062-75.


Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding.

Armstrong SP, Banks PJ, McKitrick TJ, Geldart CH, Edge CJ, Babla R, Simillis C, Franks NP, Dickinson R.

Anesthesiology. 2012 Jul;117(1):38-47. doi: 10.1097/ALN.0b013e31825ada2e.


Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?

Houston CM, McGee TP, Mackenzie G, Troyano-Cuturi K, Rodriguez PM, Kutsarova E, Diamanti E, Hosie AM, Franks NP, Brickley SG.

J Neurosci. 2012 Mar 14;32(11):3887-97. doi: 10.1523/JNEUROSCI.5406-11.2012.


Sleep and general anesthesia.

Franks NP, Zecharia AY.

Can J Anaesth. 2011 Feb;58(2):139-48. doi: 10.1007/s12630-010-9420-3. Epub 2010 Dec 18. Review.


Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection.

Dickinson R, Franks NP.

Crit Care. 2010;14(4):229. doi: 10.1186/cc9051. Epub 2010 Aug 12. Review.


Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia.

Banks P, Franks NP, Dickinson R.

Anesthesiology. 2010 Mar;112(3):614-22. doi: 10.1097/ALN.0b013e3181cea398.


An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.

Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17546-51. doi: 10.1073/pnas.0907228106. Epub 2009 Sep 24.


General anesthesia and ascending arousal pathways.

Zecharia AY, Franks NP.

Anesthesiology. 2009 Oct;111(4):695-6. doi: 10.1097/ALN.0b013e3181b061bc. No abstract available.


The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse.

Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP.

J Neurosci. 2009 Feb 18;29(7):2177-87. doi: 10.1523/JNEUROSCI.4997-08.2009.


General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal.

Franks NP.

Nat Rev Neurosci. 2008 May;9(5):370-86. doi: 10.1038/nrn2372. Review.


The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury.

Coburn M, Maze M, Franks NP.

Crit Care Med. 2008 Feb;36(2):588-95. doi: 10.1097/01.CCM.0B013E3181611F8A6.


Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology.

Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP.

Anesthesiology. 2007 Nov;107(5):756-67.


Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.

Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP.

J Biol Chem. 2007 Jul 20;282(29):20977-90. Epub 2007 Jun 4.


Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain.

Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M.

Anesthesiology. 2007 Apr;106(4):746-53.


Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel.

Bright DP, Adham SD, Lemaire LC, Benavides R, Gruss M, Taylor GW, Smith EH, Franks NP.

J Biol Chem. 2007 Apr 20;282(16):12038-47. Epub 2007 Feb 20.


The common chemical motifs within anesthetic binding sites.

Bertaccini EJ, Trudell JR, Franks NP.

Anesth Analg. 2007 Feb;104(2):318-24.


Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat.

Martin JL, Ma D, Hossain M, Xu J, Sanders RD, Franks NP, Maze M.

Br J Anaesth. 2007 Feb;98(2):236-40. Epub 2007 Jan 8.


The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study.

Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K.

Anesth Analg. 2006 Dec;103(6):1459-63.


Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models.

Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M.

Neurosci Lett. 2006 Dec 1;409(2):128-33. Epub 2006 Oct 18.


Expansion of gas bubbles by nitrous oxide and xenon.

Benavides R, Maze M, Franks NP.

Anesthesiology. 2006 Feb;104(2):299-302.


Molecular targets underlying general anaesthesia.

Franks NP.

Br J Pharmacol. 2006 Jan;147 Suppl 1:S72-81. Review.


Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.

Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M.

Ann Neurol. 2005 Aug;58(2):182-93.


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