Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 37

1.

Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.

Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR.

Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1.

2.

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.

3.

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.

Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR.

Front Synaptic Neurosci. 2018 Feb 21;10:2. doi: 10.3389/fnsyn.2018.00002. eCollection 2018.

4.

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

J Med Chem. 2017 Jul 27;60(14):6364-6383. doi: 10.1021/acs.jmedchem.7b00561. Epub 2017 Jul 13.

5.

Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias".

Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1628. doi: 10.1021/acschemneuro.7b00157. Epub 2017 May 25. No abstract available.

PMID:
28541028
6.

Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.

McLeod MC, Aubé J, Frankowski KJ.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5689-5694. doi: 10.1016/j.bmcl.2016.10.065. Epub 2016 Oct 22.

PMID:
27839919
7.

Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

Scarry SM, Lovell KM, Frankowski KJ, Bohn LM, Aubé J.

J Org Chem. 2016 Nov 4;81(21):10538-10550. Epub 2016 Aug 2.

8.

Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.

Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen FJ, Frankowski KJ, Marugan J, Zhou Y, Huang S, He C.

Autophagy. 2016 Sep;12(9):1460-71. doi: 10.1080/15548627.2016.1187367. Epub 2016 Jun 15.

9.

Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.

Gui L, Zhang X, Li K, Frankowski KJ, Li S, Wong DE, Moen DR, Porubsky PR, Lin HJ, Schoenen FJ, Chou TF.

ChemMedChem. 2016 May 6;11(9):953-7. doi: 10.1002/cmdc.201600036. Epub 2016 Apr 4.

PMID:
27043824
10.

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization.

Frankowski KJ, Liu R, Milligan GL, Moeller KD, Aubé J.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10555-8. doi: 10.1002/anie.201504775.

11.

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

ACS Comb Sci. 2015 Oct 12;17(10):641-52. doi: 10.1021/acscombsci.5b00101. Epub 2015 Sep 17.

12.

Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.

Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM.

Neuropharmacology. 2015 Dec;99:600-9. doi: 10.1016/j.neuropharm.2015.08.027. Epub 2015 Aug 25.

13.

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.

Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM.

Neuropharmacology. 2015 Dec;99:131-41. doi: 10.1016/j.neuropharm.2015.07.001. Epub 2015 Jul 6.

14.

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN.

ACS Infect Dis. 2015 Mar 13;1(3):140-148.

15.

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Ndjomou J, Corby MJ, Sweeney NL, Hanson AM, Aydin C, Ali A, Schiffer CA, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

ACS Chem Biol. 2015 Aug 21;10(8):1887-96. doi: 10.1021/acschembio.5b00101. Epub 2015 May 22.

16.

Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM.

ACS Chem Neurosci. 2015 Aug 19;6(8):1411-9. doi: 10.1021/acschemneuro.5b00092. Epub 2015 May 1. Erratum in: ACS Chem Neurosci. 2017 Jul 19;8(7):1628.

17.

Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.

Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J.

Bioorg Med Chem. 2015 Jul 15;23(14):3948-56. doi: 10.1016/j.bmc.2014.12.033. Epub 2014 Dec 23.

18.

Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex.

Fang CJ, Gui L, Zhang X, Moen DR, Li K, Frankowski KJ, Lin HJ, Schoenen FJ, Chou TF.

ChemMedChem. 2015 Jan;10(1):52-6. doi: 10.1002/cmdc.201402420. Epub 2014 Nov 6.

19.

Development of functionally selective, small molecule agonists at kappa opioid receptors.

Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM.

J Biol Chem. 2013 Dec 20;288(51):36703-16. doi: 10.1074/jbc.M113.504381. Epub 2013 Nov 1.

20.

Chemotype-selective modes of action of κ-opioid receptor agonists.

Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL.

J Biol Chem. 2013 Nov 29;288(48):34470-83. doi: 10.1074/jbc.M113.515668. Epub 2013 Oct 11.

21.

Hepatitis C Virus NS3 Helicase Inhibitor Discovery.

Li K, Frankowski KJ, Hanson AM, Ndjomou J, Shanahan MA, Mukherjee S, Kolli R, Shadrick WR, Sweeney NL, Belon CA, Neuenswander B, Ferguson J, Aubé J, Schoenen FJ, Blagg BSJ, Frick DN.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Dec 16 [updated 2013 Mar 14].

22.

Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.

Sweeney NL, Shadrick WR, Mukherjee S, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

J Biol Chem. 2013 Jul 5;288(27):19949-57. doi: 10.1074/jbc.M113.463166. Epub 2013 May 23.

23.

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

Chou TF, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ.

ChemMedChem. 2013 Feb;8(2):297-312. doi: 10.1002/cmdc.201200520. Epub 2013 Jan 11.

24.

Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.

Ndjomou J, Kolli R, Mukherjee S, Shadrick WR, Hanson AM, Sweeney NL, Bartczak D, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

Antiviral Res. 2012 Nov;96(2):245-55. doi: 10.1016/j.antiviral.2012.08.006. Epub 2012 Aug 25.

25.

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.

Mukherjee S, Hanson AM, Shadrick WR, Ndjomou J, Sweeney NL, Hernandez JJ, Bartczak D, Li K, Frankowski KJ, Heck JA, Arnold LA, Schoenen FJ, Frick DN.

Nucleic Acids Res. 2012 Sep 1;40(17):8607-21. Epub 2012 Jun 27.

26.

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, Heynen-Genel S, Mangravita-Novo A, Vicchiarelli M, Smith LH, Streicher JM, Caron MG, Barak LS, Bohn LM, Chung TD, Aubé J.

ACS Chem Neurosci. 2012 Mar 21;3(3):221-236. Epub 2012 Jan 20.

27.

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.

Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN.

J Med Chem. 2012 Apr 12;55(7):3319-30. doi: 10.1021/jm300021v. Epub 2012 Mar 22.

28.

Antagonist for the Kappa Opioid Receptor.

Hedrick MP, Gosalia P, Li K, Frankowski KJ, Shi S, Prisinzano TE, Schoenen F, Aubé J, Su Y, Stonich D, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, Heynen-Genel S, Vicchiarelli M, Mangravita-Novo A, Streicher JM, Smith LH, Chung TDY, Caron M, Bohn LM, Barak LS.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Oct 31 [updated 2011 May 26].

29.

Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands.

Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6727-32. doi: 10.1073/pnas.1016558108. Epub 2011 Feb 28. Erratum in: Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15526.

30.

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands.

Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J.

ACS Med Chem Lett. 2010 Aug 12;1(5):189-193.

31.

Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification.

Frankowski KJ, Neuenswander B, Aubé J.

J Comb Chem. 2008 Sep-Oct;10(5):721-5. doi: 10.1021/cc800078h. Epub 2008 Aug 13.

32.

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction.

Frankowski KJ, Golden JE, Zeng Y, Lei Y, Aubé J.

J Am Chem Soc. 2008 May 7;130(18):6018-24. doi: 10.1021/ja800574m. Epub 2008 Apr 9.

33.

Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Nöth J, Frankowski KJ, Neuenswander B, Aubé J, Reiser O.

J Comb Chem. 2008 May-Jun;10(3):456-9. doi: 10.1021/cc700202c. Epub 2008 Mar 14.

34.

Preparation of 2-iodo allylic alcohols from 2-butyn-1,4-diol.

Taber DF, Sikkander MI, Berry JF, Frankowski KJ.

J Org Chem. 2008 Feb 15;73(4):1605-7. doi: 10.1021/jo7021197. Epub 2008 Jan 16.

PMID:
18197678
35.

Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence.

Frankowski KJ, Hirt EE, Zeng Y, Neuenswander B, Fowler D, Schoenen F, Aubé J.

J Comb Chem. 2007 Nov-Dec;9(6):1188-92. Epub 2007 Sep 27.

PMID:
17896822
36.

Synthesis of (+)-sulcatine G.

Taber DF, Frankowski KJ.

J Org Chem. 2005 Aug 5;70(16):6417-21.

PMID:
16050704
37.

Grubbs' catalyst in paraffin: an air-stable preparation for alkene metathesis.

Taber DF, Frankowski KJ.

J Org Chem. 2003 Jul 25;68(15):6047-8.

PMID:
12868947

Supplemental Content

Loading ...
Support Center