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Items: 1 to 50 of 275

1.

Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.

Reuberson J, Horsley H, Franklin RJ, Ford D, Neuss J, Brookings D, Huang Q, Vanderhoydonck B, Gao LJ, Jang MY, Herdewijn P, Ghawalkar A, Fallah-Arani F, Khan AR, Henshall J, Jairaj M, Malcolm S, Ward E, Shuttleworth L, Lin Y, Li S, Louat T, Waer M, Herman J, Payne A, Ceska T, Doyle C, Pitt W, Calmiano M, Augustin M, Steinbacher S, Lammens A, Allen R.

J Med Chem. 2018 Aug 9;61(15):6705-6723. doi: 10.1021/acs.jmedchem.8b00521. Epub 2018 Jul 19.

PMID:
29952567
2.

Clinical implications of myelin regeneration in the central nervous system.

McMurran CE, Kodali S, Young A, Franklin RJ.

Expert Rev Neurother. 2018 Feb;18(2):111-123. doi: 10.1080/14737175.2018.1421458. Epub 2018 Jan 3.

PMID:
29285954
3.

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.

Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ.

Brain. 2018 Jan 1;141(1):85-98. doi: 10.1093/brain/awx312.

PMID:
29244098
4.

Regenerating CNS myelin - from mechanisms to experimental medicines.

Franklin RJM, Ffrench-Constant C.

Nat Rev Neurosci. 2017 Nov 16;18(12):753-769. doi: 10.1038/nrn.2017.136. Review.

PMID:
29142295
5.

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

De La Fuente AG, Lange S, Silva ME, Gonzalez GA, Tempfer H, van Wijngaarden P, Zhao C, Di Canio L, Trost A, Bieler L, Zaunmair P, Rotheneichner P, O'Sullivan A, Couillard-Despres S, Errea O, Mäe MA, Andrae J, He L, Keller A, Bátiz LF, Betsholtz C, Aigner L, Franklin RJM, Rivera FJ.

Cell Rep. 2017 Aug 22;20(8):1755-1764. doi: 10.1016/j.celrep.2017.08.007.

6.

LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination.

Sun D, Yu Z, Fang X, Liu M, Pu Y, Shao Q, Wang D, Zhao X, Huang A, Xiang Z, Zhao C, Franklin RJ, Cao L, He C.

EMBO Rep. 2017 Oct;18(10):1801-1816. doi: 10.15252/embr.201643668. Epub 2017 Aug 14.

7.

Do Not Adjust Your Mind: The Fault Is in Your Glia.

Franklin RJM, Bullmore ET.

Cell Stem Cell. 2017 Aug 3;21(2):155-156. doi: 10.1016/j.stem.2017.07.005.

8.

Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease.

Murphy NA, Franklin RJM.

Prog Brain Res. 2017;231:135-163. doi: 10.1016/bs.pbr.2016.12.013. Epub 2017 Feb 23. Review.

PMID:
28554395
9.

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, González GA, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJM, Nave KA, Kotter MRN.

Acta Neuropathol. 2017 Jul;134(1):167-168. doi: 10.1007/s00401-017-1712-z. No abstract available.

PMID:
28484846
10.

Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression.

Jagielska A, Lowe AL, Makhija E, Wroblewska L, Guck J, Franklin RJM, Shivashankar GV, Van Vliet KJ.

Front Cell Neurosci. 2017 Apr 20;11:93. doi: 10.3389/fncel.2017.00093. eCollection 2017.

11.

Efficient Remyelination Requires DNA Methylation.

Moyon S, Ma D, Huynh JL, Coutts DJC, Zhao C, Casaccia P, Franklin RJM.

eNeuro. 2017 Mar 30;4(2). pii: ENEURO.0336-16.2017. doi: 10.1523/ENEURO.0336-16.2017. eCollection 2017 Mar-Apr.

12.

Regulatory T cells promote myelin regeneration in the central nervous system.

Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC.

Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13.

13.

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

Kazanis I, Evans KA, Andreopoulou E, Dimitriou C, Koutsakis C, Karadottir RT, Franklin RJM.

Stem Cell Reports. 2017 Mar 14;8(3):685-700. doi: 10.1016/j.stemcr.2017.01.007. Epub 2017 Feb 9.

14.

Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin.

Bielecki B, Mattern C, Ghoumari AM, Javaid S, Smietanka K, Abi Ghanem C, Mhaouty-Kodja S, Ghandour MS, Baulieu EE, Franklin RJ, Schumacher M, Traiffort E.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14829-14834. doi: 10.1073/pnas.1614826113. Epub 2016 Dec 7.

15.

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

Schilling F, Ros S, Hu DE, D'Santos P, McGuire S, Mair R, Wright AJ, Mannion E, Franklin RJ, Neves AA, Brindle KM.

Nat Biotechnol. 2017 Jan;35(1):75-80. doi: 10.1038/nbt.3714. Epub 2016 Dec 5.

16.

Electric Signals Regulate the Directional Migration of Oligodendrocyte Progenitor Cells (OPCs) via β1 Integrin.

Zhu B, Nicholls M, Gu Y, Zhang G, Zhao C, Franklin RJ, Song B.

Int J Mol Sci. 2016 Nov 22;17(11). pii: E1948.

17.

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy.

Dhillon RS, Parker J, Syed YA, Edgley S, Young A, Fawcett JW, Jeffery ND, Franklin RJ, Kotter MR.

Acta Neuropathol Commun. 2016 Aug 23;4(1):89. doi: 10.1186/s40478-016-0359-7.

18.

CNS Remyelination and the Innate Immune System.

McMurran CE, Jones CA, Fitzgerald DC, Franklin RJ.

Front Cell Dev Biol. 2016 May 3;4:38. doi: 10.3389/fcell.2016.00038. eCollection 2016. Review.

19.

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, González GA, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJ, Nave KA, Kotter MR.

Acta Neuropathol. 2016 Jul;132(1):157. No abstract available.

20.

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline.

Crawford AH, Tripathi RB, Richardson WD, Franklin RJM.

Cell Rep. 2016 Apr 26;15(4):761-773. doi: 10.1016/j.celrep.2016.03.069. Epub 2016 Apr 14.

21.

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.

Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJM, Fan G, Zhu J, Dupree JL, Casaccia P.

Cell Rep. 2016 Apr 26;15(4):748-760. doi: 10.1016/j.celrep.2016.03.060. Epub 2016 Apr 14.

22.

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination.

Crawford AH, Tripathi RB, Foerster S, McKenzie I, Kougioumtzidou E, Grist M, Richardson WD, Franklin RJ.

Am J Pathol. 2016 Mar;186(3):511-6. doi: 10.1016/j.ajpath.2015.11.005. Epub 2016 Jan 7.

23.

Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes.

Natrajan MS, Komori M, Kosa P, Johnson KR, Wu T, Franklin RJ, Bielekova B.

Ann Clin Transl Neurol. 2015 Oct 27;2(12):1071-84. doi: 10.1002/acn3.260. eCollection 2015 Dec.

24.

Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, González GA, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJM, Nave KA, Kotter MRN.

Acta Neuropathol. 2016 Feb;131(2):281-298. doi: 10.1007/s00401-015-1521-1. Epub 2015 Dec 19. Erratum in: Acta Neuropathol. 2017 Jul;134(1):167-168. Acta Neuropathol. 2016 Jul;132(1):157.

25.

Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.

de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ.

J Cell Biol. 2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119.

26.

Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation.

Ossola B, Zhao C, Compston A, Pluchino S, Franklin RJ, Spillantini MG.

Glia. 2016 Mar;64(3):457-71. doi: 10.1002/glia.22940. Epub 2015 Nov 18.

27.

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nuñez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJ.

Brain. 2015 Dec;138(Pt 12):3581-97. doi: 10.1093/brain/awv289. Epub 2015 Oct 12.

28.

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors.

Gautier HO, Evans KA, Volbracht K, James R, Sitnikov S, Lundgaard I, James F, Lao-Peregrin C, Reynolds R, Franklin RJ, Káradóttir RT.

Nat Commun. 2015 Oct 6;6:8518. doi: 10.1038/ncomms9518.

29.

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models.

Chong CM, Ma D, Zhao C, Franklin RJ, Zhou ZY, Ai N, Li C, Yu H, Hou T, Sa F, Lee SM.

Free Radic Biol Med. 2015 Dec;89:1057-66. doi: 10.1016/j.freeradbiomed.2015.08.013. Epub 2015 Sep 28.

PMID:
26415025
30.

Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination.

Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ.

J Neurosci. 2015 Aug 19;35(33):11482-99. doi: 10.1523/JNEUROSCI.3655-14.2015.

31.

Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination.

Monteiro de Castro G, Deja NA, Ma D, Zhao C, Franklin RJ.

Am J Pathol. 2015 Sep;185(9):2431-40. doi: 10.1016/j.ajpath.2015.05.011. Epub 2015 Jul 17.

32.

Regenerative Medicines for Remyelination: From Aspiration to Reality.

Franklin RJ.

Cell Stem Cell. 2015 Jun 4;16(6):576-7. doi: 10.1016/j.stem.2015.05.010.

33.

Glia Disease and Repair-Remyelination.

Franklin RJ, Goldman SA.

Cold Spring Harb Perspect Biol. 2015 May 18;7(7):a020594. doi: 10.1101/cshperspect.a020594. Review.

34.

Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.

Furusho M, Roulois AJ, Franklin RJ, Bansal R.

Glia. 2015 Oct;63(10):1714-28. doi: 10.1002/glia.22838. Epub 2015 Apr 22.

35.

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.

Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ.

J Neurosci. 2015 Apr 22;35(16):6517-31. doi: 10.1523/JNEUROSCI.5218-14.2015.

36.

Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.

Kazanis I, Feichtner M, Lange S, Rotheneichner P, Hainzl S, Öller M, Schallmoser K, Rohde E, Reitsamer HA, Couillard-Despres S, Bauer HC, Franklin RJ, Aigner L, Rivera FJ.

Exp Neurol. 2015 Jul;269:75-89. doi: 10.1016/j.expneurol.2015.03.018. Epub 2015 Mar 24.

PMID:
25819103
37.

Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.

Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C.

J Neurosci. 2015 Jan 7;35(1):4-20. doi: 10.1523/JNEUROSCI.0849-14.2015.

38.

Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain.

Zhu B, Zhao C, Young FI, Franklin RJ, Song B.

Curr Protoc Stem Cell Biol. 2014 Nov 3;31:2D.17.1-15. doi: 10.1002/9780470151808.sc02d17s31. Review.

PMID:
25366898
39.

The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination.

Stoffels JM, Hoekstra D, Franklin RJ, Baron W, Zhao C.

Glia. 2015 Feb;63(2):242-56. doi: 10.1002/glia.22748. Epub 2014 Aug 25.

40.

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.

Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A.

Nat Commun. 2014 Jul 11;5:4294. doi: 10.1038/ncomms5294.

41.

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR.

Nat Med. 2014 Aug;20(8):954-960. doi: 10.1038/nm.3618. Epub 2014 Jul 6.

42.

Special issue on stem cells: "the end of the beginning".

Franklin RJ, Snyder EY.

Exp Neurol. 2014 Oct;260:1-2. doi: 10.1016/j.expneurol.2014.06.010. Epub 2014 Jun 17. No abstract available.

PMID:
24950181
43.

The VF rat with abnormal myelinogenesis has a mutation in Dopey1.

Tanaka M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T, Kuwamura M.

Glia. 2014 Sep;62(9):1530-42. doi: 10.1002/glia.22698. Epub 2014 May 24.

PMID:
24863653
44.

Multiple sclerosis genetics.

Sawcer S, Franklin RJ, Ban M.

Lancet Neurol. 2014 Jul;13(7):700-9. doi: 10.1016/S1474-4422(14)70041-9. Epub 2014 May 19. Review.

PMID:
24852507
45.

Oligodendrocyte progenitors: adult stem cells of the central nervous system?

Crawford AH, Stockley JH, Tripathi RB, Richardson WD, Franklin RJ.

Exp Neurol. 2014 Oct;260:50-5. doi: 10.1016/j.expneurol.2014.04.027. Epub 2014 May 5. Review.

PMID:
24800913
46.

Auxetic nuclei in embryonic stem cells exiting pluripotency.

Pagliara S, Franze K, McClain CR, Wylde G, Fisher CL, Franklin RJM, Kabla AJ, Keyser UF, Chalut KJ.

Nat Mater. 2014 Jun;13(6):638-644. doi: 10.1038/nmat3943. Epub 2014 Apr 20.

47.

Macrophages and CNS remyelination.

Miron VE, Franklin RJ.

J Neurochem. 2014 Jul;130(2):165-71. doi: 10.1111/jnc.12705. Epub 2014 Mar 26. Review.

48.

Profilin 1 is required for peripheral nervous system myelination.

Montani L, Buerki-Thurnherr T, de Faria JP, Pereira JA, Dias NG, Fernandes R, Gonçalves AF, Braun A, Benninger Y, Böttcher RT, Costell M, Nave KA, Franklin RJ, Meijer D, Suter U, Relvas JB.

Development. 2014 Apr;141(7):1553-61. doi: 10.1242/dev.101840. Epub 2014 Mar 5.

49.

The translational biology of remyelination: past, present, and future.

Franklin RJ, Gallo V.

Glia. 2014 Nov;62(11):1905-15. doi: 10.1002/glia.22622. Epub 2014 Jan 20.

PMID:
24446279
50.

Cell therapy for spinal cord injuries: what is really going on?

Granger N, Franklin RJ, Jeffery ND.

Neuroscientist. 2014 Dec;20(6):623-38. doi: 10.1177/1073858413514635. Epub 2014 Jan 10. Review.

PMID:
24415275

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