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Items: 1 to 50 of 155

1.

Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response.

Allen NC, Philip NH, Hui L, Zhou X, Franklin RA, Kong Y, Medzhitov R.

Sci Signal. 2019 Mar 5;12(571). pii: eaau1851. doi: 10.1126/scisignal.aau1851.

PMID:
30837303
2.

Baseline characteristics of gay and bisexual men in a HIV pre-exposure prophylaxis demonstration project with equity quotas in Auckland, New Zealand.

Saxton PJW, Azariah S, Franklin RA, Forster RF, Werder SF, Jenkins R, Myers JM, Rich JG, Te Wake WP, Fisher MD.

Sex Health. 2019 Feb;16(1):47-55. doi: 10.1071/SH18056.

PMID:
30274568
3.

Endocytosis as a stabilizing mechanism for tissue homeostasis.

Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1926-E1935. doi: 10.1073/pnas.1714377115. Epub 2018 Feb 2.

4.

Circuit Design Features of a Stable Two-Cell System.

Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R.

Cell. 2018 Feb 8;172(4):744-757.e17. doi: 10.1016/j.cell.2018.01.015. Epub 2018 Feb 1.

5.

The physical postures of yoga practices may protect against depressive symptoms, even as life stressors increase: a moderation analysis.

Franklin RA, Butler MP, Bentley JA.

Psychol Health Med. 2018 Aug;23(7):870-879. doi: 10.1080/13548506.2017.1420206. Epub 2018 Jan 8.

PMID:
29308657
6.

Urgent need to strengthen and expand screening and other cancer control programs in the CARICOM Caribbean.

Franklin RA, Simeon DT.

Cancer Causes Control. 2017 Nov;28(11):1177-1185. doi: 10.1007/s10552-017-0912-0. Epub 2017 Jun 26.

PMID:
28649692
7.

Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model.

Franklin RA, Li MO.

Bio Protoc. 2015 Aug 20;5(16). pii: e1567.

8.
9.

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.

Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO.

Cell. 2016 Jan 28;164(3):365-77. doi: 10.1016/j.cell.2016.01.002. Epub 2016 Jan 21.

10.

Comparative Survival of Patients With Anal Adenocarcinoma, Squamous Cell Carcinoma of the Anus, and Rectal Adenocarcinoma.

Franklin RA, Giri S, Valasareddy P, Lands LT, Martin MG.

Clin Colorectal Cancer. 2016 Mar;15(1):47-53. doi: 10.1016/j.clcc.2015.07.007. Epub 2015 Aug 1.

PMID:
26362848
11.

The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation.

Franklin RA, Li MO.

Oncoimmunology. 2014 Dec 13;3(9):e955346. eCollection 2014 Oct.

12.

The cellular and molecular origin of tumor-associated macrophages.

Franklin RA, Liao W, Sarkar A, Kim MV, Bivona MR, Liu K, Pamer EG, Li MO.

Science. 2014 May 23;344(6186):921-5. doi: 10.1126/science.1252510. Epub 2014 May 8.

13.

Effect of submaximal repetitive exercise on knee coactivation in young and middle-aged women.

Hodder JN, Plashkes TE, Franklin RA, Hickey HK, Maly MR.

J Appl Biomech. 2014 Apr;30(2):269-75. doi: 10.1123/jab.2013-0111. Epub 2013 Oct 15.

PMID:
24145898
14.

Signaling intermediates (MAPK and PI3K) as therapeutic targets in NSCLC.

Ciuffreda L, Incani UC, Steelman LS, Abrams SL, Falcone I, Curatolo AD, Chappell WH, Franklin RA, Vari S, Cognetti F, McCubrey JA, Milella M.

Curr Pharm Des. 2014;20(24):3944-57. Review.

PMID:
24138714
15.

Advances in targeting signal transduction pathways.

McCubrey JA, Steelman LS, Chappell WH, Sun L, Davis NM, Abrams SL, Franklin RA, Cocco L, Evangelisti C, Chiarini F, Martelli AM, Libra M, Candido S, Ligresti G, Malaponte G, Mazzarino MC, Fagone P, Donia M, Nicoletti F, Polesel J, Talamini R, Bäsecke J, Mijatovic S, Maksimovic-Ivanic D, Michele M, Tafuri A, Dulińska-Litewka J, Laidler P, D'Assoro AB, Drobot L, Umezawa D, Montalto G, Cervello M, Demidenko ZN.

Oncotarget. 2012 Dec;3(12):1505-21. Review.

16.

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.

Chappell WH, Abrams SL, Franklin RA, LaHair MM, Montalto G, Cervello M, Martelli AM, Nicoletti F, Candido S, Libra M, Polesel J, Talamini R, Milella M, Tafuri A, Steelman LS, McCubrey JA.

Cell Cycle. 2012 Dec 1;11(23):4447-61. doi: 10.4161/cc.22786. Epub 2012 Nov 16.

17.

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.

McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Franklin RA, Montalto G, Cervello M, Libra M, Candido S, Malaponte G, Mazzarino MC, Fagone P, Nicoletti F, Bäsecke J, Mijatovic S, Maksimovic-Ivanic D, Milella M, Tafuri A, Chiarini F, Evangelisti C, Cocco L, Martelli AM.

Oncotarget. 2012 Oct;3(10):1068-111. Review.

18.

Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.

Chappell WH, Abrams SL, Stadelman KM, LaHair MM, Franklin RA, Cocco L, Evangelisti C, Chiarini F, Martelli AM, Steelman LS, McCubrey JA.

Adv Biol Regul. 2013 Jan;53(1):146-55. doi: 10.1016/j.jbior.2012.09.004. Epub 2012 Sep 16. No abstract available.

PMID:
23073564
19.

Population structure, demographic history, and evolutionary patterns of a green-fruited tomato, Solanum peruvianum (Solanaceae), revealed by spatial genetics analyses.

Nakazato T, Franklin RA, Kirk BC, Housworth EA.

Am J Bot. 2012 Jul;99(7):1207-16. doi: 10.3732/ajb.1100210. Epub 2012 Jun 18.

20.

Novel approaches to target cancer initiating cells-eliminating the root of the cancer.

McCubrey JA, Abrams SL, Umezawa K, Cocco L, Martelli AM, Franklin RA, Chappell WH, Steelman LS.

Adv Biol Regul. 2012 Jan;52(1):249-64. Review. No abstract available.

PMID:
21930143
21.

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.

Steelman LS, Navolanic P, Chappell WH, Abrams SL, Wong EW, Martelli AM, Cocco L, Stivala F, Libra M, Nicoletti F, Drobot LB, Franklin RA, McCubrey JA.

Cell Cycle. 2011 Sep 1;10(17):3003-15. Epub 2011 Sep 1.

22.

T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine.

Donkor MK, Sarkar A, Savage PA, Franklin RA, Johnson LK, Jungbluth AA, Allison JP, Li MO.

Immunity. 2011 Jul 22;35(1):123-34. doi: 10.1016/j.immuni.2011.04.019. Epub 2011 Jul 14.

23.

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy.

Sokolosky ML, Stadelman KM, Chappell WH, Abrams SL, Martelli AM, Stivala F, Libra M, Nicoletti F, Drobot LB, Franklin RA, Steelman LS, McCubrey JA.

Oncotarget. 2011 Jul;2(7):538-50.

24.

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, Bäsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA.

Leukemia. 2011 Jul;25(7):1080-94. doi: 10.1038/leu.2011.66. Epub 2011 Apr 15. Review.

PMID:
21494257
25.

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.

Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, Bäsecke J, Stivala F, Donia M, Fagone P, Malaponte G, Mazzarino MC, Nicoletti F, Libra M, Maksimovic-Ivanic D, Mijatovic S, Montalto G, Cervello M, Laidler P, Milella M, Tafuri A, Bonati A, Evangelisti C, Cocco L, Martelli AM, McCubrey JA.

Oncotarget. 2011 Mar;2(3):135-64. Review.

26.

Targeting the cancer initiating cell: the Achilles' heel of cancer.

McCubrey JA, Chappell WH, Abrams SL, Franklin RA, Long JM, Sattler JA, Kempf CR, Laidler P, Steelman LS.

Adv Enzyme Regul. 2011;51(1):152-62. doi: 10.1016/j.advenzreg.2010.09.002. Epub 2010 Oct 28.

PMID:
21035484
27.

The involvement of CaM-KII in insulin induced cell proliferation.

Franklin RA, McCubrey JA.

Cell Cycle. 2009 Jul 1;8(13):1979. Epub 2009 Jul 1. No abstract available.

PMID:
19550154
28.

GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity.

McCubrey JA, Bäsecke J, Cervello M, Martelli AM, Franklin RA.

Cancer Biol Ther. 2008 Jul;7(7):1079. Epub 2008 Jun 27. No abstract available.

PMID:
18698164
29.

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.

McCubrey JA, Sokolosky ML, Lehmann BD, Taylor JR, Navolanic PM, Chappell WH, Abrams SL, Stadelman KM, Wong EW, Misaghian N, Horn S, Bäsecke J, Libra M, Stivala F, Ligresti G, Tafuri A, Milella M, Zarzycki M, Dzugaj A, Chiarini F, Evangelisti C, Martelli AM, Terrian DM, Franklin RA, Steelman LS.

Adv Enzyme Regul. 2008;48:113-35. doi: 10.1016/j.advenzreg.2008.02.006. Epub 2008 Feb 21. No abstract available.

30.

A multipronged approach to prostate cancer.

Franklin RA, McCubrey JA.

Cancer Biol Ther. 2008 Apr;7(4):594-5. Epub 2008 Mar 28. No abstract available.

PMID:
18398294
31.

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

Steelman LS, Navolanic PM, Sokolosky ML, Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Wong EW, Stadelman KM, Terrian DM, Leslie NR, Martelli AM, Stivala F, Libra M, Franklin RA, McCubrey JA.

Oncogene. 2008 Jul 3;27(29):4086-95. doi: 10.1038/onc.2008.49. Epub 2008 Mar 10.

32.

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).

Steelman LS, Navolanic PM, Franklin RA, Bonati A, Libra M, Stivala F, Martelli AM, McCubrey JA.

Mol Med Rep. 2008 Mar-Apr;1(2):139-60.

PMID:
21479390
33.

A novel study of association between Neisseria gonorrhoeae and the human carbohydrate blood groups.

Perry HE, Franklin RA, Bray SJ, Lo MK, Svensson LA, Henry SM.

Immunohematology. 2007;23(3):100-4.

PMID:
18284299
34.

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.

McCubrey JA, Steelman LS, Franklin RA, Abrams SL, Chappell WH, Wong EW, Lehmann BD, Terrian DM, Basecke J, Stivala F, Libra M, Evangelisti C, Martelli AM.

Adv Enzyme Regul. 2007;47:64-103. Epub 2007 Mar 26. No abstract available.

35.

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.

Mitchell C, Park MA, Zhang G, Han SI, Harada H, Franklin RA, Yacoub A, Li PL, Hylemon PB, Grant S, Dent P.

Mol Cancer Ther. 2007 Feb;6(2):618-32.

36.

Polyphenols in breast cancer treatment.

Franklin RA, McCubrey JA.

Cancer Biol Ther. 2007 Jan;6(1):62-3. No abstract available.

PMID:
17224638
37.

EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells.

Garcia R, Franklin RA, McCubrey JA.

Cell Cycle. 2006 Dec;5(23):2820-6. Epub 2006 Dec 1.

PMID:
17172846
38.

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA.

Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7. Review.

39.

Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress.

Franklin RA, Rodriguez-Mora OG, Lahair MM, McCubrey JA.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1807-17. Review.

PMID:
16987033
40.

Reactive oxygen species-induced activation of the MAP kinase signaling pathways.

McCubrey JA, Lahair MM, Franklin RA.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1775-89. Review.

PMID:
16987031
41.

Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.

Lahair MM, Howe CJ, Rodriguez-Mora O, McCubrey JA, Franklin RA.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1749-56.

PMID:
16987028
42.

Reactive oxygen intermediates and signaling through kinase pathways.

McCubrey JA, Franklin RA.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1745-8. No abstract available.

PMID:
16987027
43.

Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors.

Garcia R, Franklin RA, McCubrey JA.

Cell Cycle. 2006 Aug;5(16):1840-6. Epub 2006 Aug 15.

PMID:
16861904
44.

Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells.

Rodriguez-Mora OG, Lahair MM, Evans MJ, Kovacs CJ, Allison RR, Sibata CH, White KS, McCubrey JA, Franklin RA.

Cancer Biol Ther. 2006 Aug;5(8):1022-30. Epub 2006 Aug 18.

PMID:
16855386
45.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
46.

OSU-03012 in the treatment of glioblastoma.

McCubrey JA, Lahair MM, Franklin RA.

Mol Pharmacol. 2006 Aug;70(2):437-9. Epub 2006 May 4.

PMID:
16675657
47.

Two targets are better than one. Promising combination therapy to treat breast cancer.

Franklin RA, Libra M, Stivala F, McCubrey JA.

Cancer Biol Ther. 2005 Nov;4(11):1190-1. Epub 2005 Nov 18. No abstract available.

PMID:
16322681
48.

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

Shelton JG, Steelman LS, Abrams SL, Bertrand FE, Franklin RA, McMahon M, McCubrey JA.

Expert Opin Ther Targets. 2005 Oct;9(5):1009-30. Review.

PMID:
16185155
49.

Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy.

Rodriguez-Mora O, LaHair MM, Howe CJ, McCubrey JA, Franklin RA.

Expert Opin Ther Targets. 2005 Aug;9(4):791-808. Review.

PMID:
16083343

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