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Items: 25

1.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

Voight EA, Gomtsyan AR, Daanen JF, Perner RJ, Schmidt RG, Bayburt EK, DiDomenico S, McDonald HA, Puttfarcken PS, Chen J, Neelands TR, Bianchi BR, Han P, Reilly RM, Franklin PH, Segreti JA, Nelson RA, Su Z, King AJ, Polakowski JS, Baker SJ, Gauvin DM, Lewis LR, Mikusa JP, Joshi SK, Faltynek CR, Kym PR, Kort ME.

J Med Chem. 2014 Sep 11;57(17):7412-24. doi: 10.1021/jm500916t. Epub 2014 Aug 21.

PMID:
25100568
2.

Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.

Reilly RM, McDonald HA, Puttfarcken PS, Joshi SK, Lewis L, Pai M, Franklin PH, Segreti JA, Neelands TR, Han P, Chen J, Mantyh PW, Ghilardi JR, Turner TM, Voight EA, Daanen JF, Schmidt RG, Gomtsyan A, Kort ME, Faltynek CR, Kym PR.

J Pharmacol Exp Ther. 2012 Aug;342(2):416-28. doi: 10.1124/jpet.111.190314. Epub 2012 May 8.

PMID:
22570364
3.

Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition.

Franklin PH, Banfor PN, Tapang P, Segreti JA, Widomski DL, Larson KJ, Noonan WT, Gintant GA, Davidsen SK, Albert DH, Fryer RM, Cox BF.

J Pharmacol Exp Ther. 2009 Jun;329(3):928-37. doi: 10.1124/jpet.108.144816. Epub 2009 Mar 2.

PMID:
19255283
4.

Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet.

Fryer RM, Segreti JA, Widomski DL, Franklin PH, Banfor PN, Koch KA, Nakane M, Wu-Wong JR, Cox BF, Reinhart GA.

J Pharmacol Exp Ther. 2007 Oct;323(1):217-26. Epub 2007 Jul 16.

PMID:
17636005
5.

Dextrorotatory opioids induce stereotyped behavior in Sprague-Dawley and Dark Agouti rats.

Ishmael JE, Franklin PH, Murray TF.

Psychopharmacology (Berl). 1998 Nov;140(2):206-16.

PMID:
9860112
6.

Platelet activation in patients with sickle cell disease.

Wun T, Paglieroni T, Rangaswami A, Franklin PH, Welborn J, Cheung A, Tablin F.

Br J Haematol. 1998 Mar;100(4):741-9.

PMID:
9531343
7.

High level expression of the NMDAR1 glutamate receptor subunit in electroporated COS cells.

Ishmael JE, Franklin PH, Murray TF, Leid M.

J Neurochem. 1996 Oct;67(4):1500-10.

PMID:
8858933
8.
9.

Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680.

Zhang G, Franklin PH, Murray TF.

Eur J Pharmacol. 1994 Apr 1;255(1-3):239-43.

PMID:
8026549
10.

The sigma receptor ligand 1,3-di(2-tolyl)guanidine is anticonvulsant in the rat prepiriform cortex.

Roth JE, Franklin PH, Murray TF.

Eur J Pharmacol. 1993 May 19;236(2):327-31.

PMID:
8319759
11.

Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.

Zhang G, Franklin PH, Murray TF.

J Pharmacol Exp Ther. 1993 Mar;264(3):1415-24.

PMID:
8450475
12.

Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex.

Roth JE, Zhang G, Murray TF, Franklin PH.

Eur J Pharmacol. 1992 May 14;215(2-3):293-6.

PMID:
1327806
13.

Guanyl nucleotides modulate binding to steroid receptors in neuronal membranes.

Orchinik M, Murray TF, Franklin PH, Moore FL.

Proc Natl Acad Sci U S A. 1992 May 1;89(9):3830-4.

15.

A1 adenosine receptors express seizure-suppressant activity in the rat prepiriform cortex.

Murray TF, Franklin PH, Zhang G, Tripp E.

Epilepsy Res Suppl. 1992;8:255-61. No abstract available.

PMID:
1329817
16.

Identification and initial characterization of high-affinity [3H]dextrorphan binding sites in rat brain.

Franklin PH, Murray TF.

Eur J Pharmacol. 1990 Jul 31;189(1):89-93.

PMID:
2226638
17.
18.

Adenosine A1 receptor activation mediates suppression of (-) bicuculline methiodide-induced seizures in rat prepiriform cortex.

Franklin PH, Zhang G, Tripp ED, Murray TF.

J Pharmacol Exp Ther. 1989 Dec;251(3):1229-36.

PMID:
2600813
19.

Activation of adenosine receptors suppresses behavioral seizures induced by kainic acid in the rat prepiriform cortex.

Zhang G, Franklin PH, Murray TF.

Proc West Pharmacol Soc. 1989;32:149. No abstract available.

PMID:
2780579
20.

Adenosine receptor activation blocks seizures induced by bicuculline methiodide in the rat prepiriform cortex.

Franklin PH, Tripp ED, Zhang G, Gale K, Murray TF.

Eur J Pharmacol. 1988 May 20;150(1-2):207-9. No abstract available.

PMID:
3402541
21.

Characterization of low Km GTPase activity in rat brain: comparison of opioid and muscarinic receptor stimulation.

Hoss W, Franklin PH, Ghodsi-Hovsepian S.

J Pharm Sci. 1988 Apr;77(4):353-8.

PMID:
2837568
22.
23.

Characterization of cardiac A1 adenosine receptors with the antagonist radioligand 8-cyclopentyl-1,3[3H]-dipropylxanthine.

Leid M, Franklin PH, Murray TF.

Proc West Pharmacol Soc. 1988;31:103. No abstract available.

PMID:
3211886
24.

Stereospecificity of opiate-stimulated GTPase activity in brain.

Hoss W, Franklin PH.

Neuropeptides. 1984 Dec;5(1-3):185-8. No abstract available.

PMID:
6152320
25.

Opiates stimulate low Km GTPase in brain.

Franklin PH, Hoss W.

J Neurochem. 1984 Oct;43(4):1132-5.

PMID:
6147391

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