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Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer.

Oei AL, Korangath P, Mulka K, Helenius M, Coulter JB, Stewart J, Velarde E, Crezee J, Simons B, Stalpers LJA, Kok HP, Gabrielson K, Franken NAP, Ivkov R.

Int J Hyperthermia. 2019 Nov;36(sup1):47-63. doi: 10.1080/02656736.2019.1685686.


Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia.

Sharma A, Özayral S, Caserto JS, Ten Cate R, Anders NM, Barnett JD, Kandala SK, Henderson E, Stewart J, Liapi E, Rudek MA, Franken NAP, Oei AL, Korangath P, Bunz F, Ivkov R.

Int J Hyperthermia. 2019;36(1):712-720. doi: 10.1080/02656736.2019.1631494.


The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer.

Crezee H, Kok HP, Oei AL, Franken NAP, Stalpers LJA.

Front Oncol. 2019 May 21;9:412. doi: 10.3389/fonc.2019.00412. eCollection 2019. No abstract available.


Variation in Clinical Application of Hyperthermic Intraperitoneal Chemotherapy: A Review.

Helderman RFCPA, Löke DR, Kok HP, Oei AL, Tanis PJ, Franken NAPK, Crezee J.

Cancers (Basel). 2019 Jan 11;11(1). pii: E78. doi: 10.3390/cancers11010078. Review.


Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia.

Elming PB, Sørensen BS, Oei AL, Franken NAP, Crezee J, Overgaard J, Horsman MR.

Cancers (Basel). 2019 Jan 9;11(1). pii: E60. doi: 10.3390/cancers11010060. Review.


Re‑irradiation plus hyperthermia for recurrent pediatric sarcoma; a simulation study to investigate feasibility.

Kok HP, Van Dijk IWEM, Crama KF, Franken NAP, Rasch CRN, Merks JHM, Crezee J, Balgobind BV, Bel A.

Int J Oncol. 2019 Jan;54(1):209-218. doi: 10.3892/ijo.2018.4622. Epub 2018 Nov 2.


Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents.

IJff M, van Oorschot B, Oei AL, Krawczyk PM, Rodermond HM, Stalpers LJA, Kok HP, Crezee J, Franken NAP.

Int J Mol Sci. 2018 Aug 16;19(8). pii: E2420. doi: 10.3390/ijms19082420.


The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies.

van Leeuwen CM, Oei AL, Crezee J, Bel A, Franken NAP, Stalpers LJA, Kok HP.

Radiat Oncol. 2018 May 16;13(1):96. doi: 10.1186/s13014-018-1040-z. Review.


The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose.

van Leeuwen CM, Crezee J, Oei AL, Franken NAP, Stalpers LJA, Bel A, Kok HP.

Int J Hyperthermia. 2018 Nov;34(7):901-909. doi: 10.1080/02656736.2018.1468930. Epub 2018 May 11.


Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition.

Vriend LEM, van den Tempel N, Oei AL, L'Acosta M, Pieterson FJ, Franken NAP, Kanaar R, Krawczyk PM.

Oncotarget. 2017 Oct 27;8(57):97490-97503. doi: 10.18632/oncotarget.22142. eCollection 2017 Nov 14.


The clinical benefit of hyperthermia in pancreatic cancer: a systematic review.

van der Horst A, Versteijne E, Besselink MGH, Daams JG, Bulle EB, Bijlsma MF, Wilmink JW, van Delden OM, van Hooft JE, Franken NAP, van Laarhoven HWM, Crezee J, van Tienhoven G.

Int J Hyperthermia. 2018 Nov;34(7):969-979. doi: 10.1080/02656736.2017.1401126. Epub 2017 Nov 23.


Prof. Johan Broerse 1934-2017.

Franken NA.

Radiat Res. 2017 Nov;188(5):595. doi: 10.1667/RROOJB.1. Epub 2017 Aug 29. No abstract available.


Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i.

Oei AL, Ahire VR, van Leeuwen CM, Ten Cate R, Stalpers LJA, Crezee J, Kok HP, Franken NAP.

Int J Hyperthermia. 2018 Feb;34(1):39-48. doi: 10.1080/02656736.2017.1324642. Epub 2017 May 19.


Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation.

van Leeuwen CM, Oei AL, Ten Cate R, Franken NAP, Bel A, Stalpers LJA, Crezee J, Kok HP.

Int J Hyperthermia. 2018 Feb;34(1):30-38. doi: 10.1080/02656736.2017.1320812. Epub 2017 May 9.


A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer.

van Leeuwen CM, Oei AL, Chin KWTK, Crezee J, Bel A, Westermann AM, Buist MR, Franken NAP, Stalpers LJA, Kok HP.

Radiat Oncol. 2017 Apr 27;12(1):75. doi: 10.1186/s13014-017-0813-0.


Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia.

Oei AL, van Leeuwen CM, Ahire VR, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJA, Crezee J, Kok HP, Krawczyk PM, Kanaar R, Franken NAP.

Oncotarget. 2017 Apr 25;8(17):28116-28124. doi: 10.18632/oncotarget.15922.


Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination.

van Oorschot B, Uitterhoeve L, Oomen I, Ten Cate R, Medema JP, Vrieling H, Stalpers LJ, Moerland PD, Franken NA.

Cancer Res. 2017 Mar 15;77(6):1485-1491. doi: 10.1158/0008-5472.CAN-16-1966. Epub 2017 Jan 20.


Targeting therapy-resistant cancer stem cells by hyperthermia.

Oei AL, Vriend LEM, Krawczyk PM, Horsman MR, Franken NAP, Crezee J.

Int J Hyperthermia. 2017 Jun;33(4):419-427. doi: 10.1080/02656736.2017.1279757. Epub 2017 Feb 2.


3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments.

van Leeuwen CM, Crezee J, Oei AL, Franken NAP, Stalpers LJA, Bel A, Kok HP.

Int J Hyperthermia. 2017 Mar;33(2):160-169. doi: 10.1080/02656736.2016.1241431. Epub 2016 Nov 1.


Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation.

Franken NA, Kok HP, Crezee J, Barendsen GW.

Int J Radiat Biol. 2016 Sep;92(9):521-6. doi: 10.1080/09553002.2016.1206226. Epub 2016 Aug 15.


Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment.

van Oorschot B, Granata G, Di Franco S, Ten Cate R, Rodermond HM, Todaro M, Medema JP, Franken NA.

Oncotarget. 2016 Oct 4;7(40):65504-65513. doi: 10.18632/oncotarget.11798.


Sensitizing thermochemotherapy with a PARP1-inhibitor.

Oei AL, Vriend LE, van Leeuwen CM, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kanaar R, Kok HP, Krawczyk PM, Franken NA.

Oncotarget. 2017 Mar 7;8(10):16303-16312. doi: 10.18632/oncotarget.11422.


Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia.

Bergs JW, Oei AL, Ten Cate R, Rodermond HM, Stalpers LJ, Barendsen GW, Franken NA.

Int J Mol Med. 2016 Jul;38(1):243-50. doi: 10.3892/ijmm.2016.2611. Epub 2016 May 27.


Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer.

Crezee J, van Leeuwen CM, Oei AL, van Heerden LE, Bel A, Stalpers LJ, Ghadjar P, Franken NA, Kok HP.

Radiat Oncol. 2016 Feb 2;11:14. doi: 10.1186/s13014-016-0592-z.


Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.

van Oorschot B, Hovingh S, Dekker A, Stalpers LJ, Franken NA.

Radiat Res. 2016 Feb;185(2):190-8. doi: 10.1667/RR14098.1. Epub 2016 Jan 20.


Thermoradiotherapy planning: Integration in routine clinical practice.

Crezee H, van Leeuwen CM, Oei AL, Stalpers LJ, Bel A, Franken NA, Kok HP.

Int J Hyperthermia. 2016;32(1):41-9. doi: 10.3109/02656736.2015.1110757. Epub 2015 Dec 15. Review.


Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis.

Oei AL, van Leeuwen CM, ten Cate R, Rodermond HM, Buist MR, Stalpers LJ, Crezee J, Kok HP, Medema JP, Franken NA.

Cancer Res. 2015 Dec 1;75(23):5120-9. doi: 10.1158/0008-5472.CAN-15-0816. Epub 2015 Nov 16.


Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.

Oei AL, Vriend LE, Crezee J, Franken NA, Krawczyk PM.

Radiat Oncol. 2015 Aug 7;10:165. doi: 10.1186/s13014-015-0462-0. Review.


The use of equivalent radiation dose in the evaluation of late effects after childhood cancer treatment.

van Dijk IW, van Os RM, van de Kamer JB, Franken NA, van der Pal HJ, Koning CC, Caron HN, Ronckers CM, Kremer LC.

J Cancer Surviv. 2014 Dec;8(4):638-46. doi: 10.1007/s11764-014-0373-3. Epub 2014 Jun 14.


Enhancement of radiation effectiveness by hyperthermia and incorporation of halogenated pyrimidines at low radiation doses as compared with high doses: implications for mechanisms.

Franken NA, Barendsen GW.

Int J Radiat Biol. 2014 Apr;90(4):313-7. doi: 10.3109/09553002.2014.887234. Epub 2014 Mar 19.


Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions.

Kok HP, Crezee J, Franken NA, Stalpers LJ, Barendsen GW, Bel A.

Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):739-45. doi: 10.1016/j.ijrobp.2013.11.212. Epub 2014 Jan 8.


Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity.

van Oorschot B, Hovingh SE, Moerland PD, Medema JP, Stalpers LJ, Vrieling H, Franken NA.

Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):664-70. doi: 10.1016/j.ijrobp.2013.11.219. Epub 2014 Jan 8.


Decay of γ-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells.

Van Oorschot B, Oei AL, Nuijens AC, Rodermond H, Hoeben R, Stap J, Stalpers LJ, Franken NA.

Cell Mol Biol Lett. 2014 Mar;19(1):37-51. doi: 10.2478/s11658-013-0113-0. Epub 2013 Dec 23.


In regard to Ohri N et al.

Franken NA, Barendsen GW.

Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):598. doi: 10.1016/j.ijrobp.2013.04.017. No abstract available.


Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells.

van Oorschot B, Hovingh SE, Rodermond H, Güçlü A, Losekoot N, Geldof AA, Barendsen GW, Stalpers LJ, Franken NA.

Oncol Rep. 2013 Jun;29(6):2175-80. doi: 10.3892/or.2013.2364. Epub 2013 Mar 26.


Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review).

Franken NA, Oei AL, Kok HP, Rodermond HM, Sminia P, Crezee J, Stalpers LJ, Barendsen GW.

Int J Oncol. 2013 May;42(5):1501-15. doi: 10.3892/ijo.2013.1857. Epub 2013 Mar 13. Review.


Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining.

Bergs JW, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, Medema JP, Haveman J, Essers J, van Bree C, Stalpers LJ, Kanaar R, Aten JA, Franken NA.

DNA Repair (Amst). 2013 Jan 1;12(1):38-45. doi: 10.1016/j.dnarep.2012.10.008. Epub 2012 Dec 11.


[Medical and biological consequences of nuclear disasters].

Stalpers LJ, van Dullemen S, Franken NA.

Ned Tijdschr Geneeskd. 2012;156(20):A4394. Review. Dutch.


Chromatin mobility is increased at sites of DNA double-strand breaks.

Krawczyk PM, Borovski T, Stap J, Cijsouw T, ten Cate R, Medema JP, Kanaar R, Franken NA, Aten JA.

J Cell Sci. 2012 May 1;125(Pt 9):2127-33. doi: 10.1242/jcs.089847. Epub 2012 Feb 10.


Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells.

Franken NA, Hovingh S, Ten Cate R, Krawczyk P, Stap J, Hoebe R, Aten J, Barendsen GW.

Oncol Rep. 2012 Mar;27(3):769-74. doi: 10.3892/or.2011.1604. Epub 2011 Dec 21.


Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death.

Franken NA, ten Cate R, Krawczyk PM, Stap J, Haveman J, Aten J, Barendsen GW.

Radiat Oncol. 2011 Jun 8;6:64. doi: 10.1186/1748-717X-6-64.


Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, Ten Hagen TL, Kanaar R, Aten JA.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9851-6. doi: 10.1073/pnas.1101053108. Epub 2011 May 9.


Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines.

Cate RT, Krawczyk P, Stap J, Aten JA, Franken NA.

Oncol Lett. 2010 Jul;1(4):765-769. Epub 2010 Jul 1.


Cyclopentenylcytosine does not enhance cisplatin-induced radiosensitization in human lung tumour cells.

Rodermond HM, Cate RT, Haveman J, VAN Kuilenburg A, Medema JP, VAN Bree C, Franken NA.

Oncol Lett. 2010 May;1(3):537-540. Epub 2010 May 1.


Quantification of the contribution of hyperthermia to results of cervical cancer trials: in regard to Plataniotis and Dale (Int J Radiat Oncol Biol Phys 2009;73:1538-1544).

Crezee J, Barendsen GW, Westermann AM, Hulshof MC, Haveman J, Stalpers LJ, Geijsen ED, Franken NA.

Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):634; author reply 634-5. doi: 10.1016/j.ijrobp.2009.07.008. No abstract available.


PCC and COBRA-FISH a new tool to characterize primary cervical carcinomas: to assess hall-marks and stage specificity.

Darroudi F, Bergs JW, Bezrookove V, Buist MR, Stalpers LJ, Franken NA.

Cancer Lett. 2010 Jan 1;287(1):67-74. doi: 10.1016/j.canlet.2009.05.034. Epub 2009 Jun 23.


Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia.

Bergs JW, Ten Cate R, Rodermond HM, Jaarsma PA, Medema JP, Darroudi F, Buist MR, Stalpers LJ, Haveman J, Van Bree C, Franken NA.

Int J Hyperthermia. 2009 May;25(3):220-8. doi: 10.1080/02656730802665658.


G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage.

van Bree C, Rodermond HM, ten Cate R, de Vos J, Stalpers LJ, Haveman J, Medema JP, Franken NA.

Radiat Res. 2008 Aug;170(2):184-91. doi: 10.1667/RR0845.1.


Chromosome fragments have the potential to predict hyperthermia-induced radio-sensitization in two different human tumor cell lines.

Bergs JW, ten Cate R, Haveman J, Medema JP, Franken NA, van Bree C.

J Radiat Res. 2008 Sep;49(5):465-72. Epub 2008 Apr 15.


Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application.

Bergs JW, Franken NA, Haveman J, Geijsen ED, Crezee J, van Bree C.

Int J Hyperthermia. 2007 Jun;23(4):329-41. Review.


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