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Items: 1 to 50 of 115

1.

Production and Thermal Exchange of Conditional Peptide-MHC I Multimers.

Luimstra JJ, Franken KLMC, Garstka MA, Drijfhout JW, Neefjes J, Ovaa H.

Curr Protoc Immunol. 2019 Sep;126(1):e85. doi: 10.1002/cpim.85.

PMID:
31483102
2.

Application of new host biomarker profiles in quantitative point-of-care tests facilitates leprosy diagnosis in the field.

van Hooij A, van den Eeden S, Richardus R, Tjon Kon Fat E, Wilson L, Franken KLMC, Faber R, Khatun M, Alam K, Sufian Chowdhury A, Richardus JH, Corstjens P, Geluk A.

EBioMedicine. 2019 Sep;47:301-308. doi: 10.1016/j.ebiom.2019.08.009. Epub 2019 Aug 14.

3.

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana.

Adankwah E, Lundtoft C, Güler A, Franken KLMC, Ottenhoff THM, Mayatepek E, Owusu-Dabo E, Phillips RO, Nausch N, Jacobsen M.

Front Immunol. 2019 Jul 3;10:1518. doi: 10.3389/fimmu.2019.01518. eCollection 2019.

4.

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application.

Coppola M, van den Eeden SJF, Robbins N, Wilson L, Franken KLMC, Adams LB, Gillis TP, Ottenhoff THM, Geluk A.

Front Immunol. 2018 Feb 26;9:308. doi: 10.3389/fimmu.2018.00308. eCollection 2018. Review.

5.

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming.

van Dinther D, Veninga H, Iborra S, Borg EGF, Hoogterp L, Olesek K, Beijer MR, Schetters STT, Kalay H, Garcia-Vallejo JJ, Franken KL, Cham LB, Lang KS, van Kooyk Y, Sancho D, Crocker PR, den Haan JMM.

Cell Rep. 2018 Feb 6;22(6):1484-1495. doi: 10.1016/j.celrep.2018.01.021.

6.

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials.

Korbee CJ, Heemskerk MT, Kocev D, van Strijen E, Rabiee O, Franken KLMC, Wilson L, Savage NDL, Džeroski S, Haks MC, Ottenhoff THM.

Nat Commun. 2018 Jan 24;9(1):358. doi: 10.1038/s41467-017-02777-6.

7.

Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia.

Arroyo L, Marín D, Franken KLMC, Ottenhoff THM, Barrera LF.

BMC Infect Dis. 2018 Jan 8;18(1):26. doi: 10.1186/s12879-017-2929-0.

8.

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+ T cells.

Prezzemolo T, van Meijgaarden KE, Franken KLMC, Caccamo N, Dieli F, Ottenhoff THM, Joosten SA.

Eur J Immunol. 2018 Feb;48(2):293-305. doi: 10.1002/eji.201747184. Epub 2017 Dec 15.

9.

Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression.

Coppola M, Arroyo L, van Meijgaarden KE, Franken KL, Geluk A, Barrera LF, Ottenhoff THM.

Tuberculosis (Edinb). 2017 Sep;106:25-32. doi: 10.1016/j.tube.2017.06.001. Epub 2017 Jun 8.

10.

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection.

Kimuda SG, Nalwoga A, Levin J, Franken KL, Ottenhoff TH, Elliott AM, Cose S, Andia-Biraro I.

J Immunol Res. 2017;2017:1593143. doi: 10.1155/2017/1593143. Epub 2017 Feb 1.

11.

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles.

Coppola M, van Meijgaarden KE, Franken KL, Commandeur S, Dolganov G, Kramnik I, Schoolnik GK, Comas I, Lund O, Prins C, van den Eeden SJ, Korsvold GE, Oftung F, Geluk A, Ottenhoff TH.

Sci Rep. 2016 Nov 28;6:37793. doi: 10.1038/srep37793.

12.

The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection.

Panagioti E, Redeker A, van Duikeren S, Franken KL, Drijfhout JW, van der Burg SH, Arens R.

PLoS Pathog. 2016 Sep 16;12(9):e1005895. doi: 10.1371/journal.ppat.1005895. eCollection 2016 Sep.

13.

Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia.

Arroyo L, Rojas M, Franken KL, Ottenhoff TH, Barrera LF.

Clin Vaccine Immunol. 2016 Oct 4;23(10):813-824. Print 2016 Oct.

14.

Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition.

Breman E, Ruben JM, Franken KL, Heemskerk MH, Roelen DL, Claas FH, van Kooten C.

J Immunol Res. 2016;2016:4215684. doi: 10.1155/2016/4215684. Epub 2016 Jun 20.

15.

Dynamics of the T cell response to Mycobacterium tuberculosis DosR and Rpf antigens in a Colombian population of household contacts of recently diagnosed pulmonary tuberculosis patients.

Arroyo L, Rojas M, Ortíz BL, Franken KL, García LF, Ottenhoff TH, Barrera LF.

Tuberculosis (Edinb). 2016 Mar;97:97-107. doi: 10.1016/j.tube.2015.12.008. Epub 2016 Jan 21.

PMID:
26980501
16.

Detection of IgG1 antibodies against Mycobacterium tuberculosis DosR and Rpf antigens in tuberculosis patients before and after chemotherapy.

Mattos AM, Chaves AS, Franken KL, Figueiredo BB, Ferreira AP, Ottenhoff TH, Teixeira HC.

Tuberculosis (Edinb). 2016 Jan;96:65-70. doi: 10.1016/j.tube.2015.11.001. Epub 2015 Nov 30.

PMID:
26786656
17.

IFN-γ and IgA against non-methylated heparin-binding hemagglutinin as markers of protective immunity and latent tuberculosis: Results of a longitudinal study from an endemic setting.

Belay M, Legesse M, Mihret A, Ottenhoff TH, Franken KL, Bjune G, Abebe F.

J Infect. 2016 Feb;72(2):189-200. doi: 10.1016/j.jinf.2015.09.040. Epub 2015 Oct 28.

PMID:
26518056
18.

Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal.

Khadge S, Banu S, Bobosha K, van der Ploeg-van Schip JJ, Goulart IM, Thapa P, Kunwar CB, van Meijgaarden KE, van den Eeden SJ, Wilson L, Kabir S, Dey H, Goulart LR, Lobato J, Carvalho W, Bekele Y, Franken KL, Aseffa A, Spencer JS, Oskam L, Otttenhoff TH, Hagge DA, Geluk A.

BMC Infect Dis. 2015 Oct 28;15:477. doi: 10.1186/s12879-015-1128-0.

19.

Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa.

Corstjens PL, Tjon Kon Fat EM, de Dood CJ, van der Ploeg-van Schip JJ, Franken KL, Chegou NN, Sutherland JS, Howe R, Mihret A, Kassa D, van der Vyver M, Sheehama J, Simukonda F, Mayanja-Kizza H, Ottenhoff TH, Walzl G, Geluk A; AE-TBC consortium.

Clin Biochem. 2016 Jan;49(1-2):22-31. doi: 10.1016/j.clinbiochem.2015.08.013. Epub 2015 Aug 15.

PMID:
26285074
20.

The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.

Welten SP, Redeker A, Franken KL, Oduro JD, Ossendorp F, Čičin-Šain L, Melief CJ, Aichele P, Arens R.

Elife. 2015 Aug 11;4. doi: 10.7554/eLife.07486.

21.

Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis.

Coppola M, van den Eeden SJ, Wilson L, Franken KL, Ottenhoff TH, Geluk A.

Clin Vaccine Immunol. 2015 Sep;22(9):1060-9. doi: 10.1128/CVI.00271-15. Epub 2015 Jul 22.

22.

Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma.

Talebian Yazdi M, Loof NM, Franken KL, Taube C, Oostendorp J, Hiemstra PS, Welters MJ, van der Burg SH.

Cancer Immunol Immunother. 2015 Sep;64(9):1109-21. doi: 10.1007/s00262-015-1716-2. Epub 2015 May 30.

23.

Pro- and anti-inflammatory cytokines against Rv2031 are elevated during latent tuberculosis: a study in cohorts of tuberculosis patients, household contacts and community controls in an endemic setting.

Belay M, Legesse M, Mihret A, Bekele Y, Ottenhoff TH, Franken KL, Bjune G, Abebe F.

PLoS One. 2015 Apr 21;10(4):e0124134. doi: 10.1371/journal.pone.0124134. eCollection 2015.

24.

Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis.

Serra-Vidal MM, Latorre I, Franken KL, Díaz J, de Souza-Galvão ML, Casas I, Maldonado J, Milà C, Solsona J, Jimenez-Fuentes MÁ, Altet N, Lacoma A, Ruiz-Manzano J, Ausina V, Prat C, Ottenhoff TH, Domínguez J.

Front Microbiol. 2014 Oct 8;5:517. doi: 10.3389/fmicb.2014.00517. eCollection 2014.

25.

Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease.

Essone PN, Chegou NN, Loxton AG, Stanley K, Kriel M, van der Spuy G, Franken KL, Ottenhoff TH, Walzl G.

PLoS One. 2014 Jul 15;9(7):e102584. doi: 10.1371/journal.pone.0102584. eCollection 2014.

26.

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method.

Commandeur S, Coppola M, Dijkman K, Friggen AH, van Meijgaarden KE, van den Eeden SJ, Wilson L, van der Ploeg-van Schip JJ, Franken KL, Geluk A, Ottenhoff TH.

PLoS One. 2014 Jun 6;9(6):e99203. doi: 10.1371/journal.pone.0099203. eCollection 2014.

27.

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.

Commandeur S, van den Eeden SJ, Dijkman K, Clark SO, van Meijgaarden KE, Wilson L, Franken KL, Williams A, Christensen D, Ottenhoff TH, Geluk A.

Vaccine. 2014 Jun 17;32(29):3580-8. doi: 10.1016/j.vaccine.2014.05.005. Epub 2014 May 14.

PMID:
24837764
28.

Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae.

Bobosha K, Tjon Kon Fat EM, van den Eeden SJ, Bekele Y, van der Ploeg-van Schip JJ, de Dood CJ, Dijkman K, Franken KL, Wilson L, Aseffa A, Spencer JS, Ottenhoff TH, Corstjens PL, Geluk A.

PLoS Negl Trop Dis. 2014 May 8;8(5):e2845. doi: 10.1371/journal.pntd.0002845. eCollection 2014 May.

29.

The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities.

Assohou-Luty C, Raijmakers R, Benckhuijsen WE, Stammen-Vogelzangs J, de Ru A, van Veelen PA, Franken KL, Drijfhout JW, Pruijn GJ.

Biochim Biophys Acta. 2014 Apr;1844(4):829-36. doi: 10.1016/j.bbapap.2014.02.019. Epub 2014 Mar 2.

PMID:
24594197
30.

Use of resuscitation-promoting factor proteins improves the sensitivity of culture-based tuberculosis testing in special samples.

Huang W, Qi Y, Diao Y, Yang F, Zha X, Ren C, Huang D, Franken KL, Ottenhoff TH, Wu Q, Shen J.

Am J Respir Crit Care Med. 2014 Mar 1;189(5):612-4. doi: 10.1164/rccm.201310-1899LE. No abstract available. Erratum in: Am J Respir Crit Care Med. 2014 May 15;189(10):1287.

PMID:
24579840
31.

Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions.

Geluk A, van Meijgaarden KE, Wilson L, Bobosha K, van der Ploeg-van Schip JJ, van den Eeden SJ, Quinten E, Dijkman K, Franken KL, Haisma EM, Haks MC, van Hees CL, Ottenhoff TH.

J Clin Immunol. 2014 Feb;34(2):245-55. doi: 10.1007/s10875-013-9979-x. Epub 2013 Dec 27.

PMID:
24370984
32.

Interferon-γ responses to Mycobacterium tuberculosis Rpf proteins in contact investigation.

Huang W, Qi Y, Ren C, Wen H, Franken KL, Ottenhoff TH, Shen J.

Tuberculosis (Edinb). 2013 Nov;93(6):612-7. doi: 10.1016/j.tube.2013.08.005. Epub 2013 Aug 17.

PMID:
24053975
33.

Therapeutic immunization and local low-dose tumor irradiation, a reinforcing combination.

Draghiciu O, Walczak M, Hoogeboom BN, Franken KL, Melief KJ, Nijman HW, Daemen T.

Int J Cancer. 2014 Feb 15;134(4):859-72. doi: 10.1002/ijc.28418. Epub 2013 Sep 4.

34.
35.

CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.

Welten SP, Redeker A, Franken KL, Benedict CA, Yagita H, Wensveen FM, Borst J, Melief CJ, van Lier RA, van Gisbergen KP, Arens R.

J Virol. 2013 Jun;87(12):6851-65. doi: 10.1128/JVI.03305-12. Epub 2013 Apr 10.

36.

An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection.

Commandeur S, van Meijgaarden KE, Prins C, Pichugin AV, Dijkman K, van den Eeden SJ, Friggen AH, Franken KL, Dolganov G, Kramnik I, Schoolnik GK, Oftung F, Korsvold GE, Geluk A, Ottenhoff TH.

J Immunol. 2013 Feb 15;190(4):1659-71. doi: 10.4049/jimmunol.1201593. Epub 2013 Jan 14.

37.

Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal.

Bobosha K, Tang ST, van der Ploeg-van Schip JJ, Bekele Y, Martins MV, Lund O, Franken KL, Khadge S, Pontes MA, Gonçalves Hde S, Hussien J, Thapa P, Kunwar CB, Hagge DA, Aseffa A, Pessolani MC, Pereira GM, Ottenhoff TH, Geluk A.

Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:112-23.

38.

A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice.

Geluk A, van den Eeden SJ, van Meijgaarden KE, Dijkman K, Franken KL, Ottenhoff TH.

Vaccine. 2012 Dec 14;30(52):7513-21. doi: 10.1016/j.vaccine.2012.10.045. Epub 2012 Oct 24.

PMID:
23103299
39.

Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis.

Kassa D, Ran L, Geberemeskel W, Tebeje M, Alemu A, Selase A, Tegbaru B, Franken KL, Friggen AH, van Meijgaarden KE, Ottenhoff TH, Wolday D, Messele T, van Baarle D.

Clin Vaccine Immunol. 2012 Dec;19(12):1907-15. doi: 10.1128/CVI.00482-12. Epub 2012 Sep 26.

40.

The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study.

Singh SK, Tummers B, Schumacher TN, Gomez R, Franken KL, Verdegaal EM, Laske K, Gouttefangeas C, Ottensmeier C, Welters MJ, Britten CM, van der Burg SH.

Cancer Immunol Immunother. 2013 Mar;62(3):489-501. doi: 10.1007/s00262-012-1351-0. Epub 2012 Sep 18.

41.

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.

Abreu JR, Martina S, Verrijn Stuart AA, Fillié YE, Franken KL, Drijfhout JW, Roep BO.

Clin Exp Immunol. 2012 Oct;170(1):57-65. doi: 10.1111/j.1365-2249.2012.04635.x.

42.

Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.

Chegou NN, Essone PN, Loxton AG, Stanley K, Black GF, van der Spuy GD, van Helden PD, Franken KL, Parida SK, Klein MR, Kaufmann SH, Ottenhoff TH, Walzl G.

PLoS One. 2012;7(6):e38501. doi: 10.1371/journal.pone.0038501. Epub 2012 Jun 5. Erratum in: PLoS One. 2012;7(8). doi:10.1371/annotation/bc36a9c6-d5c0-4d55-bc92-9ce4a07b4f70.

43.

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.

Geluk A, Bobosha K, van der Ploeg-van Schip JJ, Spencer JS, Banu S, Martins MV, Cho SN, Franken KL, Kim HJ, Bekele Y, Uddin MK, Hadi SA, Aseffa A, Pessolani MC, Pereira GM, Dockrell HM, Ottenhoff TH.

J Immunol. 2012 May 15;188(10):4782-91. doi: 10.4049/jimmunol.1103452. Epub 2012 Apr 13.

44.

Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa.

Bobosha K, Van Der Ploeg-Van Schip JJ, Zewdie M, Sapkota BR, Hagge DA, Franken KL, Inbiale W, Aseffa A, Ottenhoff TH, Geluk A.

Lepr Rev. 2011 Dec;82(4):445-58.

PMID:
22439283
45.

Development of a mouse food pad model for detection of sub clinical leprosy.

Lahiri R, Randhawa B, Franken KL, Duthie MS, Spencer JS, Geluk A, Krahenbuhl JL.

Lepr Rev. 2011 Dec;82(4):432-44.

PMID:
22439282
46.

Cytokine responses to Mycobacterium leprae unique proteins differentiate between Mycobacterium leprae infected and naive armadillos.

Pena M, Geluk A, Van Der Ploeg-Van Schip JJ, Franken KL, Sharma R, Truman R.

Lepr Rev. 2011 Dec;82(4):422-31.

PMID:
22439281
47.

Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls.

Bobosha K, van der Ploeg-van Schip JJ, Esquenazi DA, Guimarães MM, Martins MV, Bekele Y, Fantahun Y, Aseffa A, Franken KL, Gismondi RC, Pessolani MC, Ottenhoff TH, Pereira GM, Geluk A.

J Trop Med. 2012;2012:132049. doi: 10.1155/2012/132049. Epub 2012 Jan 29.

48.

Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting.

Chegou NN, Black GF, Loxton AG, Stanley K, Essone PN, Klein MR, Parida SK, Kaufmann SH, Doherty TM, Friggen AH, Franken KL, Ottenhoff TH, Walzl G.

BMC Infect Dis. 2012 Jan 20;12:10. doi: 10.1186/1471-2334-12-10.

49.

T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia.

Riaño F, Arroyo L, París S, Rojas M, Friggen AH, van Meijgaarden KE, Franken KL, Ottenhoff TH, García LF, Barrera LF.

Tuberculosis (Edinb). 2012 Mar;92(2):148-59. doi: 10.1016/j.tube.2011.12.005. Epub 2012 Jan 5.

PMID:
22226907
50.

Simultaneous immunization against tuberculosis.

Tchilian EZ, Ronan EO, de Lara C, Lee LN, Franken KL, Vordermeier MH, Ottenhoff TH, Beverley PC.

PLoS One. 2011;6(11):e27477. doi: 10.1371/journal.pone.0027477. Epub 2011 Nov 16.

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