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Items: 1 to 50 of 134


PRAS: Predicting functional targets of RNA binding proteins based on CLIP-seq peaks.

Lin J, Zhang Y, Frankel WN, Ouyang Z.

PLoS Comput Biol. 2019 Aug 19;15(8):e1007227. doi: 10.1371/journal.pcbi.1007227. eCollection 2019 Aug.


meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays.

Gelfman S, Wang Q, Lu YF, Hall D, Bostick CD, Dhindsa R, Halvorsen M, McSweeney KM, Cotterill E, Edinburgh T, Beaumont MA, Frankel WN, Petrovski S, Allen AS, Boland MJ, Goldstein DB, Eglen SJ.

PLoS Comput Biol. 2018 Oct 1;14(10):e1006506. doi: 10.1371/journal.pcbi.1006506. eCollection 2018 Oct.


KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM.

Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15.


Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks.

McSweeney KM, Gussow AB, Bradrick SS, Dugger SA, Gelfman S, Wang Q, Petrovski S, Frankel WN, Boland MJ, Goldstein DB.

Genome Res. 2016 Oct;26(10):1411-1416. Epub 2016 Aug 11.


Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.

Asinof S, Mahaffey C, Beyer B, Frankel WN, Boumil R.

Neurobiol Dis. 2016 Nov;95:1-11. doi: 10.1016/j.nbd.2016.06.014. Epub 2016 Jun 28.


Epileptic encephalopathy-causing mutations in DNM1 impair synaptic vesicle endocytosis.

Dhindsa RS, Bradrick SS, Yao X, Heinzen EL, Petrovski S, Krueger BJ, Johnson MR, Frankel WN, Petrou S, Boumil RM, Goldstein DB.

Neurol Genet. 2015 Apr 17;1(1):e4. doi: 10.1212/01.NXG.0000464295.65736.da. eCollection 2015 Jun.


Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy.

Asinof SK, Sukoff Rizzo SJ, Buckley AR, Beyer BJ, Letts VA, Frankel WN, Boumil RM.

PLoS Genet. 2015 Jun 30;11(6):e1005347. doi: 10.1371/journal.pgen.1005347. eCollection 2015 Jun.


DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR.

PLoS One. 2015 May 1;10(5):e0125897. doi: 10.1371/journal.pone.0125897. eCollection 2015.


SWDreader: a wavelet-based algorithm using spectral phase to characterize spike-wave morphological variation in genetic models of absence epilepsy.

Richard CD, Tanenbaum A, Audit B, Arneodo A, Khalil A, Frankel WN.

J Neurosci Methods. 2015 Mar 15;242:127-40. doi: 10.1016/j.jneumeth.2014.12.016. Epub 2014 Dec 27.


A genetic interaction network model of a complex neurological disease.

Tyler AL, McGarr TC, Beyer BJ, Frankel WN, Carter GW.

Genes Brain Behav. 2014 Nov;13(8):831-40. doi: 10.1111/gbb.12178. Epub 2014 Oct 27.


Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy.

Frankel WN, Mahaffey CL, McGarr TC, Beyer BJ, Letts VA.

PLoS Genet. 2014 Jul 10;10(7):e1004454. doi: 10.1371/journal.pgen.1004454. eCollection 2014 Jul.


Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL Jr.

Epilepsia. 2014 Aug;55(8):1274-83. doi: 10.1111/epi.12657. Epub 2014 May 23.


Hidden in plain sight: spike-wave discharges in mouse inbred strains.

Letts VA, Beyer BJ, Frankel WN.

Genes Brain Behav. 2014 Jul;13(6):519-26. doi: 10.1111/gbb.12142. Epub 2014 Jun 16.


Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy.

Oliva MK, McGarr TC, Beyer BJ, Gazina E, Kaplan DI, Cordeiro L, Thomas E, Dib-Hajj SD, Waxman SG, Frankel WN, Petrou S.

Neurobiol Dis. 2014 Jul;67:180-90. doi: 10.1016/j.nbd.2014.03.007. Epub 2014 Mar 19.


Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures.

Zhang W, Peterson M, Beyer B, Frankel WN, Zhang ZW.

J Neurosci. 2014 Feb 12;34(7):2754-63. doi: 10.1523/JNEUROSCI.4900-12.2014.


Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.

Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.

J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014.


Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development.

Park HJ, Hong M, Bronson RT, Israel MA, Frankel WN, Yun K.

Stem Cells. 2013 May;31(5):1010-21. doi: 10.1002/stem.1351.


CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.

Wagnon JL, Briese M, Sun W, Mahaffey CL, Curk T, Rot G, Ule J, Frankel WN.

PLoS Genet. 2012;8(11):e1003067. doi: 10.1371/journal.pgen.1003067. Epub 2012 Nov 29.


Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.

Sun W, Wagnon JL, Mahaffey CL, Briese M, Ule J, Frankel WN.

J Physiol. 2013 Jan 1;591(1):241-55. doi: 10.1113/jphysiol.2012.240168. Epub 2012 Oct 22.


The genomic landscape shaped by selection on transposable elements across 18 mouse strains.

Nellåker C, Keane TM, Yalcin B, Wong K, Agam A, Belgard TG, Flint J, Adams DJ, Frankel WN, Ponting CP.

Genome Biol. 2012 Jun 15;13(6):R45. doi: 10.1186/gb-2012-13-6-r45.


A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy.

Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR.

Nat Neurosci. 2011 Aug 21;14(9):1167-73. doi: 10.1038/nn.2896.


Etiology of a genetically complex seizure disorder in Celf4 mutant mice.

Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT, Frankel WN.

Genes Brain Behav. 2011 Oct;10(7):765-77. doi: 10.1111/j.1601-183X.2011.00717.x. Epub 2011 Aug 3.


A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.

Tokuda S, Mahaffey CL, Monks B, Faulkner CR, Birnbaum MJ, Danzer SC, Frankel WN.

Hum Mol Genet. 2011 Mar 1;20(5):988-99. doi: 10.1093/hmg/ddq544. Epub 2010 Dec 15.


Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

Hawkins NA, Martin MS, Frankel WN, Kearney JA, Escayg A.

Neurobiol Dis. 2011 Mar;41(3):655-60. doi: 10.1016/j.nbd.2010.11.016. Epub 2010 Dec 13.


A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.

Boumil RM, Letts VA, Roberts MC, Lenz C, Mahaffey CL, Zhang ZW, Moser T, Frankel WN.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001046. doi: 10.1371/journal.pgen.1001046.


Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats.

Frankel WN.

Trends Genet. 2009 Aug;25(8):361-7. doi: 10.1016/j.tig.2009.07.001. Epub 2009 Aug 6. Review.


Szt2, a novel gene for seizure threshold in mice.

Frankel WN, Yang Y, Mahaffey CL, Beyer BJ, O'Brien TP.

Genes Brain Behav. 2009 Jul;8(5):568-76. doi: 10.1111/j.1601-183X.2009.00509.x.


Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice.

Papale LA, Beyer B, Jones JM, Sharkey LM, Tufik S, Epstein M, Letts VA, Meisler MH, Frankel WN, Escayg A.

Hum Mol Genet. 2009 May 1;18(9):1633-41. doi: 10.1093/hmg/ddp081. Epub 2009 Mar 2.


Genetic complexity of absence seizures in substrains of C3H mice.

Tokuda S, Beyer BJ, Frankel WN.

Genes Brain Behav. 2009 Apr;8(3):283-9. doi: 10.1111/j.1601-183X.2008.00472.x. Epub 2009 Dec 17.


A targeted deleterious allele of the splicing factor SCNM1 in the mouse.

Howell VM, de Haan G, Bergren S, Jones JM, Culiat CT, Michaud EJ, Frankel WN, Meisler MH.

Genetics. 2008 Nov;180(3):1419-27. doi: 10.1534/genetics.108.094227. Epub 2008 Sep 14.


PLoS Genetics turns three: looking back, looking ahead.

Frankel WN, Barsh GS.

PLoS Genet. 2008 Jul 25;4(7):e1000135. doi: 10.1371/journal.pgen.1000135. No abstract available.


Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies.

Miki T, Zwingman TA, Wakamori M, Lutz CM, Cook SA, Hosford DA, Herrup K, Fletcher CF, Mori Y, Frankel WN, Letts VA.

Neuroscience. 2008 Jul 31;155(1):31-44. doi: 10.1016/j.neuroscience.2008.05.028. Epub 2008 Jul 1.


Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4.

Beyer B, Deleuze C, Letts VA, Mahaffey CL, Boumil RM, Lew TA, Huguenard JR, Frankel WN.

Hum Mol Genet. 2008 Jun 15;17(12):1738-49. doi: 10.1093/hmg/ddn064. Epub 2008 Mar 3.


Complex seizure disorder caused by Brunol4 deficiency in mice.

Yang Y, Mahaffey CL, Bérubé N, Maddatu TP, Cox GA, Frankel WN.

PLoS Genet. 2007 Jul;3(7):e124.


Introducing PLoS Genetics.

Frankel WN.

PLoS Genet. 2005 Jul 25;1(1):e21. No abstract available.


Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse.

Yang Y, Mahaffey CL, Bérubé N, Frankel WN.

J Biol Chem. 2006 Aug 4;281(31):22352-9. Epub 2006 Jun 2.


Auditory brainstem responses in 10 inbred strains of mice.

Zhou X, Jen PH, Seburn KL, Frankel WN, Zheng QY.

Brain Res. 2006 May 26;1091(1):16-26. Epub 2006 Mar 3.


Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2.

Kearney JA, Yang Y, Beyer B, Bergren SK, Claes L, Dejonghe P, Frankel WN.

Hum Mol Genet. 2006 Mar 15;15(6):1043-8. Epub 2006 Feb 7.


A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis.

Sher RB, Aoyama C, Huebsch KA, Ji S, Kerner J, Yang Y, Frankel WN, Hoppel CL, Wood PA, Vance DE, Cox GA.

J Biol Chem. 2006 Feb 24;281(8):4938-48. Epub 2005 Dec 21.


An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.

Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M.

J Cell Biol. 2005 Aug 15;170(4):607-18.


Gait analysis detects early changes in transgenic SOD1(G93A) mice.

Wooley CM, Sher RB, Kale A, Frankel WN, Cox GA, Seburn KL.

Muscle Nerve. 2005 Jul;32(1):43-50.


Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.

Frankel WN, Beyer B, Maxwell CR, Pretel S, Letts VA, Siegel SJ.

J Neurosci. 2005 Mar 30;25(13):3452-8.


Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice.

Yang Y, Mahaffey CL, Bérubé N, Nystuen A, Frankel WN.

Exp Cell Res. 2005 Mar 10;304(1):50-8. Epub 2004 Dec 10.


A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice.

Letts VA, Mahaffey CL, Beyer B, Frankel WN.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2123-8. Epub 2005 Jan 26.


Implementing large-scale ENU mutagenesis screens in North America.

Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ.

Genetica. 2004 Sep;122(1):51-64. Review.


Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function.

Goldowitz D, Frankel WN, Takahashi JS, Holtz-Vitaterna M, Bult C, Kibbe WA, Snoddy J, Li Y, Pretel S, Yates J, Swanson DJ.

Brain Res Mol Brain Res. 2004 Dec 20;132(2):105-15. Review.


Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.

Concepcion D, Seburn KL, Wen G, Frankel WN, Hamilton BA.

Genetics. 2004 Oct;168(2):953-9.


Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.

Kitami T, Ernest S, Gallaugher L, Friedman L, Frankel WN, Nadeau JH.

Mamm Genome. 2004 Sep;15(9):698-703.


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