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Multinucleated stromal giant cells in the gastroesophageal junctional and gastric mucosa: a retrospective study.

Sachak T, Frankel WL, Arnold CA, Chen W.

Diagn Pathol. 2019 Jul 27;14(1):83. doi: 10.1186/s13000-019-0860-y.


"Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome"-reply.

Pearlman R, Hemminger J, Hampel H, Frankel WL.

Hum Pathol. 2019 Jul;89:116-117. doi: 10.1016/j.humpath.2019.04.017. Epub 2019 May 7. No abstract available.


Clinical characteristics of patients with colorectal cancer with double somatic mismatch repair mutations compared with Lynch syndrome.

Pearlman R, Haraldsdottir S, de la Chapelle A, Jonasson JG, Liyanarachchi S, Frankel WL, Rafnar T, Stefansson K, Pritchard CC, Hampel H.

J Med Genet. 2019 Jul;56(7):462-470. doi: 10.1136/jmedgenet-2018-105698. Epub 2019 Mar 15.


Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Genutis LK, Tomsic J, Bundschuh RA, Brock PL, Williams MD, Roychowdhury S, Reeser JW, Frankel WL, Alsomali M, Routbort MJ, Broaddus RR, Wakely PE Jr, Phay JE, Walker CJ, de la Chapelle A.

Thyroid. 2019 Apr;29(4):523-529. doi: 10.1089/thy.2018.0655. Epub 2019 Mar 27.


A practical guide to biomarkers for the evaluation of colorectal cancer.

Chen W, Frankel WL.

Mod Pathol. 2019 Jan;32(Suppl 1):1-15. doi: 10.1038/s41379-018-0136-1. Epub 2019 Jan 2. Review.


Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.

Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC.

Life Sci Alliance. 2018 Oct 26;1(5):e201800190. doi: 10.26508/lsa.201800190. eCollection 2018 Oct.


miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.

Fassan M, Cui R, Gasparini P, Mescoli C, Guzzardo V, Vicentini C, Munari G, Loupakis F, Lonardi S, Braconi C, Scarpa M, D'Angelo E, Pucciarelli S, Angriman I, Agostini M, D'Incá R, Farinati F, Gafà R, Lanza G, Frankel WL, Croce CM, Valeri N, Rugge M.

Transl Oncol. 2019 Feb;12(2):282-291. doi: 10.1016/j.tranon.2018.10.013. Epub 2018 Nov 16.


Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency.

Pearlman R, Markow M, Knight D, Chen W, Arnold CA, Pritchard CC, Hampel H, Frankel WL.

Mod Pathol. 2018 Dec;31(12):1891-1900. doi: 10.1038/s41379-018-0058-y. Epub 2018 Jul 2.


Crystal-storing Histiocytosis in the Stomach: A Clue to Subtle Hematolymphoid Malignancies.

Arnold CA, Frankel WL, Guo L, Krishnan C, Pfeil S, Schumacher M, Voltaggio L, Yearsley MM, Chen W.

Am J Surg Pathol. 2018 Oct;42(10):1317-1324. doi: 10.1097/PAS.0000000000001097.


Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome.

Hemminger JA, Pearlman R, Haraldsdottir S, Knight D, Jonasson JG, Pritchard CC, Hampel H, Frankel WL.

Hum Pathol. 2018 Aug;78:125-130. doi: 10.1016/j.humpath.2018.04.017. Epub 2018 May 1.


Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer.

Hampel H, Pearlman R, Beightol M, Zhao W, Jones D, Frankel WL, Goodfellow PJ, Yilmaz A, Miller K, Bacher J, Jacobson A, Paskett E, Shields PG, Goldberg RM, de la Chapelle A, Shirts BH, Pritchard CC; Ohio Colorectal Cancer Prevention Initiative Study Group.

JAMA Oncol. 2018 Jun 1;4(6):806-813. doi: 10.1001/jamaoncol.2018.0104. Erratum in: JAMA Oncol. 2018 Jun 1;4(6):891.


Lymph Node Metastasis in Colorectal Cancer.

Jin M, Frankel WL.

Surg Oncol Clin N Am. 2018 Apr;27(2):401-412. doi: 10.1016/j.soc.2017.11.011. Epub 2017 Dec 15. Review.


Dual Stain With SATB2 and CK20/Villin Is Useful to Distinguish Colorectal Carcinomas From Other Tumors.

Li Z, Rock JB, Roth R, Lehman A, Marsh WL, Suarez A, Frankel WL.

Am J Clin Pathol. 2018 Feb 17;149(3):241-246. doi: 10.1093/ajcp/aqx160.


Colorectal Carcinomas With Isolated Loss of PMS2 Staining by Immunohistochemistry.

Alpert L, Pai RK, Srivastava A, McKinnon W, Wilcox R, Yantiss RK, Arcega R, Wang HL, Robert ME, Liu X, Pai RK, Zhao L, Westerhoff M, Hampel H, Kupfer S, Setia N, Xiao SY, Hart J, Frankel WL.

Arch Pathol Lab Med. 2018 Apr;142(4):523-528. doi: 10.5858/arpa.2017-0156-OA. Epub 2018 Jan 16.


Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.

Hankey W, Frankel WL, Groden J.

Cancer Metastasis Rev. 2018 Mar;37(1):159-172. doi: 10.1007/s10555-017-9725-6. Review.


Immunohistochemical Pitfalls: Common Mistakes in the Evaluation of Lynch Syndrome.

Markow M, Chen W, Frankel WL.

Surg Pathol Clin. 2017 Dec;10(4):977-1007. doi: 10.1016/j.path.2017.07.012. Review.


Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival.

Cosgrove CM, Cohn DE, Hampel H, Frankel WL, Jones D, McElroy JP, Suarez AA, Zhao W, Chen W, Salani R, Copeland LJ, O'Malley DM, Fowler JM, Yilmaz A, Chassen AS, Pearlman R, Goodfellow PJ, Backes FJ.

Gynecol Oncol. 2017 Sep;146(3):588-595. doi: 10.1016/j.ygyno.2017.07.003. Epub 2017 Jul 11.


Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2.

Haraldsdottir S, Rafnar T, Frankel WL, Einarsdottir S, Sigurdsson A, Hampel H, Snaebjornsson P, Masson G, Weng D, Arngrimsson R, Kehr B, Yilmaz A, Haraldsson S, Sulem P, Stefansson T, Shields PG, Sigurdsson F, Bekaii-Saab T, Moller PH, Steinarsdottir M, Alexiusdottir K, Hitchins M, Pritchard CC, de la Chapelle A, Jonasson JG, Goldberg RM, Stefansson K.

Nat Commun. 2017 May 3;8:14755. doi: 10.1038/ncomms14755.


Dual Immunostain With SATB2 and CK20 Differentiates Appendiceal Mucinous Neoplasms From Ovarian Mucinous Neoplasms.

Li Z, Roth R, Rock JB, Lehman A, Marsh WL, Suarez A, Frankel WL.

Am J Clin Pathol. 2017 May 1;147(5):484-491. doi: 10.1093/ajcp/aqx023.


Molecular genetics of microsatellite-unstable colorectal cancer for pathologists.

Chen W, Swanson BJ, Frankel WL.

Diagn Pathol. 2017 Mar 4;12(1):24. doi: 10.1186/s13000-017-0613-8. Review.


Challenges to "Classic" Esophageal Candidiasis: Looks Are Usually Deceiving.

Alsomali MI, Arnold MA, Frankel WL, Graham RP, Hart PA, Lam-Himlin DM, Naini BV, Voltaggio L, Arnold CA.

Am J Clin Pathol. 2017 Jan 1;147(1):33-42. doi: 10.1093/ajcp/aqw210.


Reply to L. Casadaban et al.

Niedzwiecki D, Frankel WL, Venook AP, Ye X, Friedman PN, Goldberg RM, Mayer RJ, Colacchio TA, Mulligan JM, Davison TS, O'Brien E, Kerr P, Johnston PG, Kennedy RD, Harkin DP, Schilsky RL, Bertagnolli MM, Warren RS, Innocenti F.

J Clin Oncol. 2017 Apr 20;35(12):1373-1374. doi: 10.1200/JCO.2016.71.2646. Epub 2017 Jan 23. No abstract available.


Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.

Shaddy SM, Arnold MA, Shilo K, Frankel WL, Harzman AE, Stanich PP, Singhi AD, Yearsley MM, Arnold CA.

Am J Surg Pathol. 2017 Apr;41(4):564-569. doi: 10.1097/PAS.0000000000000790.


Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model.

Teng KY, Han J, Zhang X, Hsu SH, He S, Wani NA, Barajas JM, Snyder LA, Frankel WL, Caligiuri MA, Jacob ST, Yu J, Ghoshal K.

Mol Cancer Ther. 2017 Feb;16(2):312-322. doi: 10.1158/1535-7163.MCT-16-0124. Epub 2016 Dec 15.


Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.

Pearlman R, Frankel WL, Swanson B, Zhao W, Yilmaz A, Miller K, Bacher J, Bigley C, Nelsen L, Goodfellow PJ, Goldberg RM, Paskett E, Shields PG, Freudenheim JL, Stanich PP, Lattimer I, Arnold M, Liyanarachchi S, Kalady M, Heald B, Greenwood C, Paquette I, Prues M, Draper DJ, Lindeman C, Kuebler JP, Reynolds K, Brell JM, Shaper AA, Mahesh S, Buie N, Weeman K, Shine K, Haut M, Edwards J, Bastola S, Wickham K, Khanduja KS, Zacks R, Pritchard CC, Shirts BH, Jacobson A, Allen B, de la Chapelle A, Hampel H; Ohio Colorectal Cancer Prevention Initiative Study Group.

JAMA Oncol. 2017 Apr 1;3(4):464-471. doi: 10.1001/jamaoncol.2016.5194.


Hydrophilic Polymer-associated Ischemic Enterocolitis.

Chavez JA, Chen W, Frankel WL, Arnold CA.

Am J Surg Pathol. 2017 Feb;41(2):271-276. doi: 10.1097/PAS.0000000000000765.


Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

Chey WY, Frankel WL, Roy S, Datta S, Sen CK, Dillhoff M, Muscarella P, Soergel KH, Tompkins RK, Chang TM, Bradley EL 3rd, Ellison EC.

Ann Surg. 2017 Aug;266(2):346-352. doi: 10.1097/SLA.0000000000001938.


Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance).

Niedzwiecki D, Frankel WL, Venook AP, Ye X, Friedman PN, Goldberg RM, Mayer RJ, Colacchio TA, Mulligan JM, Davison TS, O'Brien E, Kerr P, Johnston PG, Kennedy RD, Harkin DP, Schilsky RL, Bertagnolli MM, Warren RS, Innocenti F.

J Clin Oncol. 2016 Sep 1;34(25):3047-53. doi: 10.1200/JCO.2015.65.4699. Epub 2016 Jul 18.


A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett's esophagus.

Kresty LA, Fromkes JJ, Frankel WL, Hammond CD, Seeram NP, Baird M, Stoner GD.

Oncotarget. 2016 Jul 7;9(82):35356-35372. doi: 10.18632/oncotarget.10457. eCollection 2018 Oct 19.


Appendiceal Mixed Adeno-Neuroendocrine Carcinoma: A Population-Based Study of the Surveillance, Epidemiology, and End Results Registry.

Brathwaite S, Yearsley MM, Bekaii-Saab T, Wei L, Schmidt CR, Dillhoff ME, Frankel WL, Hays JL, Wu C, Abdel-Misih S.

Front Oncol. 2016 Jun 13;6:148. doi: 10.3389/fonc.2016.00148. eCollection 2016.


Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms:  A Recommendation for Screening Synchronous/Metachronous Neoplasms.

Roth RM, Haraldsdottir S, Hampel H, Arnold CA, Frankel WL.

Am J Clin Pathol. 2016 Jul;146(1):50-6. doi: 10.1093/ajcp/aqw067. Epub 2016 Jun 29.


Liver Metastases of Neuroendocrine Tumors Rarely Show Overlapping Immunoprofile with Hepatocellular Carcinomas.

Jin M, Zhou X, Yearsley M, Frankel WL.

Endocr Pathol. 2016 Sep;27(3):253-8. doi: 10.1007/s12022-016-9442-7.


Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity.

Brathwaite S, Rock J, Yearsley MM, Bekaii-Saab T, Wei L, Frankel WL, Hays J, Wu C, Abdel-Misih S.

Ann Surg Oncol. 2016 Jul;23(7):2281-6. doi: 10.1245/s10434-016-5179-2. Epub 2016 Mar 10.


Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses.

Haraldsdottir S, Hampel H, Wu C, Weng DY, Shields PG, Frankel WL, Pan X, de la Chapelle A, Goldberg RM, Bekaii-Saab T.

Genet Med. 2016 Sep;18(9):863-8. doi: 10.1038/gim.2015.184. Epub 2016 Feb 11.


Perineural Invasion Predicts for Distant Metastasis in Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation and Surgery.

Chablani P, Nguyen P, Pan X, Robinson A, Walston S, Wu C, Frankel WL, Chen W, Bekaii-Saab T, Chakravarti A, Wuthrick E, Williams TM.

Am J Clin Oncol. 2017 Dec;40(6):561-568. doi: 10.1097/COC.0000000000000214.


Mismatch repair deficiency concordance between primary colorectal cancer and corresponding metastasis.

Haraldsdottir S, Roth R, Pearlman R, Hampel H, Arnold CA, Frankel WL.

Fam Cancer. 2016 Apr;15(2):253-60. doi: 10.1007/s10689-015-9856-2.


Neutropenic Enterocolitis: New Insights Into a Deadly Entity.

Sachak T, Arnold MA, Naini BV, Graham RP, Shah SS, Cruise M, Park JY, Clark L, Lamps L, Frankel WL, Theodoropoulos N, Arnold CA.

Am J Surg Pathol. 2015 Dec;39(12):1635-42. doi: 10.1097/PAS.0000000000000517.


Blood and lymphatic vessel invasion in pT1 colorectal cancer: an international concordance study.

Kojima M, Puppa G, Kirsch R, Basturk O, Frankel WL, Vieth M, Lugli A, Sheahan K, Yeh M, Lauwers GY, Risio M, Shimazaki H, Iwaya K, Kage M, Akiba J, Ohkura Y, Horiguchi S, Shomori K, Kushima R, Nomura S, Ajioka Y, Adsay V, Ochiai A.

J Clin Pathol. 2015 Aug;68(8):628-32. doi: 10.1136/jclinpath-2014-202805. Epub 2015 Apr 30.


Significance of paneth cell metaplasia in Barrett esophagus: a morphologic and clinicopathologic study.

Chen W, Frankel WL, Cronley KM, Yu L, Zhou X, Yearsley MM.

Am J Clin Pathol. 2015 May;143(5):665-71. doi: 10.1309/AJCPVUJMCVBC9PKM.


A triple stain of reticulin, glypican-3, and glutamine synthetase: a useful aid in the diagnosis of liver lesions.

Swanson BJ, Yearsley MM, Marsh W, Frankel WL.

Arch Pathol Lab Med. 2015 Apr;139(4):537-42. doi: 10.5858/arpa.2013-0645-OA.


The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms.

Basturk O, Yang Z, Tang LH, Hruban RH, Adsay V, McCall CM, Krasinskas AM, Jang KT, Frankel WL, Balci S, Sigel C, Klimstra DS.

Am J Surg Pathol. 2015 May;39(5):683-90. doi: 10.1097/PAS.0000000000000408.


A modified Lynch syndrome screening algorithm in colon cancer: BRAF immunohistochemistry is efficacious and cost beneficial.

Roth RM, Hampel H, Arnold CA, Yearsley MM, Marsh WL, Frankel WL.

Am J Clin Pathol. 2015 Mar;143(3):336-43. doi: 10.1309/AJCP4D7RXOBHLKGJ.


Serosal surfaces, mucin pools, and deposits, oh my: challenges in staging colorectal carcinoma.

Frankel WL, Jin M.

Mod Pathol. 2015 Jan;28 Suppl 1:S95-108. doi: 10.1038/modpathol.2014.128. Review.


The impact of tumor deposits on colonic adenocarcinoma AJCC TNM staging and outcome.

Jin M, Roth R, Rock JB, Washington MK, Lehman A, Frankel WL.

Am J Surg Pathol. 2015 Jan;39(1):109-15. doi: 10.1097/PAS.0000000000000320.


Perceptual clustering for automatic hotspot detection from Ki-67-stained neuroendocrine tumour images.

Khan Niazi MK, Yearsley MM, Zhou X, Frankel WL, Gurcan MN.

J Microsc. 2014 Dec;256(3):213-25. doi: 10.1111/jmi.12176. Epub 2014 Sep 16.


Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations.

Haraldsdottir S, Hampel H, Tomsic J, Frankel WL, Pearlman R, de la Chapelle A, Pritchard CC.

Gastroenterology. 2014 Dec;147(6):1308-1316.e1. doi: 10.1053/j.gastro.2014.08.041. Epub 2014 Sep 3.


Gastrointestinal tract-derived pulse granulomata: clues to an underrecognized pseudotumor.

Nowacki NB, Arnold MA, Frankel WL, Harzman A, Limketkai BN, Yearsley MM, Arnold CA.

Am J Surg Pathol. 2015 Jan;39(1):84-92. doi: 10.1097/PAS.0000000000000308.


Collagen immunostains can distinguish capsular fibrous tissue from septal fibrosis and may help stage liver fibrosis.

Chen W, Rock JB, Yearsley MM, Hanje AJ, Frankel WL.

Appl Immunohistochem Mol Morphol. 2014 Nov-Dec;22(10):735-40. doi: 10.1097/PAI.0000000000000010.


Deletions of RDINK4/ARF enhancer in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors.

Poi MJ, Drosdeck J, Frankel WL, Muscarella P, Li J.

Pancreas. 2014 Oct;43(7):1009-13. doi: 10.1097/MPA.0000000000000165.


Colesevelam and colestipol: novel medication resins in the gastrointestinal tract.

Arnold MA, Swanson BJ, Crowder CD, Frankel WL, Lam-Himlin D, Singhi AD, Stanich PP, Arnold CA.

Am J Surg Pathol. 2014 Nov;38(11):1530-7. doi: 10.1097/PAS.0000000000000260.


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