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Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions.

Sanchez-Garrido J, Slater SL, Clements A, Shenoy AR, Frankel G.

Cell Microbiol. 2020 Apr;22(4):e13184. doi: 10.1111/cmi.13184. Review.


Self-accelerated corrosion of nuclear waste forms at material interfaces.

Guo X, Gin S, Lei P, Yao T, Liu H, Schreiber DK, Ngo D, Viswanathan G, Li T, Kim SH, Vienna JD, Ryan JV, Du J, Lian J, Frankel GS.

Nat Mater. 2020 Mar;19(3):310-316. doi: 10.1038/s41563-019-0579-x. Epub 2020 Jan 27.


Faecal neutrophil elastase-antiprotease balance reflects colitis severity.

Barry R, Ruano-Gallego D, Radhakrishnan ST, Lovell S, Yu L, Kotik O, Glegola-Madejska I, Tate EW, Choudhary JS, Williams HRT, Frankel G.

Mucosal Immunol. 2020 Mar;13(2):322-333. doi: 10.1038/s41385-019-0235-4. Epub 2019 Nov 26.


Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease.

Carson D, Barry R, Hopkins EGD, Roumeliotis TI, García-Weber D, Mullineaux-Sanders C, Elinav E, Arrieumerlou C, Choudhary JS, Frankel G.

Cell Microbiol. 2020 Jan;22(1):e13126. doi: 10.1111/cmi.13126. Epub 2019 Oct 30.


Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism.

Mullineaux-Sanders C, Sanchez-Garrido J, Hopkins EGD, Shenoy AR, Barry R, Frankel G.

Nat Rev Microbiol. 2019 Nov;17(11):701-715. doi: 10.1038/s41579-019-0252-z. Epub 2019 Sep 20. Review.


OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo.

Wong JLC, Romano M, Kerry LE, Kwong HS, Low WW, Brett SJ, Clements A, Beis K, Frankel G.

Nat Commun. 2019 Sep 2;10(1):3957. doi: 10.1038/s41467-019-11756-y.


A nanobody targeting the translocated intimin receptor inhibits the attachment of enterohemorrhagic E. coli to human colonic mucosa.

Ruano-Gallego D, Yara DA, Di Ianni L, Frankel G, Schüller S, Fernández LÁ.

PLoS Pathog. 2019 Aug 29;15(8):e1008031. doi: 10.1371/journal.ppat.1008031. eCollection 2019 Aug.


The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin.

McDowell MA, Byrne AM, Mylona E, Johnson R, Sagfors A, Crepin VF, Lea S, Frankel G.

Life Sci Alliance. 2019 May 29;2(3). pii: e201800272. doi: 10.26508/lsa.201800272. Print 2019 Jun.


Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.

Goddard PJ, Sanchez-Garrido J, Slater SL, Kalyan M, Ruano-Gallego D, Marchès O, Fernández LÁ, Frankel G, Shenoy AR.

Cell Rep. 2019 Apr 23;27(4):1008-1017.e6. doi: 10.1016/j.celrep.2019.03.100.


Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic Citrobacter rodentium Infection.

Hopkins EGD, Roumeliotis TI, Mullineaux-Sanders C, Choudhary JS, Frankel G.

mBio. 2019 Apr 2;10(2). pii: e00062-19. doi: 10.1128/mBio.00062-19.


The Galleria mellonella Infection Model for Investigating the Molecular Mechanisms of Legionella Virulence.

Frankel G, Schroeder GN.

Methods Mol Biol. 2019;1921:333-346. doi: 10.1007/978-1-4939-9048-1_22.


Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification.

So EC, Mousnier A, Frankel G, Schroeder GN.

Methods Mol Biol. 2019;1921:289-303. doi: 10.1007/978-1-4939-9048-1_19.


More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells.

Gomez-Valero L, Rusniok C, Carson D, Mondino S, Pérez-Cobas AE, Rolando M, Pasricha S, Reuter S, Demirtas J, Crumbach J, Descorps-Declere S, Hartland EL, Jarraud S, Dougan G, Schroeder GN, Frankel G, Buchrieser C.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2265-2273. doi: 10.1073/pnas.1808016116. Epub 2019 Jan 18.


The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase.

Levanova N, Mattheis C, Carson D, To KN, Jank T, Frankel G, Aktories K, Schroeder GN.

J Biol Chem. 2019 Feb 22;294(8):2862-2879. doi: 10.1074/jbc.RA118.005952. Epub 2018 Dec 20.


Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Connolly JPR, Slater SL, O'Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DGE, Douce GR, Frankel G, Roe AJ.

Nat Commun. 2018 Nov 29;9(1):5148. doi: 10.1038/s41467-018-07612-0.


The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.

Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Serafini N, Pevsner-Fischer M, Yu L, Elinav E, Di Santo JP, Choudhary JS, Frankel G.

PLoS Pathog. 2018 Oct 26;14(10):e1007406. doi: 10.1371/journal.ppat.1007406. eCollection 2018 Oct.


Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Connolly JPR, Slater SL, O'Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DGE, Douce GR, Frankel G, Roe AJ.

Nat Commun. 2018 Oct 10;9(1):4187. doi: 10.1038/s41467-018-06701-4. Erratum in: Nat Commun. 2018 Nov 29;9(1):5148.


The Type III Secretion System of Pathogenic Escherichia coli.

Slater SL, Sågfors AM, Pollard DJ, Ruano-Gallego D, Frankel G.

Curr Top Microbiol Immunol. 2018;416:51-72. doi: 10.1007/82_2018_116. Review.


Mechanism of Etching of Al-4.5Mg-1.0Mn Alloy.

Gabbardo AD, Wang X, Huggins A, Frankel GS.

Microsc Microanal. 2018 Aug;24(4):374-386. doi: 10.1017/S1431927618012400. Epub 2018 Jul 26.


Typhoidal Salmonella: Distinctive virulence factors and pathogenesis.

Johnson R, Mylona E, Frankel G.

Cell Microbiol. 2018 Sep;20(9):e12939. doi: 10.1111/cmi.12939. Epub 2018 Aug 9. Review.


Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.

Pollard DJ, Berger CN, So EC, Yu L, Hadavizadeh K, Jennings P, Tate EW, Choudhary JS, Frankel G.

mBio. 2018 Apr 10;9(2). pii: e00170-18. doi: 10.1128/mBio.00170-18.


Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells.

Baumann D, Salia H, Greune L, Norkowski S, Körner B, Uckeley ZM, Frankel G, Guenot M, Rüter C, Schmidt MA.

Int J Med Microbiol. 2018 Apr;308(3):387-404. doi: 10.1016/j.ijmm.2018.03.005. Epub 2018 Mar 12.


Sieving through gut models of colonization resistance.

Mullineaux-Sanders C, Suez J, Elinav E, Frankel G.

Nat Microbiol. 2018 Feb;3(2):132-140. doi: 10.1038/s41564-017-0095-1. Epub 2018 Jan 22. Review.


Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa.

Mullineaux-Sanders C, Collins JW, Ruano-Gallego D, Levy M, Pevsner-Fischer M, Glegola-Madejska IT, Sågfors AM, Wong JLC, Elinav E, Crepin VF, Frankel G.

Cell Rep. 2017 Dec 19;21(12):3381-3389. doi: 10.1016/j.celrep.2017.11.086.


Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.

Johnson R, Ravenhall M, Pickard D, Dougan G, Byrne A, Frankel G.

Infect Immun. 2018 Feb 20;86(3). pii: e00490-17. doi: 10.1128/IAI.00490-17. Print 2018 Mar.


Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic Escherichia coli.

Portaliou AG, Tsolis KC, Loos MS, Balabanidou V, Rayo J, Tsirigotaki A, Crepin VF, Frankel G, Kalodimos CG, Karamanou S, Economou A.

EMBO J. 2017 Dec 1;36(23):3517-3531. doi: 10.15252/embj.201797515. Epub 2017 Nov 6.


Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors.

Cepeda-Molero M, Berger CN, Walsham ADS, Ellis SJ, Wemyss-Holden S, Schüller S, Frankel G, Fernández LÁ.

PLoS Pathog. 2017 Oct 30;13(10):e1006706. doi: 10.1371/journal.ppat.1006706. eCollection 2017 Oct.


Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.

Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Carson D, Pevsner-Fischer M, Furniss RCD, Dougan G, Dori-Bachash M, Yu L, Clements A, Collins JW, Elinav E, Larrouy-Maumus GJ, Choudhary JS, Frankel G.

Cell Metab. 2017 Nov 7;26(5):738-752.e6. doi: 10.1016/j.cmet.2017.09.003. Epub 2017 Oct 5.


Potentiodynamic polarization study of the corrosion behavior of palladium-silver dental alloys.

Sun D, Brantley WA, Frankel GS, Heshmati RH, Johnston WM.

J Prosthet Dent. 2018 Apr;119(4):650-656. doi: 10.1016/j.prosdent.2017.06.026. Epub 2017 Sep 28.


The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner.

Sandu P, Crepin VF, Drechsler H, McAinsh AD, Frankel G, Berger CN.

Infect Immun. 2017 Aug 18;85(9). pii: e00244-17. doi: 10.1128/IAI.00244-17. Print 2017 Sep.


Non-invasive three-dimensional imaging of Escherichia coli K1 infection using diffuse light imaging tomography combined with micro-computed tomography.

Witcomb LA, Czupryna J, Francis KP, Frankel G, Taylor PW.

Methods. 2017 Aug 15;127:62-68. doi: 10.1016/j.ymeth.2017.05.005. Epub 2017 May 15. Review.


Glucosamine and chondroitin use in canines for osteoarthritis: A review.

Bhathal A, Spryszak M, Louizos C, Frankel G.

Open Vet J. 2017;7(1):36-49. doi: 10.4314/ovj.v7i1.6. Epub 2017 Feb 24. Review.


Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Feb 13;2:17024. doi: 10.1038/nmicrobiol.2017.24. No abstract available.


EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Erratum in: Nat Microbiol. 2017 Feb 13;2:17024.


The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

Johnson R, Byrne A, Berger CN, Klemm E, Crepin VF, Dougan G, Frankel G.

J Bacteriol. 2017 Jan 30;199(4). pii: e00647-16. doi: 10.1128/JB.00647-16. Print 2017 Feb 15.


Model of Host-Pathogen Interaction Dynamics Links In Vivo Optical Imaging and Immune Responses.

Ale A, Crepin VF, Collins JW, Constantinou N, Habibzay M, Babtie AC, Frankel G, Stumpf MPH.

Infect Immun. 2016 Dec 29;85(1). pii: e00606-16. doi: 10.1128/IAI.00606-16. Print 2017 Jan.


The Type III Secretion System Effector SeoC of Salmonella enterica subsp. salamae and S. enterica subsp. arizonae ADP-Ribosylates Src and Inhibits Opsonophagocytosis.

Pollard DJ, Young JC, Covarelli V, Herrera-León S, Connor TR, Fookes M, Walker D, Echeita A, Thomson NR, Berger CN, Frankel G.

Infect Immun. 2016 Nov 18;84(12):3618-3628. Print 2016 Dec.


Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells.

Pallett MA, Crepin VF, Serafini N, Habibzay M, Kotik O, Sanchez-Garrido J, Di Santo JP, Shenoy AR, Berger CN, Frankel G.

Mucosal Immunol. 2017 May;10(3):602-612. doi: 10.1038/mi.2016.77. Epub 2016 Sep 14.


Citrobacter rodentium mouse model of bacterial infection.

Crepin VF, Collins JW, Habibzay M, Frankel G.

Nat Protoc. 2016 Oct;11(10):1851-76. doi: 10.1038/nprot.2016.100. Epub 2016 Sep 8.


Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection.

Furniss RC, Slater S, Frankel G, Clements A.

J Mol Biol. 2016 Aug 28;428(17):3399-407. doi: 10.1016/j.jmb.2016.05.023. Epub 2016 May 31.


Five things every community pharmacist should know when dispensing for 4-legged patients.

Frankel G, Kusno A, Louizos C.

Can Pharm J (Ott). 2016 Mar;149(2):99-106. doi: 10.1177/1715163516628543. Epub 2016 Feb 5. Review. No abstract available. Erratum in: Can Pharm J (Ott). 2016 Mar;149(2):NP1.


The Rab-binding Profiles of Bacterial Virulence Factors during Infection.

So EC, Schroeder GN, Carson D, Mattheis C, Mousnier A, Broncel M, Tate EW, Frankel G.

J Biol Chem. 2016 Mar 11;291(11):5832-43. doi: 10.1074/jbc.M115.700930. Epub 2016 Jan 11.


Magnesium alloys: Ready for the road.

Frankel GS.

Nat Mater. 2015 Dec;14(12):1189-90. doi: 10.1038/nmat4453. Epub 2015 Oct 19. No abstract available.


Bioluminescent imaging reveals novel patterns of colonization and invasion in systemic Escherichia coli K1 experimental infection in the neonatal rat.

Witcomb LA, Collins JW, McCarthy AJ, Frankel G, Taylor PW.

Infect Immun. 2015 Dec;83(12):4528-40. doi: 10.1128/IAI.00953-15. Epub 2015 Sep 8.


Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.

Schroeder GN, Aurass P, Oates CV, Tate EW, Hartland EL, Flieger A, Frankel G.

Infect Immun. 2015 Oct;83(10):3989-4002. doi: 10.1128/IAI.00785-15. Epub 2015 Jul 27.


Corrosion control: general discussion.

Cook A, Frankel G, Davenport A, Hughes T, Gibbon S, Williams D, Bluhm H, Maurice V, Lyth S, Marcus P, Shoesmith D, Wren C, Wharton J, Hunt G, Lyon S, Majchrowski T, Lindsay R, Williams G, Rico Oller B, Todorova M, Nixon S, Cheng ST, Scully J, Wilson A, Renner F, Chen YH, Taylor C, Habazaki H, Michaelides A, Morsch S, Visser P, Kyhl L, Kokalj A.

Faraday Discuss. 2015;180:543-76. doi: 10.1039/c5fd90047f. No abstract available.


Corrosion scales and passive films: general discussion.

Frankel G, Mauzeroll J, Thornton G, Bluhm H, Morrison J, Maurice V, Rayment T, Williams D, Cook A, Joshi G, Davenport A, Gibbon S, Kramer D, Acres M, Tautschnig M, Habazaki H, Marcus P, Shoesmith D, Wren C, Majchrowski T, Lindsay R, Wood M, Todorova M, Scully J, Renner F, Kokalj A, Taylor C, Virtanen S, Wharton J.

Faraday Discuss. 2015;180:205-32. doi: 10.1039/c5fd90045j. Epub 2015 Jul 2. No abstract available.


Localised corrosion: general discussion.

Frankel G, Thornton G, Street S, Rayment T, Williams D, Cook A, Davenport A, Gibbon S, Engelberg D, Örnek C, Mol A, Marcus P, Shoesmith D, Wren C, Yliniemi K, Williams G, Lyon S, Lindsay R, Hughes T, Lützenkirchen J, Cheng ST, Scully J, Lee SF, Newman R, Taylor C, Springell R, Mauzeroll J, Virtanen S, Heurtault S, Sullivan J.

Faraday Discuss. 2015;180:381-414. doi: 10.1039/c5fd90046h. No abstract available.


Solid/fluid interface: general discussion.

Mauzeroll J, Thornton G, Rayment T, Maurice V, Williams D, Heberling F, Marcus P, Wren C, Yliniemi K, Lindsay R, Lyth S, Majchrowski T, Hussain H, Hunt G, Renner F, Williams G, Newman R, Frankel G, Lützenkirchen J, Bluhm H.

Faraday Discuss. 2015;180:81-96. doi: 10.1039/c5fd90044a. Epub 2015 Jun 30. No abstract available.


The Locus of Enterocyte Effacement and Associated Virulence Factors of Enterohemorrhagic Escherichia coli.

Stevens MP, Frankel GM.

Microbiol Spectr. 2014 Aug;2(4):EHEC-0007-2013. doi: 10.1128/microbiolspec.EHEC-0007-2013. Review.


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