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Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function.

Couto E Silva A, Wu CY, Citadin CT, Clemons GA, Possoit HE, Grames MS, Lien CF, Minagar A, Lee RH, Frankel A, Lin HW.

Mol Neurobiol. 2019 Dec 10. doi: 10.1007/s12035-019-01850-z. [Epub ahead of print] Review.


HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma.

Courtney KD, Ma Y, Diaz de Leon A, Christie A, Xie Z, Woolford L, Singla N, Joyce A, Hill H, Madhuranthakam AJ, Yuan Q, Xi Y, Zhang Y, Chang J, Fatunde O, Arriaga Y, Frankel AE, Kalva S, Zhang S, McKenzie T, Reig Torras O, Figlin RA, Rini BI, McKay RM, Kapur P, Wang T, Pedrosa I, Brugarolas J.

Clin Cancer Res. 2019 Nov 14. doi: 10.1158/1078-0432.CCR-19-1459. [Epub ahead of print]


The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.

Brown JI, Page BDG, Frankel A.

Methods. 2019 Nov 11. pii: S1046-2023(19)30127-6. doi: 10.1016/j.ymeth.2019.11.004. [Epub ahead of print]


Associations Between a New Disruptive Behaviors Scale and Teamwork, Patient Safety, Work-Life Balance, Burnout, and Depression.

Rehder KJ, Adair KC, Hadley A, McKittrick K, Frankel A, Leonard M, Frankel TC, Sexton JB.

Jt Comm J Qual Patient Saf. 2020 Jan;46(1):18-26. doi: 10.1016/j.jcjq.2019.09.004. Epub 2019 Nov 6.


Challenges in management of diabetic ketoacidosis in hemodialysis patients, case presentation and review of literature.

Seddik AA, Bashier A, Alhadari AK, AlAlawi F, Alnour HH, Bin Hussain AA, Frankel A, Railey MJ.

Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2481-2487. doi: 10.1016/j.dsx.2019.06.022. Epub 2019 Jun 28. Review.


Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma.

Khushman M, Patel GK, Laurini JA, Bhardwaj A, Roveda K, Donnell R, Sherling K, Case B, Frankel AE, Pai S, Taylor W, Tan MCB, Mizrahi M, Nelson C, Wyatt M, Patton M, McClellan S, Singh S, Wang B, Singh AP.

J Gastrointest Oncol. 2019 Aug;10(4):695-702. doi: 10.21037/jgo.2018.07.02.


Autoimmune Bell's Palsy Following Immunotherapy For Metastatic Melanoma: A Report of 2 Cases.

Zieman D, Frankel AE.

J Immunother. 2019 Oct;42(8):318-320. doi: 10.1097/CJI.0000000000000291.


Fin whale singing decreases with increased swimming speed.

Clark CW, Gagnon GJ, Frankel AS.

R Soc Open Sci. 2019 Jun 5;6(6):180525. doi: 10.1098/rsos.180525. eCollection 2019 Jun.


The Human Microbiota in Multiple Myeloma and Proteasome Inhibitors.

Alkharabsheh O, Sidiqi MH, Aljama MA, Gertz MA, Frankel AE.

Acta Haematol. 2019 Jul 16:1-6. doi: 10.1159/000500976. [Epub ahead of print] Review.


ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ.

Cell Host Microbe. 2019 Jul 10;26(1):86-99.e7. doi: 10.1016/j.chom.2019.05.008. Epub 2019 Jun 25.


Visual and verbal learning and memory in cystinosis.

Frankel AM, Trauner DA.

Brain Cogn. 2019 Oct;135:103578. doi: 10.1016/j.bandc.2019.103578. Epub 2019 Jun 21.


The Prevalence of DPYD*9A(c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated Analysis.

Maharjan AS, McMillin GA, Patel GK, Awan S, Taylor WR, Pai S, Frankel AE, Nelson C, Wang B, Hosein PJ, Singh AP, Khushman M.

Clin Colorectal Cancer. 2019 Sep;18(3):e280-e286. doi: 10.1016/j.clcc.2019.04.005. Epub 2019 May 3.


Subcutaneous neostigmine appears safe and effective for acute colonic pseudo-obstruction (Ogilvie's syndrome).

Frankel A, Gillespie C, Lu CT, Hewett P, Wattchow D.

ANZ J Surg. 2019 Jun;89(6):700-705. doi: 10.1111/ans.15265. Epub 2019 May 13.


Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota.

Frankel AE, Deshmukh S, Reddy A, Lightcap J, Hayes M, McClellan S, Singh S, Rabideau B, Glover TG, Roberts B, Koh AY.

Integr Cancer Ther. 2019 Jan-Dec;18:1534735419846379. doi: 10.1177/1534735419846379. Review.


Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability.

Jayaraman B, Fernandes JD, Yang S, Smith C, Frankel AD.

Sci Rep. 2019 Mar 26;9(1):5139. doi: 10.1038/s41598-019-41582-7.


Clinical Activity and Tolerability of SL-401 (Tagraxofusp): Recombinant Diphtheria Toxin and Interleukin-3 in Hematologic Malignancies.

Alkharabsheh O, Frankel AE.

Biomedicines. 2019 Jan 5;7(1). pii: E6. doi: 10.3390/biomedicines7010006. Review.


Measurement of glomerular filtration rate in patients undergoing obesity surgery.

Chuah LL, Miras AD, Perry LM, Frankel AH, Towey DJ, Al-Mayahi Z, Svensson W, le Roux CW.

BMC Nephrol. 2018 Dec 29;19(1):383. doi: 10.1186/s12882-018-1188-7.


Delayed presentation of large intra-abdominal wooden splinter after blunt trauma: a case report.

McCombe A, Frankel A.

ANZ J Surg. 2019 Dec;89(12):E578-E579. doi: 10.1111/ans.14979. Epub 2018 Dec 18. No abstract available.


The Improvement Readiness scale of the SCORE survey: a metric to assess capacity for quality improvement in healthcare.

Adair KC, Quow K, Frankel A, Mosca PJ, Profit J, Hadley A, Leonard M, Bryan Sexton J.

BMC Health Serv Res. 2018 Dec 17;18(1):975. doi: 10.1186/s12913-018-3743-0.


Evaluation of kinetic data: What the numbers tell us about PRMTs.

Frankel A, Brown JI.

Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):306-316. doi: 10.1016/j.bbapap.2018.10.010. Epub 2018 Oct 17. Review.


Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis.

Gerber DE, Beg MS, Fattah F, Frankel AE, Fatunde O, Arriaga Y, Dowell JE, Bisen A, Leff RD, Meek CC, Putnam WC, Kallem RR, Subramaniyan I, Dong Y, Bolluyt J, Sarode V, Luo X, Xie Y, Schwartz B, Boothman DA.

Br J Cancer. 2018 Oct;119(8):928-936. doi: 10.1038/s41416-018-0278-4. Epub 2018 Oct 15.


Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.

Dai Y, Wynn JE, Peralta AN, Sherpa C, Jayaraman B, Li H, Verma A, Frankel AD, Le Grice SF, Santos WL.

J Med Chem. 2018 Nov 8;61(21):9611-9620. doi: 10.1021/acs.jmedchem.8b01076. Epub 2018 Oct 18.


An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo.

Galassi TV, Jena PV, Shah J, Ao G, Molitor E, Bram Y, Frankel A, Park J, Jessurun J, Ory DS, Haimovitz-Friedman A, Roxbury D, Mittal J, Zheng M, Schwartz RE, Heller DA.

Sci Transl Med. 2018 Oct 3;10(461). pii: eaar2680. doi: 10.1126/scitranslmed.aar2680.


Management of adults with diabetes on the haemodialysis unit: summary of guidance from the Joint British Diabetes Societies and the Renal Association.

Frankel AH, Kazempour-Ardebili S, Bedi R, Chowdhury TA, De P, El-Sherbini N, Game F, Gray S, Hardy D, James J, Kong MF, Ramlan G, Southcott E, Winocour P.

Diabet Med. 2018 Aug;35(8):1018-1026. doi: 10.1111/dme.13676.


Tumor endothelial marker 8 promotes cancer progression and metastasis.

Høye AM, Tolstrup SD, Horton ER, Nicolau M, Frost H, Woo JH, Mauldin JP, Frankel AE, Cox TR, Erler JT.

Oncotarget. 2018 Jul 10;9(53):30173-30188. doi: 10.18632/oncotarget.25734. eCollection 2018 Jul 10.


Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.

Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais MA, Frankel AS, Chiriboga L, Cullen J, Nahass RG, Lutgehetmann M, Toettcher JE, Wiles MV, Schwartz RE, Ploss A.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaap9328. doi: 10.1126/scitranslmed.aap9328.


Pneumatic oscillating microsagittal saw: a novel method for removal of a rectal foreign body.

McCombe AJ, Frankel AJ, Morris B.

ANZ J Surg. 2019 Oct;89(10):E446-E447. doi: 10.1111/ans.14739. Epub 2018 Jun 12. No abstract available.


The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

Faust TB, Li Y, Bacon CW, Jang GM, Weiss A, Jayaraman B, Newton BW, Krogan NJ, D'Orso I, Frankel AD.

Elife. 2018 May 30;7. pii: e31879. doi: 10.7554/eLife.31879.


Central airway obstruction caused by adenoid cystic carcinoma in pregnancy: a case report and review of the literature.

Shafiee S, Adno A, French B, Johansson C, Frankel A, Williamson JP.

Respirol Case Rep. 2018 Apr 20;6(5):e00317. doi: 10.1002/rcr2.317. eCollection 2018 Jul.


Complications of Polydioxanone Foil Use in Nasal Surgery: A Case Series.

Wang LL, Frankel AS, Friedman O.

Facial Plast Surg. 2018 Jun;34(3):312-317. doi: 10.1055/s-0038-1632399. Epub 2018 Apr 27.


Building a safety culture in global health: lessons from Guatemala.

Rice HE, Lou-Meda R, Saxton AT, Johnston BE, Ramirez CC, Mendez S, Rice EN, Aidar B, Taicher B, Baumgartner JN, Milne J, Frankel AS, Sexton JB.

BMJ Glob Health. 2018 Mar 9;3(2):e000630. doi: 10.1136/bmjgh-2017-000630. eCollection 2018. Review.


Sexting, Risk Behavior, and Mental Health in Adolescents: An Examination of 2015 Pennsylvania Youth Risk Behavior Survey Data.

Frankel AS, Bass SB, Patterson F, Dai T, Brown D.

J Sch Health. 2018 Mar;88(3):190-199. doi: 10.1111/josh.12596.


Defining Phenotypes in Diabetic Nephropathy: a novel approach using a cross-sectional analysis of a single centre cohort.

Montero RM, Herath A, Qureshi A, Esfandiari E, Pusey CD, Frankel AH, Tam FWK.

Sci Rep. 2018 Jan 8;8(1):53. doi: 10.1038/s41598-017-18595-1.


Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism.

Brown JI, Koopmans T, van Strien J, Martin NI, Frankel A.

Chembiochem. 2018 Jan 4;19(1):85-99. doi: 10.1002/cbic.201700521. Epub 2017 Nov 29.


Providing feedback following Leadership WalkRounds is associated with better patient safety culture, higher employee engagement and lower burnout.

Sexton JB, Adair KC, Leonard MW, Frankel TC, Proulx J, Watson SR, Magnus B, Bogan B, Jamal M, Schwendimann R, Frankel AS.

BMJ Qual Saf. 2018 Apr;27(4):261-270. doi: 10.1136/bmjqs-2016-006399. Epub 2017 Oct 9.


Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.

Faust TB, Binning JM, Gross JD, Frankel AD.

Annu Rev Virol. 2017 Sep 29;4(1):241-260. doi: 10.1146/annurev-virology-101416-041654. Review.


Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients.

Frankel AE, Coughlin LA, Kim J, Froehlich TW, Xie Y, Frenkel EP, Koh AY.

Neoplasia. 2017 Oct;19(10):848-855. doi: 10.1016/j.neo.2017.08.004. Epub 2017 Sep 15.


Modification of Chin Projection and Aesthetics With OnabotulinumtoxinA Injection.

Hsu AK, Frankel AS.

JAMA Facial Plast Surg. 2017 Dec 1;19(6):522-527. doi: 10.1001/jamafacial.2017.0606.


Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.

Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS.

Blood. 2017 Aug 10;130(6):722-731. doi: 10.1182/blood-2017-04-779405. Epub 2017 Jun 6.


Complicated silicosis resulting from occupational exposure to engineered stone products.

Matar E, Frankel A, Blake LKM, Silverstone EJ, Johnson AR, Yates DH.

Med J Aust. 2017 May 15;206(9):385-386. No abstract available.


A STING-activating nanovaccine for cancer immunotherapy.

Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y, Du M, Huang G, Wang C, Chen X, Porembka MR, Lea J, Frankel AE, Fu YX, Chen ZJ, Gao J.

Nat Nanotechnol. 2017 Jul;12(7):648-654. doi: 10.1038/nnano.2017.52. Epub 2017 Apr 24.


Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes.

Nakamura RL, Burlingame MA, Yang S, Crosby DC, Talbot DJ, Chui K, Frankel AD, Renslo AR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02366-16. doi: 10.1128/AAC.02366-16. Print 2017 Jul.


PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.

Faust TB, Li Y, Jang GM, Johnson JR, Yang S, Weiss A, Krogan NJ, Frankel AD.

Sci Rep. 2017 Mar 27;7:45394. doi: 10.1038/srep45394.


Academic Cancer Center Phase I Program Development.

Frankel AE, Flaherty KT, Weiner GJ, Chen R, Azad NS, Pishvaian MJ, Thompson JA, Taylor MH, Mahadevan D, Lockhart AC, Vaishampayan UN, Berlin JD, Smith DC, Sarantopoulos J, Riese M, Saleh MN, Ahn C, Frenkel EP.

Oncologist. 2017 Apr;22(4):369-374. doi: 10.1634/theoncologist.2016-0409. Epub 2017 Mar 17.


Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients.

Frankel AE, Eskiocak U, Gill JG, Yuan S, Ramesh V, Froehlich TW, Ahn C, Morrison SJ.

Neoplasia. 2017 Apr;19(4):255-260. doi: 10.1016/j.neo.2017.01.010. Epub 2017 Mar 6.


PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X.

Vhuiyan MI, Pak ML, Park MA, Thomas D, Lakowski TM, Chalfant CE, Frankel A.

J Biochem. 2017 Jul 1;162(1):17-25. doi: 10.1093/jb/mvw102.


Assessment of complex dissociative disorder patients and simulated dissociation in forensic contexts.

Brand BL, Webermann AR, Frankel AS.

Int J Law Psychiatry. 2016 Nov - Dec;49(Pt B):197-204. doi: 10.1016/j.ijlp.2016.10.006. Epub 2016 Oct 29.


Functional Segregation of Overlapping Genes in HIV.

Fernandes JD, Faust TB, Strauli NB, Smith C, Crosby DC, Nakamura RL, Hernandez RD, Frankel AD.

Cell. 2016 Dec 15;167(7):1762-1773.e12. doi: 10.1016/j.cell.2016.11.031.


Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells.

Thorburn J, Staskiewicz L, Goodall ML, Dimberg L, Frankel AE, Ford HL, Thorburn A.

Mol Pharmacol. 2017 Jan;91(1):58-64. Epub 2016 Nov 9.


Blastic plasmacytoid dendritic cell neoplasm with t(11;19)(q23;p13.3);KMT2A(MLL) rearranged: a diagnostic challenge.

Gehlbach D, Koduru P, John G, Fuda F, Frankel AE, Chen W.

Br J Haematol. 2017 Jan;176(1):8. doi: 10.1111/bjh.14389. Epub 2016 Oct 24. No abstract available.


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