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Items: 32

1.

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.

Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T.

Cell. 2019 Oct 3;179(2):417-431.e19. doi: 10.1016/j.cell.2019.09.009.

PMID:
31585081
2.

A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155.

Husain B, Ramani SR, Chiang E, Lehoux I, Paduchuri S, Arena TA, Patel A, Wilson B, Chan P, Franke Y, Wong AW, Lill JR, Turley SJ, Gonzalez LC, Grogan JL, Martinez-Martin N.

Mol Cell Proteomics. 2019 Jul 15. pii: mcp.TIR119.001433. doi: 10.1074/mcp.TIR119.001433. [Epub ahead of print]

3.

Semiautomated Small-Scale Purification Method for High-Throughput Expression Analysis of Recombinant Proteins.

Kraft E, Franke Y, Heeringa K, Shriver S, Zilberleyb I, Kugel C, Dela Vega T, Wong A, Brillantes B, Ciferri C, Dutina G, Lee G, Lehoux I, Li ZR, Lior-Hoffmann L, Hwang J, Lonergan C, Martin L, Mortara K, Nguyen L, Payandeh J, Perez A, Sampang J, Singh L, Schroeder K, Tam C, Ti S, Win YN, Bowman K.

Methods Mol Biol. 2019;2025:51-68. doi: 10.1007/978-1-4939-9624-7_3.

PMID:
31267448
4.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.

Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J.

Cell. 2019 Feb 21;176(5):1238-1239. doi: 10.1016/j.cell.2019.01.047. No abstract available.

PMID:
30794776
5.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.

Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J.

Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17. Erratum in: Cell. 2019 Feb 21;176(5):1238-1239.

PMID:
30661758
6.

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain.

Ultsch M, Li W, Eigenbrot C, Di Lello P, Lipari MT, Gerhardy S, AhYoung AP, Quinn J, Franke Y, Chen Y, Kong Beltran M, Peterson A, Kirchhofer D.

J Mol Biol. 2019 Mar 1;431(5):885-903. doi: 10.1016/j.jmb.2018.11.025. Epub 2019 Jan 15.

PMID:
30653992
7.

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Wu P, Sneeringer CJ, Pitts KE, Day ES, Chan BK, Wei B, Lehoux I, Mortara K, Li H, Wu J, Franke Y, Moffat JG, Grogan JL, Heffron TP, Wang W.

Structure. 2019 Jan 2;27(1):125-133.e4. doi: 10.1016/j.str.2018.10.025. Epub 2018 Nov 29.

PMID:
30503777
8.

Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN.

Nat Chem Biol. 2018 Sep;14(9):902. doi: 10.1038/s41589-018-0069-5.

PMID:
29728602
9.

Structural basis for dual-mode inhibition of the ABC transporter MsbA.

Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM.

Nature. 2018 May;557(7704):196-201. doi: 10.1038/s41586-018-0083-5. Epub 2018 May 2.

PMID:
29720648
10.

Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer.

Maun HR, Liu PS, Franke Y, Eigenbrot C, Forrest WF, Schwartz LB, Lazarus RA.

J Biol Chem. 2018 Jun 22;293(25):9614-9628. doi: 10.1074/jbc.M117.812016. Epub 2018 Apr 16.

11.

A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN.

Nat Chem Biol. 2018 Jun;14(6):582-590. doi: 10.1038/s41589-018-0035-2. Epub 2018 Apr 9. Erratum in: Nat Chem Biol. 2018 May 4;:.

PMID:
29632413
12.

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.

Johnson AR, Kohli PB, Katewa A, Gogol E, Belmont LD, Choy R, Penuel E, Burton L, Eigenbrot C, Yu C, Ortwine DF, Bowman K, Franke Y, Tam C, Estevez A, Mortara K, Wu J, Li H, Lin M, Bergeron P, Crawford JJ, Young WB.

ACS Chem Biol. 2016 Oct 21;11(10):2897-2907. Epub 2016 Sep 7.

PMID:
27571029
13.

Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking.

Gao X, Stanger K, Kaluarachchi H, Maurer T, Ciepla P, Chalouni C, Franke Y, Hannoush RN.

Sci Rep. 2016 Oct 13;6:35179. doi: 10.1038/srep35179.

14.

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.

Ferrao R, Wallweber HJ, Ho H, Tam C, Franke Y, Quinn J, Lupardus PJ.

Structure. 2016 Jun 7;24(6):897-905. doi: 10.1016/j.str.2016.03.023. Epub 2016 Apr 28.

15.

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP Jr, Wu P, Li J, Coons M, Tam C, Brillantes B, Sampang H, Mortara K, Bowman KK, Clark KR, Estevez A, Xie Z, Verschoof H, Grimwood M, Dehnhardt C, Andrez JC, Focken T, Sutherlin DP, Safina BS, Starovasnik MA, Ortwine DF, Franke Y, Cohen CJ, Hackos DH, Koth CM, Payandeh J.

Science. 2015 Dec 18;350(6267):aac5464. doi: 10.1126/science.aac5464.

PMID:
26680203
16.

Backbone cyclization of a recombinant cystine-knot peptide by engineered Sortase A.

Stanger K, Maurer T, Kaluarachchi H, Coons M, Franke Y, Hannoush RN.

FEBS Lett. 2014 Nov 28;588(23):4487-96.

17.

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2.

Wallweber HJ, Tam C, Franke Y, Starovasnik MA, Lupardus PJ.

Nat Struct Mol Biol. 2014 May;21(5):443-8. doi: 10.1038/nsmb.2807. Epub 2014 Apr 6.

18.

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.

Parikh C, Janakiraman V, Wu WI, Foo CK, Kljavin NM, Chaudhuri S, Stawiski E, Lee B, Lin J, Li H, Lorenzo MN, Yuan W, Guillory J, Jackson M, Rondon J, Franke Y, Bowman KK, Sagolla M, Stinson J, Wu TD, Wu J, Stokoe D, Stern HM, Brandhuber BJ, Lin K, Skelton NJ, Seshagiri S.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19368-73. doi: 10.1073/pnas.1204384109. Epub 2012 Nov 7.

19.

The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.

de Leon-Boenig G, Bowman KK, Feng JA, Crawford T, Everett C, Franke Y, Oh A, Stanley M, Staben ST, Starovasnik MA, Wallweber HJ, Wu J, Wu LC, Johnson AR, Hymowitz SG.

Structure. 2012 Oct 10;20(10):1704-14. doi: 10.1016/j.str.2012.07.013. Epub 2012 Aug 23.

20.

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.

Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Krylova I, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN.

Nat Chem Biol. 2012 Jul;8(7):655-60. doi: 10.1038/nchembio.967. Epub 2012 Jun 10. Erratum in: Nat Chem Biol. 2012 Jul;8(7). doi: 10.1038/nchembio.967. Krylova, Irina [added]. Nat Chem Biol. 2013 Jul;9(7):466.

PMID:
22683611
21.

A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.

Schaefer G, Haber L, Crocker LM, Shia S, Shao L, Dowbenko D, Totpal K, Wong A, Lee CV, Stawicki S, Clark R, Fields C, Lewis Phillips GD, Prell RA, Danilenko DM, Franke Y, Stephan JP, Hwang J, Wu Y, Bostrom J, Sliwkowski MX, Fuh G, Eigenbrot C.

Cancer Cell. 2011 Oct 18;20(4):472-86. doi: 10.1016/j.ccr.2011.09.003.

22.

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.

Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, Franke Y, Cochran AG.

Structure. 2011 Oct 12;19(10):1433-42. doi: 10.1016/j.str.2011.07.005. Epub 2011 Sep 22.

23.

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.

J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21.

24.

Chemical genetics reveals an RGS/G-protein role in the action of a compound.

Fitzgerald K, Tertyshnikova S, Moore L, Bjerke L, Burley B, Cao J, Carroll P, Choy R, Doberstein S, Dubaquie Y, Franke Y, Kopczynski J, Korswagen H, Krystek SR, Lodge NJ, Plasterk R, Starrett J, Stouch T, Thalody G, Wayne H, van der Linden A, Zhang Y, Walker SG, Cockett M, Wardwell-Swanson J, Ross-Macdonald P, Kindt RM.

PLoS Genet. 2006 Apr;2(4):e57. Epub 2006 Apr 21.

25.

Images in cardiovascular medicine. Aortic endocarditis caused by inadvertent left ventricular pacemaker lead placement.

Schulze MR, Ostermaier R, Franke Y, Matschke K, Braun MU, Strasser RH.

Circulation. 2005 Dec 20;112(25):e361-3. No abstract available.

PMID:
16365199
26.

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.

Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P.

Cancer Cell. 2005 Apr;7(4):325-36.

27.

A physical map, including a BAC/PAC clone contig, of the Williams-Beuren syndrome--deletion region at 7q11.23.

Peoples R, Franke Y, Wang YK, Pérez-Jurado L, Paperna T, Cisco M, Francke U.

Am J Hum Genet. 2000 Jan;66(1):47-68.

28.

Identification of GTF2IRD1, a putative transcription factor within the Williams-Beuren syndrome deletion at 7q11.23.

Franke Y, Peoples RJ, Francke U.

Cytogenet Cell Genet. 1999;86(3-4):296-304.

PMID:
10575229
29.

Maternal UPD 20 in a hyperactive child with severe growth retardation.

Chudoba I, Franke Y, Senger G, Sauerbrei G, Demuth S, Beensen V, Neumann A, Hansmann I, Claussen U.

Eur J Hum Genet. 1999 Jul;7(5):533-40.

30.

Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides.

Fiedler A, Knorre C, Franke Y, Henne-Bruns D, Kremer B, Lüttges J, Maier M, Gerster M, Bleicher K, Bayer E, Kalthoff H.

Langenbecks Arch Surg. 1998 Aug;383(3-4):269-75.

PMID:
9776455
31.

Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).

Zimmer M, Fink TM, Franke Y, Lichter P, Spiess J.

Gene. 1995 Jul 4;159(2):219-23.

PMID:
7622053
32.

Construction of a human MluI YAC library.

Franke Y, Zimmer M.

Genomics. 1994 May 1;21(1):58-62.

PMID:
8088816

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