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Items: 1 to 50 of 56

1.

Context-dependent expression of a conditionally-inducible form of active Akt.

Park S, Burke RE, Kareva T, Kholodilov N, Aimé P, Franke TF, Levy O, Greene LA.

PLoS One. 2018 Jun 19;13(6):e0197899. doi: 10.1371/journal.pone.0197899. eCollection 2018.

2.

Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells.

Gocher AM, Azabdaftari G, Euscher LM, Dai S, Karacosta LG, Franke TF, Edelman AM.

J Biol Chem. 2017 Aug 25;292(34):14188-14204. doi: 10.1074/jbc.M117.778464. Epub 2017 Jun 20.

3.

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.

Levenga J, Krishnamurthy P, Rajamohamedsait H, Wong H, Franke TF, Cain P, Sigurdsson EM, Hoeffer CA.

Acta Neuropathol Commun. 2013 Jul 11;1:34. doi: 10.1186/2051-5960-1-34.

4.

The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression.

Lonjedo M, Poch E, Mocholí E, Hernández-Sánchez M, Ivorra C, Franke TF, Guasch RM, Pérez-Roger I.

J Biol Chem. 2013 Oct 25;288(43):30872-82. doi: 10.1074/jbc.M113.511105. Epub 2013 Sep 17.

5.

Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.

Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR.

Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15.

PMID:
22705768
6.

Opposite effects of fear conditioning and extinction on dendritic spine remodelling.

Lai CS, Franke TF, Gan WB.

Nature. 2012 Feb 19;483(7387):87-91. doi: 10.1038/nature10792.

PMID:
22343895
7.

Androgen receptor levels are upregulated by Akt in prostate cancer.

Ha S, Ruoff R, Kahoud N, Franke TF, Logan SK.

Endocr Relat Cancer. 2011 Mar 9;18(2):245-55. doi: 10.1530/ERC-10-0204. Print 2011 Apr.

8.

PI3K/Akt: getting it right matters.

Franke TF.

Oncogene. 2008 Oct 27;27(50):6473-88. doi: 10.1038/onc.2008.313. Review.

PMID:
18955974
9.

Intracellular signaling by Akt: bound to be specific.

Franke TF.

Sci Signal. 2008 Jun 17;1(24):pe29. doi: 10.1126/scisignal.124pe29. Review.

PMID:
18560018
10.

Inhibition of 5-HT1A receptor-dependent cell survival by cAMP/protein kinase A: role of protein phosphatase 2A and Bax.

Hsiung SC, Tin A, Tamir H, Franke TF, Liu KP.

J Neurosci Res. 2008 Aug 1;86(10):2326-38. doi: 10.1002/jnr.21676.

PMID:
18459133
12.

Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling.

Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB.

Oncogene. 2008 Feb 14;27(8):1114-21. Epub 2007 Aug 20.

PMID:
17704808
14.

Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.

Stoica GE, Franke TF, Wellstein A, Morgan E, Czubayko F, List HJ, Reiter R, Martin MB, Stoica A.

Oncogene. 2005 Mar 10;24(11):1964. No abstract available.

PMID:
15759010
15.

PI3K/Akt and apoptosis: size matters.

Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C.

Oncogene. 2003 Dec 8;22(56):8983-98. Review.

PMID:
14663477
16.

Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.

Stoica GE, Franke TF, Moroni M, Mueller S, Morgan E, Iann MC, Winder AD, Reiter R, Wellstein A, Martin MB, Stoica A.

Oncogene. 2003 Sep 11;22(39):7998-8011.

PMID:
12970748
18.
19.

Calcium receptor-induced serotonin secretion by parafollicular cells: role of phosphatidylinositol 3-kinase-dependent signal transduction pathways.

Liu KP, Russo AF, Hsiung SC, Adlersberg M, Franke TF, Gershon MD, Tamir H.

J Neurosci. 2003 Mar 15;23(6):2049-57.

20.

Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

Stoica GE, Franke TF, Wellstein A, Czubayko F, List HJ, Reiter R, Morgan E, Martin MB, Stoica A.

Mol Endocrinol. 2003 May;17(5):818-30. Epub 2003 Jan 23. Retraction in: Mol Endocrinol. 2004 Aug;18(8):2096.

PMID:
12554767
21.

Activation of ERK, controlled by Rac1 and Cdc42 via Akt, is required for anoikis.

Rul W, Zugasti O, Roux P, Peyssonnaux C, Eychene A, Franke TF, Lenormand P, Fort P, Hibner U.

Ann N Y Acad Sci. 2002 Nov;973:145-8.

PMID:
12485852
22.

Akt/protein kinase B promotes organ growth in transgenic mice.

Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S.

Mol Cell Biol. 2002 Apr;22(8):2799-809.

23.

Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses.

Hsu JH, Shi Y, Hu L, Fisher M, Franke TF, Lichtenstein A.

Oncogene. 2002 Feb 21;21(9):1391-400.

24.

The AKT kinase is activated in multiple myeloma tumor cells.

Hsu J, Shi Y, Krajewski S, Renner S, Fisher M, Reed JC, Franke TF, Lichtenstein A.

Blood. 2001 Nov 1;98(9):2853-5.

25.

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.

Zugasti O, Rul W, Roux P, Peyssonnaux C, Eychene A, Franke TF, Fort P, Hibner U.

Mol Cell Biol. 2001 Oct;21(19):6706-17.

26.

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo.

Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A.

Circulation. 2001 Jul 17;104(3):330-5.

PMID:
11457753
27.

Characterization of a novel isoform of caspase-9 that inhibits apoptosis.

Angelastro JM, Moon NY, Liu DX, Yang AS, Greene LA, Franke TF.

J Biol Chem. 2001 Apr 13;276(15):12190-200. Epub 2001 Jan 22.

28.

IGF-I promotes Schwann cell motility and survival via activation of Akt.

Cheng HL, Steinway M, Delaney CL, Franke TF, Feldman EL.

Mol Cell Endocrinol. 2000 Dec 22;170(1-2):211-5.

PMID:
11162904
29.

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

Kim AH, Khursigara G, Sun X, Franke TF, Chao MV.

Mol Cell Biol. 2001 Feb;21(3):893-901.

30.

Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells.

Bang OS, Park EK, Yang SI, Lee SR, Franke TF, Kang SS.

J Cell Sci. 2001 Jan;114(Pt 1):81-88.

31.

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I.

Martin MB, Franke TF, Stoica GE, Chambon P, Katzenellenbogen BS, Stoica BA, McLemore MS, Olivo SE, Stoica A.

Endocrinology. 2000 Dec;141(12):4503-11.

PMID:
11108261
32.

Assays for Akt.

Franke TF.

Methods Enzymol. 2000;322:400-10.

PMID:
10914036
33.

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

Kim YB, Peroni OD, Franke TF, Kahn BB.

Diabetes. 2000 May;49(5):847-56.

PMID:
10905496
34.

Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival.

Wang X, McCullough KD, Franke TF, Holbrook NJ.

J Biol Chem. 2000 May 12;275(19):14624-31.

35.

Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal.

Li W, Zhang J, Flechner L, Hyun T, Yam A, Franke TF, Pierce JH.

Oncogene. 1999 Nov 11;18(47):6564-72.

36.

Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro.

Matsui T, Li L, del MonteF, Fukui Y, Franke TF, Hajjar RJ, Rosenzweig A.

Circulation. 1999 Dec 7;100(23):2373-9.

PMID:
10587343
37.

Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B.

Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC, Franke TF, Marsh CB.

J Biol Chem. 1999 Sep 10;274(37):26393-8.

38.

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.

Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC.

Nature. 1999 Jun 10;399(6736):597-601. Erratum in: Nature 1999 Aug 19;400(6746):792.

39.

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.

Science. 1999 Apr 9;284(5412):339-43.

40.

Regulation of cell death protease caspase-9 by phosphorylation.

Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC.

Science. 1998 Nov 13;282(5392):1318-21.

41.

Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation.

Cerezo A, Martínez-A C, Lanzarot D, Fischer S, Franke TF, Rebollo A.

Mol Biol Cell. 1998 Nov;9(11):3107-18.

42.

Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells.

Eder AM, Dominguez L, Franke TF, Ashwell JD.

J Biol Chem. 1998 Oct 23;273(43):28025-31.

43.

Apoptosis. A Bad kinase makes good.

Franke TF, Cantley LC.

Nature. 1997 Nov 13;390(6656):116-7. No abstract available.

PMID:
9367147
44.

Interleukin 3-dependent survival by the Akt protein kinase.

Songyang Z, Baltimore D, Cantley LC, Kaplan DR, Franke TF.

Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11345-50.

45.

PI3K: downstream AKTion blocks apoptosis.

Franke TF, Kaplan DR, Cantley LC.

Cell. 1997 Feb 21;88(4):435-7. Review. No abstract available.

46.

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.

Franke TF, Kaplan DR, Cantley LC, Toker A.

Science. 1997 Jan 31;275(5300):665-8.

47.

Regulation of neuronal survival by the serine-threonine protein kinase Akt.

Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME.

Science. 1997 Jan 31;275(5300):661-5.

48.

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.

Cell. 1995 Jun 2;81(5):727-36.

49.

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation.

Datta K, Franke TF, Chan TO, Makris A, Yang SI, Kaplan DR, Morrison DK, Golemis EA, Tsichlis PN.

Mol Cell Biol. 1995 Apr;15(4):2304-10.

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