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CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.

Egusquiaguirre SP, Liu S, Tošić I, Jiang K, Walker SR, Nicolais M, Saw TY, Xiang M, Bartel K, Nelson EA, Frank DA.

Neoplasia. 2019 Nov 22;22(1):47-59. doi: 10.1016/j.neo.2019.10.002. [Epub ahead of print]


Inhibit versus Destroy: Are PROTAC Degraders the Solution to Targeting STAT3?

Heppler LN, Frank DA.

Cancer Cell. 2019 Nov 11;36(5):459-461. doi: 10.1016/j.ccell.2019.10.010.


SNAP, Young Children's Health, and Family Food Security and Healthcare Access.

Ettinger de Cuba SA, Bovell-Ammon AR, Cook JT, Coleman SM, Black MM, Chilton MM, Casey PH, Cutts DB, Heeren TC, Sandel MT, Sheward R, Frank DA.

Am J Prev Med. 2019 Oct;57(4):525-532. doi: 10.1016/j.amepre.2019.04.027. Erratum in: Am J Prev Med. 2019 Dec;57(6):873.


Maternal place of birth, socioeconomic characteristics, and child health in US-Born Latinx children in Boston.

Tang MN, Ettinger de Cuba S, Coleman SM, Heeran T, Sandel M, Chilton M, Frank DA, Huh SY.

Acad Pediatr. 2019 Sep 18. pii: S1876-2859(19)30388-2. doi: 10.1016/j.acap.2019.09.005. [Epub ahead of print]


Human decision-making biases in the moral dilemmas of autonomous vehicles.

Frank DA, Chrysochou P, Mitkidis P, Ariely D.

Sci Rep. 2019 Sep 11;9(1):13080. doi: 10.1038/s41598-019-49411-7.


Food Insecurity, Health, and Development in Children Under Age Four Years.

Drennen CR, Coleman SM, Ettinger de Cuba S, Frank DA, Chilton M, Cook JT, Cutts DB, Heeren T, Casey PH, Black MM.

Pediatrics. 2019 Oct;144(4). pii: e20190824. doi: 10.1542/peds.2019-0824. Epub 2019 Sep 9.


Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

Niu J, Sun Y, Chen B, Zheng B, Jarugumilli GK, Walker SR, Hata AN, Mino-Kenudson M, Frank DA, Wu X.

Nature. 2019 Sep;573(7772):139-143. doi: 10.1038/s41586-019-1511-x. Epub 2019 Aug 28.


Housing Instability Among Families With Young Children With Special Health Care Needs.

Rose-Jacobs R, Ettinger de Cuba S, Bovell-Ammon A, Black MM, Coleman SM, Cutts D, Chilton M, Heeren T, Casey P, Ochoa E, Frank DA, Sandel M.

Pediatrics. 2019 Aug;144(2). pii: e20181704. doi: 10.1542/peds.2018-1704. Epub 2019 Jul 10.


Loss Of SNAP Is Associated With Food Insecurity And Poor Health In Working Families With Young Children.

Ettinger de Cuba S, Chilton M, Bovell-Ammon A, Knowles M, Coleman SM, Black MM, Cook JT, Cutts DB, Casey PH, Heeren TC, Frank DA.

Health Aff (Millwood). 2019 May;38(5):765-773. doi: 10.1377/hlthaff.2018.05265.


Trends in Food Insecurity and SNAP Participation among Immigrant Families U.S.-Born Young Children.

Bovell-Ammon A, Cuba SE, Coleman S, Ahmad N, Black MM, Frank DA, Ochoa E Jr, Cutts DB.

Children (Basel). 2019 Apr 4;6(4). pii: E55. doi: 10.3390/children6040055.


Do Differences in Learning Performance Precede or Follow Initiation of Marijuana Use?

Barthelemy OJ, Richardson MA, Heeren TC, Chen CA, Liebschutz JM, Forman LS, Cabral HJ, Frank DA, Rose-Jacobs R.

J Stud Alcohol Drugs. 2019 Jan;80(1):5-14.


Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.

Chen CH, Bhasin S, Khanna P, Joshi M, Joslin PM, Saxena R, Amin S, Liu S, Sindhu S, Walker SR, Catalano P, Frank DA, Alper SL, Bhasin M, Bhatt RS.

Oncogenesis. 2019 Feb 22;8(3):15. doi: 10.1038/s41389-019-0121-7.


The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.

Liu S, Marneth AE, Alexe G, Walker SR, Gandler HI, Ye DQ, Labella K, Mathur R, Toniolo PA, Tillgren M, Gokhale PC, Barbie D, Mullally A, Stegmaier K, Frank DA.

Blood Adv. 2018 Dec 11;2(23):3428-3442. doi: 10.1182/bloodadvances.2018016733.


Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S, Lopez R, Pradhan K, Giricz O, Ravipati G, Wong LF, Cole S, Bhagat TD, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan VJ, Wickrema A, Ye BH, Frank DA, Pellagatti A, Boultwood J, Zhou T, Kim Y, MacLeod AR, Epling-Burnette PK, Ye M, McCoon P, Woessner R, Steidl U, Will B, Verma A.

J Clin Invest. 2018 Dec 3;128(12):5479-5488. doi: 10.1172/JCI120156. Epub 2018 Nov 5.


Timing and Duration of Pre- and Postnatal Homelessness and the Health of Young Children.

Sandel M, Sheward R, Ettinger de Cuba S, Coleman S, Heeren T, Black MM, Casey PH, Chilton M, Cook J, Cutts DB, Rose-Jacobs R, Frank DA.

Pediatrics. 2018 Oct;142(4). pii: e20174254. doi: 10.1542/peds.2017-4254. Epub 2018 Sep 3.


IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.

Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Dunagin MC, Raj A, Diehl JA, Wong KK, Bass AJ, Rustgi AK.

Cancer Res. 2018 Sep 1;78(17):4957-4970. doi: 10.1158/0008-5472.CAN-17-2268. Epub 2018 Jul 5.


Childhood Trauma Questionnaire (CTQ) correlations with prospective violence assessment in a longitudinal cohort.

Liebschutz JM, Buchanan-Howland K, Chen CA, Frank DA, Richardson MA, Heeren TC, Cabral HJ, Rose-Jacobs R.

Psychol Assess. 2018 Jun;30(6):841-845. doi: 10.1037/pas0000549.


The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.

Egusquiaguirre SP, Yeh JE, Walker SR, Liu S, Frank DA.

Neoplasia. 2018 May;20(5):489-498. doi: 10.1016/j.neo.2018.03.004. Epub 2018 Apr 2.


Unstable Housing and Caregiver and Child Health in Renter Families.

Sandel M, Sheward R, Ettinger de Cuba S, Coleman SM, Frank DA, Chilton M, Black M, Heeren T, Pasquariello J, Casey P, Ochoa E, Cutts D.

Pediatrics. 2018 Feb;141(2). pii: e20172199. doi: 10.1542/peds.2017-2199. Epub 2018 Jan 22.


Rare mutations provide unique insight into oncogenic potential of STAT transcription factors.

Heppler LN, Frank DA.

J Clin Invest. 2018 Jan 2;128(1):113-115. doi: 10.1172/JCI98619. Epub 2017 Dec 4.


Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors.

Heppler LN, Frank DA.

Trends Cancer. 2017 Dec;3(12):816-827. doi: 10.1016/j.trecan.2017.10.004. Epub 2017 Nov 10. Review.


State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.

Xi D, Bao T, Chen Q, Chen S, Cheng YC, Cullen J, Frank DA, Friedberg JW, Kronish I, Lee JE, Levine M, Li P, Li S, Lu W, Mao JJ, O'Keefe S, Rubinstein L, Shah MA, Standish L, Paller CJ, Chu E.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx003.


Mothers' Adverse Childhood Experiences and Their Young Children's Development.

Sun J, Patel F, Rose-Jacobs R, Frank DA, Black MM, Chilton M.

Am J Prev Med. 2017 Dec;53(6):882-891. doi: 10.1016/j.amepre.2017.07.015. Epub 2017 Sep 14.


The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.

Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K.

Cancer Immunol Immunother. 2018 Jan;67(1):13-23. doi: 10.1007/s00262-017-2057-0. Epub 2017 Sep 5.


Intrauterine exposure to tobacco and executive functioning in high school.

Rose-Jacobs R, Richardson MA, Buchanan-Howland K, Chen CA, Cabral H, Heeren TC, Liebschutz J, Forman L, Frank DA.

Drug Alcohol Depend. 2017 Jul 1;176:169-175. doi: 10.1016/j.drugalcdep.2017.02.022. Epub 2017 May 10.


Marrying Step Feed with Secondary Clarifier Improvements to Significantly Increase Peak Wet Weather Treatment Capacity: An Integrated Methodology.

Daigger GT, Siczka JS, Smith TF, Frank DA, McCorquodale JA.

Water Environ Res. 2017 Aug 1;89(8):724-731. doi: 10.2175/106143017X14839994523983. Epub 2017 Mar 22.


Growth-and Documentation-Deficits: Where To Start in Helping Families.

Hernandez W, Frank DA, Morton S, Palacios C, Augustyn M.

J Dev Behav Pediatr. 2017 Feb/Mar;38 Suppl 1:S82-S83. doi: 10.1097/DBP.0000000000000398.


Association of Food Insecurity with Children's Behavioral, Emotional, and Academic Outcomes: A Systematic Review.

Shankar P, Chung R, Frank DA.

J Dev Behav Pediatr. 2017 Feb/Mar;38(2):135-150. doi: 10.1097/DBP.0000000000000383. Review.


An Algorithm for Diagnosing and Treating Primary and Recurrent Patellar Instability.

Duerr RA, Chauhan A, Frank DA, DeMeo PJ, Akhavan S.

JBJS Rev. 2016 Sep 13;4(9). pii: 01874474-201609000-00003. doi: 10.2106/JBJS.RVW.15.00102.


NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ.

Cell Discov. 2016 Sep 20;2:16030. doi: 10.1038/celldisc.2016.30. eCollection 2016.


Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.

Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, Frank DA.

Blood. 2016 Oct 6;128(14):1845-1853. doi: 10.1182/blood-2015-07-660506. Epub 2016 Aug 16.


Posterior Shoulder Instability in Athletes.

Chauhan A, Mosier B, Kelly B, Akhavan S, Frank DA.

JBJS Rev. 2015 Aug 4;3(8). pii: 01874474-201508000-00001. doi: 10.2106/JBJS.RVW.N.00090. No abstract available.


Characterizing shallow secondary clarifier performance where conventional flux theory over-estimates allowable solids loading rate.

Daigger GT, Siczka JS, Smith TF, Frank DA, McCorquodale JA.

Water Sci Technol. 2016;74(2):324-32. doi: 10.2166/wst.2016.177.


Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia.

Laidlaw KM, Berhan S, Liu S, Silvestri G, Holyoake TL, Frank DA, Aggarwal B, Bonner MY, Perrotti D, Jørgensen HG, Arbiser JL.

Oncotarget. 2016 Aug 9;7(32):51651-51664. doi: 10.18632/oncotarget.10541.


Prenatal, perinatal, and adolescent exposure to marijuana: Relationships with aggressive behavior.

Barthelemy OJ, Richardson MA, Cabral HJ, Frank DA.

Neurotoxicol Teratol. 2016 Nov - Dec;58:60-77. doi: 10.1016/ Epub 2016 Jun 23. Review.


Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia.

Toniolo PA, Liu S, Yeh JE, Ye DQ, Barbuto JA, Frank DA.

Oncotarget. 2016 Jul 19;7(29):46301-46314. doi: 10.18632/oncotarget.10093.


Children with Special Health Care Needs, Supplemental Security Income, and Food Insecurity.

Rose-Jacobs R, Fiore JG, Ettinger de Cuba S, Black M, Cutts DB, Coleman SM, Heeren T, Chilton M, Casey P, Cook J, Frank DA.

J Dev Behav Pediatr. 2016 Feb-Mar;37(2):140-7. doi: 10.1097/DBP.0000000000000260.


Targeting BCL6 and STAT3 in triple negative breast cancer: the one-two punch?

Walker SR, Frank DA.

Oncoscience. 2015 Nov 21;2(11):912. eCollection 2015. No abstract available.


Young investigator challenge: Application of cytologic techniques to circulating tumor cell specimens: Detecting activation of the oncogenic transcription factor STAT3.

Lowe AC, Pignon JC, Carvo I, Drage MG, Constantine NM, Jones N, Kroll Y, Frank DA, Signoretti S, Cibas ES.

Cancer Cytopathol. 2015 Dec;123(12):696-706. doi: 10.1002/cncy.21640.


STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy.

Yeh JE, Frank DA.

ChemMedChem. 2016 Apr 19;11(8):795-801. doi: 10.1002/cmdc.201500482. Epub 2015 Dec 10. Review.


Effects of intrauterine substance and postnatal violence exposure on aggression in children.

Barthelemy OJ, Richardson MA, Rose-Jacobs R, Forman LS, Cabral HJ, Frank DA.

Aggress Behav. 2016 May-Jun;42(3):209-21. doi: 10.1002/ab.21607. Epub 2015 Dec 10.


Childhood Adversity and Adult Reports of Food Insecurity Among Households With Children.

Sun J, Knowles M, Patel F, Frank DA, Heeren TC, Chilton M.

Am J Prev Med. 2016 May;50(5):561-572. doi: 10.1016/j.amepre.2015.09.024. Epub 2015 Nov 16.


Trajectory of Material Hardship and Income Poverty in Families of Children Undergoing Chemotherapy: A Prospective Cohort Study.

Bona K, London WB, Guo D, Frank DA, Wolfe J.

Pediatr Blood Cancer. 2016 Jan;63(1):105-11. doi: 10.1002/pbc.25762. Epub 2015 Sep 23.


More of the same? In situ leaf and root decomposition rates do not vary between 80 native and nonnative deciduous forest species.

Jo I, Fridley JD, Frank DA.

New Phytol. 2016 Jan;209(1):115-22. doi: 10.1111/nph.13619. Epub 2015 Sep 3. Erratum in: New Phytol. 2016 Oct;212(2):523-5.


Development of Selective Covalent Janus Kinase 3 Inhibitors.

Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.

J Med Chem. 2015 Aug 27;58(16):6589-606. doi: 10.1021/acs.jmedchem.5b00710. Epub 2015 Aug 18.


Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.

Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW.

J Biol Chem. 2015 Sep 25;290(39):23553-62. doi: 10.1074/jbc.M115.662445. Epub 2015 Aug 4.


Psychological Distress Among School-Aged Children with and Without Intrauterine Cocaine Exposure: Perinatal Versus Contextual Effects.

Richardson MA, Grant-Knight W, Beeghly M, Rose-Jacobs R, Chen CA, Appugliese DP, Cabral HJ, Liebschutz JM, Frank DA.

J Abnorm Child Psychol. 2016 Apr;44(3):547-60. doi: 10.1007/s10802-015-0052-5.


Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity.

Hu T, Yeh JE, Pinello L, Jacob J, Chakravarthy S, Yuan GC, Chopra R, Frank DA.

Mol Cell Biol. 2015 Oct;35(19):3284-300. doi: 10.1128/MCB.00060-15. Epub 2015 Jul 13.


Prenatal substance exposure: What predicts behavioral resilience by early adolescence?

Liebschutz JM, Crooks D, Rose-Jacobs R, Cabral HJ, Heeren TC, Gerteis J, Appugliese DP, Heymann OD, Lange AV, Frank DA.

Psychol Addict Behav. 2015 Jun;29(2):329-37. doi: 10.1037/adb0000082.


Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.

Yeh JE, Kreimer S, Walker SR, Emori MM, Krystal H, Richardson A, Ivanov AR, Frank DA.

Genes Cancer. 2015 Mar;6(3-4):153-68.

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