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Items: 48

1.

Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis.

Zarbin MA, Francom S, Grzeschik S, Tuomi L, Haskova Z, Macfadden W, Margaron P, Snow H, Cruess A, Staurenghi G, Dunger-Baldauf C.

Ophthalmol Retina. 2018 Nov;2(11):1087-1096. doi: 10.1016/j.oret.2018.04.018. Epub 2018 Jun 11.

PMID:
31047547
2.

The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration.

Dugel PU, Singh N, Francom S, Cantrell RA, Grzeschik SM, Fung AE.

Ophthalmol Retina. 2018 Jul;2(7):667-675. doi: 10.1016/j.oret.2018.01.010. Epub 2018 Feb 27.

PMID:
31047375
3.

Vascular Safety of Ranibizumab in Patients With Diabetic Macular Edema: A Pooled Analysis of Patient-Level Data From Randomized Clinical Trials.

Zarbin MA, Dunger-Baldauf C, Haskova Z, Koovejee P, Mousseau MC, Margaron P, Snow H, Beaumont PE, Staurenghi G, Francom S.

JAMA Ophthalmol. 2017 May 1;135(5):424-431. doi: 10.1001/jamaophthalmol.2017.0455.

4.

Author reply: To PMID 24393349.

Bakri SJ, Moshfeghi DM, Francom S, Rundle AC, Reshef DS, Lee PP, Schaeffer C, Rubio RG, Lai P.

Ophthalmology. 2015 Mar;122(3):e19. doi: 10.1016/j.ophtha.2014.08.010. No abstract available.

PMID:
25703472
5.

Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials.

Bakri SJ, Moshfeghi DM, Francom S, Rundle AC, Reshef DS, Lee PP, Schaeffer C, Rubio RG, Lai P.

Ophthalmology. 2014 May;121(5):1102-8. doi: 10.1016/j.ophtha.2013.11.029. Epub 2014 Jan 6.

PMID:
24393349
6.

Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials.

Bressler NM, Boyer DS, Williams DF, Butler S, Francom SF, Brown B, Di Nucci F, Cramm T, Tuomi LL, Ianchulev T, Rubio RG.

Retina. 2012 Oct;32(9):1821-8.

PMID:
23011184
7.

Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: the phase III FILM trial.

Stohl W, Gomez-Reino J, Olech E, Dudler J, Fleischmann RM, Zerbini CA, Ashrafzadeh A, Grzeschik S, Bieraugel R, Green J, Francom S, Dummer W.

Ann Rheum Dis. 2012 Aug;71(8):1289-96. doi: 10.1136/annrheumdis-2011-200706. Epub 2012 Feb 2.

8.

A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration.

Boyer DS, Heier JS, Brown DM, Francom SF, Ianchulev T, Rubio RG.

Ophthalmology. 2009 Sep;116(9):1731-9. doi: 10.1016/j.ophtha.2009.05.024. Epub 2009 Jul 29.

PMID:
19643495
9.

Comparison of QTinno, a fully automated electrocardiographic analysis program, to semiautomated electrocardiographic analysis methods in a drug safety study in healthy subjects.

Sarapa N, Gussak I, Vajdic B, George S, Hadzievski L, Francom SF, Kowey P.

J Electrocardiol. 2009 Jul-Aug;42(4):358-66. doi: 10.1016/j.jelectrocard.2009.02.001. Epub 2009 Apr 10.

PMID:
19362316
10.

Detection of clinically significant QTc prolongation in phase I studies in healthy participants: comparison of 2 semiautomated QT measurement methods.

Sarapa N, Francom SF, Azzam SM, Wickremasingha PK, Tyl B.

J Clin Pharmacol. 2009 Jan;49(1):103-8. doi: 10.1177/0091270008326717. Epub 2008 Oct 28. No abstract available.

PMID:
18957527
11.

Field gradient electrophoresis.

Warnick KF, Francom SJ, Humble PH, Kelly RT, Woolley AT, Lee ML, Tolley HD.

Electrophoresis. 2005 Jan;26(2):405-14.

PMID:
15657888
12.

Comparing methods of measurement for detecting drug-induced changes in the QT interval: implications for thoroughly conducted ECG studies.

Azie NE, Adams G, Darpo B, Francom SF, Polasek EC, Wisser JM, Fleishaker JC.

Ann Noninvasive Electrocardiol. 2004 Apr;9(2):166-74.

PMID:
15084215
13.

Single oral dose safety, tolerability, and pharmacokinetics of PNU-96391 in healthy volunteers.

Rodríguez CA, Azie NE, Adams G, Donaldson K, Francom SF, Staton BA, Bombardt PA.

J Clin Pharmacol. 2004 Mar;44(3):276-83.

PMID:
14973308
14.

Electrocardiographic identification of drug-induced QT prolongation: assessment by different recording and measurement methods.

Sarapa N, Morganroth J, Couderc JP, Francom SF, Darpo B, Fleishaker JC, McEnroe JD, Chen WT, Zareba W, Moss AJ.

Ann Noninvasive Electrocardiol. 2004 Jan;9(1):48-57.

PMID:
14731216
15.

The pharmacokinetics of linezolid are not affected by concomitant intake of the antioxidant vitamins C and E.

Gordi T, Tan LH, Hong C, Hopkins NJ, Francom SF, Slatter JG, Antal EJ.

J Clin Pharmacol. 2003 Oct;43(10):1161-7.

PMID:
14517199
16.

Valdecoxib, a COX-2-specific inhibitor, does not affect cardiac repolarization.

Sarapa N, Britto MR, Cotton B, Cox SR, Francom SF, Jin N, Polasek ED, Sainati SM, Crosby-Sessoms SL, Fleishaker JC.

J Clin Pharmacol. 2003 Sep;43(9):974-82.

PMID:
12971029
17.

Anticipatory anxiety in moderately to highly-anxious oral surgery patients as a screening model for anxiolytics: evaluation of alprazolam.

Wolf DL, Desjardins PJ, Black PM, Francom SR, Mohanlal RW, Fleishaker JC.

J Clin Psychopharmacol. 2003 Feb;23(1):51-7.

PMID:
12544376
18.

Cardiovascular effect of almotriptan in treated hypertensive patients.

Fleishaker JC, McEnroe JD, Azie NE, Francom SF, Carel BJ.

Clin Pharmacol Ther. 2002 Mar;71(3):169-75.

PMID:
11907491
19.

Lack of effect of reboxetine on cardiac repolarization.

Fleishaker JC, Francom SF, Herman BD, Knuth DW, Azie NE.

Clin Pharmacol Ther. 2001 Sep;70(3):261-9.

PMID:
11557914
20.

Pharmacokinetics and tolerability of a novel 5-HT1D agonist, PNU-142633F.

Fleishaker JC, Pearson LK, Knuth DW, Gomez-Mancilla B, Francom SF, McIntosh MJ, Freestone S, Azie NE.

Int J Clin Pharmacol Ther. 1999 Oct;37(10):487-92.

PMID:
10543315
21.

Effect of systemic corticoid and antihistamine alone or in combination on elements of the response to a two dose nasal allergen challenge.

Brooks CD, Chene BL, Klott KA, Busboom SD, Francom SF.

Am J Rhinol. 1997 Mar-Apr;11(2):117-22.

PMID:
9129753
22.

Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans.

Hughes GS Jr, Antal EJ, Locker PK, Francom SF, Adams WJ, Jacobs EE Jr.

Crit Care Med. 1996 May;24(5):756-64.

PMID:
8706450
23.

Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry.

Hughes GS, Francom SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, Jacobs EE.

Ann Emerg Med. 1996 Feb;27(2):164-9.

PMID:
8629746
24.

Pharmacy records at the Archives of Ontario: their form, content, and value for research.

Francom S.

Can Bull Med Hist. 1996;13(1):151-7. No abstract available.

PMID:
11613338
25.

Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans.

Hughes GS Jr, Yancey EP, Albrecht R, Locker PK, Francom SF, Orringer EP, Antal EJ, Jacobs EE Jr.

Clin Pharmacol Ther. 1995 Oct;58(4):434-43.

PMID:
7586936
26.

Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolemia. Lifibrol Study Group.

Locker PK, Jungbluth GL, Francom SF, Hughes GS Jr.

Clin Pharmacol Ther. 1995 Jan;57(1):73-88.

PMID:
7828385
27.

ATGAM skin test standardization. Comparison of skin testing techniques in horse-sensitive and unselected human volunteers.

Brooks CD, Karl KJ, Francom SF.

Transplantation. 1994 Nov 27;58(10):1135-7. No abstract available.

PMID:
7974723
28.

Lack of effects of beta-carotene on lipids and sex steroid hormones in hyperlipidemics.

Hughes GS Jr, Ringer TV, Francom SF, Means LK, DeLoof MJ.

Am J Med Sci. 1994 Jul;308(1):16-22.

PMID:
8010332
31.

Oral methylprednisolone acetate (Medrol Tablets) for seasonal rhinitis: examination of dose and symptom response.

Brooks CD, Karl KJ, Francom SF.

J Clin Pharmacol. 1993 Sep;33(9):816-22.

PMID:
8227478
32.

A double stopcock technique for repeated sampling of venous blood.

Hanover CK, Spillers CR, Francom SF, Locker PK, Hughes GS Jr.

Methods Find Exp Clin Pharmacol. 1992 Sep;14(7):537-43.

PMID:
1287378
33.

Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time.

Friedman H, Greenblatt DJ, Peters GR, Metzler CM, Charlton MD, Harmatz JS, Antal EJ, Sanborn EC, Francom SF.

Clin Pharmacol Ther. 1992 Aug;52(2):139-50.

PMID:
1505149
34.

Synergistic effects of oral nonsteroidal drugs and topical corticosteroids in the therapy of sunburn in humans.

Hughes GS, Francom SF, Means LK, Bohan DF, Caruana C, Holland M.

Dermatology. 1992;184(1):54-8.

PMID:
1558996
35.

Effects of fish oil and endorphins on the cold pressor test in hypertension.

Hughes GS Jr, Ringer TV, Francom SF, Caswell KC, DeLoof MJ, Spillers CR.

Clin Pharmacol Ther. 1991 Nov;50(5 Pt 1):538-46.

PMID:
1934867
36.
37.

Evaluation of intraosseous vs intravenous antibiotic levels in a porcine model.

Jaimovich DG, Kumar A, Francom S.

Am J Dis Child. 1991 Aug;145(8):946-9. Erratum in: Am J Dis Child 1991 Nov;145(11):1241.

PMID:
1858734
38.

Beta-carotene's effects on serum lipoproteins and immunologic indices in humans.

Ringer TV, DeLoof MJ, Winterrowd GE, Francom SF, Gaylor SK, Ryan JA, Sanders ME, Hughes GS.

Am J Clin Nutr. 1991 Mar;53(3):688-94.

PMID:
2000823
39.

Human safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F).

Novak E, Paxton LM, Bye A, Patel R, Zurenko GE, Francom SF.

Antimicrob Agents Chemother. 1990 Dec;34(12):2342-7.

40.

Fish oil produces an atherogenic lipid profile in hypertensive men.

Hughes GS, Ringer TV, Watts KC, DeLoof MJ, Francom SF, Spillers CR.

Atherosclerosis. 1990 Oct;84(2-3):229-37.

PMID:
2282101
41.

Multiple-dose, double-blind, placebo controlled intravenous tolerance and pharmacokinetic study of trospectomycin sulfate (U-63, 366F) in healthy male volunteers.

Peters GR, Novak E, Batts DH, Bye A, Nichols DJ, Francom SF.

Int J Clin Pharmacol Ther Toxicol. 1990 Sep;28(9):361-8.

PMID:
2146231
42.
43.

Clinical pharmacology of predisintegrated ibuprofen 800 mg tablets: an endoscopic and pharmacokinetic study.

Friedman H, Seckman C, Lanza F, Royer G, Perry K, Francom S.

J Clin Pharmacol. 1990 Jan;30(1):57-63.

PMID:
2303582
44.

The effect of ketoconazole and transdermal estradiol on serum sex steroid hormones levels.

Hughes GS, Francom SF, Spillers CR, Ringer TV.

Eur J Clin Pharmacol. 1990;38(6):555-60.

PMID:
2164934
45.

Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established.

Brooks CD, Karl KJ, Francom SF.

Clin Exp Allergy. 1990 Jan;20(1):21-6. Review.

PMID:
2107013
46.

A log-linear model for ordinal data to characterize differential change among treatments.

Francom SF, Chuang-Stein C, Landis JR.

Stat Med. 1989 May;8(5):571-82.

PMID:
2727476
47.
48.

Adrenal suppression with high-potency corticosteroid ointment formulations in normal subjects.

Novak E, Francom SF, Schlagel CA.

Clin Ther. 1983;6(1):59-71.

PMID:
6370438

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