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Heterogeneity of human prostate carcinoma-associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment.

Vickman RE, Broman MM, Lanman NA, Franco OE, Sudyanti PAG, Ni Y, Ji Y, Helfand BT, Petkewicz J, Paterakos MC, Crawford SE, Ratliff TL, Hayward SW.

Prostate. 2020 Feb;80(2):173-185. doi: 10.1002/pros.23929. Epub 2019 Nov 25.


Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy.

Day JH, Nicholson TM, Su X, van Neel TL, Clinton I, Kothandapani A, Lee J, Greenberg MH, Amory JK, Walsh TJ, Muller CH, Franco OE, Jefcoate CR, Crawford SE, Jorgensen JS, Theberge AB.

Lab Chip. 2020 Jan 7;20(1):107-119. doi: 10.1039/c9lc00706g. Epub 2019 Nov 12.


Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF.

Nardi F, Fitchev P, Brooks KM, Franco OE, Cheng K, Hayward SW, Welte MA, Crawford SE.

Lab Invest. 2019 Dec;99(12):1822-1834. doi: 10.1038/s41374-019-0296-8. Epub 2019 Aug 13.


Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Aaron-Brooks LM, Sasaki T, Vickman RE, Wei L, Franco OE, Ji Y, Crawford SE, Hayward SW.

Prostate. 2019 Jun;79(9):980-993. doi: 10.1002/pros.23809. Epub 2019 Apr 18.


DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130.

Nardi F, Franco OE, Fitchev P, Morales A, Vickman RE, Hayward SW, Crawford SE.

Sci Rep. 2019 Feb 28;9(1):3035. doi: 10.1038/s41598-019-39537-z.


Tyrosine kinase inhibitor therapy prescribed for non-urologic diseases can modify PSA titers in urology patients.

Sasaki T, Franco OE, Ohishi K, Filipovich Y, Ishii K, Crawford SE, Takahashi N, Katayama N, Sugimura Y, Hayward SW.

Prostate. 2019 Feb;79(3):259-264. doi: 10.1002/pros.23730. Epub 2018 Oct 28.


Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men.

Gillard M, Javier R, Ji Y, Zheng SL, Xu J, Brendler CB, Crawford SE, Pierce BL, Griend DJV, Franco OE.

Cancer Res. 2018 Nov 1;78(21):6134-6145. doi: 10.1158/0008-5472.CAN-17-3810. Epub 2018 Sep 4.


PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts.

Nardi F, Fitchev P, Franco OE, Ivanisevic J, Scheibler A, Hayward SW, Brendler CB, Welte MA, Crawford SE.

J Cell Sci. 2018 Jul 11;131(13). pii: jcs213579. doi: 10.1242/jcs.213579.


Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.

Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ.

J Cell Biol. 2017 Nov 6;216(11):3799-3816. doi: 10.1083/jcb.201704053. Epub 2017 Oct 11.


Interaction of prostate carcinoma-associated fibroblasts with human epithelial cell lines in vivo.

Sasaki T, Franco OE, Hayward SW.

Differentiation. 2017 Jul - Aug;96:40-48. doi: 10.1016/j.diff.2017.07.002. Epub 2017 Jul 20. Review.


Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ.

Sameni M, Cavallo-Medved D, Franco OE, Chalasani A, Ji K, Aggarwal N, Anbalagan A, Chen X, Mattingly RR, Hayward SW, Sloane BF.

Breast Cancer Res. 2017 May 15;19(1):56. doi: 10.1186/s13058-017-0847-0.


Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts.

Nash C, Boufaied N, Mills IG, Franco OE, Hayward SW, Thomson AA.

Mol Cell Endocrinol. 2018 Aug 15;471:1-14. doi: 10.1016/j.mce.2017.05.006. Epub 2017 May 5.


Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90.

Henke A, Franco OE, Stewart GD, Riddick AC, Katz E, Hayward SW, Thomson AA.

Cancers (Basel). 2016 Aug 24;8(9). pii: E77. doi: 10.3390/cancers8090077.


Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia.

Aaron L, Franco OE, Hayward SW.

Urol Clin North Am. 2016 Aug;43(3):279-88. doi: 10.1016/j.ucl.2016.04.012. Review.


Altered TGF-α/β signaling drives cooperation between breast cancer cell populations.

Franco OE, Tyson DR, Konvinse KC, Udyavar AR, Estrada L, Quaranta V, Crawford SE, Hayward SW.

FASEB J. 2016 Oct;30(10):3441-3452. Epub 2016 Jul 6.


NF-κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.

Austin DC, Strand DW, Love HL, Franco OE, Grabowska MM, Miller NL, Hameed O, Clark PE, Matusik RJ, Jin RJ, Hayward SW.

Prostate. 2016 Aug;76(11):1004-18. doi: 10.1002/pros.23195. Epub 2016 May 16.


Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.

Bianchi-Frias D, Basom R, Delrow JJ, Coleman IM, Dakhova O, Qu X, Fang M, Franco OE, Ericson NG, Bielas JH, Hayward SW, True L, Morrissey C, Brown L, Bhowmick NA, Rowley D, Ittmann M, Nelson PS.

Mol Cancer Res. 2016 Apr;14(4):374-84. doi: 10.1158/1541-7786.MCR-15-0330. Epub 2016 Jan 11.


NF-κB and androgen receptor variant expression correlate with human BPH progression.

Austin DC, Strand DW, Love HL, Franco OE, Jang A, Grabowska MM, Miller NL, Hameed O, Clark PE, Fowke JH, Matusik RJ, Jin RJ, Hayward SW.

Prostate. 2016 Apr;76(5):491-511. doi: 10.1002/pros.23140. Epub 2015 Dec 28.


Isolation and analysis of discreet human prostate cellular populations.

Strand DW, Aaron L, Henry G, Franco OE, Hayward SW.

Differentiation. 2016 Apr-Jun;91(4-5):139-51. doi: 10.1016/j.diff.2015.10.013. Epub 2015 Nov 3. Review.


Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration.

Osuala KO, Sameni M, Shah S, Aggarwal N, Simonait ML, Franco OE, Hong Y, Hayward SW, Behbod F, Mattingly RR, Sloane BF.

BMC Cancer. 2015 Aug 13;15:584. doi: 10.1186/s12885-015-1576-3.


Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.

Huynh TP, Barwe SP, Lee SJ, McSpadden R, Franco OE, Hayward SW, Damoiseaux R, Grubbs SS, Petrelli NJ, Rajasekaran AK.

PLoS One. 2015 Apr 2;10(4):e0122442. doi: 10.1371/journal.pone.0122442. eCollection 2015.


Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion.

Nolan KD, Franco OE, Hance MW, Hayward SW, Isaacs JS.

J Biol Chem. 2015 Mar 27;290(13):8271-82. doi: 10.1074/jbc.M115.637496. Epub 2015 Feb 10.


Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression.

Jin R, Yamashita H, Yu X, Wang J, Franco OE, Wang Y, Hayward SW, Matusik RJ.

Oncogene. 2015 Jul;34(28):3700-10. doi: 10.1038/onc.2014.302. Epub 2014 Sep 15.


SOX2 expression in the developing, adult, as well as, diseased prostate.

Yu X, Cates JM, Morrissey C, You C, Grabowska MM, Zhang J, DeGraff DJ, Strand DW, Franco OE, Lin-Tsai O, Hayward SW, Matusik RJ.

Prostate Cancer Prostatic Dis. 2014 Dec;17(4):301-9. doi: 10.1038/pcan.2014.29. Epub 2014 Aug 5.


A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.

Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R.

Eur Urol. 2013 Nov;64(5):753-61. doi: 10.1016/j.eururo.2013.03.054. Epub 2013 Apr 6.


Deficiency in metabolic regulators PPARγ and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration.

Strand DW, DeGraff DJ, Jiang M, Sameni M, Franco OE, Love HD, Hayward WJ, Lin-Tsai O, Wang AY, Cates JM, Sloane BF, Matusik RJ, Hayward SW.

Am J Pathol. 2013 Feb;182(2):449-59. doi: 10.1016/j.ajpath.2012.10.007. Epub 2012 Dec 6.


Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1.

Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA.

Dis Model Mech. 2013 Mar;6(2):530-6. doi: 10.1242/dmm.010355. Epub 2012 Nov 7.


Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.

Pruitt FL, He Y, Franco OE, Jiang M, Cates JM, Hayward SW.

Prostate. 2013 Apr;73(5):476-88. doi: 10.1002/pros.22589. Epub 2012 Sep 19.


Targeting the tumor stroma as a novel therapeutic approach for prostate cancer.

Franco OE, Hayward SW.

Adv Pharmacol. 2012;65:267-313. doi: 10.1016/B978-0-12-397927-8.00009-9. Review.


PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.

Strand DW, Jiang M, Murphy TA, Yi Y, Konvinse KC, Franco OE, Wang Y, Young JD, Hayward SW.

Cell Death Dis. 2012 Aug 9;3:e361. doi: 10.1038/cddis.2012.99.


Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis.

Anderson PD, McKissic SA, Logan M, Roh M, Franco OE, Wang J, Doubinskaia I, van der Meer R, Hayward SW, Eischen CM, Eltoum IE, Abdulkadir SA.

J Clin Invest. 2012 May;122(5):1907-19. doi: 10.1172/JCI58540. Epub 2012 Apr 9.


Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate.

Orr B, Riddick AC, Stewart GD, Anderson RA, Franco OE, Hayward SW, Thomson AA.

Oncogene. 2012 Mar 1;31(9):1130-42. doi: 10.1038/onc.2011.312. Epub 2011 Aug 1.


PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia.

Jiang M, Strand DW, Franco OE, Clark PE, Hayward SW.

Differentiation. 2011 Nov-Dec;82(4-5):220-36. doi: 10.1016/j.diff.2011.05.008. Epub 2011 Jun 8. Review.


Role for stromal heterogeneity in prostate tumorigenesis.

Kiskowski MA, Jackson RS 2nd, Banerjee J, Li X, Kang M, Iturregui JM, Franco OE, Hayward SW, Bhowmick NA.

Cancer Res. 2011 May 15;71(10):3459-70. doi: 10.1158/0008-5472.CAN-10-2999. Epub 2011 Mar 28.


Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.

Franco OE, Jiang M, Strand DW, Peacock J, Fernandez S, Jackson RS 2nd, Revelo MP, Bhowmick NA, Hayward SW.

Cancer Res. 2011 Feb 15;71(4):1272-81. doi: 10.1158/0008-5472.CAN-10-3142. Epub 2011 Feb 8.


Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia.

Orr B, Vanpoucke G, Grace OC, Smith L, Anderson RA, Riddick AC, Franco OE, Hayward SW, Thomson AA.

Prostate. 2011 Feb 15;71(3):305-17. doi: 10.1002/pros.21244. Epub 2010 Sep 1.


Perspectives on tissue interactions in development and disease.

Strand DW, Franco OE, Basanta D, Anderson AR, Hayward SW.

Curr Mol Med. 2010 Feb;10(1):95-112. Review.


Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma.

Wang J, Kim J, Roh M, Franco OE, Hayward SW, Wills ML, Abdulkadir SA.

Oncogene. 2010 Apr 29;29(17):2477-87. doi: 10.1038/onc.2010.10. Epub 2010 Feb 8.


Cancer associated fibroblasts in cancer pathogenesis.

Franco OE, Shaw AK, Strand DW, Hayward SW.

Semin Cell Dev Biol. 2010 Feb;21(1):33-9. doi: 10.1016/j.semcdb.2009.10.010. Epub 2009 Nov 5. Review.


The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach.

Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR.

Cancer Res. 2009 Sep 1;69(17):7111-20. doi: 10.1158/0008-5472.CAN-08-3957. Epub 2009 Aug 25.


A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells.

Roh M, Franco OE, Hayward SW, van der Meer R, Abdulkadir SA.

PLoS One. 2008 Jul 2;3(7):e2572. doi: 10.1371/journal.pone.0002572.


Gene targeting to the stroma of the prostate and bone.

Jackson RS 2nd, Franco OE, Bhowmick NA.

Differentiation. 2008 Jul;76(6):606-23. doi: 10.1111/j.1432-0436.2008.00273.x. Epub 2008 May 20. Review.


Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease.

Vanpoucke G, Orr B, Grace OC, Chan R, Ashley GR, Williams K, Franco OE, Hayward SW, Thomson AA.

Genome Biol. 2007;8(10):R213.


Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression.

He Y, Franco OE, Jiang M, Williams K, Love HD, Coleman IM, Nelson PS, Hayward SW.

Cancer Res. 2007 Sep 1;67(17):8188-97.


Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model.

Oottamasathien S, Williams K, Franco OE, Wills ML, Thomas JC, Sharif-Afshar AR, DeMarco RT, Brock JW 3rd, Bhowmick NA, Hayward SW, Pope JC 4th.

J Urol. 2007 Oct;178(4 Pt 2):1643-9. Epub 2007 Aug 16.


Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium.

Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW.

Cancer Res. 2007 May 1;67(9):4244-53.


Directed differentiation of embryonic stem cells into bladder tissue.

Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW 3rd, Hayward SW, Pope JC 4th, Matusik RJ.

Dev Biol. 2007 Apr 15;304(2):556-66. Epub 2007 Jan 12.


A G/A polymorphism in the androgen response element 1 of prostate-specific antigen gene correlates with the response to androgen deprivation therapy in Japanese population.

Shibahara T, Onishi T, Franco OE, Arima K, Nishikawa K, Yanagawa M, Hioki T, Watanabe M, Hirokawa Y, Shiraishi T, Sugimura Y.

Anticancer Res. 2006 Sep-Oct;26(5A):3365-71.


Bladder tissue formation from cultured bladder urothelium.

Oottamasathien S, Williams K, Franco OE, Thomas JC, Saba K, Bhowmick NA, Staack A, Demarco RT, Brock JW 3rd, Hayward SW, Pope JC 4th.

Dev Dyn. 2006 Oct;235(10):2795-801.


Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer.

Joesting MS, Perrin S, Elenbaas B, Fawell SE, Rubin JS, Franco OE, Hayward SW, Cunha GR, Marker PC.

Cancer Res. 2005 Nov 15;65(22):10423-30.

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