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Idiopathic anaphylaxis and systemic mastocytosis.

Francischetti IMB, Maric I.

Int J Hematol. 2019 Dec;110(6):643-644. doi: 10.1007/s12185-019-02747-2. Epub 2019 Oct 12. No abstract available.


NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.

De Paula VS, Sgourakis NG, Francischetti IMB, Almeida FCL, Monteiro RQ, Valente AP.

Blood. 2019 Aug 22;134(8):699-708. doi: 10.1182/blood.2018889493. Epub 2019 May 27.


Hairy cell leukemia coexistent with chronic lymphocytic leukemia.

Francischetti IMB, Calvo KR.

Blood. 2019 Mar 14;133(11):1264. doi: 10.1182/blood-2018-12-885145. No abstract available.


Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis.

Assumpção TC, Mizurini DM, Ma D, Monteiro RQ, Ahlstedt S, Reyes M, Kotsyfakis M, Mather TN, Andersen JF, Lukszo J, Ribeiro JMC, Francischetti IMB.

Sci Rep. 2018 Mar 19;8(1):4806. doi: 10.1038/s41598-018-22780-1.


1H, 15N and 13C resonance assignments of Ixolaris, a tissue factor pathway inhibitor from the tick salivary gland.

De Paula VS, Silva FHS, Francischetti IMB, Monteiro RQ, Valente AP.

Biomol NMR Assign. 2017 Oct;11(2):293-296. doi: 10.1007/s12104-017-9766-3. Epub 2017 Aug 30.


Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy.

Schechter ME, Andrade BB, He T, Richter GH, Tosh KW, Policicchio BB, Singh A, Raehtz KD, Sheikh V, Ma D, Brocca-Cofano E, Apetrei C, Tracy R, Ribeiro RM, Sher A, Francischetti IMB, Pandrea I, Sereti I.

Sci Transl Med. 2017 Aug 30;9(405). pii: eaam5441. doi: 10.1126/scitranslmed.aam5441.


Recombinant expression of Ixolaris, a Kunitz-type inhibitor from the tick salivary gland, for NMR studies.

De Paula VS, Silva FHS, Francischetti IMB, Monteiro RQ, Valente AP.

Protein Expr Purif. 2017 Nov;139:49-56. doi: 10.1016/j.pep.2017.07.012. Epub 2017 Jul 19.


Laboratory and clinical predictors of 30-day survival for patients on Extracorporeal Membrane Oxygenation (ECMO): 8-Year experience at Albert Einstein College of Medicine, Montefiore Medical Center.

Francischetti IMB, Szymanski J, Rodriguez D, Heo M, Wolgast LR.

J Crit Care. 2017 Aug;40:136-144. doi: 10.1016/j.jcrc.2017.03.027. Epub 2017 Mar 31.


Incidental primary mediastinal choriocarcinoma diagnosed by endobronchial ultrasound-guided fine needle aspiration in a patient presenting with transient ischemic attack and stroke.

Francischetti IMB, Cajigas A, Suhrland M, Farinhas JM, Khader S.

Diagn Cytopathol. 2017 Aug;45(8):738-743. doi: 10.1002/dc.23719. Epub 2017 Apr 11.


An insight into the sialome of Hyalomma excavatum.

Ribeiro JM, Slovák M, Francischetti IM.

Ticks Tick Borne Dis. 2017 Feb;8(2):201-207. doi: 10.1016/j.ttbdis.2016.08.011. Epub 2016 Dec 21.


Molecular Diversity between Salivary Proteins from New World and Old World Sand Flies with Emphasis on Bichromomyia olmeca, the Sand Fly Vector of Leishmania mexicana in Mesoamerica.

Abdeladhim M, V Coutinho-Abreu I, Townsend S, Pasos-Pinto S, Sanchez L, Rasouli M, B Guimaraes-Costa A, Aslan H, Francischetti IM, Oliveira F, Becker I, Kamhawi S, Ribeiro JM, Jochim RC, Valenzuela JG.

PLoS Negl Trop Dis. 2016 Jul 13;10(7):e0004771. doi: 10.1371/journal.pntd.0004771. eCollection 2016 Jul.


In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.

Assumpção TC, Ma D, Mizurini DM, Kini RM, Ribeiro JM, Kotsyfakis M, Monteiro RQ, Francischetti IM.

PLoS Negl Trop Dis. 2016 Jan 8;10(1):e0004298. doi: 10.1371/journal.pntd.0004298. eCollection 2016 Jan.


Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions.

Chmelař J, Kotál J, Karim S, Kopacek P, Francischetti IMB, Pedra JHF, Kotsyfakis M.

Trends Parasitol. 2016 Mar;32(3):242-254. doi: 10.1016/ Epub 2015 Oct 28. Review.


An insight into the sialome of the horse fly, Tabanus bromius.

Ribeiro JM, Kazimirova M, Takac P, Andersen JF, Francischetti IM.

Insect Biochem Mol Biol. 2015 Oct;65:83-90. doi: 10.1016/j.ibmb.2015.09.002. Epub 2015 Sep 11.


A Deep Insight Into the Sialotranscriptome of the Chagas Disease Vector, Panstrongylus megistus (Hemiptera: Heteroptera).

Ribeiro JM, Schwarz A, Francischetti IM.

J Med Entomol. 2015 May;52(3):351-8. doi: 10.1093/jme/tjv023. Epub 2015 Mar 29.


Modulation of host immunity by tick saliva.

Kotál J, Langhansová H, Lieskovská J, Andersen JF, Francischetti IM, Chavakis T, Kopecký J, Pedra JH, Kotsyfakis M, Chmelař J.

J Proteomics. 2015 Oct 14;128:58-68. doi: 10.1016/j.jprot.2015.07.005. Epub 2015 Jul 17. Review.


Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis.

Mizurini DM, Aslan JS, Gomes T, Ma D, Francischetti IM, Monteiro RQ.

PLoS Negl Trop Dis. 2015 Jun 25;9(6):e0003869. doi: 10.1371/journal.pntd.0003869. eCollection 2015.


(99m)Tc-ixolaris targets glioblastoma-associated tissue factor: in vitro and pre-clinical applications.

Barboza T, Gomes T, Mizurini DM, Monteiro RQ, König S, Francischetti IM, Signoretti PV, Ramos IP, Gutfilen B, Souza SA.

Thromb Res. 2015 Aug;136(2):432-9. doi: 10.1016/j.thromres.2015.05.032. Epub 2015 Jun 6.


The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum.

Ma D, Francischetti IM, Ribeiro JM, Andersen JF.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):643-9. doi: 10.1107/S2053230X1500271X. Epub 2015 May 20.


Sexual differences in the sialomes of the zebra tick, Rhipicephalus pulchellus.

Tan AW, Francischetti IM, Slovak M, Kini RM, Ribeiro JM.

J Proteomics. 2015 Mar 18;117:120-44. doi: 10.1016/j.jprot.2014.12.014. Epub 2015 Jan 7.


Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Waisberg M, Molina-Cruz A, Mizurini DM, Gera N, Sousa BC, Ma D, Leal AC, Gomes T, Kotsyfakis M, Ribeiro JM, Lukszo J, Reiter K, Porcella SF, Oliveira CJ, Monteiro RQ, Barillas-Mury C, Pierce SK, Francischetti IM.

PLoS Pathog. 2014 Sep 11;10(9):e1004338. doi: 10.1371/journal.ppat.1004338. eCollection 2014 Sep.


Evidence for a lectin specific for sulfated glycans in the salivary gland of the malaria vector, Anopheles gambiae.

Francischetti IM, Ma D, Andersen JF, Ribeiro JM.

PLoS One. 2014 Sep 10;9(9):e107295. doi: 10.1371/journal.pone.0107295. eCollection 2014.


Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar Lonomia obliqua.

Veiga AB, Ribeiro JM, Francischetti IM, Xu X, Guimarães JA, Andersen JF.

PLoS One. 2014 Jun 27;9(6):e95424. doi: 10.1371/journal.pone.0095424. eCollection 2014.


Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.

Francischetti IM, Gordon E, Bizzarro B, Gera N, Andrade BB, Oliveira F, Ma D, Assumpção TC, Ribeiro JM, Pena M, Qi CF, Diouf A, Moretz SE, Long CA, Ackerman HC, Pierce SK, Sá-Nunes A, Waisberg M.

PLoS One. 2014 Feb 28;9(2):e87140. doi: 10.1371/journal.pone.0087140. eCollection 2014.


Purification of a serine protease and evidence for a protein C activator from the saliva of the tick, Ixodes scapularis.

Pichu S, Ribeiro JM, Mather TN, Francischetti IM.

Toxicon. 2014 Jan;77:32-9. doi: 10.1016/j.toxicon.2013.10.025. Epub 2013 Oct 31.


Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo.

Ma D, Mizurini DM, Assumpção TC, Li Y, Qi Y, Kotsyfakis M, Ribeiro JM, Monteiro RQ, Francischetti IM.

Blood. 2013 Dec 12;122(25):4094-106. doi: 10.1182/blood-2013-08-517474. Epub 2013 Oct 24.


Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.

Alvarenga PH, Xu X, Oliveira F, Chagas AC, Nascimento CR, Francischetti IM, Juliano MA, Juliano L, Scharfstein J, Valenzuela JG, Ribeiro JM, Andersen JF.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2759-70. doi: 10.1161/ATVBAHA.113.302482. Epub 2013 Oct 3.


Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine.

Oliveira CJ, Anatriello E, de Miranda-Santos IK, Francischetti IM, Sá-Nunes A, Ferreira BR, Ribeiro JM.

Ticks Tick Borne Dis. 2013 Dec;4(6):469-77. doi: 10.1016/j.ttbdis.2013.05.001. Epub 2013 Sep 9.


Aegyptin inhibits collagen-induced coagulation activation in vitro and thromboembolism in vivo.

Mizurini DM, Francischetti IM, Monteiro RQ.

Biochem Biophys Res Commun. 2013 Jun 28;436(2):235-9. doi: 10.1016/j.bbrc.2013.05.082. Epub 2013 May 30.


Salivary antigen-5/CAP family members are Cu2+-dependent antioxidant enzymes that scavenge O₂₋. and inhibit collagen-induced platelet aggregation and neutrophil oxidative burst.

Assumpção TC, Ma D, Schwarz A, Reiter K, Santana JM, Andersen JF, Ribeiro JM, Nardone G, Yu LL, Francischetti IM.

J Biol Chem. 2013 May 17;288(20):14341-61. doi: 10.1074/jbc.M113.466995. Epub 2013 Apr 5.


The "Vampirome": Transcriptome and proteome analysis of the principal and accessory submaxillary glands of the vampire bat Desmodus rotundus, a vector of human rabies.

Francischetti IM, Assumpção TC, Ma D, Li Y, Vicente EC, Uieda W, Ribeiro JM.

J Proteomics. 2013 Apr 26;82:288-319. doi: 10.1016/j.jprot.2013.01.009. Epub 2013 Feb 11.


Evolutionarily conserved interaction between the phosphoproteins and X proteins of bornaviruses from different vertebrate species.

Fujino K, Horie M, Honda T, Nakamura S, Matsumoto Y, Francischetti IM, Tomonaga K.

PLoS One. 2012;7(12):e51161. doi: 10.1371/journal.pone.0051161. Epub 2012 Dec 7.


An insight into the sialotranscriptome of the cat flea, Ctenocephalides felis.

Ribeiro JM, Assumpção TC, Ma D, Alvarenga PH, Pham VM, Andersen JF, Francischetti IM, Macaluso KR.

PLoS One. 2012;7(9):e44612. doi: 10.1371/journal.pone.0044612. Epub 2012 Sep 25.


The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells.

Carneiro-Lobo TC, Schaffner F, Disse J, Ostergaard H, Francischetti IM, Monteiro RQ, Ruf W.

J Thromb Haemost. 2012 Sep;10(9):1849-58. doi: 10.1111/j.1538-7836.2012.04864.x.


Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo.

Collin N, Assumpção TC, Mizurini DM, Gilmore DC, Dutra-Oliveira A, Kotsyfakis M, Sá-Nunes A, Teixeira C, Ribeiro JM, Monteiro RQ, Valenzuela JG, Francischetti IM.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2185-98. doi: 10.1161/ATVBAHA.112.253906. Epub 2012 Jul 12.


Disintegrins from hematophagous sources.

Assumpcao TC, Ribeiro JM, Francischetti IM.

Toxins (Basel). 2012 May;4(5):296-322. doi: 10.3390/toxins4050296. Epub 2012 Apr 26. Review.


Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma.

de Oliveira Ada S, Lima LG, Mariano-Oliveira A, Machado DE, Nasciutti LE, Andersen JF, Petersen LC, Francischetti IM, Monteiro RQ.

Thromb Res. 2012 Sep;130(3):e163-70. doi: 10.1016/j.thromres.2012.05.021. Epub 2012 Jun 9.


An insight into the sialotranscriptome of Triatoma rubida (Hemiptera: Heteroptera).

Ribeiro JM, Assumpção TC, Pham VM, Francischetti IM, Reisenman CE.

J Med Entomol. 2012 May;49(3):563-72.


An insight into the sialotranscriptome of Triatoma matogrossensis, a kissing bug associated with fogo selvagem in South America.

Assumpção TC, Eaton DP, Pham VM, Francischetti IM, Aoki V, Hans-Filho G, Rivitti EA, Valenzuela JG, Diaz LA, Ribeiro JM.

Am J Trop Med Hyg. 2012 Jun;86(6):1005-14. doi: 10.4269/ajtmh.2012.11-0690.


Tick salivary secretion as a source of antihemostatics.

Chmelar J, Calvo E, Pedra JH, Francischetti IM, Kotsyfakis M.

J Proteomics. 2012 Jul 16;75(13):3842-54. doi: 10.1016/j.jprot.2012.04.026. Epub 2012 Apr 27. Review.


Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P.

Waisberg M, Cerqueira GC, Yager SB, Francischetti IM, Lu J, Gera N, Srinivasan P, Miura K, Rada B, Lukszo J, Barbian KD, Leto TL, Porcella SF, Narum DL, El-Sayed N, Miller LH, Pierce SK.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5429-34. doi: 10.1073/pnas.1202689109. Epub 2012 Mar 19.


Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses.

Tsujimoto H, Kotsyfakis M, Francischetti IM, Eum JH, Strand MR, Champagne DE.

PLoS One. 2012;7(2):e29964. doi: 10.1371/journal.pone.0029964. Epub 2012 Feb 23.


Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain.

Xu X, Francischetti IM, Lai R, Ribeiro JM, Andersen JF.

J Biol Chem. 2012 Mar 30;287(14):10967-76. doi: 10.1074/jbc.M112.340471. Epub 2012 Feb 6.


The sialotranscriptome of Antricola delacruzi female ticks is compatible with non-hematophagous behavior and an alternative source of food.

Ribeiro JM, Labruna MB, Mans BJ, Maruyama SR, Francischetti IM, Barizon GC, de Miranda Santos IK.

Insect Biochem Mol Biol. 2012 May;42(5):332-42. doi: 10.1016/j.ibmb.2012.01.003. Epub 2012 Jan 24.


Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of Chagas disease, binds to TXA(2) but does not interact with glycoprotein PVI.

Ma D, Assumpção TC, Li Y, Andersen JF, Ribeiro J, Francischetti IM.

Thromb Haemost. 2012 Jan;107(1):111-23. doi: 10.1160/TH11-10-0685. Epub 2011 Dec 8.


Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria.

Francischetti IM, Oliveira CJ, Ostera GR, Yager SB, Debierre-Grockiego F, Carregaro V, Jaramillo-Gutierrez G, Hume JC, Jiang L, Moretz SE, Lin CK, Ribeiro JM, Long CA, Vickers BK, Schwarz RT, Seydel KB, Iacobelli M, Ackerman HC, Srinivasan P, Gomes RB, Wang X, Monteiro RQ, Kotsyfakis M, Sá-Nunes A, Waisberg M.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):786-98. doi: 10.1161/ATVBAHA.111.240291. Epub 2011 Nov 23.


An insight into the sialotranscriptome and proteome of the coarse bontlegged tick, Hyalomma marginatum rufipes.

Francischetti IM, Anderson JM, Manoukis N, Pham VM, Ribeiro JM.

J Proteomics. 2011 Nov 18;74(12):2892-908. doi: 10.1016/j.jprot.2011.07.015. Epub 2011 Aug 7.


Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity.

Calvo E, Mizurini DM, Sá-Nunes A, Ribeiro JM, Andersen JF, Mans BJ, Monteiro RQ, Kotsyfakis M, Francischetti IM.

J Biol Chem. 2011 Aug 12;286(32):27998-8010. doi: 10.1074/jbc.M111.247924. Epub 2011 Jun 14.


Cysteine proteases from bloodfeeding arthropod ectoparasites.

Sojka D, Francischetti IM, Calvo E, Kotsyfakis M.

Adv Exp Med Biol. 2011;712:177-91. doi: 10.1007/978-1-4419-8414-2_11. Review.


A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis.

Ma D, Xu X, An S, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JM, Francischetti IM, Lai R.

Thromb Haemost. 2011 Jun;105(6):1032-45. doi: 10.1160/TH11-01-0029. Epub 2011 Apr 7.

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