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Items: 8

1.

The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.

Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM.

Dev Cell. 2013 Apr 15;25(1):15-28. doi: 10.1016/j.devcel.2013.03.005. Epub 2013 Apr 4.

2.

Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.

Frasa MA, Maximiano FC, Smolarczyk K, Francis RE, Betson ME, Lozano E, Goldenring J, Seabra MC, Rak A, Ahmadian MR, Braga VM.

Curr Biol. 2010 Feb 9;20(3):198-208. doi: 10.1016/j.cub.2009.12.053. Epub 2010 Jan 28.

3.

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.

Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam EW.

Int J Oncol. 2009 Jul;35(1):57-68.

4.

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer.

McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM, Polychronis A, Coombes RC, Lam EW.

Mol Cancer Ther. 2009 Mar;8(3):582-91. doi: 10.1158/1535-7163.MCT-08-0805. Epub 2009 Mar 10.

5.

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells.

Hui RC, Francis RE, Guest SK, Costa JR, Gomes AR, Myatt SS, Brosens JJ, Lam EW.

Mol Cancer Ther. 2008 Mar;7(3):670-8. doi: 10.1158/1535-7163.MCT-07-0397.

6.

The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells.

Krol J, Francis RE, Albergaria A, Sunters A, Polychronis A, Coombes RC, Lam EW.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3169-79.

7.

FOXO transcription factors: key regulators of cell fate.

Lam EW, Francis RE, Petkovic M.

Biochem Soc Trans. 2006 Nov;34(Pt 5):722-6.

PMID:
17052182
8.

The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells.

Madureira PA, Varshochi R, Constantinidou D, Francis RE, Coombes RC, Yao KM, Lam EW.

J Biol Chem. 2006 Sep 1;281(35):25167-76. Epub 2006 Jun 28.

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