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Items: 1 to 50 of 203

1.

Correction: Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.

Chaudhury S, Brookes KJ, Patel T, Fallows A, Guetta-Baranes T, Turton JC, Guerreiro R, Bras J, Hardy J, Francis PT, Croucher R, Holmes C, Morgan K.

Transl Psychiatry. 2019 Jun 11;9(1):167. doi: 10.1038/s41398-019-0503-9.

PMID:
31186402
2.

Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.

Chaudhury S, Brookes KJ, Patel T, Fallows A, Guetta-Baranes T, Turton JC, Guerreiro R, Bras J, Hardy J, Francis PT, Croucher R, Holmes C, Morgan K, Thomas AJ.

Transl Psychiatry. 2019 May 24;9(1):154. doi: 10.1038/s41398-019-0485-7. Erratum in: Transl Psychiatry. 2019 Jun 11;9(1):167.

3.

Brains for Dementia Research: The Importance of Cohorts in Brain Banking.

Francis PT, Hayes GM, Costello H, Whitfield DR.

Neurosci Bull. 2019 Apr;35(2):289-294. doi: 10.1007/s12264-018-0327-2. Epub 2019 Jan 2. No abstract available.

PMID:
30604278
4.

Brains for Dementia Research: Evolution in a Longitudinal Brain Donation Cohort to Maximize Current and Future Value.

Francis PT, Costello H, Hayes GM.

J Alzheimers Dis. 2018;66(4):1635-1644. doi: 10.3233/JAD-180699.

5.

Factors affecting withdrawal and donation attrition in the brains for dementia research cohort.

Costello H, Hayes GM, Francis PT.

Int J Geriatr Psychiatry. 2018 Dec;33(12):1709-1716. doi: 10.1002/gps.4975. Epub 2018 Sep 12.

PMID:
30209830
6.

Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease.

Chappell S, Patel T, Guetta-Baranes T, Sang F, Francis PT, Morgan K, Brookes KJ.

BMC Res Notes. 2018 Sep 4;11(1):646. doi: 10.1186/s13104-018-3732-8.

7.

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.

Chai YL, Chong JR, Weng J, Howlett D, Halsey A, Lee JH, Attems J, Aarsland D, Francis PT, Chen CP, Lai MKP.

Brain Pathol. 2019 Jan;29(1):63-74. doi: 10.1111/bpa.12631. Epub 2018 Oct 17.

PMID:
30051532
8.

Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort.

Brookes KJ, McConnell G, Williams K, Chaudhury S, Madhan G, Patel T, Turley C, Guetta-Baranes T, Bras J, Guerreiro R, Hardy J, Francis PT, Morgan K.

J Alzheimers Dis. 2018;64(2):355-362. doi: 10.3233/JAD-180191.

PMID:
29914034
9.

Associations between ZnT3, tau pathology, agitation, and delusions in dementia.

Whitfield DR, Francis PT, Ballard C, Williams G.

Int J Geriatr Psychiatry. 2018 Aug;33(8):1146-1152. doi: 10.1002/gps.4908. Epub 2018 Jun 1.

PMID:
29856089
10.

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.

Bereczki E, Branca RM, Francis PT, Pereira JB, Baek JH, Hortobágyi T, Winblad B, Ballard C, Lehtiö J, Aarsland D.

Brain. 2018 Feb 1;141(2):582-595. doi: 10.1093/brain/awx352. Erratum in: Brain. 2019 Jun 1;142(6):e24.

11.

Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease.

Chai YL, Xing H, Chong JR, Francis PT, Ballard CG, Chen CP, Lai MKP.

J Alzheimers Dis. 2018;61(2):793-801. doi: 10.3233/JAD-170613.

PMID:
29254089
12.

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.

Patel T, Brookes KJ, Turton J, Chaudhury S, Guetta-Baranes T, Guerreiro R, Bras J, Hernandez D, Singleton A, Francis PT, Hardy J, Morgan K.

Neuropathol Appl Neurobiol. 2018 Aug;44(5):506-521. doi: 10.1111/nan.12452. Epub 2018 Jan 7.

13.

Increased Levels of Brain Adrenomedullin in the Neuropathology of Alzheimer's Disease.

Ferrero H, Larrayoz IM, Martisova E, Solas M, Howlett DR, Francis PT, Gil-Bea FJ, Martínez A, Ramírez MJ.

Mol Neurobiol. 2018 Jun;55(6):5177-5183. doi: 10.1007/s12035-017-0700-6. Epub 2017 Sep 2.

PMID:
28866832
14.

An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias.

Datta A, Chai YL, Tan JM, Lee JH, Francis PT, Chen CP, Sze SK, Lai MKP.

Mol Brain. 2017 Aug 11;10(1):36. doi: 10.1186/s13041-017-0316-9.

15.

Corrigendum: Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease.

Kassaar O, Pereira Morais M, Xu S, Adam EL, Chamberlain RC, Jenkins B, James TD, Francis PT, Ward S, Williams RJ, van den Elsen J.

Sci Rep. 2017 Apr 5;7:45417. doi: 10.1038/srep45417. No abstract available.

16.

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia.

Alghamdi A, Vallortigara J, Howlett DR, Broadstock M, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Attems J, Francis PT, Whitfield DR.

J Alzheimers Dis. 2017;57(2):373-386. doi: 10.3233/JAD-160946.

17.

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease.

Kassaar O, Pereira Morais M, Xu S, Adam EL, Chamberlain RC, Jenkins B, James TD, Francis PT, Ward S, Williams RJ, van den Elsen J.

Sci Rep. 2017 Feb 23;7:42874. doi: 10.1038/srep42874. Erratum in: Sci Rep. 2017 Apr 05;7:45417.

18.

Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease.

Hussain AA, Lee Y, Zhang JJ, Francis PT, Marshall J.

J Neurodegener Dis. 2017;2017:4810232. doi: 10.1155/2017/4810232. Epub 2017 Jan 18.

19.

Utilization of Anganwadi Services in a Rural Population of Kerala.

Francis PT, Paul N.

Indian Pediatr. 2017 Jan 15;54(1):65-66. No abstract available.

20.

Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status.

Ferrero H, Solas M, Francis PT, Ramirez MJ.

CNS Drugs. 2017 Jan;31(1):19-32. doi: 10.1007/s40263-016-0399-3. Review.

PMID:
27914038
21.

Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.

Chong JR, Chai YL, Lee JH, Howlett D, Attems J, Ballard CG, Aarsland D, Francis PT, Chen CP, Lai MK.

J Alzheimers Dis. 2017;56(1):157-166. doi: 10.3233/JAD-160781.

PMID:
27911312
22.

Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia.

Lee JH, Francis PT, Ballard CG, Aarsland D, Kalaria RN, Wong PT, Chen CP, Lai MK.

J Parkinsons Dis. 2016 Oct 19;6(4):733-739.

PMID:
27662332
23.

A pilot study of potential brain donor satisfaction and attitudes towards telephone assessment.

Costello H, Hayes GM, Highton-Williamson E, Nurock S, Hanbury D, Francis PT.

Int J Geriatr Psychiatry. 2017 Dec;32(12):1247-1256. doi: 10.1002/gps.4605. Epub 2016 Oct 7.

PMID:
27714914
24.

Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias.

Xing H, Lim YA, Chong JR, Lee JH, Aarsland D, Ballard CG, Francis PT, Chen CP, Lai MK.

Mol Brain. 2016 Sep 8;9(1):84. doi: 10.1186/s13041-016-0264-9.

25.

Apathy associated with neurocognitive disorders: Recent progress and future directions.

Lanctôt KL, Agüera-Ortiz L, Brodaty H, Francis PT, Geda YE, Ismail Z, Marshall GA, Mortby ME, Onyike CU, Padala PR, Politis AM, Rosenberg PB, Siegel E, Sultzer DL, Abraham EH.

Alzheimers Dement. 2017 Jan;13(1):84-100. doi: 10.1016/j.jalz.2016.05.008. Epub 2016 Jun 27. Review.

PMID:
27362291
26.

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.

Bereczki E, Francis PT, Howlett D, Pereira JB, Höglund K, Bogstedt A, Cedazo-Minguez A, Baek JH, Hortobágyi T, Attems J, Ballard C, Aarsland D.

Alzheimers Dement. 2016 Nov;12(11):1149-1158. doi: 10.1016/j.jalz.2016.04.005. Epub 2016 May 22.

PMID:
27224930
27.

Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency.

Gatt AP, Duncan OF, Attems J, Francis PT, Ballard CG, Bateman JM.

Mov Disord. 2016 Mar;31(3):352-9. doi: 10.1002/mds.26513. Epub 2016 Feb 8.

PMID:
26853899
28.

Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia.

Vallortigara J, Whitfield D, Quelch W, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, O'Brien JT, Thomas A, Ballard CG, Aarsland D, Francis PT.

J Alzheimers Dis. 2016;50(1):101-10. doi: 10.3233/JAD-150707.

PMID:
26639969
29.

An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease.

Lee C, Low CY, Francis PT, Attems J, Wong PT, Lai MK, Tan MG.

J Neurochem. 2016 Feb;136(3):637-50. doi: 10.1111/jnc.13429. Epub 2015 Dec 10.

30.

Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients.

Lee JH, Koh SQ, Guadagna S, Francis PT, Esiri MM, Chen CP, Wong PT, Dawe GS, Lai MK.

Psychopharmacology (Berl). 2016 Feb;233(4):591-8. doi: 10.1007/s00213-015-4131-7. Epub 2015 Nov 6.

PMID:
26542729
31.

Spreading pathologies precede cognitive decline in Alzheimer's disease.

Howlett DR, Attems J, Francis PT.

Biol Psychiatry. 2015 Apr 15;77(8):678-9. doi: 10.1016/j.biopsych.2015.02.001. No abstract available.

PMID:
25835285
32.

Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

Cox CJ, Choudhry F, Peacey E, Perkinton MS, Richardson JC, Howlett DR, Lichtenthaler SF, Francis PT, Williams RJ.

Neurobiol Aging. 2015 Jan;36(1):178-87. doi: 10.1016/j.neurobiolaging.2014.07.032. Epub 2014 Jul 30.

33.

Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease.

Mohamed NE, Lee JH, Francis PT, Esiri MM, Chen CP, Lai MK.

J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.

PMID:
25261450
34.

Lab testing is not a commodity.

Francis PT.

MLO Med Lab Obs. 2014 Jul;46(7):56-7. No abstract available.

PMID:
25158410
35.

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.

Whitfield DR, Vallortigara J, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, Newhouse S, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT.

Neurobiol Aging. 2014 Dec;35(12):2836-2844. doi: 10.1016/j.neurobiolaging.2014.06.015. Epub 2014 Jun 17.

PMID:
25104558
36.

Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.

Howlett DR, Whitfield D, Johnson M, Attems J, O'Brien JT, Aarsland D, Lai MK, Lee JH, Chen C, Ballard C, Hortobágyi T, Francis PT.

Brain Pathol. 2015 Jul;25(4):401-8. doi: 10.1111/bpa.12182. Epub 2014 Oct 30.

PMID:
25103200
37.

Stage-specific changes in neurogenic and glial markers in Alzheimer's disease.

Ekonomou A, Savva GM, Brayne C, Forster G, Francis PT, Johnson M, Perry EK, Attems J, Somani A, Minger SL, Ballard CG; Medical Research Council Cognitive Function and Ageing Neuropathology Study.

Biol Psychiatry. 2015 Apr 15;77(8):711-9. doi: 10.1016/j.biopsych.2014.05.021. Epub 2014 Jun 9.

PMID:
25022604
38.

Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.

Whitfield DR, Vallortigara J, Alghamdi A, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT.

Am J Geriatr Psychiatry. 2015 Feb;23(2):141-8. doi: 10.1016/j.jagp.2014.05.001. Epub 2014 May 14.

PMID:
24953873
39.

Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status.

Ramirez MJ, Lai MK, Tordera RM, Francis PT.

Drugs. 2014 May;74(7):729-36. doi: 10.1007/s40265-014-0217-5. Review.

PMID:
24802806
40.

Dynamin protein in stroke and vascular dementia.

Mulugeta E, Vallortigara J, Francis PT, Hye A, Kalaria RN, Perry EK, Lovestone S, Ballard CG.

Neurosci Lett. 2014 Mar 20;563:118-22. doi: 10.1016/j.neulet.2014.01.045. Epub 2014 Jan 31.

PMID:
24486840
41.

Sales efficiency and effectiveness: how delicate is the balance at your lab?

Francis PT.

MLO Med Lab Obs. 2013 Aug;45(8):48. No abstract available.

PMID:
24205546
42.

Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden.

Tan MG, Lee C, Lee JH, Francis PT, Williams RJ, Ramírez MJ, Chen CP, Wong PT, Lai MK.

Neurochem Int. 2014 Jan;64:29-36. doi: 10.1016/j.neuint.2013.10.013. Epub 2013 Nov 5.

PMID:
24200817
43.

Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies.

Gatt AP, Jones EL, Francis PT, Ballard C, Bateman JM.

Neurosci Lett. 2013 Dec 17;557 Pt B:177-80. doi: 10.1016/j.neulet.2013.10.045. Epub 2013 Oct 30. Erratum in: Neurosci Lett. 2014 Mar 20;563:44.

PMID:
24184878
44.

Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias.

Mohamed NE, Howlett DR, Ma L, Francis PT, Aarsland D, Ballard CG, McKeith IG, Chen CP, Lai MK.

J Neural Transm (Vienna). 2014 Jan;121(1):71-8. doi: 10.1007/s00702-013-1067-0. Epub 2013 Jul 12.

PMID:
23846847
45.

Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future.

Geda YE, Schneider LS, Gitlin LN, Miller DS, Smith GS, Bell J, Evans J, Lee M, Porsteinsson A, Lanctôt KL, Rosenberg PB, Sultzer DL, Francis PT, Brodaty H, Padala PP, Onyike CU, Ortiz LA, Ancoli-Israel S, Bliwise DL, Martin JL, Vitiello MV, Yaffe K, Zee PC, Herrmann N, Sweet RA, Ballard C, Khin NA, Alfaro C, Murray PS, Schultz S, Lyketsos CG; Neuropsychiatric Syndromes Professional Interest Area of ISTAART.

Alzheimers Dement. 2013 Sep;9(5):602-8. doi: 10.1016/j.jalz.2012.12.001. Epub 2013 Apr 3. Review.

46.

Clusterin associates specifically with Aβ40 in Alzheimer's disease brain tissue.

Howlett DR, Hortobágyi T, Francis PT.

Brain Pathol. 2013 Nov;23(6):623-32. doi: 10.1111/bpa.12057. Epub 2013 Apr 21.

PMID:
23521156
47.

Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer's disease.

Francis PT, Parsons CG, Jones RW.

Expert Rev Neurother. 2012 Nov;12(11):1351-65. doi: 10.1586/ern.12.124. Review.

PMID:
23234396
48.

Sales principles to help grow lab revenues--Part II.

Francis PT.

MLO Med Lab Obs. 2012 Jul;44(7):44, 46-7. No abstract available.

PMID:
22855953
49.

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients.

Solas M, Francis PT, Franco R, Ramirez MJ.

Neurobiol Aging. 2013 Mar;34(3):805-8. doi: 10.1016/j.neurobiolaging.2012.06.005. Epub 2012 Jul 2.

PMID:
22763024
50.

Sales principles to help grow lab revenues-Part I.

Francis PT.

MLO Med Lab Obs. 2012 May;44(5):28, 30. No abstract available.

PMID:
22655311

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