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C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT.

Francis NA, Gillespie D, White P, Bates J, Lowe R, Sewell B, Phillips R, Stanton H, Kirby N, Wootton M, Thomas-Jones E, Hood K, Llor C, Cals J, Melbye H, Naik G, Gal M, Fitzsimmons D, Alam MF, Riga E, Cochrane A, Butler CC.

Health Technol Assess. 2020 Mar;24(15):1-108. doi: 10.3310/hta24150.


Neoadjuvant strategies in resectable carcinoma esophagus: a meta-analysis of randomized trials.

Kumar T, Pai E, Singh R, Francis NJ, Pandey M.

World J Surg Oncol. 2020 Mar 21;18(1):59. doi: 10.1186/s12957-020-01830-x. Review.


Enduring consequences of perinatal fentanyl exposure in mice.

Alipio JB, Brockett AT, Fox ME, Tennyson SS, deBettencourt CA, El-Metwally D, Francis NA, Kanold PO, Lobo MK, Roesch MR, Keller A.

Addict Biol. 2020 Mar 18:e12895. doi: 10.1111/adb.12895. [Epub ahead of print]


Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation.

Zhao N, Yang X, Calvelli HR, Cao Y, Francis NL, Chmielowski RA, Joseph LB, Pang ZP, Uhrich KE, Baum J, Moghe PV.

Front Bioeng Biotechnol. 2020 Feb 21;8:112. doi: 10.3389/fbioe.2020.00112. eCollection 2020.


Antibiotic use and serious complications following acute otitis media and acute sinusitis: a retrospective cohort study.

Cushen R, Francis NA.

Br J Gen Pract. 2020 Mar 26;70(693):e255-e263. doi: 10.3399/bjgp20X708821. Print 2020 Apr.


Development and early outcomes of the national training initiative for transanal total mesorectal excision in the UK.

Francis N, Penna M, Carter F, Mortensen NJ, Hompes R; ACPGBI Pilot National TaTME Training Initiative Steering Group.

Colorectal Dis. 2020 Feb 17. doi: 10.1111/codi.15022. [Epub ahead of print]


An evaluation of the implementation of Safewards on an assessment and treatment unit for people with an intellectual disability.

Davies B, Silver J, Josham S, Grist E, Jones L, Francis N, Truelove C, Shindler M, Jones S, Gwatkin A.

J Intellect Disabil. 2020 Feb 12:1744629520901637. doi: 10.1177/1744629520901637. [Epub ahead of print]


Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model.

Robison LS, Francis N, Popescu DL, Anderson ME, Hatfield J, Xu F, Anderson BJ, Van Nostrand WE, Robinson JK.

Int J Mol Sci. 2020 Jan 28;21(3). pii: E843. doi: 10.3390/ijms21030843.


The feasibility of measuring calprotectin from a throat swab as a marker of infections caused by group A streptococcus: a case-control feasibility study.

Schofield B, Gregory C, Gal M, Gillespie D, Naik G, Hay A, Francis N.

BJGP Open. 2020 Jan 21. pii: bjgpopen20X101006. doi: 10.3399/bjgpopen20X101006. [Epub ahead of print]


Antibiotic prescribing for acute uncomplicated cystitis in Lebanese community pharmacies using a simulated patient.

Yaacoub SG, Koyess V, Lahoud N, Rahme D, Francis N, Saleh N, Maison P.

Pharm Pract (Granada). 2019 Oct-Dec;17(4):1604. doi: 10.18549/PharmPract.2019.4.1604. Epub 2019 Dec 12.


Adopting a flipped classroom approach for teaching molar calculations to biochemistry and genetics students.

Francis N, Morgan A, Holm S, Davey R, Bodger O, Dudley E.

Biochem Mol Biol Educ. 2019 Dec 30. doi: 10.1002/bmb.21328. [Epub ahead of print]


Dietary Polyphenols and Gene Expression in Molecular Pathways Associated with Type 2 Diabetes Mellitus: A Review.

Kang GG, Francis N, Hill R, Waters D, Blanchard C, Santhakumar AB.

Int J Mol Sci. 2019 Dec 24;21(1). pii: E140. doi: 10.3390/ijms21010140. Review.


Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms.

Gadalla AAH, Friberg IM, Kift-Morgan A, Zhang J, Eberl M, Topley N, Weeks I, Cuff S, Wootton M, Gal M, Parekh G, Davis P, Gregory C, Hood K, Hughes K, Butler C, Francis NA.

Sci Rep. 2019 Dec 23;9(1):19694. doi: 10.1038/s41598-019-55523-x.


The effect of ventilation tube insertion on quality of life in children with persistent otitis media with effusion.

Sanyaolu LN, Cannings-John R, Butler CC, Francis NA.

Clin Otolaryngol. 2020 Mar;45(2):239-247. doi: 10.1111/coa.13502. Epub 2020 Jan 6.


Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial.

Butler CC, van der Velden AW, Bongard E, Saville BR, Holmes J, Coenen S, Cook J, Francis NA, Lewis RJ, Godycki-Cwirko M, Llor C, Chlabicz S, Lionis C, Seifert B, Sundvall PD, Colliers A, Aabenhus R, Bjerrum L, Jonassen Harbin N, Lindbæk M, Glinz D, Bucher HC, Kovács B, Radzeviciene Jurgute R, Touboul Lundgren P, Little P, Murphy AW, De Sutter A, Openshaw P, de Jong MD, Connor JT, Matheeussen V, Ieven M, Goossens H, Verheij TJ.

Lancet. 2020 Jan 4;395(10217):42-52. doi: 10.1016/S0140-6736(19)32982-4. Epub 2019 Dec 12.


C-Reactive Protein for Antibiotic Use in COPD Exacerbations. Reply.

Butler CC, Gillespie D, Francis NA.

N Engl J Med. 2019 Dec 12;381(24):2372. doi: 10.1056/NEJMc1912624. No abstract available.


Macrofluidic Coaxial Flow Platforms to Produce Tunable Magnetite Nanoparticles: A Study of the Effect of Reaction Conditions and Biomineralisation Protein Mms6.

Norfolk L, Rawlings AE, Bramble JP, Ward K, Francis N, Waller R, Bailey A, Staniland SS.

Nanomaterials (Basel). 2019 Dec 4;9(12). pii: E1729. doi: 10.3390/nano9121729.


Voluntary Wheel Running Reduces Amyloid-β42 and Rescues Behavior in Aged Tg2576 Mouse Model of Alzheimer's Disease.

Francis N, Robison LS, Popescu DL, Michaelos M, Hatfield J, Xu F, Zhu X, Davis J, Anderson ME, Anderson BJ, Van Nostrand WE, Robinson JK.

J Alzheimers Dis. 2020;73(1):359-374. doi: 10.3233/JAD-190810.


Early exposure to antibiotics in the neonatal intensive care unit alters the taxonomic and functional infant gut microbiome.

Bender JM, Li F, Purswani H, Capretz T, Cerini C, Zabih S, Hung L, Francis N, Chin S, Pannaraj PS, Aldrovandi G.

J Matern Fetal Neonatal Med. 2019 Nov 19:1-9. doi: 10.1080/14767058.2019.1684466. [Epub ahead of print]


Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review.

Saji N, Francis N, Schwarz LJ, Blanchard CL, Santhakumar AB.

Nutrients. 2019 Nov 12;11(11). pii: E2736. doi: 10.3390/nu11112736. Review.


Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus.

Poncin K, Roba A, Jimmidi R, Potemberg G, Fioravanti A, Francis N, Willemart K, Zeippen N, Machelart A, Biondi EG, Muraille E, Vincent SP, De Bolle X.

Nat Commun. 2019 Oct 24;10(1):4847. doi: 10.1038/s41467-019-12516-8.


Assessing the efficacy and safety of laparoscopic antireflux procedures for the management of gastroesophageal reflux disease: a systematic review with network meta-analysis.

Andreou A, Watson DI, Mavridis D, Francis NK, Antoniou SA.

Surg Endosc. 2020 Feb;34(2):510-520. doi: 10.1007/s00464-019-07208-9. Epub 2019 Oct 18. Review.


Star-PAP controlled alternative polyadenylation coupled poly(A) tail length regulates protein expression in hypertrophic heart.

Sudheesh AP, Mohan N, Francis N, Laishram RS, Anderson RA.

Nucleic Acids Res. 2019 Nov 18;47(20):10771-10787. doi: 10.1093/nar/gkz875.


Engineering Tumor-Targeting Nanoparticles as Vehicles for Precision Nanomedicine.

Gonda A, Zhao N, Shah JV, Calvelli HR, Kantamneni H, Francis NL, Ganapathy V.

Med One. 2019;4. pii: e190021. doi: 10.20900/mo.20190021. Epub 2019 Sep 30.


Factors Predicting Operative Difficulty of Laparoscopic Total Mesorectal Excision.

Curtis NJ, Thomas C, Dennison G, Ockrim JB, Conti JA, Dalton R, Allison AS, Francis NK.

Dis Colon Rectum. 2019 Dec;62(12):1467-1476. doi: 10.1097/DCR.0000000000001490.


What the public think about participation in medical research during an influenza pandemic: an international cross-sectional survey.

Gobat N, Butler CC, Mollison J, Francis NA, Gal M, Harris V, Webb SAR, Byrne JP, Watkins A, Sukumar P, Hood K, Nichol A.

Public Health. 2019 Dec;177:80-94. doi: 10.1016/j.puhe.2019.07.005. Epub 2019 Sep 23.


Rice Bran Phenolic Compounds Regulate Genes Associated with Antioxidant and Anti-Inflammatory Activity in Human Umbilical Vein Endothelial Cells with Induced Oxidative Stress.

Saji N, Francis N, Blanchard CL, Schwarz LJ, Santhakumar AB.

Int J Mol Sci. 2019 Sep 23;20(19). pii: E4715. doi: 10.3390/ijms20194715.


Black Sorghum Phenolic Extract Regulates Expression of Genes Associated with Oxidative Stress and Inflammation in Human Endothelial Cells.

Francis N, Rao S, Blanchard C, Santhakumar A.

Molecules. 2019 Sep 12;24(18). pii: E3321. doi: 10.3390/molecules24183321.


Peptide-Based Scaffolds for the Culture and Transplantation of Human Dopaminergic Neurons.

Francis NL, Zhao N, Calvelli HR, Saini A, Gifford JJ, Wagner GC, Cohen RI, Pang ZP, Moghe PV.

Tissue Eng Part A. 2020 Feb;26(3-4):193-205. doi: 10.1089/ten.TEA.2019.0094. Epub 2019 Oct 17.


Automated Behavioral Experiments in Mice Reveal Periodic Cycles of Task Engagement within Circadian Rhythms.

Francis NA, Bohlke K, Kanold PO.

eNeuro. 2019 Oct 2;6(5). pii: ENEURO.0121-19.2019. doi: 10.1523/ENEURO.0121-19.2019. Print 2019 Sep/Oct.


Competency assessment tool for laparoscopic suturing: development and reliability evaluation.

IJgosse WM, Leijte E, Ganni S, Luursema JM, Francis NK, Jakimowicz JJ, Botden SMBI.

Surg Endosc. 2019 Aug 26. doi: 10.1007/s00464-019-07077-2. [Epub ahead of print]


Antibiotic exposure and 'response failure' for subsequent respiratory tract infections: an observational cohort study of UK preschool children in primary care.

van Hecke O, Fuller A, Bankhead C, Jenkins-Jones S, Francis N, Moore M, Butler C, Wang K.

Br J Gen Pract. 2019 Aug 29;69(686):e638-e646. doi: 10.3399/bjgp19X705089. Print 2019 Sep.


Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study.

Brookes-Howell L, Thomas-Jones E, Bates J, Bekkers MJ, Brugman C, Coulman E, Francis N, Hashmi K, Hood K, Kirby N, Llor C, Little P, Moore M, Moragas A, Rumsby K, Verheij T, Butler C.

BJGP Open. 2019 Jul 23;3(2). pii: bjgpopen18X101630. doi: 10.3399/bjgpopen18X101630. Print 2019 Jul.


Mild-to-moderate renal pelvis dilatation identified during pregnancy and hospital admissions in childhood: An electronic birth cohort study in Wales, UK.

Hurt L, Wright M, Demmler J, VanDerVoort J, Morris S, Brook F, Tucker D, Chapman M, Francis NA, Daniel R, Fone D, Brophy S, Paranjothy S.

PLoS Med. 2019 Jul 30;16(7):e1002859. doi: 10.1371/journal.pmed.1002859. eCollection 2019 Jul.


Artificial Neural Network Individualised Prediction of Time to Colorectal Cancer Surgery.

Curtis NJ, Dennison G, Salib E, Hashimoto DA, Francis NK.

Gastroenterol Res Pract. 2019 Jul 9;2019:1285931. doi: 10.1155/2019/1285931. eCollection 2019.


Feasibility of perioperative volatile organic compound breath testing for prediction of paralytic ileus following laparoscopic colorectal resection.

Francis NK, Curtis NJ, Salib E, de Lacy Costello B, Lemm NM, Gould O, Crilly L, Allison J, Ratcliffe N.

Colorectal Dis. 2020 Jan;22(1):86-94. doi: 10.1111/codi.14788. Epub 2019 Oct 3.


Cutaneotrichosporon (Trichosporon) debeurmannianum associated with a subcutaneous mycotic cyst successfully treated with voriconazole.

Noy ML, Abdolrasouli A, Borman AM, Fraser M, Francis N, Moore LSP, Merika EE.

Clin Exp Dermatol. 2020 Mar;45(2):250-253. doi: 10.1111/ced.14037. Epub 2019 Jul 22. No abstract available.


Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.

Hay AD, Downing H, Francis NA, Young GJ, Clement C, Harris SD, Ahern A, Schofield B, Thomas TE, Horwood J, Blair PS, Hollingworth W, Wilson V, Metcalfe C, Stoddart P, Nunez D, Lyttle MD, Little P, Moore MV.

Health Technol Assess. 2019 Jul;23(34):1-48. doi: 10.3310/hta23340.


Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy.

Robison LS, Popescu DL, Anderson ME, Francis N, Hatfield J, Sullivan JK, Beigelman SI, Xu F, Anderson BJ, Van Nostrand WE, Robinson JK.

J Neuroinflammation. 2019 Jul 11;16(1):144. doi: 10.1186/s12974-019-1534-0.


C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations.

Butler CC, Gillespie D, White P, Bates J, Lowe R, Thomas-Jones E, Wootton M, Hood K, Phillips R, Melbye H, Llor C, Cals JWL, Naik G, Kirby N, Gal M, Riga E, Francis NA.

N Engl J Med. 2019 Jul 11;381(2):111-120. doi: 10.1056/NEJMoa1803185.


Clinical Evaluation of Intraoperative Near Misses in Laparoscopic Rectal Cancer Surgery.

Curtis NJ, Dennison G, Brown CSB, Hewett PJ, Hanna GB, Stevenson ARL, Francis NK.

Ann Surg. 2019 Jul 3. doi: 10.1097/SLA.0000000000003452. [Epub ahead of print]


A nationwide study on the adoption and short-term outcomes of transanal total mesorectal excision in the UK.

Roodbeen SX, Penna M, Arnold S, Wynn G, Warusavitarne J, Francis N, Moran B, Hompes R; UK TaTME Registry Collaborative.

Minerva Chir. 2019 Aug;74(4):279-288. doi: 10.23736/S0026-4733.19.08064-7.


EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice.

Francis NK, Sylla P, Abou-Khalil M, Arolfo S, Berler D, Curtis NJ, Dolejs SC, Garfinkle R, Gorter-Stam M, Hashimoto DA, Hassinger TE, Molenaar CJL, Pucher PH, Schuermans V, Arezzo A, Agresta F, Antoniou SA, Arulampalam T, Boutros M, Bouvy N, Campbell K, Francone T, Haggerty SP, Hedrick TL, Stefanidis D, Truitt MS, Kelly J, Ket H, Dunkin BJ, Pietrabissa A.

Surg Endosc. 2019 Sep;33(9):2726-2741. doi: 10.1007/s00464-019-06882-z. Epub 2019 Jun 27.


Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial.

Owen-Jones E, Lowe R, Lown M, Gillespie D, Addison K, Bayer T, Calder PC, Davies J, Davoudianfar M, Downs J, Edwards A, Francis NA, Fuller R, Hobbs R, Hood K, Lau M, Little P, Moore M, Shepherd V, Stanton H, Toghill A, Wootton M, Butler CC.

BMJ Open. 2019 Jun 20;9(6):e027513. doi: 10.1136/bmjopen-2018-027513.


Male genital lichen sclerosus and filaggrin.

Shim TN, Brown SJ, Francis ND, Dinneen M, Hawkins D, Muneer A, Minhas S, Irwin McLean WH, Bunker CB.

Clin Exp Dermatol. 2020 Jan;45(1):127-128. doi: 10.1111/ced.14023. Epub 2019 Jul 5. No abstract available.


Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation.

Jones N, Vincent EE, Cronin JG, Panetti S, Chambers M, Holm SR, Owens SE, Francis NJ, Finlay DK, Thornton CA.

Nat Commun. 2019 May 3;10(1):2042. doi: 10.1038/s41467-019-10023-4.


Impact of antibiotic treatment duration on outcomes in older men with suspected urinary tract infection: Retrospective cohort study.

Ahmed H, Farewell D, Francis NA, Paranjothy S, Butler CC.

Pharmacoepidemiol Drug Saf. 2019 Jun;28(6):857-866. doi: 10.1002/pds.4791. Epub 2019 May 2.


Awareness of surgical expenditure amongst UK trainees and consultants: A questionnaire study.

Povey M, Francis N, Healy R, Blacker S, Vimalachandran D, Sutton PA.

Int J Surg. 2019 Jul;67:8-12. doi: 10.1016/j.ijsu.2019.04.008. Epub 2019 Apr 22.


Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study.

Lugg-Widger FV, Angel L, Cannings-John R, Jones H, Lau M, Butler C, Francis NA, Hay AD, Heginbothom M, Hood K, Paranjothy S, Vandervoort J, Hughes K.

BMJ Open. 2019 Apr 20;9(4):e024210. doi: 10.1136/bmjopen-2018-024210.


Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts.

Andersen YMF, Egeberg A, Ban L, Gran S, Williams HC, Francis NA, Knop FK, Gislason GH, Skov L, Thyssen JP.

Diabetes Care. 2019 Jun;42(6):1095-1103. doi: 10.2337/dc18-2158. Epub 2019 Apr 1.


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