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Novel in vivo mouse model of shoulder implant infection.

Sheppard WL, Mosich GM, Smith RA, Hamad CD, Park HY, Zoller SD, Trikha R, McCoy TK, Borthwell R, Hoang J, Truong N, Cevallos N, Clarkson S, Hori KR, van Dijl JM, Francis KP, Petrigliano FA, Bernthal NM.

J Shoulder Elbow Surg. 2020 Jan 31. pii: S1058-2746(19)30803-1. doi: 10.1016/j.jse.2019.10.032. [Epub ahead of print]


Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections.

Miller RJ, Crosby HA, Schilcher K, Wang Y, Ortines RV, Mazhar M, Dikeman DA, Pinsker BL, Brown ID, Joyce DP, Zhang J, Archer NK, Liu H, Alphonse MP, Czupryna J, Anderson WR, Bernthal NM, Fortuno-Miranda L, Bulte JWM, Francis KP, Horswill AR, Miller LS.

Sci Rep. 2019 Nov 13;9(1):16663. doi: 10.1038/s41598-019-52982-0.


Preclinical Models and Methodologies for Monitoring Staphylococcus aureus Infections Using Noninvasive Optical Imaging.

Archer NK, Wang Y, Ortines RV, Liu H, Nolan SJ, Liu Q, Alphonse MP, Dikeman DA, Mazhar M, Miller RJ, Anderson LS, Francis KP, Simon SI, Miller LS.

Methods Mol Biol. 2020;2069:197-228. doi: 10.1007/978-1-4939-9849-4_15.


Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice.

Miyazaki T, Gharib SA, Hsu YA, Xu K, Khodakivskyi P, Kobayashi A, Paragas J, Klose AD, Francis KP, Dubikovskaya E, Page-McCaw PS, Barasch J, Paragas N.

Commun Biol. 2019 Sep 2;2:326. doi: 10.1038/s42003-019-0571-7. eCollection 2019.


Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.

Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A.

Front Microbiol. 2019 Mar 26;10:518. doi: 10.3389/fmicb.2019.00518. eCollection 2019.


Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.

Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A.

Front Microbiol. 2019 Feb 14;10:159. doi: 10.3389/fmicb.2019.00159. eCollection 2019. Erratum in: Front Microbiol. 2019 Mar 26;10:518.


Multimodal imaging guides surgical management in a preclinical spinal implant infection model.

Zoller SD, Park HY, Olafsen T, Zamilpa C, Burke ZD, Blumstein G, Sheppard WL, Hamad CD, Hori KR, Tseng JC, Czupryna J, McMannus C, Lee JT, Bispo M, Romero Pastrana F, Raineri EJ, Miller JF, Miller LS, van Dijl JM, Francis KP, Bernthal NM.

JCI Insight. 2019 Feb 7;4(3). pii: 124813. doi: 10.1172/jci.insight.124813. [Epub ahead of print]


Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS.

JCI Insight. 2018 Sep 6;3(17). pii: 121737. doi: 10.1172/jci.insight.121737. eCollection 2018 Sep 6.


Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer.

Momcilovic M, Bailey ST, Lee JT, Zamilpa C, Jones A, Abdelhady G, Mansfield J, Francis KP, Shackelford DB.

J Vis Exp. 2018 Jul 21;(137). doi: 10.3791/57167.


Can 3D imaging provide insights into spatial variations in bacterial infection patterns?

Taylor PW, Francis KP.

Future Microbiol. 2018 Jun 1;13:897-901. doi: 10.2217/fmb-2017-0272. Epub 2018 Jun 7.


Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.

Romero Pastrana F, Thompson JM, Heuker M, Hoekstra H, Dillen CA, Ortines RV, Ashbaugh AG, Pickett JE, Linssen MD, Bernthal NM, Francis KP, Buist G, van Oosten M, van Dam GM, Thorek DLJ, Miller LS, van Dijl JM.

Virulence. 2018 Jan 1;9(1):262-272. doi: 10.1080/21505594.2017.1403004. Epub 2017 Dec 26.


NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice.

Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A.

Front Immunol. 2017 Oct 31;8:1337. doi: 10.3389/fimmu.2017.01337. eCollection 2017.


Development of a Click Beetle Luciferase Reporter System for Enhanced Bioluminescence Imaging of Listeria monocytogenes: Analysis in Cell Culture and Murine Infection Models.

Ur Rahman S, Stanton M, Casey PG, Spagnuolo A, Bensi G, Hill C, Francis KP, Tangney M, Gahan CGM.

Front Microbiol. 2017 Sep 26;8:1797. doi: 10.3389/fmicb.2017.01797. eCollection 2017.


Non-invasive three-dimensional imaging of Escherichia coli K1 infection using diffuse light imaging tomography combined with micro-computed tomography.

Witcomb LA, Czupryna J, Francis KP, Frankel G, Taylor PW.

Methods. 2017 Aug 15;127:62-68. doi: 10.1016/j.ymeth.2017.05.005. Epub 2017 May 15. Review.


Combinatory antibiotic therapy increases rate of bacterial kill but not final outcome in a novel mouse model of Staphylococcus aureus spinal implant infection.

Hu Y, Hegde V, Johansen D, Loftin AH, Dworsky E, Zoller SD, Park HY, Hamad CD, Nelson GE, Francis KP, Scaduto A, Bernthal NM.

PLoS One. 2017 Feb 28;12(2):e0173019. doi: 10.1371/journal.pone.0173019. eCollection 2017.


Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection.

Wang Y, Thompson JM, Ashbaugh AG, Khodakivskyi P, Budin G, Sinisi R, Heinmiller A, van Oosten M, van Dijl JM, van Dam GM, Francis KP, Bernthal NM, Dubikovskaya EA, Miller LS.

J Am Acad Orthop Surg. 2017 Feb;25 Suppl 1:S7-S12. doi: 10.5435/JAAOS-D-16-00630.


Novel in vivo mouse model of implant related spine infection.

Dworsky EM, Hegde V, Loftin AH, Richman S, Hu Y, Lord E, Francis KP, Miller LS, Wang JC, Scaduto A, Bernthal NM.

J Orthop Res. 2017 Jan;35(1):193-199. doi: 10.1002/jor.23273. Epub 2016 May 8.


Application of Fluorescent Protein Expressing Strains to Evaluation of Anti-Tuberculosis Therapeutic Efficacy In Vitro and In Vivo.

Kong Y, Yang D, Cirillo SL, Li S, Akin A, Francis KP, Maloney T, Cirillo JD.

PLoS One. 2016 Mar 2;11(3):e0149972. doi: 10.1371/journal.pone.0149972. eCollection 2016.


In Vivo Bioluminescence Imaging of Intratumoral Bacteria.

Cronin M, Akin AR, Francis KP, Tangney M.

Methods Mol Biol. 2016;1409:69-77. doi: 10.1007/978-1-4939-3515-4_7.


Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses.

Tran V, Poole DS, Jeffery JJ, Sheahan TP, Creech D, Yevtodiyenko A, Peat AJ, Francis KP, You S, Mehle A.

Viruses. 2015 Oct 13;7(10):5319-27. doi: 10.3390/v7102873.


Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.

Vorobyeva AG, Stanton M, Godinat A, Lund KB, Karateev GG, Francis KP, Allen E, Gelovani JG, McCormack E, Tangney M, Dubikovskaya EA.

PLoS One. 2015 Jun 25;10(6):e0131037. doi: 10.1371/journal.pone.0131037. eCollection 2015.


Targeted imaging of bacterial infections: advances, hurdles and hopes.

van Oosten M, Hahn M, Crane LM, Pleijhuis RG, Francis KP, van Dijl JM, van Dam GM.

FEMS Microbiol Rev. 2015 Nov;39(6):892-916. doi: 10.1093/femsre/fuv029. Epub 2015 Jun 24. Review.


Azithromycin inhibits nuclear factor-κB activation during lung inflammation: an in vivo imaging study.

Stellari FF, Sala A, Donofrio G, Ruscitti F, Caruso P, Topini TM, Francis KP, Li X, Carnini C, Civelli M, Villetti G.

Pharmacol Res Perspect. 2014 Oct;2(5):e00058. doi: 10.1002/prp2.58. Epub 2014 Jul 2.


Combined in vivo optical and µCT imaging to monitor infection, inflammation, and bone anatomy in an orthopaedic implant infection in mice.

Bernthal NM, Taylor BN, Meganck JA, Wang Y, Shahbazian JH, Niska JA, Francis KP, Miller LS.

J Vis Exp. 2014 Oct 16;(92):e51612. doi: 10.3791/51612.


Real-time bioluminescence imaging of mixed mycobacterial infections.

Chang M, Anttonen KP, Cirillo SL, Francis KP, Cirillo JD.

PLoS One. 2014 Sep 29;9(9):e108341. doi: 10.1371/journal.pone.0108341. eCollection 2014.


Efficacy of enrofloxacin in a mouse model of sepsis.

Slate AR, Bandyopadhyay S, Francis KP, Papich MG, Karolewski B, Hod EA, Prestia KA.

J Am Assoc Lab Anim Sci. 2014 Jul;53(4):381-6.


α-Intercalated cells defend the urinary system from bacterial infection.

Paragas N, Kulkarni R, Werth M, Schmidt-Ott KM, Forster C, Deng R, Zhang Q, Singer E, Klose AD, Shen TH, Francis KP, Ray S, Vijayakumar S, Seward S, Bovino ME, Xu K, Takabe Y, Amaral FE, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin CS, Qiu A, Al-Awqati Q, Ratner AJ, Barasch J.

J Clin Invest. 2014 Jul;124(7):2963-76. doi: 10.1172/JCI71630. Epub 2014 Jun 17. Erratum in: J Clin Invest. 2014 Dec 1;124(12):5521.


Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice.

Prestia K, Bandyopadhyay S, Slate A, Francis RO, Francis KP, Spitalnik SL, Fidock DA, Brittenham GM, Hod EA.

Transfusion. 2014 Nov;54(11):2842-51. doi: 10.1111/trf.12712. Epub 2014 May 19.


Opening up the optical imaging window using nano-luciferin.

Patel AR, Lim E, Francis KP, Singh M.

Pharm Res. 2014 Nov;31(11):3073-84. doi: 10.1007/s11095-014-1400-9. Epub 2014 May 16.


Microbiota of human breast tissue.

Urbaniak C, Cummins J, Brackstone M, Macklaim JM, Gloor GB, Baban CK, Scott L, O'Hanlon DM, Burton JP, Francis KP, Tangney M, Reid G.

Appl Environ Microbiol. 2014 May;80(10):3007-14. doi: 10.1128/AEM.00242-14. Epub 2014 Mar 7.


Combination prophylactic therapy with rifampin increases efficacy against an experimental Staphylococcus epidermidis subcutaneous implant-related infection.

Stavrakis AI, Niska JA, Shahbazian JH, Loftin AH, Ramos RI, Billi F, Francis KP, Otto M, Bernthal NM, Uslan DZ, Miller LS.

Antimicrob Agents Chemother. 2014;58(4):2377-86. doi: 10.1128/AAC.01943-13. Epub 2014 Feb 10.


Theranostic tumor homing nanocarriers for the treatment of lung cancer.

Patel AR, Chougule MB, Lim E, Francis KP, Safe S, Singh M.

Nanomedicine. 2014 Jul;10(5):1053-63. doi: 10.1016/j.nano.2013.12.002. Epub 2013 Dec 17.


Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin.

van Oosten M, Schäfer T, Gazendam JA, Ohlsen K, Tsompanidou E, de Goffau MC, Harmsen HJ, Crane LM, Lim E, Francis KP, Cheung L, Olive M, Ntziachristos V, van Dijl JM, van Dam GM.

Nat Commun. 2013;4:2584. doi: 10.1038/ncomms3584.


4D multimodality imaging of Citrobacter rodentium infections in mice.

Collins JW, Meganck JA, Kuo C, Francis KP, Frankel G.

J Vis Exp. 2013 Aug 13;(78). doi: 10.3791/50450.


Vancomycin-rifampin combination therapy has enhanced efficacy against an experimental Staphylococcus aureus prosthetic joint infection.

Niska JA, Shahbazian JH, Ramos RI, Francis KP, Bernthal NM, Miller LS.

Antimicrob Agents Chemother. 2013 Oct;57(10):5080-6. doi: 10.1128/AAC.00702-13. Epub 2013 Aug 5.


Use of optical imaging to progress novel therapeutics to the clinic.

Byrne WL, DeLille A, Kuo C, de Jong JS, van Dam GM, Francis KP, Tangney M.

J Control Release. 2013 Dec 10;172(2):523-34. doi: 10.1016/j.jconrel.2013.05.004. Epub 2013 May 13. Review.


Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles.

Zhang N, Francis KP, Prakash A, Ansaldi D.

Nat Med. 2013 Apr;19(4):500-5. doi: 10.1038/nm.3110. Epub 2013 Mar 3.


Bioluminescent bacterial imaging in vivo.

Baban CK, Cronin M, Akin AR, O'Brien A, Gao X, Tabirca S, Francis KP, Tangney M.

J Vis Exp. 2012 Nov 4;(69):e4318. doi: 10.3791/4318.


Monitoring bacterial burden, inflammation and bone damage longitudinally using optical and μCT imaging in an orthopaedic implant infection in mice.

Niska JA, Meganck JA, Pribaz JR, Shahbazian JH, Lim E, Zhang N, Rice BW, Akin A, Ramos RI, Bernthal NM, Francis KP, Miller LS.

PLoS One. 2012;7(10):e47397. doi: 10.1371/journal.pone.0047397. Epub 2012 Oct 17.


Bacterial vectors for imaging and cancer gene therapy: a review.

Cronin M, Stanton RM, Francis KP, Tangney M.

Cancer Gene Ther. 2012 Nov;19(11):731-40. doi: 10.1038/cgt.2012.59. Epub 2012 Sep 21. Review.


Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity.

Collins JW, Akin AR, Kosta A, Zhang N, Tangney M, Francis KP, Frankel G.

Microbiology. 2012 Nov;158(Pt 11):2826-2834. doi: 10.1099/mic.0.060830-0. Epub 2012 Aug 17.


Daptomycin and tigecycline have broader effective dose ranges than vancomycin as prophylaxis against a Staphylococcus aureus surgical implant infection in mice.

Niska JA, Shahbazian JH, Ramos RI, Pribaz JR, Billi F, Francis KP, Miller LS.

Antimicrob Agents Chemother. 2012 May;56(5):2590-7. doi: 10.1128/AAC.06291-11. Epub 2012 Feb 27.


High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting.

Cronin M, Akin AR, Collins SA, Meganck J, Kim JB, Baban CK, Joyce SA, van Dam GM, Zhang N, van Sinderen D, O'Sullivan GC, Kasahara N, Gahan CG, Francis KP, Tangney M.

PLoS One. 2012;7(1):e30940. doi: 10.1371/journal.pone.0030940. Epub 2012 Jan 25.


Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.

Yan J, Meng X, Wancket LM, Lintner K, Nelin LD, Chen B, Francis KP, Smith CV, Rogers LK, Liu Y.

J Immunol. 2012 Mar 1;188(5):2316-27. doi: 10.4049/jimmunol.1102683. Epub 2012 Jan 25.


In vivo optical imaging in gene & cell therapy.

Tangney M, Francis KP.

Curr Gene Ther. 2012 Feb 1;12(1):2-11. Review.


Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8.

Ansaldi D, Hod EA, Stellari F, Kim JB, Lim E, Roskey M, Francis KP, Singh R, Zhang N.

PLoS One. 2011;6(9):e25093. doi: 10.1371/journal.pone.0025093. Epub 2011 Sep 22.


Mouse model of chronic post-arthroplasty infection: noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study.

Pribaz JR, Bernthal NM, Billi F, Cho JS, Ramos RI, Guo Y, Cheung AL, Francis KP, Miller LS.

J Orthop Res. 2012 Mar;30(3):335-40. doi: 10.1002/jor.21519. Epub 2011 Aug 11.


Visualization of plant viral suppressor silencing activity in intact leaf lamina by quantitative fluorescent imaging.

Stephan D, Slabber C, George G, Ninov V, Francis KP, Burger JT.

Plant Methods. 2011 Aug 3;7:25. doi: 10.1186/1746-4811-7-25.


Whole-body imaging of infection using bioluminescence.

Kong Y, Shi Y, Chang M, Akin AR, Francis KP, Zhang N, Troy TL, Yao H, Rao J, Cirillo SL, Cirillo JD.

Curr Protoc Microbiol. 2011 May;Chapter 2:Unit 2C.4. doi: 10.1002/9780471729259.mc02c04s21.


Whole-body imaging of infection using fluorescence.

Kong Y, Akin AR, Francis KP, Zhang N, Troy TL, Xie H, Rao J, Cirillo SL, Cirillo JD.

Curr Protoc Microbiol. 2011 May;Chapter 2:Unit 2C.3. doi: 10.1002/9780471729259.mc02c03s21.


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