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Items: 1 to 50 of 102

1.

Pathways of smooth muscle foam cell formation in atherosclerosis.

Pryma CS, Ortega C, Dubland JA, Francis GA.

Curr Opin Lipidol. 2019 Jan 16. doi: 10.1097/MOL.0000000000000574. [Epub ahead of print]

PMID:
30664015
2.

Multiplexed LC-ESI-MRM-MS-based Assay for Identification of Coronary Artery Disease Biomarkers in Human Plasma.

Anwar MA, Dai DL, Wilson-McManus J, Smith D, Francis GA, Borchers CH, McManus BM, Hill JS, Cohen Freue GV.

Proteomics Clin Appl. 2019 Jan 11:e1700111. doi: 10.1002/prca.201700111. [Epub ahead of print]

PMID:
30632678
3.

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018.

Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M, Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, St-Pierre J, Henderson M, Hegele RA, Genest J, Goguen J, Gaudet D, Paré G, Romney J, Ransom T, Bernard S, Katz P, Joy TR, Bewick D, Brophy J.

Can J Cardiol. 2018 Dec;34(12):1553-1563. doi: 10.1016/j.cjca.2018.09.005.

PMID:
30527143
4.

Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivors.

Genga KR, Lo C, Cirstea MS, Leitao Filho FS, Walley KR, Russell JA, Linder A, Francis GA, Boyd JH.

EBioMedicine. 2018 Dec;38:257-264. doi: 10.1016/j.ebiom.2018.11.032. Epub 2018 Nov 23.

5.

CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis.

Genga KR, Trinder M, Kong HJ, Li X, Leung AKK, Shimada T, Walley KR, Russell JA, Francis GA, Brunham LR, Boyd JH.

Sci Rep. 2018 Nov 13;8(1):16764. doi: 10.1038/s41598-018-35261-2.

6.

Nonfasting lipid testing: the new standard for cardiovascular risk assessment.

Darras P, Mattman A, Francis GA.

CMAJ. 2018 Nov 12;190(45):E1317-E1318. doi: 10.1503/cmaj.180804. No abstract available.

PMID:
30420386
7.

Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.

Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J.

Atherosclerosis. 2018 Oct;277:419-424. doi: 10.1016/j.atherosclerosis.2018.05.040.

PMID:
30270080
8.

Simplified Canadian Definition for Familial Hypercholesterolemia.

Ruel I, Brisson D, Aljenedil S, Awan Z, Baass A, Bélanger A, Bergeron J, Bewick D, Brophy JM, Brunham LR, Couture P, Dufour R, Francis GA, Frohlich J, Gagné C, Gaudet D, Grégoire JC, Gupta M, Hegele RA, Mancini GBJ, McCrindle BW, Pang J, Raggi P, Tu JV, Watts GF, Genest J.

Can J Cardiol. 2018 Sep;34(9):1210-1214. doi: 10.1016/j.cjca.2018.05.015. Epub 2018 May 19.

9.

Attainment of Recommended Lipid Targets in Patients With Familial Hypercholesterolemia: Real-World Experience With PCSK9 Inhibitors.

Razek O, Cermakova L, Armani H, Lee T, Francis GA, Mancini GBJ, Frohlich J, Brunham LR.

Can J Cardiol. 2018 Aug;34(8):1004-1009. doi: 10.1016/j.cjca.2018.04.014. Epub 2018 Apr 20.

PMID:
30056842
10.

The design and rationale of SAVE BC: The Study to Avoid CardioVascular Events in British Columbia.

Brunham LR, Lynch K, English A, Sutherland R, Weng J, Cho R, Wong GC, Anis AH, Francis GA, Khan NA, McManus B, Wood D, Walley KR, Leipsic J, Humphries KH, Hoens A, Krahn AD, John Mancini GB, Pimstone S.

Clin Cardiol. 2018 Jul;41(7):888-895. doi: 10.1002/clc.22959. Epub 2018 Jun 11.

11.

LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo.

Bowden KL, Dubland JA, Chan T, Xu YH, Grabowski GA, Du H, Francis GA.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1191-1201. doi: 10.1161/ATVBAHA.117.310507. Epub 2018 Mar 29.

PMID:
29599133
12.

Response by Kusters et al to Letter Regarding Article, "Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label)".

Kusters DM, Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagne C, Gaudet D, Morrison KM, Wiegman A, Turner T, Miller E, Raichlen J, Martin PD, Stein EA, Kastelein JJP, Hutten BA.

Circulation. 2018 Feb 6;137(6):641-642. doi: 10.1161/CIRCULATIONAHA.117.031676. No abstract available.

PMID:
29431667
13.

Smooth muscle cell fate and plasticity in atherosclerosis.

Allahverdian S, Chaabane C, Boukais K, Francis GA, Bochaton-Piallat ML.

Cardiovasc Res. 2018 Mar 15;114(4):540-550. doi: 10.1093/cvr/cvy022.

PMID:
29385543
14.

Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe.

Ruel I, Aljenedil S, Sadri I, de Varennes É, Hegele RA, Couture P, Bergeron J, Wanneh E, Baass A, Dufour R, Gaudet D, Brisson D, Brunham LR, Francis GA, Cermakova L, Brophy JM, Ryomoto A, Mancini GBJ, Genest J.

Clin Chem. 2018 Feb;64(2):355-362. doi: 10.1373/clinchem.2017.279422. Epub 2017 Oct 16.

15.

Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label).

Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagne C, Gaudet D, Morrison KM, Wiegman A, Turner T, Miller E, Kusters DM, Raichlen JS, Martin PD, Stein EA, Kastelein JJP, Hutten BA.

Circulation. 2017 Jul 25;136(4):359-366. doi: 10.1161/CIRCULATIONAHA.116.025158. Epub 2017 Jun 7.

PMID:
28592434
16.

Contemporary Trends in the Management and Outcomes of Patients With Familial Hypercholesterolemia in Canada: A Prospective Observational Study.

Brunham LR, Cermakova L, Lee T, Priecelova I, Alloul K, de Chantal M, Francis GA, Frohlich J.

Can J Cardiol. 2017 Mar;33(3):385-392. doi: 10.1016/j.cjca.2016.08.016. Epub 2016 Sep 3.

17.

2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult.

Anderson TJ, Grégoire J, Pearson GJ, Barry AR, Couture P, Dawes M, Francis GA, Genest J Jr, Grover S, Gupta M, Hegele RA, Lau DC, Leiter LA, Lonn E, Mancini GB, McPherson R, Ngui D, Poirier P, Sievenpiper JL, Stone JA, Thanassoulis G, Ward R.

Can J Cardiol. 2016 Nov;32(11):1263-1282. doi: 10.1016/j.cjca.2016.07.510. Epub 2016 Jul 25. Review.

PMID:
27712954
18.

So Much Cholesterol: the unrecognized importance of smooth muscle cells in atherosclerotic foam cell formation.

Dubland JA, Francis GA.

Curr Opin Lipidol. 2016 Apr;27(2):155-61. doi: 10.1097/MOL.0000000000000279. Review.

PMID:
26836481
19.

Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study.

Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Wiegman A, Turner T, Kusters DM, Miller E, Raichlen JS, Wissmar J, Martin PD, Stein EA, Kastelein JJP.

J Clin Lipidol. 2015 Nov-Dec;9(6):741-750. doi: 10.1016/j.jacl.2015.07.011. Epub 2015 Aug 1.

PMID:
26687694
20.

Colesevelam as an Add-On Treatment for Control of Dyslipidemia and Hyperglycemia in Type 2 Diabetes.

Sandhu S, Moosavi M, Golmohammadi K, Francis GA.

Can J Diabetes. 2016 Apr;40(2):112-4. doi: 10.1016/j.jcjd.2015.07.008. Epub 2015 Nov 12. Review. No abstract available.

PMID:
26584788
21.

Targeted next-generation sequencing to diagnose disorders of HDL cholesterol.

Sadananda SN, Foo JN, Toh MT, Cermakova L, Trigueros-Motos L, Chan T, Liany H, Collins JA, Gerami S, Singaraja RR, Hayden MR, Francis GA, Frohlich J, Khor CC, Brunham LR.

J Lipid Res. 2015 Oct;56(10):1993-2001. doi: 10.1194/jlr.P058891. Epub 2015 Aug 8.

22.

The Central Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Septic Pathogen Lipid Transport and Clearance.

Walley KR, Francis GA, Opal SM, Stein EA, Russell JA, Boyd JH.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1275-86. doi: 10.1164/rccm.201505-0876CI.

PMID:
26252194
23.

Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism.

Dubland JA, Francis GA.

Front Cell Dev Biol. 2015 Feb 2;3:3. doi: 10.3389/fcell.2015.00003. eCollection 2015. Review.

24.

Response to letter regarding article, "contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis".

Francis GA, Allahverdian S, Cheroudi AC, Abraham T, McManus BM.

Circulation. 2015 Jan 20;131(3):e25. doi: 10.1161/CIRCULATIONAHA.114.012817. No abstract available.

PMID:
25601956
25.

Are the ACC/AHA guidelines on the treatment of blood cholesterol a game changer? A perspective from the Canadian Cardiovascular Society Dyslipidemia Panel.

Anderson TJ, Grégoire J, Hegele RA, Couture P, Mancini GB, McPherson R, Francis GA, Poirier P, Lau DC, Grover S, Genest J Jr, Carpentier AC, Dufour R, Gupta M, Ward R, Leiter LA, Lonn E, Ng DS, Pearson GJ, Yates GM, Stone JA, Ur E.

Can J Cardiol. 2014 Apr;30(4):377-80. doi: 10.1016/j.cjca.2014.01.009. Epub 2014 Jan 17. No abstract available.

PMID:
24589194
26.

Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis.

Allahverdian S, Chehroudi AC, McManus BM, Abraham T, Francis GA.

Circulation. 2014 Apr 15;129(15):1551-9. doi: 10.1161/CIRCULATIONAHA.113.005015. Epub 2014 Jan 30.

PMID:
24481950
27.

Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia.

Kusters DM, Hutten BA, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Langslet G, Kastelein JJ, Wiegman A.

J Clin Lipidol. 2013 Sep-Oct;7(5):408-13. doi: 10.1016/j.jacl.2013.06.010. Epub 2013 Jun 29.

PMID:
24079281
28.

Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10).

Miyata R, Hiraiwa K, Cheng JC, Bai N, Vincent R, Francis GA, Sin DD, Van Eeden SF.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):1-11. doi: 10.1016/j.taap.2013.05.033. Epub 2013 Jun 10.

PMID:
23756175
29.

2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult.

Anderson TJ, Grégoire J, Hegele RA, Couture P, Mancini GB, McPherson R, Francis GA, Poirier P, Lau DC, Grover S, Genest J Jr, Carpentier AC, Dufour R, Gupta M, Ward R, Leiter LA, Lonn E, Ng DS, Pearson GJ, Yates GM, Stone JA, Ur E.

Can J Cardiol. 2013 Feb;29(2):151-67. doi: 10.1016/j.cjca.2012.11.032. Review.

PMID:
23351925
30.

Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: not all roads lead to Rome.

Pannu PS, Allahverdian S, Francis GA.

Mol Cell Endocrinol. 2013 Apr 10;368(1-2):99-107. doi: 10.1016/j.mce.2012.07.013. Epub 2012 Aug 3. Review.

PMID:
22884520
31.

Factors affecting quality and safety of fresh-cut produce.

Francis GA, Gallone A, Nychas GJ, Sofos JN, Colelli G, Amodio ML, Spano G.

Crit Rev Food Sci Nutr. 2012;52(7):595-610. doi: 10.1080/10408398.2010.503685. Review.

PMID:
22530712
32.

Advances in high density lipoprotein formation and metabolism: a tribute to John F. Oram (1945-2010).

Francis GA, Heinecke JW.

Biochim Biophys Acta. 2012 Mar;1821(3):343-4. doi: 10.1016/j.bbalip.2012.02.006. No abstract available.

PMID:
22364764
33.

Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation.

Allahverdian S, Pannu PS, Francis GA.

Cardiovasc Res. 2012 Jul 15;95(2):165-72. doi: 10.1093/cvr/cvs094. Epub 2012 Feb 15. Review.

PMID:
22345306
34.

Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I.

Hossain MA, Ngeth S, Chan T, Oda MN, Francis GA.

BMC Biochem. 2012 Jan 16;13:1. doi: 10.1186/1471-2091-13-1.

35.

ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.

Boadu E, Nelson RC, Francis GA.

Biochim Biophys Acta. 2012 Mar;1821(3):396-404. doi: 10.1016/j.bbalip.2011.11.013. Epub 2011 Dec 10.

PMID:
22179027
36.

Incidence of pancreatitis, secondary causes, and treatment of patients referred to a specialty lipid clinic with severe hypertriglyceridemia: a retrospective cohort study.

Sandhu S, Al-Sarraf A, Taraboanta C, Frohlich J, Francis GA.

Lipids Health Dis. 2011 Sep 11;10:157. doi: 10.1186/1476-511X-10-157.

37.

Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease.

Bowden KL, Bilbey NJ, Bilawchuk LM, Boadu E, Sidhu R, Ory DS, Du H, Chan T, Francis GA.

J Biol Chem. 2011 Sep 2;286(35):30624-35. doi: 10.1074/jbc.M111.274381. Epub 2011 Jul 10.

38.

Thyrotoxicosis presenting as acute bulbar palsy.

Mathew B, Devasia AJ, Ayyar V, Thyagaraj V, Francis GA.

J Assoc Physicians India. 2011 Jun;59:386-7.

PMID:
21751598
39.

Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins.

Fleischer JG, Rossignol D, Francis GA, Chan T, Lynn M, Wasan KM.

Innate Immun. 2012 Feb;18(1):171-8. doi: 10.1177/1753425910394395. Epub 2011 Mar 7.

PMID:
21382909
40.

Cholesterol homeostasis and high-density lipoprotein formation in arterial smooth muscle cells.

Allahverdian S, Francis GA.

Trends Cardiovasc Med. 2010 Apr;20(3):96-102. doi: 10.1016/j.tcm.2010.09.002. Review.

PMID:
21130953
41.

Prevalence of dyslipidemia in statin-treated patients in Canada: results of the DYSlipidemia International Study (DYSIS).

Goodman SG, Langer A, Bastien NR, McPherson R, Francis GA, Genest JJ Jr, Leiter LA; DYSIS Canadian Investigators.

Can J Cardiol. 2010 Nov;26(9):e330-5.

42.

The complexity of HDL.

Francis GA.

Biochim Biophys Acta. 2010 Dec;1801(12):1286-93. doi: 10.1016/j.bbalip.2010.08.009. Epub 2010 Aug 21. Review.

PMID:
20736082
43.

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations.

Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, Couture P, Dufour R, Fodor G, Francis GA, Grover S, Gupta M, Hegele RA, Lau DC, Leiter L, Lewis GF, Lonn E, Mancini GB, Ng D, Pearson GJ, Sniderman A, Stone JA, Ur E.

Can J Cardiol. 2009 Oct;25(10):567-79. Review.

44.

Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments.

Jelinek D, Patrick SM, Kitt KN, Chan T, Francis GA, Garver WS.

J Cell Biochem. 2009 Dec 1;108(5):1102-16. doi: 10.1002/jcb.22339.

PMID:
19746448
45.

The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes.

Garver WS, Jelinek D, Meaney FJ, Flynn J, Pettit KM, Shepherd G, Heidenreich RA, Vockley CM, Castro G, Francis GA.

J Lipid Res. 2010 Feb;51(2):406-15. doi: 10.1194/jlr.P000331. Epub 2009 Sep 9.

46.
47.

ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells.

Choi HY, Rahmani M, Wong BW, Allahverdian S, McManus BM, Pickering JG, Chan T, Francis GA.

Circulation. 2009 Jun 30;119(25):3223-31. doi: 10.1161/CIRCULATIONAHA.108.841130. Epub 2009 Jun 15.

PMID:
19528336
48.

Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.

Zhao Y, Su B, Jacobs RL, Kennedy B, Francis GA, Waddington E, Brosnan JT, Vance JE, Vance DE.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1349-55. doi: 10.1161/ATVBAHA.109.188672. Epub 2009 Jun 11.

PMID:
19520976
49.

Maintenance of improved lipid levels following attendance at a cardiovascular risk reduction clinic: a 10-year experience.

Pearson GJ, Olson KL, Panich NE, Majumdar SR, Tsuyuki RT, Gilchrist DM, Damani A, Francis GA.

Vasc Health Risk Manag. 2008;4(5):1127-35.

50.

A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase.

Robichaud JC, Francis GA, Vance DE.

J Biol Chem. 2008 Dec 19;283(51):35496-506. doi: 10.1074/jbc.M807433200. Epub 2008 Oct 8.

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