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The Contribution of the Adipose Tissue-Liver Axis in Pediatric Patients with Nonalcoholic Fatty Liver Disease after Laparoscopic Sleeve Gastrectomy.

Franchitto A, Carpino G, Alisi A, De Peppo F, Overi D, De Stefanis C, Romito I, De Vito R, Caccamo R, Sonia B, Alessandra S, Mosca A, Alterio A, Onori P, Gaudio E, Nobili V.

J Pediatr. 2019 Sep 13. pii: S0022-3476(19)30889-3. doi: 10.1016/j.jpeds.2019.07.037. [Epub ahead of print]


Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes.

Pugliese GM, Salaris F, Palermo V, Marabitti V, Morina N, Rosa A, Franchitto A, Pichierri P.

Dis Model Mech. 2019 Oct 17;12(10). pii: dmm039487. doi: 10.1242/dmm.039487.


Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis.

Carpino G, Nevi L, Overi D, Cardinale V, Lu WY, Di Matteo S, Safarikia S, Berloco PB, Venere R, Onori P, Franchitto A, Forbes SJ, Alvaro D, Gaudio E.

Hepatology. 2019 Jul 22. doi: 10.1002/hep.30871. [Epub ahead of print]


Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.

Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, Gershwin ME, Bernuzzi F, Franchitto A, Alvaro D, Marzioni M, Onori P, Gaudio E, Sybenga A, Fabris L, Meng F, Glaser S, Alpini G.

FASEB J. 2019 Sep;33(9):10269-10279. doi: 10.1096/fj.201802606R. Epub 2019 Jun 28.


RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.

Aiello FA, Palma A, Malacaria E, Zheng L, Campbell JL, Shen B, Franchitto A, Pichierri P.

Nucleic Acids Res. 2019 Jul 26;47(13):6796-6810. doi: 10.1093/nar/gkz431.


Peribiliary gland damage due to liver transplantation involves peribiliary vascular plexus and vascular endothelial growth factor.

Franchitto A, Overi D, Mancinelli R, Mitterhofer AP, Muiesan P, Tinti F, Umbro I, Hubscher SG, Onori P, Gaudio E, Carpino G.

Eur J Histochem. 2019 May 10;63(2). doi: 10.4081/ejh.2019.3022.


Author Correction: Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation.

Malacaria E, Pugliese GM, Honda M, Marabitti V, Aiello FA, Spies M, Franchitto A, Pichierri P.

Nat Commun. 2019 May 1;10(1):2023. doi: 10.1038/s41467-019-10072-9.


Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation.

Malacaria E, Pugliese GM, Honda M, Marabitti V, Aiello FA, Spies M, Franchitto A, Pichierri P.

Nat Commun. 2019 Mar 29;10(1):1412. doi: 10.1038/s41467-019-09196-9. Erratum in: Nat Commun. 2019 May 1;10(1):2023.


ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells.

Marabitti V, Lillo G, Malacaria E, Palermo V, Sanchez M, Pichierri P, Franchitto A.

Nucleic Acids Res. 2019 Apr 23;47(7):3485-3502. doi: 10.1093/nar/gkz025.


Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases.

Overi D, Carpino G, Cardinale V, Franchitto A, Safarikia S, Onori P, Alvaro D, Gaudio E.

Int J Mol Sci. 2018 Sep 25;19(10). pii: E2917. doi: 10.3390/ijms19102917. Review.


The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-β1-Mediated Biliary Senescence.

Wu N, Meng F, Zhou T, Venter J, Giang TK, Kyritsi K, Wu C, Alvaro D, Onori P, Mancinelli R, Gaudio E, Francis H, Alpini G, Glaser S, Franchitto A.

Am J Pathol. 2018 Oct;188(10):2264-2280. doi: 10.1016/j.ajpath.2018.06.015. Epub 2018 Jul 21.


Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes.

Zhou T, Wu N, Meng F, Venter J, Giang TK, Francis H, Kyritsi K, Wu C, Franchitto A, Alvaro D, Marzioni M, Onori P, Mancinelli R, Gaudio E, Glaser S, Alpini G.

Lab Invest. 2018 Nov;98(11):1449-1464. doi: 10.1038/s41374-018-0093-9. Epub 2018 Jul 5.


Phosphorylation by CK2 regulates MUS81/EME1 in mitosis and after replication stress.

Palma A, Pugliese GM, Murfuni I, Marabitti V, Malacaria E, Rinalducci S, Minoprio A, Sanchez M, Mazzei F, Zolla L, Franchitto A, Pichierri P.

Nucleic Acids Res. 2018 Jun 1;46(10):5109-5124. doi: 10.1093/nar/gky280.


Role of lactoferrin and its receptors on biliary epithelium.

Mancinelli R, Olivero F, Carpino G, Overi D, Rosa L, Lepanto MS, Cutone A, Franchitto A, Alpini G, Onori P, Valenti P, Gaudio E.

Biometals. 2018 Jun;31(3):369-379. doi: 10.1007/s10534-018-0094-6. Epub 2018 Mar 17.


CSA and CSB play a role in the response to DNA breaks.

Pascucci B, Fragale A, Marabitti V, Leuzzi G, Calcagnile AS, Parlanti E, Franchitto A, Dogliotti E, D'Errico M.

Oncotarget. 2018 Jan 29;9(14):11581-11591. doi: 10.18632/oncotarget.24342. eCollection 2018 Feb 20.


Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis.

Carpino G, Cardinale V, Folseraas T, Overi D, Floreani A, Franchitto A, Onori P, Cazzagon N, Berloco PB, Karlsen TH, Alvaro D, Gaudio E.

Am J Pathol. 2018 Mar;188(3):627-639. doi: 10.1016/j.ajpath.2017.11.010. Epub 2017 Dec 15.


Laparoscopic Sleeve Gastrectomy Improves Nonalcoholic Fatty Liver Disease-Related Liver Damage in Adolescents by Reshaping Cellular Interactions and Hepatic Adipocytokine Production.

Nobili V, Carpino G, De Peppo F, Caccamo R, Mosca A, Romito I, Overi D, Franchitto A, Onori P, Alisi A, Gaudio E.

J Pediatr. 2018 Mar;194:100-108.e3. doi: 10.1016/j.jpeds.2017.10.036. Epub 2017 Dec 1.


Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.

Wu N, Meng F, Zhou T, Han Y, Kennedy L, Venter J, Francis H, DeMorrow S, Onori P, Invernizzi P, Bernuzzi F, Mancinelli R, Gaudio E, Franchitto A, Glaser S, Alpini G.

FASEB J. 2017 Oct;31(10):4305-4324. doi: 10.1096/fj.201700097R. Epub 2017 Jun 20.


Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.

Kyritsi K, Meng F, Zhou T, Wu N, Venter J, Francis H, Kennedy L, Onori P, Franchitto A, Bernuzzi F, Invernizzi P, McDaniel K, Mancinelli R, Alvaro D, Gaudio E, Alpini G, Glaser S.

Am J Pathol. 2017 Jul;187(7):1551-1565. doi: 10.1016/j.ajpath.2017.03.013. Epub 2017 May 12.


SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells.

Malacaria E, Franchitto A, Pichierri P.

Sci Rep. 2017 Mar 14;7:44464. doi: 10.1038/srep44464.


Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks.

Palermo V, Rinalducci S, Sanchez M, Grillini F, Franchitto A, Pichierri P.

Mol Cell Oncol. 2016 Dec 9;4(1):e1268243. doi: 10.1080/23723556.2016.1268243. eCollection 2017.


WRNIP1: A new guardian of genome integrity at stalled replication forks.

Leuzzi G, Marabitti V, Pichierri P, Franchitto A.

Mol Cell Oncol. 2016 Aug 3;3(5):e1215777. eCollection 2016.


Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease.

Mancinelli R, Franchitto A, Glaser S, Vetuschi A, Venter J, Sferra R, Pannarale L, Olivero F, Carpino G, Alpini G, Onori P, Gaudio E.

Lab Invest. 2016 Nov;96(11):1147-1155. doi: 10.1038/labinvest.2016.93. Epub 2016 Aug 29.


CDK1 phosphorylates WRN at collapsed replication forks.

Palermo V, Rinalducci S, Sanchez M, Grillini F, Sommers JA, Brosh RM Jr, Zolla L, Franchitto A, Pichierri P.

Nat Commun. 2016 Sep 16;7:12880. doi: 10.1038/ncomms12880.


Crosstalk between mismatch repair and base excision repair in human gastric cancer.

Simonelli V, Leuzzi G, Basile G, D'Errico M, Fortini P, Franchitto A, Viti V, Brown AR, Parlanti E, Pascucci B, Palli D, Giuliani A, Palombo F, Sobol RW, Dogliotti E.

Oncotarget. 2016 Jun 20;8(49):84827-84840. doi: 10.18632/oncotarget.10185. eCollection 2017 Oct 17.


Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway.

Carpino G, Nobili V, Renzi A, De Stefanis C, Stronati L, Franchitto A, Alisi A, Onori P, De Vito R, Alpini G, Gaudio E.

PLoS One. 2016 Jun 16;11(6):e0157246. doi: 10.1371/journal.pone.0157246. eCollection 2016.


WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.

Leuzzi G, Marabitti V, Pichierri P, Franchitto A.

EMBO J. 2016 Jul 1;35(13):1437-51. doi: 10.15252/embj.201593265. Epub 2016 May 30.


The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice.

Wu N, Meng F, Invernizzi P, Bernuzzi F, Venter J, Standeford H, Onori P, Marzioni M, Alvaro D, Franchitto A, Gaudio E, Glaser S, Alpini G.

Hepatology. 2016 Sep;64(3):865-79. doi: 10.1002/hep.28622. Epub 2016 Jun 11.


Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration.

Carpino G, Renzi A, Franchitto A, Cardinale V, Onori P, Reid L, Alvaro D, Gaudio E.

Stem Cells Int. 2016;2016:3658013. doi: 10.1155/2016/3658013. Epub 2016 Jan 10. Review.


Progenitor cell niches in the human pancreatic duct system and associated pancreatic duct glands: an anatomical and immunophenotyping study.

Carpino G, Renzi A, Cardinale V, Franchitto A, Onori P, Overi D, Rossi M, Berloco PB, Alvaro D, Reid LM, Gaudio E.

J Anat. 2016 Mar;228(3):474-86. doi: 10.1111/joa.12418. Epub 2015 Nov 27.


Ischemia reperfusion of the hepatic artery induces the functional damage of large bile ducts by changes in the expression of angiogenic factors.

Mancinelli R, Glaser S, Francis H, Carpino G, Franchitto A, Vetuschi A, Sferra R, Pannarale L, Venter J, Meng F, Alpini G, Onori P, Gaudio E.

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G865-73. doi: 10.1152/ajpgi.00015.2015. Epub 2015 Oct 8.


The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.

Iannascoli C, Palermo V, Murfuni I, Franchitto A, Pichierri P.

Nucleic Acids Res. 2015 Nov 16;43(20):9788-803. doi: 10.1093/nar/gkv836. Epub 2015 Aug 14.


Profiles of cancer stem cell subpopulations in cholangiocarcinomas.

Cardinale V, Renzi A, Carpino G, Torrice A, Bragazzi MC, Giuliante F, DeRose AM, Fraveto A, Onori P, Napoletano C, Franchitto A, Cantafora A, Grazi G, Caporaso N, D'Argenio G, Alpini G, Reid LM, Gaudio E, Alvaro D.

Am J Pathol. 2015 Jun;185(6):1724-39. doi: 10.1016/j.ajpath.2015.02.010. Epub 2015 Apr 17.


Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms.

Ray D, Han Y, Franchitto A, DeMorrow S, Meng F, Venter J, McMillin M, Kennedy L, Francis H, Onori P, Mancinelli R, Gaudio E, Alpini G, Glaser SS.

Am J Pathol. 2015 Apr;185(4):1061-72. doi: 10.1016/j.ajpath.2014.12.004.


Expression of brain derivated neurotrophic factor and of its receptors: TrKB and p75NT in normal and bile duct ligated rat liver.

Vivacqua G, Renzi A, Carpino G, Franchitto A, Gaudio E.

Ital J Anat Embryol. 2014;119(2):111-29.


Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis.

Cardinale V, Carpino G, Gentile R, Napoletano C, Rahimi H, Franchitto A, Semeraro R, Nuti M, Onori P, Berloco PB, Rossi M, Bosco D, Brunelli R, Fraveto A, Napoli C, Torrice A, Gatto M, Venere R, Bastianelli C, Aliberti C, Salvatori FM, Bresadola L, Bezzi M, Attili AF, Reid L, Gaudio E, Alvaro D.

BMC Gastroenterol. 2014 Dec 4;14:204. doi: 10.1186/s12876-014-0204-z.


Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.

Basile G, Leuzzi G, Pichierri P, Franchitto A.

Nucleic Acids Res. 2014 Nov 10;42(20):12628-39. doi: 10.1093/nar/gku1022. Epub 2014 Oct 28.


Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology.

Franchitto A, Onori P, Renzi A, Carpino G, Mancinelli R, Alvaro D, Gaudio E.

Ann Transl Med. 2013 Oct;1(3):27. doi: 10.3978/j.issn.2305-5839.2012.10.03. Review.


Replication fork recovery and regulation of common fragile sites stability.

Franchitto A, Pichierri P.

Cell Mol Life Sci. 2014 Dec;71(23):4507-17. doi: 10.1007/s00018-014-1718-9. Epub 2014 Sep 13. Review.


Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.

Han Y, Onori P, Meng F, DeMorrow S, Venter J, Francis H, Franchitto A, Ray D, Kennedy L, Greene J, Renzi A, Mancinelli R, Gaudio E, Glaser S, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2014 Nov 1;307(9):G894-904. doi: 10.1152/ajpgi.00288.2014. Epub 2014 Sep 11.


Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes.

Renzi A, Mancinelli R, Onori P, Franchitto A, Alpini G, Glaser S, Gaudio E.

Hepatobiliary Surg Nutr. 2014 Feb;3(1):4-10. doi: 10.3978/j.issn.2304-3881.2014.01.02.


Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.

Glaser S, Meng F, Han Y, Onori P, Chow BK, Francis H, Venter J, McDaniel K, Marzioni M, Invernizzi P, Ueno Y, Lai JM, Huang L, Standeford H, Alvaro D, Gaudio E, Franchitto A, Alpini G.

Gastroenterology. 2014 Jun;146(7):1795-808.e12. doi: 10.1053/j.gastro.2014.02.030. Epub 2014 Feb 25.


Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases.

Franchitto A, Onori P, Renzi A, Carpino G, Mancinelli R, Alvaro D, Gaudio E.

Hepatobiliary Surg Nutr. 2013 Apr;2(2):68-77. doi: 10.3978/j.issn.2304-3881.2012.10.11.


Evidence for multipotent endodermal stem/progenitor cell populations in human gallbladder.

Carpino G, Cardinale V, Gentile R, Onori P, Semeraro R, Franchitto A, Wang Y, Bosco D, Iossa A, Napoletano C, Cantafora A, D'Argenio G, Nuti M, Caporaso N, Berloco P, Venere R, Oikawa T, Reid L, Alvaro D, Gaudio E.

J Hepatol. 2014 Jun;60(6):1194-202. doi: 10.1016/j.jhep.2014.01.026. Epub 2014 Feb 13.


Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease.

Nobili V, Carpino G, Alisi A, De Vito R, Franchitto A, Alpini G, Onori P, Gaudio E.

PLoS One. 2014 Feb 4;9(2):e88005. doi: 10.1371/journal.pone.0088005. eCollection 2014.


Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.

Murfuni I, Basile G, Subramanyam S, Malacaria E, Bignami M, Spies M, Franchitto A, Pichierri P.

PLoS Genet. 2013 Oct;9(10):e1003910. doi: 10.1371/journal.pgen.1003910. Epub 2013 Oct 31.


Genome instability at common fragile sites: searching for the cause of their instability.

Franchitto A.

Biomed Res Int. 2013;2013:730714. doi: 10.1155/2013/730714. Epub 2013 Sep 5. Review.


Recent advances in the morphological and functional heterogeneity of the biliary epithelium.

Han Y, Glaser S, Meng F, Francis H, Marzioni M, McDaniel K, Alvaro D, Venter J, Carpino G, Onori P, Gaudio E, Alpini G, Franchitto A.

Exp Biol Med (Maywood). 2013 May;238(5):549-65. doi: 10.1177/1535370213489926. Review.


Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms.

DeMorrow S, Meng F, Venter J, Leyva-Illades D, Francis H, Frampton G, Pae HY, Quinn M, Onori P, Glaser S, McDaniel K, Mancinelli R, Gaudio E, Alpini G, Franchitto A.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G250-7. doi: 10.1152/ajpgi.00140.2013. Epub 2013 May 23.


Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease.

Onori P, Mancinelli R, Franchitto A, Carpino G, Renzi A, Brozzetti S, Venter J, Francis H, Glaser S, Jefferson DM, Alpini G, Gaudio E.

Liver Int. 2013 Jul;33(6):914-25. doi: 10.1111/liv.12177. Epub 2013 Apr 25.

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