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Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES).

Balmes JR, Arjomandi M, Bromberg PA, Costantini MG, Dagincourt N, Hazucha MJ, Hollenbeck-Pringle D, Rich DQ, Stark P, Frampton MW.

PLoS One. 2019 Sep 25;14(9):e0222601. doi: 10.1371/journal.pone.0222601. eCollection 2019.


Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization.

Breitner S, Peters A, Zareba W, Hampel R, Oakes D, Wiltshire J, Frampton MW, Hopke PK, Cyrys J, Utell MJ, Kane C, Schneider A, Rich DQ.

Sci Rep. 2019 Feb 13;9(1):1946. doi: 10.1038/s41598-019-38531-9.


Does Breathing Wood Smoke Make the Flu Worse? Sex Might Matter.

Frampton MW.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):940-941. doi: 10.1164/rccm.201810-2030ED. No abstract available.


Influenza Virus Infection of Human Lymphocytes Occurs in the Immune Cell Cluster of the Developing Antiviral Response.

Mock DJ, Frampton MW, Nichols JE, Domurat FM, Signs DJ, Roberts NJ Jr.

Viruses. 2018 Aug 10;10(8). pii: E420. doi: 10.3390/v10080420.


Cardiovascular function and ozone exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES).

Rich DQ, Balmes JR, Frampton MW, Zareba W, Stark P, Arjomandi M, Hazucha MJ, Costantini MG, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg PA.

Environ Int. 2018 Oct;119:193-202. doi: 10.1016/j.envint.2018.06.014. Epub 2018 Jul 4.


Respiratory Responses to Ozone Exposure. MOSES (The Multicenter Ozone Study in Older Subjects).

Arjomandi M, Balmes JR, Frampton MW, Bromberg P, Rich DQ, Stark P, Alexis NE, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha MJ.

Am J Respir Crit Care Med. 2018 May 15;197(10):1319-1327. doi: 10.1164/rccm.201708-1613OC.


Ambient and Controlled Particle Exposures as Triggers for Acute ECG Changes.

Rich DQ, Peters A, Schneider A, Zareba W, Breitner S, Oakes D, Wiltshire J, Kane C, Frampton MW, Hampel R, Hopke PK, Cyrys J, Utell MJ.

Res Rep Health Eff Inst. 2016 May;(186):5-75.


A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework.

Thurston GD, Kipen H, Annesi-Maesano I, Balmes J, Brook RD, Cromar K, De Matteis S, Forastiere F, Forsberg B, Frampton MW, Grigg J, Heederik D, Kelly FJ, Kuenzli N, Laumbach R, Peters A, Rajagopalan ST, Rich D, Ritz B, Samet JM, Sandstrom T, Sigsgaard T, Sunyer J, Brunekreef B.

Eur Respir J. 2017 Jan 11;49(1). pii: 1600419. doi: 10.1183/13993003.00419-2016. Print 2017 Jan.


Does Particle Size Matter? Ultrafine Particles and Hospital Visits in Eastern Europe.

Frampton MW, Rich DQ.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1180-1182. No abstract available.


Human Alveolar Macrophages May Not Be Susceptible to Direct Infection by a Human Influenza Virus.

Ettensohn DB, Frampton MW, Nichols JE, Roberts NJ Jr.

J Infect Dis. 2016 Dec 1;214(11):1658-1665. Epub 2016 Sep 6.


Does total antioxidant capacity modify adverse cardiac responses associated with ambient ultrafine, accumulation mode, and fine particles in patients undergoing cardiac rehabilitation?

Wang M, Utell MJ, Schneider A, Zareba W, Frampton MW, Oakes D, Hopke PK, Wiltshire J, Kane C, Peters A, Breitner S, Chalupa D, Rich DQ.

Environ Res. 2016 Aug;149:15-22. doi: 10.1016/j.envres.2016.04.031. Epub 2016 May 10.


Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study.

Becerra AZ, Georas S, Brenna JT, Hopke PK, Kane C, Chalupa D, Frampton MW, Block R, Rich DQ.

J Toxicol Environ Health A. 2016;79(6):287-98. doi: 10.1080/15287394.2016.1157539. Epub 2016 Mar 30.


Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.

Frampton MW, Pietropaoli A, Dentler M, Chalupa D, Little EL, Stewart J, Frasier L, Oakes D, Wiltshire J, Vora R, Utell MJ.

Inhal Toxicol. 2015 Feb;27(2):113-9. doi: 10.3109/08958378.2014.996272.


Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.

Vora R, Zareba W, Utell MJ, Pietropaoli AP, Chalupa D, Little EL, Oakes D, Bausch J, Wiltshire J, Frampton MW.

Part Fibre Toxicol. 2014 Jul 16;11:31. doi: 10.1186/s12989-014-0031-y.


Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study.

Gardner B, Ling F, Hopke PK, Frampton MW, Utell MJ, Zareba W, Cameron SJ, Chalupa D, Kane C, Kulandhaisamy S, Topf MC, Rich DQ.

Part Fibre Toxicol. 2014 Jan 2;11:1. doi: 10.1186/1743-8977-11-1.


Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes.

Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ.

Inhal Toxicol. 2012 Oct;24(12):831-8. doi: 10.3109/08958378.2012.724117.


Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation?

Rich DQ, Zareba W, Beckett W, Hopke PK, Oakes D, Frampton MW, Bisognano J, Chalupa D, Bausch J, O'Shea K, Wang Y, Utell MJ.

Environ Health Perspect. 2012 Aug;120(8):1162-9. doi: 10.1289/ehp.1104262. Epub 2012 Apr 27. Erratum in: Environ Health Perspect. 2012 Sep;120(9):A345.


Brachial artery reactivity in patients with severe sepsis: an observational study.

Wexler O, Morgan MA, Gough MS, Steinmetz SD, Mack CM, Darling DC, Doolin KP, Apostolakos MJ, Graves BT, Frampton MW, Chen X, Pietropaoli AP.

Crit Care. 2012 Dec 12;16(2):R38. doi: 10.1186/cc11223.


Ozone air pollution: how low can you go?

Frampton MW.

Am J Respir Crit Care Med. 2011 Jul 15;184(2):150-1. doi: 10.1164/rccm.201104-0606ED. No abstract available.


The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis.

Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP.

Crit Care Med. 2011 Jun;39(6):1351-8. doi: 10.1097/CCM.0b013e318212097c.


Vascular effects of ultrafine particles in persons with type 2 diabetes.

Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW.

Environ Health Perspect. 2010 Dec;118(12):1692-8. doi: 10.1289/ehp.1002237. Epub 2010 Sep 7.


Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.

Huang YC, Schmitt M, Yang Z, Que LG, Stewart JC, Frampton MW, Devlin RB.

Inhal Toxicol. 2010 Aug;22(10):835-46. doi: 10.3109/08958378.2010.486419.


Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.

Morgan MA, Frasier LM, Stewart JC, Mack CM, Gough MS, Graves BT, Apostolakos MJ, Doolin KP, Darling DC, Frampton MW, Pietropaoli AP.

Crit Care Med. 2010 Apr;38(4):1069-77. doi: 10.1097/CCM.0b013e3181d16a3e.


Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season.

Hampel R, Breitner S, Rückerl R, Frampton MW, Koenig W, Phipps RP, Wichmann HE, Peters A, Schneider A.

Occup Environ Med. 2010 Jun;67(6):408-16. doi: 10.1136/oem.2009.048660. Epub 2009 Nov 2.


Critical considerations in evaluating scientific evidence of health effects of ambient ozone: a conference report.

McClellan RO, Frampton MW, Koutrakis P, McDonnell WF, Moolgavkar S, North DW, Smith AE, Smith RL, Utell MJ.

Inhal Toxicol. 2009 Sep;21 Suppl 2:1-36. doi: 10.1080/08958370903176735. Review.


NOx--NOx: who's there?

Frampton MW, Greaves IA; ATS Environmental Health Policy Committee.

Am J Respir Crit Care Med. 2009 Jun 15;179(12):1077-8. doi: 10.1164/rccm.200903-0485ED. No abstract available.


ECG parameters and exposure to carbon ultrafine particles in young healthy subjects.

Zareba W, Couderc JP, Oberdörster G, Chalupa D, Cox C, Huang LS, Peters A, Utell MJ, Frampton MW.

Inhal Toxicol. 2009 Feb;21(3):223-33. doi: 10.1080/08958370802492407 .


Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects.

Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang LS, Utell MJ, Frampton MW.

Environ Health Perspect. 2008 Mar;116(3):375-80. doi: 10.1289/ehp.10323.


Does inhalation of ultrafine particles cause pulmonary vascular effects in humans?

Frampton MW.

Inhal Toxicol. 2007;19 Suppl 1:75-9. Review.


Smokers have reduced nitric oxide production by conducting airways but normal levels in the alveoli.

Pietropaoli AP, Perillo IB, Perkins PT, Frasier LM, Speers DM, Frampton MW, Utell MJ, Hyde RW.

Inhal Toxicol. 2007 May;19(6-7):533-41.


Changes in fluorescence intensity of selected leukocyte surface markers following fixation.

Stewart JC, Villasmil ML, Frampton MW.

Cytometry A. 2007 Jun;71(6):379-85.


Changes in markers of epithelial permeability and inflammation in chronic smokers switching to a nonburning tobacco device (Eclipse).

Stewart JC, Hyde RW, Boscia J, Chow MY, O'Mara RE, Perillo I, Pietropaoli A, Smith CJ, Torres A, Utell MJ, Frampton MW.

Nicotine Tob Res. 2006 Dec;8(6):773-83.


Inflammation and airborne particles.

Frampton MW.

Clin Occup Environ Med. 2006;5(4):797-815. Review.


Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans.

Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ.

Environ Health Perspect. 2006 Jan;114(1):51-8.


Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma.

Frampton MW, Utell MJ, Zareba W, Oberdörster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J.

Res Rep Health Eff Inst. 2004 Dec;(126):1-47; discussion 49-63.


Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study.

Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang LS, Cox C, Zareba W, Oberdörster G.

Am J Respir Crit Care Med. 2005 May 15;171(10):1129-35. Epub 2005 Feb 25.


Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles.

Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ.

Inhal Toxicol. 2004;16 Suppl 1:59-72.


Ultrafine particle deposition in subjects with asthma.

Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW.

Environ Health Perspect. 2004 Jun;112(8):879-82.


Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.

Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT.

Inflammation. 2003 Jun;27(3):137-45.


Ultrafine particle deposition in humans during rest and exercise.

Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW.

Inhal Toxicol. 2003 May;15(6):539-52.


Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing.

Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE.

Inhal Toxicol. 2002 Dec;14(12):1231-47.


Nitrogen dioxide exposure: effects on airway and blood cells.

Frampton MW, Boscia J, Roberts NJ Jr, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ.

Am J Physiol Lung Cell Mol Physiol. 2002 Jan;282(1):L155-65.


Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans.

Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE 2nd, Utell MJ, Frampton MW.

J Appl Physiol (1985). 2001 Nov;91(5):1931-40.


Neutrophils in lung inflammation: Which reactive oxygen species are being measured?

Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW.

Inhal Toxicol. 2001 Jun;13(6):485-95.


Ozone exposure and the production of reactive oxygen species by bronchoalveolar cells in humans.

Voter KZ, Whitin JC, Torres A, Morrow PE, Cox C, Tsai Y, Utell MJ, Frampton MW.

Inhal Toxicol. 2001 Jun;13(6):465-83.


Acute health effects of ambient air pollution: the ultrafine particle hypothesis.

Utell MJ, Frampton MW.

J Aerosol Med. 2000 Winter;13(4):355-59.


Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung.

Avissar NE, Reed CK, Cox C, Frampton MW, Finkelstein JN.

Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1342-7.


Toxicologic methods: controlled human exposures.

Utell MJ, Frampton MW.

Environ Health Perspect. 2000 Aug;108 Suppl 4:605-13. Review.


Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure.

Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ.

Res Rep Health Eff Inst. 1999 Nov;(90):1-15; discussion 17-8.


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